LOCUS       NM_031628               4401 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 4, group A, member 3
            (Nr4a3), mRNA.
ACCESSION   NM_031628
VERSION     NM_031628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4401)
  AUTHORS   Terashima,R., Laoharatchatathanin,T., Kurusu,S. and Kawaminami,M.
  TITLE     Sequential preovulatory expression of a gonadotropin-releasing
            hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the
            pituitary gland of female rats
  JOURNAL   J Reprod Dev 67 (3), 217-221 (2021)
   PUBMED   33840679
  REMARK    GeneRIF: Sequential preovulatory expression of a
            gonadotropin-releasing hormone-inducible gene, Nr4a3, and its
            suppressor Anxa5 in the pituitary gland of female rats.
REFERENCE   2  (bases 1 to 4401)
  AUTHORS   Reynolds,M.S., Hancock,C.R., Ray,J.D., Kener,K.B., Draney,C.,
            Garland,K., Hardman,J., Bikman,B.T. and Tessem,J.S.
  TITLE     beta-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes
            mitochondrial respiration and insulin secretion
  JOURNAL   Am J Physiol Endocrinol Metab 311 (1), E186-E201 (2016)
   PUBMED   27221116
  REMARK    GeneRIF: Loss of Nr4a1 and Nr4a3 impedes production of ATP and
            ultimately inhibits glucose-stimulated insulin secretion. These
            data demonstrate for the first time that the orphan nuclear
            receptors Nr4a1 and Nr4a3 are critical for beta-cell mitochondrial
            function and insulin secretion.
REFERENCE   3  (bases 1 to 4401)
  AUTHORS   Medunjanin,S., Daniel,J.M., Weinert,S., Dutzmann,J., Burgbacher,F.,
            Brecht,S., Bruemmer,D., Kahne,T., Naumann,M., Sedding,D.G.,
            Zuschratter,W. and Braun-Dullaeus,R.C.
  TITLE     DNA-dependent protein kinase (DNA-PK) permits vascular smooth
            muscle cell proliferation through phosphorylation of the orphan
            nuclear receptor NOR1
  JOURNAL   Cardiovasc Res 106 (3), 488-497 (2015)
   PUBMED   25852083
REFERENCE   4  (bases 1 to 4401)
  AUTHORS   Feng,X.J., Gao,H., Gao,S., Li,Z., Li,H., Lu,J., Wang,J.J.,
            Huang,X.Y., Liu,M., Zou,J., Ye,J.T. and Liu,P.Q.
  TITLE     The orphan receptor NOR1 participates in isoprenaline-induced
            cardiac hypertrophy by regulating PARP-1
  JOURNAL   Br J Pharmacol 172 (11), 2852-2863 (2015)
   PUBMED   25625556
REFERENCE   5  (bases 1 to 4401)
  AUTHORS   Zhao,Y., Nomiyama,T., Findeisen,H.M., Qing,H., Aono,J., Jones,K.L.,
            Heywood,E.B. and Bruemmer,D.
  TITLE     Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by
            histone acetylation
  JOURNAL   FEBS Lett 588 (24), 4825-4830 (2014)
   PUBMED   25451221
  REMARK    GeneRIF: mechanisms of NOR1 regulation
REFERENCE   6  (bases 1 to 4401)
  AUTHORS   Cheng,L.E., Chan,F.K., Cado,D. and Winoto,A.
  TITLE     Functional redundancy of the Nur77 and Nor-1 orphan steroid
            receptors in T-cell apoptosis
  JOURNAL   EMBO J 16 (8), 1865-1875 (1997)
   PUBMED   9155013
REFERENCE   7  (bases 1 to 4401)
  AUTHORS   Zetterstrom,R.H., Solomin,L., Mitsiadis,T., Olson,L. and
            Perlmann,T.
  TITLE     Retinoid X receptor heterodimerization and developmental expression
            distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
  JOURNAL   Mol Endocrinol 10 (12), 1656-1666 (1996)
   PUBMED   8961274
REFERENCE   8  (bases 1 to 4401)
  AUTHORS   Petropoulos,I., Part,D., Ochoa,A., Zakin,M.M. and Lamas,E.
  TITLE     NOR-2 (neuron-derived orphan receptor), a brain zinc finger
            protein, is highly induced during liver regeneration
  JOURNAL   FEBS Lett 372 (2-3), 273-278 (1995)
   PUBMED   7556683
REFERENCE   9  (bases 1 to 4401)
  AUTHORS   Ohkura,N., Hijikuro,M., Yamamoto,A. and Miki,K.
  TITLE     Molecular cloning of a novel thyroid/steroid receptor superfamily
            gene from cultured rat neuronal cells
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1959-1965 (1994)
   PUBMED   7811288
REFERENCE   10 (bases 1 to 4401)
  AUTHORS   Pena de Ortiz,S., Cannon,M.M. and Jamieson,G.A. Jr.
  TITLE     Expression of nuclear hormone receptors within the rat hippocampus:
            identification of novel orphan receptors
  JOURNAL   Brain Res Mol Brain Res 23 (3), 278-283 (1994)
   PUBMED   7914660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On May 1, 2024 this sequence was replaced by NM_031628.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031628.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38530.1, DQ268830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               JAXUCZ010000005.1  67157198-67157720
            524-703             JAXUCZ010000005.1  67160945-67161124
            704-1662            JAXUCZ010000005.1  67163219-67164177
            1663-1792           JAXUCZ010000005.1  67167904-67168033
            1793-1965           JAXUCZ010000005.1  67168504-67168676
            1966-2165           JAXUCZ010000005.1  67179424-67179623
            2166-2344           JAXUCZ010000005.1  67182850-67183028
            2345-4401           JAXUCZ010000005.1  67194985-67197041
FEATURES             Location/Qualifiers
     source          1..4401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4401
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /note="nuclear receptor subfamily 4, group A, member 3"
                     /db_xref="GeneID:58853"
                     /db_xref="RGD:61882"
     exon            1..523
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..703
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1662
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             706..2592
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /note="neuron-derived orphan receptor 1; neuron-derived
                     orphan receptor 1/2; nuclear hormone receptor NOR-1/NOR-2"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 3"
                     /protein_id="NP_113816.1"
                     /db_xref="GeneID:58853"
                     /db_xref="RGD:61882"
                     /translation="MPCVQAQYSPSPPGSTYATQTYGSEYTTEIMNPDYAKLTMDLGS
                     TGIMATATTSLPSFSTFMEGYPSSCELKPSCLYQMPPSGPRPLIKMEEGREHGYHHHH
                     HHHHHHHHHHQQQQPSIPPPSGPEDEVLPSTSMYFKQSPPSTPTTPGFPPQAGALWDD
                     ELPSAPGCIAPGPLLDPQMKAVPPMAAAARFPIFFKPSPPHPPAPSPAGGHHLGYDPT
                     AAAALSLPLGAAAAAGSQAAALEGHPYGLPLAKRTATLTFPPLGLTASPTASSLLGES
                     PSLPSPPNRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANK
                     NCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPS
                     PPSPPICMMNALVRALTDATPRDLDYSRYCPTDQATAGTDAEHVQQFYNLLTASIDVS
                     RSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQC
                     LRGFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITS
                     SLKDHQRKGQALEPSEPKVLRALVELRKICTQGLQRIFYLKLEDLVSPPSVIDKLFLD
                     TLPF"
     exon            1663..1792
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1965
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2165
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2344
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..4401
                     /gene="Nr4a3"
                     /gene_synonym="NOR-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagtctcc tgcctcccgc cccccacccc tccagcgcct gctcctcctc cgctccccat
       61 acacagacac gctcacaccc gctccttcac ttgcacacac agacacacgc gcgctcacac
      121 gctccgcaca cacactccac tctctcccgc gcgctcacac ccctctctct cggcgccctc
      181 gccggtgtcg cgccgcgccg cgccgcgccg cagccggacg cccctccagg gctcactttg
      241 caacgctgac agagcgggca gtggccgtgg aggtgggaaa cgtggcgaca tcctagcccc
      301 tggtcgcagc cggagactgg acgcctgcgg aacctctcgg cggcgctctc ccatgagttg
      361 ggatcgcagc atccccagcc agccgctgct caccgcctct gggagccgct gggtttgtgc
      421 accgcagccc ttccgggaca gcagctgtga ctctccccca atccagattt cggggtcgct
      481 ctctagaaac tcgctctaaa gacggaacct ccacagaacc caaagcccac tgcgggagag
      541 cgcagcccga caagcccggg cgctgagcct ggaccctcaa cagagcgggc cagcacagcg
      601 gcggcggctg cttcgcctat cccgacgtcc ccgcctccta cactctcagc ctccgctgga
      661 gagaccccca gccccaccat tcagcgcgca agataccctc cagatatgcc ctgcgtgcaa
      721 gcccaatata gcccttcgcc tccggggtcc acttatgcca cgcagactta tggctcggaa
      781 tacaccacag aaatcatgaa ccccgactat gccaagctga ccatggacct cggtagcacg
      841 gggatcatgg ccacggccac gacgtccctg cccagcttca gtaccttcat ggagggctac
      901 cccagcagct gcgaactcaa gccctcctgc ctgtaccaaa tgccgccttc tgggcctcgg
      961 cctttgatca agatggaaga gggtcgcgag catggctacc accaccacca ccaccatcac
     1021 catcatcatc accaccacca ccagcagcag cagccgtcca ttcctcctcc ctctggcccc
     1081 gaggacgagg tactgcccag cacctccatg tacttcaagc agtctccgcc gtctacgccg
     1141 accactccag gcttcccccc gcaggcgggg gcgctgtggg acgacgagct gccctctgcg
     1201 cctggctgca tcgctccggg accgctgctg gacccgcaga tgaaggcagt gcccccaatg
     1261 gccgctgctg cgcgcttccc gatcttcttc aagccctcac cgccacaccc tcccgcgccc
     1321 agcccagccg gcggccacca cctgggctat gaccccacgg ccgcagctgc gctcagtcta
     1381 cccctgggag ccgcggccgc cgcgggcagc caagctgctg cgctcgaggg ccatccgtac
     1441 gggctcccgc tggccaagag gacggccacg ttgaccttcc ctccgctggg cctcacagcg
     1501 tcccctaccg cgtccagcct gctgggagag agccccagcc taccatcgcc acccaatagg
     1561 agctcatcat ccggcgaggg cacgtgtgct gtgtgcgggg acaatgctgc ctgccagcac
     1621 tacggagtcc gcacctgcga gggctgcaag ggcttcttca agagaacggt gcagaaaaac
     1681 gcaaaatatg tttgcttggc aaataaaaac tgcccggtag acaagagacg tcgaaatcga
     1741 tgtcagtact gcaggtttca gaagtgtctc agtgtcggga tggtgaagga agttgtgcgt
     1801 acagatagtc tgaaagggag gagaggtcgt ctgccttcca aaccaaagag cccactacaa
     1861 caggagccct cgcagccctc cccaccatct cctccgatct gtatgatgaa cgcccttgtc
     1921 cgagctttaa cagacgcaac gcccagagac cttgattact ccagatactg tcccaccgac
     1981 caggccactg cgggcacaga cgctgagcac gtgcagcagt tctacaacct tctgacggcc
     2041 tccatcgacg tgtccagaag ctgggcagaa aagatccccg gattcactga tctccccaaa
     2101 gaagatcaga cgttacttat agaatcagcc tttttggagc tgttcgttct tagactttct
     2161 atcaggtcaa acactgctga agataagttt gtgttctgca atggacttgt cctgcaccga
     2221 cttcagtgcc ttcgcggatt tggggagtgg ctcgactcca ttaaagactt ttctttaaat
     2281 ttgcagagcc tgaaccttga tatccaagcc ttagcctgcc tgtcagcact gagtatgatc
     2341 acagagcgac atgggttaaa agaaccaaag agagtggagg agctatgcaa caagatcaca
     2401 agcagcttaa aggaccacca gaggaaggga caggctctgg agccctcaga gcccaaggtc
     2461 ctgcgcgcac tggtggaact gaggaagatc tgcacccagg gcctccagcg catcttctac
     2521 ctgaagctgg aggacttggt gtccccacct tctgtcatcg acaagctctt ccttgatacc
     2581 ctgcctttct gagcagggga agcctgagca gagagctact tgctctgctg gcactggtca
     2641 ttaagtgagc aaaaggatgg gtttgaacac ctgcccctct atccttcctc caggggaaaa
     2701 agcagctccc atagaaagca aagacttttt tttttttcct ggcacctttc cttacaacct
     2761 aaagccagaa accttgcaga gtattgtgtt ggggttgtgt tttatattta ggctttggtg
     2821 ggtgggctgg gagggggtaa aatagttcat gaggcttttc taagaaattg ctgacgaagc
     2881 acttttggat gatgctatcc cagcagtggg gtggggagaa aggataatat aactgtttta
     2941 aaaactcttt ccgggggaat atgactatgg ttgctttgta tttaaaaata agaacagcca
     3001 agggctgttt accagggtag ggctgtgtct taagactgat ccctttagta tgtacttccc
     3061 ggatcgaggc acataagtgg tgcaaatgag gcggggaaat tcttcatttc ttcatttctt
     3121 tcttcttctt aaaataaaat ggcaaaaaaa aaaagatgga agattatcta caaatcagac
     3181 ttagcaaaat gataatggct attcgcttcc acatacaagt gcaatttttt agagtgctgt
     3241 cttactaagt cttgtttgtg aactctccct cattttatat gaaaataaga aggaggcagt
     3301 catgttatca aacggcgtgc tcattttcct agctcaccct tggtccacct gccctgtaga
     3361 acccttcgga ggtatggccc ttctaagact ttcaggccac tcttgatgga attcgacacc
     3421 cctcccccca acccatgact atccagatgt cctgaagggg gatcaggtta taaaatggat
     3481 tgcatatgac tgtgttcgct gtgtgtttgt caacctggac agagttctct aaaccttctt
     3541 tagttgtagc aagttcctga ttcctccatt cagaagccca aggagcattg ggtgactcga
     3601 tcaagggtta accctaggag aacatgcaaa taagtaggaa ctgggtcaga cagggtaagc
     3661 accagagatg ataaggattt atatataaat atatataaaa ttaatttttg ttattggtta
     3721 tagacaattt tggaaagcaa gagaatcatc tctttttttt tttaaagagg aaaagatagt
     3781 attgatgtat tagcaaagat tagtgggtta cggttcaaca ttccgtgttt gtgccccctt
     3841 ttctatgttt ctactgttga tggcatatta ttatgaaatg attcgttgca tagtgtcctt
     3901 atttgtatga acatttgtat gcacgttcta ttgtaatcgc tttgcctgta tttattgcaa
     3961 gaccaccagc tcctggaggc tgagttacag aataatcaaa tggggtgttc gtggtgactt
     4021 ggatacaccg gttagaaatt aaataagcat atatatatat aaaaacatag caggttacat
     4081 atatatttat aatgtgtctt tttattaacc atttgtacaa taaatgtcac ttcccacgca
     4141 gttattttat cctttgtttg cagtgacctt taaggcagca ctgtttagca ctttgatatg
     4201 aaatttttgc ttatgttttg ctaaattcaa ataacgtttg aagattttta ggtctaaaag
     4261 tctttatatt atatactctg tatcaagtca agataccttt ggccgttttg ctaagactca
     4321 aactttgaat gtcaaaccaa tgtcacggta gcttctgtta gcttttaatc atttttgctt
     4381 tagtcttttt ttttaaaaaa a
//
