LOCUS       NM_019328               2582 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 4, group A, member 2
            (Nr4a2), mRNA.
ACCESSION   NM_019328
VERSION     NM_019328.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Gao,J., Wang,Y., Jia,Z., Xue,J., Zhou,T. and Zu,G.
  TITLE     (-)-Epigallocatechin-3-gallate promotes intestinal epithelial
            proliferation and barrier function after ischemia/reperfusion
            injury via activation of Nurr1
  JOURNAL   Pharm Biol 61 (1), 1310-1317 (2023)
   PUBMED   37621064
  REMARK    GeneRIF: (-)-Epigallocatechin-3-gallate promotes intestinal
            epithelial proliferation and barrier function after
            ischemia/reperfusion injury via activation of Nurr1.
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Hu,D., Xie,X. and Zhang,H.
  TITLE     [Protective effect of nuclear receptor related 1 (Nurr1) on nerves
            in rats with cerebral occlusion/reperfusion injury and its
            mechanism]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (3), 231-236 (2022)
   PUBMED   35365988
  REMARK    GeneRIF: [Protective effect of nuclear receptor related 1 (Nurr1)
            on nerves in rats with cerebral occlusion/reperfusion injury and
            its mechanism].
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Miao,H., Li,X., Zhou,C., Liang,Y., Li,D. and Ji,Q.
  TITLE     NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats
            by transcriptionally suppressing CCR5 and inducing M2 polarization
            of macrophages
  JOURNAL   Microvasc Res 140, 104279 (2022)
   PUBMED   34774582
  REMARK    GeneRIF: NR4A2 alleviates cardiomyocyte loss and myocardial injury
            in rats by transcriptionally suppressing CCR5 and inducing M2
            polarization of macrophages.
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Gao,H., Wang,D., Jiang,S., Mao,J. and Yang,X.
  TITLE     NF-kappaB is negatively associated with Nurr1 to reduce the
            inflammatory response in Parkinson's disease
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33864663
  REMARK    GeneRIF: NFkappaB is negatively associated with Nurr1 to reduce the
            inflammatory response in Parkinson's disease.
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Rajan,S., Jang,Y., Kim,C.H., Kim,W., Toh,H.T., Jeon,J., Song,B.,
            Serra,A., Lescar,J., Yoo,J.Y., Beldar,S., Ye,H., Kang,C., Liu,X.W.,
            Feitosa,M., Kim,Y., Hwang,D., Goh,G., Lim,K.L., Park,H.M.,
            Lee,C.H., Oh,S.F., Petsko,G.A., Yoon,H.S. and Kim,K.S.
  TITLE     PGE1 and PGA1 bind to Nurr1 and activate its transcriptional
            function
  JOURNAL   Nat Chem Biol 16 (8), 876-886 (2020)
   PUBMED   32451509
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Pena de Ortiz,S. and Jamieson,G.A. Jr.
  TITLE     HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT:
            induction upon membrane depolarization and seizures
  JOURNAL   Brain Res Mol Brain Res 38 (1), 1-13 (1996)
   PUBMED   8737662
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Mages,H.W., Rilke,O., Bravo,R., Senger,G. and Kroczek,R.A.
  TITLE     NOT, a human immediate-early response gene closely related to the
            steroid/thyroid hormone receptor NAK1/TR3
  JOURNAL   Mol Endocrinol 8 (11), 1583-1591 (1994)
   PUBMED   7877627
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Pena de Ortiz,S., Cannon,M.M. and Jamieson,G.A. Jr.
  TITLE     Expression of nuclear hormone receptors within the rat hippocampus:
            identification of novel orphan receptors
  JOURNAL   Brain Res Mol Brain Res 23 (3), 278-283 (1994)
   PUBMED   7914660
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Scearce,L.M., Laz,T.M., Hazel,T.G., Lau,L.F. and Taub,R.
  TITLE     RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is
            rapidly induced in regenerating liver
  JOURNAL   J Biol Chem 268 (12), 8855-8861 (1993)
   PUBMED   8473329
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   Law,S.W., Conneely,O.M., DeMayo,F.J. and O'Malley,B.W.
  TITLE     Identification of a new brain-specific transcription factor, NURR1
  JOURNAL   Mol Endocrinol 6 (12), 2129-2135 (1992)
   PUBMED   1491694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L08595.1, DQ092633.1, CB606493.1 and AW534944.1.
            
            On Oct 11, 2005 this sequence version replaced NM_019328.2.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, F344 and Sprague-Dawley, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L08595.1, U01146.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-653               L08595.1           1-653
            654-1908            DQ092633.1         421-1675
            1909-2345           L08595.1           1906-2342
            2346-2570           CB606493.1         1-225               c
            2571-2582           AW534944.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2582
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /note="nuclear receptor subfamily 4, group A, member 2"
                     /db_xref="GeneID:54278"
                     /db_xref="RGD:3202"
     exon            1..109
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..975
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1908
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /note="nuclear receptor subfamily 4 group A member 2
                     variant NURR1c; nuclear receptor subfamily 4 group A
                     member 2 variant NURR2c; nuclear receptor subfamily 4
                     group A member 2 variant NURR1a; nuclear receptor
                     subfamily 4 group A member 2 variant NURR1b; nuclear
                     receptor subfamily 4 group A member 2 variant TINUR;
                     RNR-1; SL-322; NUR-related factor 1; nuclear orphan
                     receptor HZF-3; orphan nuclear receptor NURR1;
                     regenerating liver nuclear receptor 1; nur related protein
                     1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 2"
                     /protein_id="NP_062201.2"
                     /db_xref="GeneID:54278"
                     /db_xref="RGD:3202"
                     /translation="MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSM
                     DLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQ
                     HSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPGFQVQHSPMWDDPGSLHNFHQNYVATT
                     HMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTF
                     AVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYG
                     VRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVR
                     TDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPD
                     YQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLR
                     LAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAA
                     LAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLC
                     TQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF"
     exon            976..1105
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1269
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1472
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1651
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..2572
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
     polyA_site      2572
                     /gene="Nr4a2"
                     /gene_synonym="Nurr1; RNR1"
ORIGIN      
        1 tggatcccca aattgctttt taaaaaatat cttggaaact ttgtcctttg ctgaattacg
       61 acactgtcca cctttaattt cctcgaaaac tccaatcact cggctgaagc catgccttgt
      121 gttcaggcgc agtatgggtc ctcgcctcaa ggagccagcc ccgcttctca gagctacagt
      181 taccactctt cgggagaata cagctccgat ttcttaactc cagagtttgt caagtttagc
      241 atggacctca ccaacactga aattactgcc accacttctc tccccagctt cagtaccttt
      301 atggacaact acagcacagg ctacgacgtc aagccacctt gcttgtacca aatgcccctg
      361 tccggacagc agtcctccat taaggtagaa gacattcaga tgcacaacta ccagcaacac
      421 agccacctgc cccctcagtc cgaggagatg atgccacaca gcgggtcggt ttactacaag
      481 ccctcttcgc ccccgacacc cagcaccccg ggcttccagg tgcagcatag cccgatgtgg
      541 gacgatccgg gctcccttca caacttccac cagaactacg tggccactac gcatatgatc
      601 gagcagagga agacacctgt ctcccgcctt tcactcttct cctttaagca gtcgcccccg
      661 ggcactcctg tgtctagctg ccagatgcgc tttgacgggc ctctgcacgt ccccatgaac
      721 ccggagcccg cgggcagcca ccacgtagtg gatgggcaga ccttcgccgt gcccaatccc
      781 attcgcaagc cggcatccat gggcttcccg ggcctgcaga tcggccacgc gtcgcagttg
      841 cttgacacgc aggtgccctc gccgccgtcc cggggctctc cctccaatga gggtctgtgc
      901 gctgtttgcg gtgacaacgc ggcctgtcag cattacggtg ttcgcacttg tgagggctgc
      961 aaaggtttct ttaagcgcac ggtgcaaaaa aacgcgaaat atgtgtgttt agcaaataaa
     1021 aattgcccag tggataagcg ccgccgaaat cgttgtcagt actgtcggtt tcagaagtgc
     1081 ctggctgttg ggatggttaa agaagtggtt cgcacggaca gtttaaaagg ccggagaggt
     1141 cgtctaccct caaaaccgaa gagcccacag gatccctctc ccccctcacc tccggtgagt
     1201 ctgatcagtg ccctcgtcag agcccacgtc gactccaatc cggcaatgac cagcctggac
     1261 tattccaggt tccaggcaaa ccctgactat cagatgagtg gagatgatac tcaacatatc
     1321 cagcagttct acgatctcct gactggctct atggagatca tcagagggtg ggcagagaag
     1381 attcctggct ttgctgacct gcccaaagcc gatcaggacc tgctttttga atcagctttc
     1441 ttagaattat ttgttctacg cttagcatac aggtccaacc cagtggaggg taaactcatc
     1501 ttttgcaatg gggtggtctt gcacaggttg caatgcgtgc gtggctttgg ggaatggatt
     1561 gattccattg ttgaattctc ctccaacttg cagaatatga acatcgacat ttctgccttc
     1621 tcctgcattg ctgccctggc tatggtcaca gagagacacg ggctcaagga acccaagaga
     1681 gtggaagagc tacaaaacaa aattgtaaat tgtcttaaag accatgtgac tttcaataat
     1741 gggggattga accgacccaa ctacctgtcc aaactgttgg ggaagctccc agaacttcgc
     1801 accctttgca cacaggggct ccagcgcatt ttctacctga aattggaaga cttggtacca
     1861 ccaccagcaa taattgacaa acttttcctg gacaccttac ctttctaaga ctttctccca
     1921 tgcacgtcaa agaactggaa agaaaaaaaa aatccagagg gggctggtca agatgggtag
     1981 agagctggct gaagtgtccg gttcatgtct cccttctgta gacccctagc cctcacccct
     2041 aaagtaaaca aacaaacaag caaacaaaca aacacaaatt aaaaactgtt gctatttcct
     2101 aacctgcagg cagaacgtga aagggcattt tggctccggg gcatcctgga tttagaaaac
     2161 ggacaacata cacagtacag tggtataaac ttttttatta tcagttcaaa atcagtttat
     2221 tgttcagaag gaagattgca aatgtatgat gggaaatgtt tggccatgct tgcttgttgc
     2281 agttaagaca aatgtaaggc aaatgtaaca cacacacaca cacacacaca cacacacaca
     2341 cacacacacc tcttaatggg accctcatat tttgcccttt aacaagactt caaagttttc
     2401 tgctgtaaag aaagctgtaa tatatagtaa aactaaatgt tgcgtgggtg gcatgaattg
     2461 aaggcagagg cttgtaaatt ttatccaatg cagtttggct ttttaaatta ttttgtgcct
     2521 atttatgaat aaatattaca aattctaaaa agtaagtgtg tttgcaaaaa aaaaaaaaaa
     2581 aa
//
