LOCUS       NM_001191099            2183 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 5, group A, member 1
            (Nr5a1), mRNA.
ACCESSION   NM_001191099 XM_001072904
VERSION     NM_001191099.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Ma,B., Qiao,H., Guo,Y., Wei,J., Yang,Q., Feng,X. and Li,Z.
  TITLE     TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and
            LRH-1-dependent CYP19 expression in rat Leydig cellsdagger
  JOURNAL   Biol Reprod 108 (5), 778-790 (2023)
   PUBMED   36857632
  REMARK    GeneRIF: TGF-beta1 induced activations of Smad2 and miRNAs inhibit
            SF-1- and LRH-1-dependent CYP19 expression in rat Leydig
            cellsdagger.
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Ameli,M., Moghimian,M., Saeb,F., Bashtani,E., Shokoohi,M.,
            Salimnejad,R. and Abtahi,H.
  TITLE     The effect of clomiphene citrate and human chorionic gonadotropin
            on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as
            well as the structural changes in testicular tissue of adult rats
  JOURNAL   Mol Reprod Dev 86 (6), 738-748 (2019)
   PUBMED   31041823
  REMARK    GeneRIF: The effect of clomiphene citrate and human chorionic
            gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and
            SF1 genes, as well as the structural changes in testicular tissue
            of adult rats.
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Zielinska-Gorska,M., Gorski,K., Biernacka,K., Sawosy,E.,
            Kaminska,T. and Gajewska,A.
  TITLE     Gonadotropin-releasing hormone and kisseptin-10 regulate nuclear
            receptor subfamily 5 group a member 1/catenin beta 1/ nuclear
            receptor subfamily 0 group B member 1 activity in female rat
            anterior pituitary gland
  JOURNAL   J Physiol Pharmacol 69 (3) (2018)
   PUBMED   30342431
  REMARK    GeneRIF: In conclusion, the presented data revealed that the
            pituitary Nr5a1/Ctnnb1/Nr0b1 system is controlled by endogenous
            Gnrh network activity, and hypothalamic-derived regulatory inputs
            can affect the processes responsible for gene transcription,
            translation, and protein intracellular translocation.
REFERENCE   4  (bases 1 to 2183)
  AUTHORS   Wang,W., Sun,Y., Guo,Y., Cai,P., Li,Y., Liu,J., Cai,G., Kiyoshi,A.
            and Zhang,W.
  TITLE     Continuous soy isoflavones exposure from weaning to maturity
            induces downregulation of ovarian steroidogenic factor 1 gene
            expression and corresponding changes in DNA methylation pattern
  JOURNAL   Toxicol Lett 281, 175-183 (2017)
   PUBMED   28964809
  REMARK    GeneRIF: DNA methylation might play a role in the downregulation of
            SF-1 gene expression induced by soy isoflavones.
REFERENCE   5  (bases 1 to 2183)
  AUTHORS   Swartz,J.M., Ciarlo,R., Guo,M.H., Abrha,A., Weaver,B.,
            Diamond,D.A., Chan,Y.M. and Hirschhorn,J.N.
  TITLE     A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by
            a Steroidogenic Factor-1 (NR5A1) Variant
  JOURNAL   Horm Res Paediatr 87 (3), 191-195 (2017)
   PUBMED   27855412
REFERENCE   6  (bases 1 to 2183)
  AUTHORS   Kabe,Y., Goto,M., Shima,D., Imai,T., Wada,T., Morohashi,Ki.,
            Shirakawa,M., Hirose,S. and Handa,H.
  TITLE     The role of human MBF1 as a transcriptional coactivator
  JOURNAL   J Biol Chem 274 (48), 34196-34202 (1999)
   PUBMED   10567391
REFERENCE   7  (bases 1 to 2183)
  AUTHORS   Kawabe,K., Shikayama,T., Tsuboi,H., Oka,S., Oba,K., Yanase,T.,
            Nawata,H. and Morohashi,K.
  TITLE     Dax-1 as one of the target genes of Ad4BP/SF-1
  JOURNAL   Mol Endocrinol 13 (8), 1267-1284 (1999)
   PUBMED   10446902
REFERENCE   8  (bases 1 to 2183)
  AUTHORS   Achermann,J.C., Ito,M., Ito,M., Hindmarsh,P.C. and Jameson,J.L.
  TITLE     A mutation in the gene encoding steroidogenic factor-1 causes XY
            sex reversal and adrenal failure in humans
  JOURNAL   Nat Genet 22 (2), 125-126 (1999)
   PUBMED   10369247
REFERENCE   9  (bases 1 to 2183)
  AUTHORS   Nomura,M., Bartsch,S., Nawata,H., Omura,T. and Morohashi,K.
  TITLE     An E box element is required for the expression of the ad4bp gene,
            a mammalian homologue of ftz-f1 gene, which is essential for
            adrenal and gonadal development
  JOURNAL   J Biol Chem 270 (13), 7453-7461 (1995)
   PUBMED   7706291
REFERENCE   10 (bases 1 to 2183)
  AUTHORS   Lynch,J.P., Lala,D.S., Peluso,J.J., Luo,W., Parker,K.L. and
            White,B.A.
  TITLE     Steroidogenic factor 1, an orphan nuclear receptor, regulates the
            expression of the rat aromatase gene in gonadal tissues
  JOURNAL   Mol Endocrinol 7 (6), 776-786 (1993)
   PUBMED   8395654
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_001191099.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001191099.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JACYVU010000115.1  15943021-15943149   c
            130-246             JACYVU010000115.1  15939379-15939495   c
            247-388             JACYVU010000115.1  15939133-15939274   c
            389-1017            JACYVU010000115.1  15936645-15937273   c
            1018-1137           JACYVU010000115.1  15930873-15930992   c
            1138-1285           JACYVU010000115.1  15929068-15929215   c
            1286-2183           JACYVU010000115.1  15922323-15923220   c
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2183
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /note="nuclear receptor subfamily 5, group A, member 1"
                     /db_xref="GeneID:83826"
                     /db_xref="RGD:68350"
     exon            1..129
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..246
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1533
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /note="STF-1; adrenal 4-binding protein; fushi tarazu
                     factor homolog 1; steroid hormone receptor Ad4BP"
                     /codon_start=1
                     /product="steroidogenic factor 1"
                     /protein_id="NP_001178028.1"
                     /db_xref="GeneID:83826"
                     /db_xref="RGD:68350"
                     /translation="MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNN
                     KHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRD
                     RALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGP
                     LGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPF
                     SGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFIS
                     IVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVEL
                     STVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVK
                     DAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRN
                     NLLIEMLQAKQT"
     exon            247..388
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..1017
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1137
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1285
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2183
                     /gene="Nr5a1"
                     /gene_synonym="Ad4bp; Ad4BP/SF-1; Ftzf1; Sf-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgctgg gggaagaagt tcctgacagc ccgatagcca ctgccctacc tggggcctgg
       61 gaacctcccc accaggaccc tggtgcccag tgtccaccct tatccggctg agaattctcc
      121 ttccgttcag cggacgccgc gggcatggac tattcgtacg acgaggacct ggacgagctg
      181 tgtccagtgt gtggtgacaa ggtgtcgggc taccactacg ggctgctcac gtgcgagagc
      241 tgcaagggct tcttcaagcg cacagtccag aacaacaagc attacacgtg caccgagagt
      301 cagagctgca aaatcgacaa gacgcagcgt aagcgctgtc ccttctgccg cttccagaag
      361 tgcctgacgg tgggcatgcg cctggaagct gtgcgtgctg atcgaatgcg gggcggccgg
      421 aacaagtttg ggcccatgta caagagagac cgggccttga agcagcagaa gaaagcacag
      481 attcgggcca atggcttcaa actggagacc ggaccaccga tgggggttcc cccgccaccc
      541 cctcccccac cggactacat gttaccccct agcctgcatg caccggagcc caaggccctg
      601 gtctctggcc cacccagtgg gccgctgggt gactttggag ccccatctct gcccatggcc
      661 gtgcctggtc cccacgggcc tctggctggc tacctctatc ctgccttctc taaccgcacc
      721 atcaagtctg agtatccaga gccctacgcc agcccccctc aacagccagg gccaccctac
      781 agctatccgg agcccttctc aggagggccc aatgtaccag agctcatatt gcagctgctg
      841 caactagagc cagaggagga ccaggtgcgt gctcgcatcg tgggctgcct gcaggagcca
      901 gccaaaagcc gccctgacca gccagcgccc ttcagcctcc tctgcaggat ggcggaccag
      961 acctttatct ccattgtcga ctgggcacga aggtgcatgg tatttaagga gctggaggtg
     1021 gctgaccaga tgacactgct gcagaactgc tggagtgagc tgctggtgct ggaccacatc
     1081 taccgccagg tccagtacgg caaggaagac agcatcttgc tggtcactgg acaggaggtg
     1141 gagctgagca cggtggctgt gcaggctggc tccctgctgc acagcctggt gctgcgggca
     1201 caggagttgg tgctgcagct gcatgccctg caactggacc gccaggagtt tgtctgtctc
     1261 aagttcctca tcctcttcag cctcgatgtg aaattcctga acaaccacag cctggtaaag
     1321 gacgcccagg agaaggccaa cgccgccctg ctggattaca ccttgtgtca ctacccacac
     1381 tgcggggaca aattccagca gttgctattg tgcctggtgg aggtgcgggc actgagcatg
     1441 caggccaagg agtatctgta ccataagcat ttgggcaacg agatgccccg caacaacctt
     1501 ctcattgaga tgctgcaggc caagcagact tgagcctggg tgccaggcag cgggcagtag
     1561 gcagggatgc cactgcctcc aaaagactcc ttgcattagg tgatccagga gccctgtccc
     1621 taagcccctg cccctgagct ccagagctgt gtgtttggga tgatgggcaa ggatgggcgg
     1681 ggactgcccg ggacaggttg ccttcgctag ccactggcat gtgtctgcca cttggagtgc
     1741 cccagagggg tgacttctaa ccactccttc ctccgtctgc ccccagcttt ttttcctggt
     1801 atctgaggtc ccaggaggag gcttgggatt ccttggtggg cctgaatgtc tgttgggtca
     1861 gaggtcatcc tttccctctc tcctgtgatc agaggcagag gaaggtctgt aggcatcaat
     1921 gaaggcaggg gagggggggt ctccagactc ccctgaagca gggaaggaag tccactattg
     1981 caaactgagt ttgctaaatt gggtctctag aggacaccat gagagcggat agggcaaaaa
     2041 gaccccctcc agcccccccc cccccatcta attctgatcc actccctgga aagggacttt
     2101 gttgtgatca tccttttcct gcatcccagc tacccaagga ggaggaggag tctggccctg
     2161 ccctccacca gctggctggg ctg
//
