LOCUS       NM_024388               2495 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 4, group A, member 1
            (Nr4a1), mRNA.
ACCESSION   NM_024388
VERSION     NM_024388.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Mao,C., Huang,J., Liu,H., Liu,Y., Hu,Z. and Xu,R.
  TITLE     Nur77 induced by HIF-1alpha mediates vascular remodeling in hypoxic
            pulmonary hypertension
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 233-237 (2024)
   PUBMED   38836656
  REMARK    GeneRIF: Nur77 induced by HIF-1alpha mediates vascular remodeling
            in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Jiang,N.X., Zhao,W.J., Shen,H.R., Du,D.F. and Li,X.L.
  TITLE     Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling:
            new insight into polycystic ovary syndrome (PCOS)-related
            infertility
  JOURNAL   J Ovarian Res 17 (1), 31 (2024)
   PUBMED   38310251
  REMARK    GeneRIF: Hyperinsulinemia impairs decidualization via AKT-NR4A1
            signaling: new insight into polycystic ovary syndrome
            (PCOS)-related infertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Cui,L., Bao,H., Zhu,W., Tang,Y., Luo,Q., Si,Y., Fu,Q. and Jiang,Z.
  TITLE     hUMSCs Transplantation Regulates AMPK/NR4A1 Signaling Axis to
            Inhibit Ovarian Fibrosis in POI Rats
  JOURNAL   Stem Cell Rev Rep 19 (5), 1449-1465 (2023)
   PUBMED   36307672
  REMARK    GeneRIF: hUMSCs Transplantation Regulates AMPK/NR4A1 Signaling Axis
            to Inhibit Ovarian Fibrosis in POI Rats.
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Brivio,P., Gallo,M.T., Gruca,P., Lason,M., Litwa,E., Fumagalli,F.,
            Papp,M. and Calabrese,F.
  TITLE     Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the
            Immediate Early Gene Nr4a1 in Response to an Acute Challenge in
            Male Rats: Comparison with the Antidepressant Venlafaxine
  JOURNAL   Int J Mol Sci 24 (8), 7321 (2023)
   PUBMED   37108481
  REMARK    GeneRIF: Chronic N-Acetyl-Cysteine Treatment Enhances the
            Expression of the Immediate Early Gene Nr4a1 in Response to an
            Acute Challenge in Male Rats: Comparison with the Antidepressant
            Venlafaxine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Zheng,Y., Tao,Y., Zhan,X. and Wu,Q.
  TITLE     Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against
            hypoxia-reperfusion injury in vitro by activating liver kinase B1
            (LKB1)/AMP-activated protein kinase (AMPK) signaling
  JOURNAL   Bioengineered 13 (4), 8349-8359 (2022)
   PUBMED   35311465
  REMARK    GeneRIF: Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte
            against hypoxia-reperfusion injury in vitro by activating liver
            kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling.
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Lee,S., Barbanel,G. and Rivier,C.
  TITLE     Systemic endotoxin increases steady-state gene expression of
            hypothalamic nitric oxide synthase: comparison with
            corticotropin-releasing factor and vasopressin gene transcripts
  JOURNAL   Brain Res 705 (1-2), 136-148 (1995)
   PUBMED   8821744
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Hirata,Y., Kiuchi,K., Chen,H.C., Milbrandt,J. and Guroff,G.
  TITLE     The phosphorylation and DNA binding of the DNA-binding domain of
            the orphan nuclear receptor NGFI-B
  JOURNAL   J Biol Chem 268 (33), 24808-24812 (1993)
   PUBMED   8227042
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Wilson,T.E., Fahrner,T.J. and Milbrandt,J.
  TITLE     The orphan receptors NGFI-B and steroidogenic factor 1 establish
            monomer binding as a third paradigm of nuclear receptor-DNA
            interaction
  JOURNAL   Mol Cell Biol 13 (9), 5794-5804 (1993)
   PUBMED   8395013
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Wilson,T.E., Paulsen,R.E., Padgett,K.A. and Milbrandt,J.
  TITLE     Participation of non-zinc finger residues in DNA binding by two
            nuclear orphan receptors
  JOURNAL   Science 256 (5053), 107-110 (1992)
   PUBMED   1314418
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Milbrandt,J.
  TITLE     Nerve growth factor induces a gene homologous to the glucocorticoid
            receptor gene
  JOURNAL   Neuron 1 (3), 183-188 (1988)
   PUBMED   3272167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB581975.1 and U17254.1.
            
            On Aug 4, 2012 this sequence version replaced NM_024388.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097313.1, U17254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CB581975.1         1-7
            8-2495              U17254.1           1-2488
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2495
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /note="nuclear receptor subfamily 4, group A, member 1"
                     /db_xref="GeneID:79240"
                     /db_xref="RGD:620029"
     exon            1..115
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     exon            116..990
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1911
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /note="nerve growth factor induced protein I-B; Orphan
                     nuclear receptor HMR; immediate early gene transcription
                     factor NGFI-B"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 1"
                     /protein_id="NP_077364.2"
                     /db_xref="GeneID:79240"
                     /db_xref="RGD:620029"
                     /translation="MPCIQAQYGTPATSPGPRDHLTGDPLALEFSKPTMDLASPETAP
                     TAPATLPSFSTFMDGGYTGEFDTFLYQLPGTAQPCSSASSTSSSSSSATSPASASFKF
                     EDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPPTPNFQPSQLSPWDGSFGHF
                     SPSQTYEGLRVWTEQLPKASGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPAPATHQLG
                     EGESYSVPAAFPGLAPTSPNCDTSGILDAPVTSTKARSGSSGGSEGRCAVCGDNASCQ
                     HYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKE
                     VVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLP
                     RFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRL
                     AYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSAL
                     VLITDRHGLQDPRRVEELQNRIASCLKEHMAAVAGDPQPASCLSRLLGKLPELRTLCT
                     QGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF"
     exon            991..1120
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1272
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1475
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1654
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2491
                     /gene="Nr4a1"
                     /gene_synonym="HMR; Ngfi-b; Nur77"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggctgcg aaagttgggg tagtgtgcga gaaggattgc agagcgcacg cggaaccaga
       61 ctgcgactgg gtcctgggtc gctggtcccg gccacgggga gcgggagccg gccggagatg
      121 ccctgtatcc aagctcaata tggaacacca gcaaccagcc caggaccgcg tgaccacctg
      181 acaggtgacc ccctggccct tgagttcagc aagcccacca tggacctggc cagccccgag
      241 acggcgccca ccgcacctgc caccctgccc agtttcagca ccttcatgga cggcggatac
      301 accggagagt ttgacacctt cctataccag ctgccgggga cagcccagcc gtgctcctcg
      361 gcctcctcca catcttcttc ctcgtcctcg gccacctctc ccgcgtcggc ttcctttaag
      421 tttgaggact ttcaggtgta tggctgctac cctggcaccc tgagcggccc attagacgag
      481 accctgtcct ccagtggctc tgattactat ggaagcccct gctcagcccc gtcaccacct
      541 acacccaact tccagccatc ccagctctcc ccttgggatg gttcatttgg ccacttctcc
      601 cccagccaga cttatgaagg ccttcgggta tggactgagc agttgcccaa ggcttccggg
      661 cctccgccac ctccaacctt cttctccttc agtcctccca ccggtcccag ccccagcctg
      721 gcccagagtt ccctgaagtt gttcccagca ccagccaccc accagctagg ggagggggag
      781 agctattccg tgccagccgc tttcccgggc ttggcaccca cctctccgaa ctgtgacact
      841 tccggcattc tggacgcacc cgtaacctcc accaaggccc gcagtgggtc ttcagggggc
      901 agtgagggcc gctgtgctgt ctgtggagac aacgcttcgt gccagcatta tggggtccgc
      961 acctgtgagg gctgcaaagg cttcttcaag cgcacagtac agaaaagtgc caagtacatc
     1021 tgcctggcaa acaaggactg ccctgtggac aagaggcggc ggaaccgctg ccagttctgt
     1081 cgcttccaga agtgcctggc tgtgggcatg gtgaaggaag ttgtccggac agacagccta
     1141 aaggggcggc ggggccggct accttcaaaa cccaagcagc ccccagatgc ctcccctacc
     1201 aatctcctca cgtccctcat tcgagcacat ttggactccg ggcctaacac tgccaagttg
     1261 gactattcca agttccagga actggtgctg ccccgctttg gaaaggaaga tgccggtgac
     1321 gtgcagcaat tttatgactt gctctctggc tccctggacg tcatccggaa gtgggcggaa
     1381 aagatcccgg gcttcattga gctttcccca ggagaccaag acctgttgct agagtccgcc
     1441 tttctggagc tctttatcct ccgcctggcc taccgatcta agcccggtga ggggaagctc
     1501 atcttctgct caggcctggt gctacaccgg ctgcagtgtg cccgcggctt tggtgactgg
     1561 atagacaaca ttctagcctt ctcacggtcc ctgcacagct tgggtgttga tgttcctgcc
     1621 tttgcctgcc tgtctgctct ggtcctcatc actgatcgac atggcctcca ggaccctcgg
     1681 cgggtggagg agctgcagaa ccgcattgct agctgtctga aggaacacat ggccgccgtg
     1741 gcaggagacc cacagccggc cagctgcctg tcacgtctgc tgggcaaact gcctgagctc
     1801 cggactctgt gcacccaagg cctacagcgc atcttttgcc tcaagctgga ggacttggtg
     1861 ccccctccac ctatcgtgga caagatcttt atggacacct tgtctttctg accctgcccc
     1921 gaacacgcgt gcacactcac gtgcatgttc ttcttgtcac ccacgtgcct ttaagcccat
     1981 agcccacgga cccccagacc accccacccc ccagcctgtt ttttgagcta agactgatgt
     2041 atctcctcat tccagaagat ggacagagag agagagagag ctcaagacct gggggggagg
     2101 gtgtgtattc acgggggtga ccccactatt tctcttatcc ctcccagctc agacctggcc
     2161 ttccgcgtgt ttttgtaaga taaaccattt ttaacacata ccactctgct gtatataagc
     2221 tgacgctgct gtaaatacag aaaggaagag gtcggggtgg gggtttgaga ggaagggtgg
     2281 gccccccaac cccgccagct gggcaagcct ctcgagcctc caacttgaga tctcttccgc
     2341 tctccttcca tgtgtacata gctgtcactc aagaaggtga ttgacagatt ctgatttata
     2401 tttgtgtatt tttttcctgg atttatagga tgtgactttt tctgattaat atatttaata
     2461 tattaaataa aaactagaca tgtagctgaa aaaaa
//
