LOCUS       NM_001395077            5513 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 3, group C, member 2
            (Nr3c2), transcript variant 2, mRNA.
ACCESSION   NM_001395077
VERSION     NM_001395077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5513)
  AUTHORS   Manso,J., Pedron,M.C., Mondin,A., Censi,S., Pennelli,G.,
            Galuppini,F., Barollo,S., Bertazza,L., Radu,C.M., Ghini,F.,
            Simioni,P., Sabbadin,C., Ceccato,F., Armanini,D. and Mian,C.
  TITLE     First Evidence of Mineralocorticoid Receptor Gene and Protein
            Expression in Rat and Human Thyroid Tissues and Cell Cultures
  JOURNAL   Int J Mol Sci 25 (2), 754 (2024)
   PUBMED   38255827
  REMARK    GeneRIF: First Evidence of Mineralocorticoid Receptor Gene and
            Protein Expression in Rat and Human Thyroid Tissues and Cell
            Cultures.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5513)
  AUTHORS   Feng,X., Chen,L., Zhou,R., Bao,X., Mou,H., Ye,L. and Yang,P.
  TITLE     Blocking the Mineralocorticoid Receptor Improves Cognitive
            Impairment after Anesthesia/Splenectomy in Rats
  JOURNAL   Int J Med Sci 18 (2), 387-397 (2021)
   PUBMED   33390808
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5513)
  AUTHORS   Makhijani,V.H., Irukulapati,P., Van Voorhies,K., Fortino,B. and
            Besheer,J.
  TITLE     Central amygdala mineralocorticoid receptors modulate alcohol
            self-administration
  JOURNAL   Neuropharmacology 181, 108337 (2020)
   PUBMED   33007359
REFERENCE   4  (bases 1 to 5513)
  AUTHORS   Hu,D., Dong,R., Zhang,Y., Yang,Y., Chen,Z., Tang,Y., Fu,M., Xu,X.
            and Tu,L.
  TITLE     Age-related changes in mineralocorticoid receptors in rat hearts
  JOURNAL   Mol Med Rep 22 (3), 1859-1867 (2020)
   PUBMED   32582979
  REMARK    GeneRIF: Agerelated changes in mineralocorticoid receptors in rat
            hearts.
REFERENCE   5  (bases 1 to 5513)
  AUTHORS   Baker,M.E. and Katsu,Y.
  TITLE     Progesterone: An enigmatic ligand for the mineralocorticoid
            receptor
  JOURNAL   Biochem Pharmacol 177, 113976 (2020)
   PUBMED   32305433
  REMARK    GeneRIF: Progesterone: An enigmatic ligand for the
            mineralocorticoid receptor.
            Review article
REFERENCE   6  (bases 1 to 5513)
  AUTHORS   Liu,W., Wang,J., Sauter,N.K. and Pearce,D.
  TITLE     Steroid receptor heterodimerization demonstrated in vitro and in
            vivo
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12480-12484 (1995)
   PUBMED   8618925
REFERENCE   7  (bases 1 to 5513)
  AUTHORS   Bloem,L.J., Guo,C. and Pratt,J.H.
  TITLE     Identification of a splice variant of the rat and human
            mineralocorticoid receptor genes
  JOURNAL   J Steroid Biochem Mol Biol 55 (2), 159-162 (1995)
   PUBMED   7495694
REFERENCE   8  (bases 1 to 5513)
  AUTHORS   Furuta,H., Mori,N., Sato,C., Hoshikawa,H., Sakai,S., Iwakura,S. and
            Doi,K.
  TITLE     Mineralocorticoid type I receptor in the rat cochlea: mRNA
            identification by polymerase chain reaction (PCR) and in situ
            hybridization
  JOURNAL   Hear Res 78 (2), 175-180 (1994)
   PUBMED   7982810
REFERENCE   9  (bases 1 to 5513)
  AUTHORS   Castren,M. and Damm,K.
  TITLE     A functional promoter directing expression of a novel type of rat
            mineralocorticoid receptor mRNA in brain
  JOURNAL   J Neuroendocrinol 5 (4), 461-466 (1993)
   PUBMED   8401570
REFERENCE   10 (bases 1 to 5513)
  AUTHORS   Patel,P.D., Sherman,T.G., Goldman,D.J. and Watson,S.J.
  TITLE     Molecular cloning of a mineralocorticoid (type I) receptor
            complementary DNA from rat hippocampus
  JOURNAL   Mol Endocrinol 3 (11), 1877-1885 (1989)
   PUBMED   2558305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001395077.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35926.1,
                                           SRR26643285.53493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000019.1  47962186-47962284   c
            100-1861            JAXUCZ010000019.1  47954011-47955772   c
            1862-2001           JAXUCZ010000019.1  47785672-47785811   c
            2002-2118           JAXUCZ010000019.1  47717663-47717779   c
            2119-2457           JAXUCZ010000019.1  47680829-47681167   c
            2458-2602           JAXUCZ010000019.1  47679235-47679379   c
            2603-2733           JAXUCZ010000019.1  47651996-47652126   c
            2734-2891           JAXUCZ010000019.1  47644790-47644947   c
            2892-5513           JAXUCZ010000019.1  47619853-47622474   c
FEATURES             Location/Qualifiers
     source          1..5513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..5513
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /note="nuclear receptor subfamily 3, group C, member 2"
                     /db_xref="GeneID:25672"
                     /db_xref="RGD:3094"
     exon            1..99
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            100..1861
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3047
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /note="MR; Mineralocorticoid receptor (aldosterone
                     receptor)"
                     /codon_start=1
                     /product="mineralocorticoid receptor"
                     /protein_id="NP_001382006.1"
                     /db_xref="GeneID:25672"
                     /db_xref="RGD:3094"
                     /translation="METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYME
                     IVNVSCVSGAIPNNSTQGSSKEKHELLPCIQQDNSRSGILPSDIKTELESKELSATVA
                     ESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRP
                     LRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTT
                     SFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPP
                     SHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSI
                     GSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGP
                     LNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNP
                     FPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEGSAFPVGIKQEPDDGSYYPEAS
                     IPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGD
                     LSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSC
                     KVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKL
                     KGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILE
                     NIEPETVYAGYDNSKPDTAESLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITL
                     IQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQF
                     VRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQS
                     WQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGN
                     AKPLYFHRK"
     exon            1862..2001
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2118
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2457
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2602
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2733
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2891
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..5513
                     /gene="Nr3c2"
                     /gene_synonym="MCR; Mlr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcttttcc tgcgtggtta aaacaaggaa actgaaatcg agtgggaacg agatcctctg
       61 gctttccgac cgcggagatt acggctgctc ggcagggagc tatggaaacc aaaggctacc
      121 acagtctccc tgaaggccta gacatggaaa ggcgctggag tcaagtgtct cagaccttgg
      181 agcgttcttc acttggacct gcagagagga ccactgagaa caactacatg gagattgtca
      241 acgtcagctg cgtttccggt gctattccga acaacagtac tcaaggaagc agcaaagaaa
      301 agcacgaatt actcccttgc attcagcaag acaatagtcg gtctgggatt ttgccatcag
      361 atattaaaac tgagctggaa tccaaggaac tttcagccac ggtagctgag tccatgggtt
      421 tatatatgga ttctgtgaga gatgccgagt acacttacga tcagcagaac caacaaggaa
      481 gcctgagccc aacaaagatt tatcaaaaca tggagcagct ggtgaagttt tacaaagaga
      541 atggtcacag gtcctccaca ctgagtgcta tgagcagacc tttgaggtca ttcatgcctg
      601 actctgcagc ctccatgaat ggtggggcct tgcgtgccat cgtgaagagc cctatcatct
      661 gtcatgagaa gagctcttct gttagcagcc cgctgaacat ggcatcttca gtatgcagcc
      721 ctgtgggcat caactccatg tcctcctcca cgactagctt tggcagtttc ccagtgcaca
      781 gtcccatcac tcaaggaacc tcactgacat gctcccccag tgtcgaaaac agaggctcaa
      841 ggtcacacag ccccacacat gcgagcaacg tgggctcccc tctttcaagt ccattgagca
      901 gcatgaaatc tccaatctcc agccctccaa gtcattgcag tgtaaaatct ccagtctcca
      961 gtccaaataa cgtccctctg cgctcctctg tgtccagccc ggcaaatctc aacaactcaa
     1021 ggtgctccgt ttccagccct tccaacaaca ccaacaatag atccacactc tccagcccga
     1081 cagccagcac agtggggtcc atcggcagcc ccatcagcaa tgccttcagc tatgccactt
     1141 caggcgcttc tgctggagcc ggtgccatcc aggatgtggt tcctagtcca gacacccacg
     1201 agaaaggtgc tcacgacgtt cctttcccta agacagagga agtcgagaag gccatctcca
     1261 atggtgtgac tggcccgctc aacattgtcc agtacataaa atcagaacca gatggggctt
     1321 tcagcagttc ctgtctagga ggaaacagca aaatcagccc cagttctcca ttctctgtac
     1381 caataaagca agagtcaagc aagcactcat gttcaggcgc ctcttttaaa gggaacccca
     1441 cggtcaaccc atttccattc atggatggct cctacttttc ctttatggat gataaggact
     1501 attattccct atcaggaatc ttaggaccac ctgtgcccgg ctttgatggt agctgcgagg
     1561 gcagcgcatt cccagtgggg attaagcaag aaccagatga tgggagctat taccctgaag
     1621 ccagcatccc atcatctgct atcgttggtg tgaattcggg tggacagtcc tttcactacc
     1681 ggattggtgc tcaaggtaca atatctttat cacggtcacc tagagaccaa tctttccaac
     1741 acttgagttc cttcccacct gtcaatacat tagtggaatc atggaaacca cacggtgacc
     1801 tgtcatctag gagaagtgat gggtatcccg tcctagagta cattccagaa aacgtgtcaa
     1861 gctctacttt acgaagtgtt tctactggat cctcaagacc ttccaagatc tgtttggtgt
     1921 gtggagatga ggcttctggg tgtcactatg gggtagtgac ctgtggcagc tgcaaagtct
     1981 tcttcaaaag agccgtggaa gggcaacaca actatctgtg tgctggaaga aatgactgca
     2041 ttattgataa gattcggcga aagaactgtc ctgcctgcag gctccagaaa tgccttcaag
     2101 ctggcatgaa cttaggagct cgaaagtcaa agaagctggg gaagttaaaa ggcctccacg
     2161 aggagcaacc acagcagccc ccaccaccgc caccccagag tccagaagag gggaccacat
     2221 acatcgctcc gaccaaggag ccatcggtga actctgcgct ggtcccgcag ctcacctcca
     2281 ttacgcatgc actcacacca tccccggcca tgatcctgga gaacatcgag cctgagaccg
     2341 tgtatgcagg ctacgacaat tccaagcccg acaccgccga gagcctgctc tccacgctca
     2401 accgcctggc aggcaaacag atgatccagg tcgtgaagtg ggccaaggta cttccaggat
     2461 ttaaaaactt gcctctcgag gaccaaatca ccctcatcca gtattcttgg atgtgtctat
     2521 catcgttcgc tttgagttgg agatcgtaca aacacacgaa cagccaactc ctctattttg
     2581 ctccagacct agtttttaat gaagagaaga tgcatcagtc tgccatgtat gaactgtgcc
     2641 aggggatgcg ccagatcagc cttcaattcg tgcggctgca gctgaccttt gaggagtact
     2701 ccataatgaa ggttttgctg ctactaagca cagttccaaa agatggcctc aagagccagg
     2761 ctgcatttga ggagatgagg acaaattaca tcaaagaact gaggaaaatg gtcaccaagt
     2821 gtcccaacag ttctggacag agttggcaga ggttctacca actgaccaag cttctagact
     2881 ccatgcatga tctcgtgagt gacctgctag aattctgctt ctacaccttc cgagaatccc
     2941 aggctctgaa ggtggagttt cccgccatgc tggtggagat catcaccgac cagctgccaa
     3001 aggtggagtc tgggaatgcc aaaccccttt actttcacag aaagtgacgg gagataccgg
     3061 ccaggaagaa cttcgcctta agtttcccca cgtggttcta tgcctacgaa ggacccaaga
     3121 aatcacattt ttaacatgtg atggctgatt gacagttggt cggcagtttc tcaagtttaa
     3181 aaatcacgtc aagggtctgg agccgggaaa gccatgagac gtggatttgg caaggcctga
     3241 gctggctaaa ggactcttcc ctctccactc ccagcgctta gaaaacatgt tcccgttcct
     3301 ctggatgaaa agccatatct agtcaataac tctgattttg atattttaac aggtggaagt
     3361 tttaactatg ccatgtggtt tctggtatct ctcgcttgtt ttcaaagggt tcaaaggact
     3421 agagaacttt ttaaagctta cccttggttt gcacataaaa acgtctagtc aatatggggc
     3481 attactattc ttttgttatt taaaaacaca caaacacata cacaaaatgc atacagatcc
     3541 ctggtatgta ataacagaac acgtggcgtg gaactgtggc ctaccgggca cgttttttct
     3601 gcatcgctgg catacgcact cgttagtgtc catttattat ttaattagaa tggataagat
     3661 gttaaatgcc ttggtttcaa atttctagta tctattgtgt tggctttaca aataattttt
     3721 tgcagtcttt ttgctgtgct gtatattact gtatgtataa attgtgaagg acctgaaaca
     3781 aggtgtaagg agcttttgta aatgaaacac attagaaaaa agtctttaat ggttaatagg
     3841 ttgaatggga aagtattttt gaaagaattc tattttgctg gagactattt aagtactatc
     3901 tttgtctaaa caaggtaaaa ttttcttttg taacgtgaga tgctctgcat gcgtactgac
     3961 cgtttacagt gtatttaaga gagacaaagc tgtgcctttt tttagcttca tatctaattt
     4021 accattttac agtctgttgt aaataaccac acttagacct cttcggttgt ctctaagcct
     4081 ttctactttt tcagtactat ttgttttgtt cttggtctcc cgcgtgggaa gtgttcgtga
     4141 gactctagtg cgcagctctg gcttctgctt cttcccgctt ccatccggga tgctgctgca
     4201 gtgtctgcag ctcctggcag gtgacaggaa ccactggtcc tgagagtgct gtcctccccc
     4261 ctctgtcaca agaagcagag cctgctctct cagaaaggga gactggaaac atggcccaga
     4321 gagcacaatt ctcccatttc cagaaaatct gattttctcc tcttggggaa aatattccat
     4381 gcaccctcca cacctgtcaa agatcagaaa gccgcctcta gccttggaca gggtccttca
     4441 ctcctggagc cggtcatggg gacagcaaat atggcaggag gtacaggcaa ctcatctggg
     4501 tatgagtcag acagaatggc gtggagaccc acagatcact agaaggtttt tagatttttt
     4561 aaaggtaggt tttaaaaatg aaaattttat acataaacag ttttggagga aaaaaaccac
     4621 aaaaacacta cgaatcatgt aagcaagaca gtggcactaa aattttaatt cattaatctg
     4681 tccaatactg atgcgattta tggctttttt cttgccccaa atcacagaca tgtgtatctc
     4741 tggggaactt cggtatgatt gcactaaatg atctctgaat agaggccaaa ttaatctttc
     4801 aaacatggtg atgcctctca tcacgaattc ccaaaaccta aaagctgacg cagaaggctg
     4861 gggcaaggct tgagtgggtc agcggtttcc cacagggttc accatgcagg caacattacc
     4921 gtgtctctca aacgacgcct gccttctgca aggggagacc cagggacgct gaactcaaag
     4981 ggtgggggct ttcttacatc atttgcaact tcaaggattt aatttatagg cagatcttta
     5041 aacacagtca acttacacgc acagcaatat gaaaaccata cttcgaaggc gataaacaca
     5101 tacagcatgc agacgaggtg tttctggggg aaaggggctg agttaacgct gtgaaactgg
     5161 atttccatct tagccaggat tgaggtggag aaggtctaca ttagcttttt gtattaatga
     5221 agttactggc tcctcatgtg tctccgggta actctgctta actaaacagc aaagccatat
     5281 tctctaaatt cactgttgaa tgcctgtccc gggccaaact gtctgctctt atttttgtac
     5341 catattgctc ttaaaaatct tggtttggta caattcataa ttcaccaaaa ctccttcaaa
     5401 taattataac actaaattag tttaaaatga agcaatttat atctttatgc aaaaacatgt
     5461 ctgtctttgc aaaggattgt aaacagatta caataaatcc tttactttaa tca
//
