LOCUS       NM_012576               6733 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 3, group C, member 1
            (Nr3c1), transcript variant 1, mRNA.
ACCESSION   NM_012576 XM_008772065
VERSION     NM_012576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6733)
  AUTHORS   Zhu,T., Li,Y., Zhu,L., Xu,J., Feng,Z., Chen,H., Shi,S., Liu,C.,
            Ou,Q., Gao,F., Zhang,J., Jin,C., Xu,J., Li,J., Zhang,J., Bi,Y.,
            Xu,G.T., Wang,J., Tian,H. and Lu,L.
  TITLE     GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal
            degeneration in a streptozotocin-induced rat diabetes model
  JOURNAL   Glia 72 (3), 504-528 (2024)
   PUBMED   37904673
REFERENCE   2  (bases 1 to 6733)
  AUTHORS   Rowson,S., Bekhbat,M., Kelly,S., Hyer,M.M., Dyer,S., Weinshenker,D.
            and Neigh,G.
  TITLE     Chronic adolescent stress alters GR-FKBP5 interactions in the
            hippocampus of adult female rats
  JOURNAL   Stress 27 (1), 2312467 (2024)
   PUBMED   38557197
  REMARK    GeneRIF: Chronic adolescent stress alters GR-FKBP5 interactions in
            the hippocampus of adult female rats.
REFERENCE   3  (bases 1 to 6733)
  AUTHORS   Udagawa,H., Funahashi,N., Nishimura,W., Uebanso,T., Kawaguchi,M.,
            Asahi,R., Nakajima,S., Nammo,T., Hiramoto,M. and Yasuda,K.
  TITLE     Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin
            secretion in pancreatic beta-cells
  JOURNAL   Sci Rep 13 (1), 17958 (2023)
   PUBMED   37863964
  REMARK    GeneRIF: Glucocorticoid receptor-NECAB1 axis can negatively
            regulate insulin secretion in pancreatic beta-cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6733)
  AUTHORS   Islas-Preciado,D., Lopez-Rubalcava,C., Estrada-Camarena,E., de
            Gortari,P. and Castro-Garcia,M.
  TITLE     Effect of chronic unpredictable stress in female Wistar-Kyoto rats
            subjected to progesterone withdrawal: Relevance for Premenstrual
            Dysphoric Disorder neurobiology
  JOURNAL   Psychoneuroendocrinology 155, 106331 (2023)
   PUBMED   37437420
REFERENCE   5  (bases 1 to 6733)
  AUTHORS   Martin,F.M., Alzamendi,A., Harnichar,A.E., Castrogiovanni,D.,
            Zubiria,M.G., Spinedi,E. and Giovambattista,A.
  TITLE     Role of glucocorticoid receptor (GR) in white adipose tissue
            beiging
  JOURNAL   Life Sci 322, 121681 (2023)
   PUBMED   37040814
  REMARK    GeneRIF: Role of glucocorticoid receptor (GR) in white adipose
            tissue beiging.
REFERENCE   6  (bases 1 to 6733)
  AUTHORS   Remerowski,M.L., Kellenbach,E., Boelens,R., van der Marel,G.A., van
            Boom,J.H., Maler,B.A., Yamamoto,K.R. and Kaptein,R.
  TITLE     1H NMR studies of DNA recognition by the glucocorticoid receptor:
            complex of the DNA binding domain with a half-site response element
  JOURNAL   Biochemistry 30 (50), 11620-11624 (1991)
   PUBMED   1751485
REFERENCE   7  (bases 1 to 6733)
  AUTHORS   Chakraborti,P.K., Garabedian,M.J., Yamamoto,K.R. and Simons,S.S.
            Jr.
  TITLE     Creation of 'super' glucocorticoid receptors by point mutations in
            the steroid binding domain
  JOURNAL   J Biol Chem 266 (33), 22075-22078 (1991)
   PUBMED   1939229
REFERENCE   8  (bases 1 to 6733)
  AUTHORS   Kellenbach,E., Maler,B.A., Yamamoto,K.R., Boelens,R. and Kaptein,R.
  TITLE     Identification of the metal coordinating residues in the DNA
            binding domain of the glucocorticoid receptor by 113Cd-1H
            heteronuclear NMR spectroscopy
  JOURNAL   FEBS Lett 291 (2), 367-370 (1991)
   PUBMED   1936288
REFERENCE   9  (bases 1 to 6733)
  AUTHORS   LeClerc,S., Palaniswami,R., Xie,B.X. and Govindan,M.V.
  TITLE     Molecular cloning and characterization of a factor that binds the
            human glucocorticoid receptor gene and represses its expression
  JOURNAL   J Biol Chem 266 (26), 17333-17340 (1991)
   PUBMED   1894621
REFERENCE   10 (bases 1 to 6733)
  AUTHORS   Luisi,B.F., Xu,W.X., Otwinowski,Z., Freedman,L.P., Yamamoto,K.R.
            and Sigler,P.B.
  TITLE     Crystallographic analysis of the interaction of the glucocorticoid
            receptor with DNA
  JOURNAL   Nature 352 (6335), 497-505 (1991)
   PUBMED   1865905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 12, 2022 this sequence version replaced
            XM_008772065.3, NM_012576.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.51367.1,
                                           SRR26360172.1647568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000018.1  31613034-31613439   c
            407-1660            JAXUCZ010000018.1  31609579-31610832   c
            1661-1824           JAXUCZ010000018.1  31543896-31544059   c
            1825-1941           JAXUCZ010000018.1  31539690-31539806   c
            1942-2217           JAXUCZ010000018.1  31537075-31537350   c
            2218-2362           JAXUCZ010000018.1  31536004-31536148   c
            2363-2493           JAXUCZ010000018.1  31532475-31532605   c
            2494-2651           JAXUCZ010000018.1  31527954-31528111   c
            2652-6733           JAXUCZ010000018.1  31522783-31526864   c
FEATURES             Location/Qualifiers
     source          1..6733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..6733
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /note="nuclear receptor subfamily 3, group C, member 1"
                     /db_xref="GeneID:24413"
                     /db_xref="RGD:2741"
     exon            1..406
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            407..1660
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..2804
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /codon_start=1
                     /product="glucocorticoid receptor"
                     /protein_id="NP_036708.2"
                     /db_xref="GeneID:24413"
                     /db_xref="RGD:2741"
                     /translation="MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSA
                     SSPSVAAASQADSKQQRILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQPDLSKAV
                     SLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPK
                     SSTSATGCATPTEKEFPKTHSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLE
                     FSAGSPGKDTNESPWRSDLLIDENLLSPLAGEDDPFLLEGDTNEDCKPLILPDTKPKI
                     KDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNK
                     MSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGED
                     SLTSLGALNFPGRSVFSNGYSSPGMRPDVSSPPSSSSAATGPPPKLCLVCSDEASGCH
                     YGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA
                     RKTKKKIKGIQQATAGVSQDTSENPNKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYD
                     SSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFA
                     LGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQCKHMLFVSSELQRLQVSYEEYLC
                     MKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLD
                     SMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK"
     exon            1661..1824
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1941
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2217
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2362
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2493
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2651
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..6733
                     /gene="Nr3c1"
                     /gene_synonym="Gcr; GR; Grl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcggtccc gctcgcctgc cgcggccggg cggccctttc gcgtgtccgc gctccccccc
       61 ctcccctccg cctcctccat tttgcgagct cgagtcagtg cctggagccc gagtcgccgc
      121 ccgcccgtcg gggacggatt ctaagtgggt ggaacaagac gccgcagccg ggcggcgcgg
      181 cgccgggacg ggggacgcgc gcgggagacg ggagcggcgc gggggcccgg cttgtcagcc
      241 gggaacgggt gactttcagc gctaggggct ctcccctccc ccatggagaa gagggggcga
      301 ctgttgactt ccttctccgt gacacgcgcg cctcccgcgt ccgcacgccg acttgtttat
      361 ctggctgcgg tgggagccgc gagcgggcga gcgcgcgggt gctgagttaa tatttgccaa
      421 tggactccaa agaatcctta gctccccctg gtagagacga agtccctggc agtttgcttg
      481 gccaggggag ggggagcgta atggactttt ataaaagcct gaggggagga gctacagtca
      541 aggtttctgc atcttcgccc tcagtggctg ctgcttctca ggcagattcc aagcagcaga
      601 ggattctcct tgatttctcg aaaggctcca caagcaatgt gcagcagcga cagcagcagc
      661 agcagcagca gcagcagcag cagcagcagc agcagcagca gcagccagac ttatccaaag
      721 ccgtttcact gtccatgggg ctgtatatgg gagagacaga aacaaaagtg atggggaatg
      781 acttgggcta cccacagcag ggccaacttg gcctttcctc tggggaaaca gactttcggc
      841 ttctggaaga aagcattgca aacctcaata ggtcgaccag cgttccagag aaccccaaga
      901 gttcaacgtc tgcaactggg tgtgctaccc cgacagagaa ggagtttccc aaaactcact
      961 cggatgcatc ttcagaacag caaaatcgaa aaagccagac cggcaccaac ggaggcagtg
     1021 tgaaattgta tcccacagac caaagcacct ttgacctctt gaaggatttg gagttttccg
     1081 ctgggtcccc aggtaaagac acaaacgaga gtccctggag atcagacctg ttgatagatg
     1141 aaaacttgct ttctcctttg gcgggagaag atgatccatt ccttctcgaa ggggacacga
     1201 atgaggattg taagcctctt attttaccgg acactaaacc taaaattaag gatactggag
     1261 atacaatctt atcaagtccc agcagtgtgg cactgcccca agtgaaaaca gaaaaagatg
     1321 atttcattga actttgcacc cccggggtaa ttaagcaaga gaaactgggc ccagtttatt
     1381 gtcaggcaag cttttctggg acaaatataa ttggtaataa aatgtctgcc atttctgttc
     1441 atggtgtgag tacctctgga ggacagatgt accactatga catgaataca gcatcccttt
     1501 ctcagcagca ggatcagaag cctgttttta atgtcattcc accaattcct gttggttctg
     1561 aaaactggaa taggtgccaa ggctccggag aggacagcct gacttccttg ggggctctga
     1621 acttcccagg ccggtcagtg ttttctaatg ggtactcaag ccctggaatg agaccagatg
     1681 taagctctcc tccatccagc tcgtcagcag ccacgggacc acctcccaag ctctgcctgg
     1741 tgtgctccga tgaagcttca ggatgtcatt acggggtgct gacatgtgga agctgcaaag
     1801 tattctttaa aagagcagtg gaaggacagc acaattacct ttgtgctgga agaaacgatt
     1861 gcatcattga taaaattcga aggaaaaact gcccagcatg ccgctatcgg aaatgtcttc
     1921 aggctggaat gaaccttgaa gctcgaaaaa caaagaaaaa aatcaaaggg attcagcaag
     1981 ccactgcagg agtctcacaa gacacttcgg aaaatcctaa caaaacaata gttcctgcag
     2041 cattaccaca gctcacccct accttggtgt cactgctgga ggtgattgaa cccgaggtgt
     2101 tgtatgcagg atatgatagc tctgttccag attcagcatg gagaattatg accacactca
     2161 acatgttagg tgggcgtcaa gtgattgcag cagtgaaatg ggcaaaggcg ataccaggct
     2221 tcagaaactt acacctggat gaccaaatga ccctgctaca gtactcatgg atgtttctca
     2281 tggcatttgc cctgggttgg agatcataca gacaatcaag tggaaacctg ctctgctttg
     2341 ctcctgatct gattattaat gagcagagaa tgtctctacc ctgcatgtat gaccaatgta
     2401 aacacatgct gtttgtctcc tctgaattac aaagattgca ggtatcctat gaagagtatc
     2461 tctgtatgaa aaccttactg cttctctcct cagttcctaa ggaaggtctg aagagccaag
     2521 agttatttga tgagattcga atgacttata tcaaagagct aggaaaagcc atcgtcaaaa
     2581 gggaagggaa ctccagtcag aactggcaac ggttttacca actgacaaag cttctggact
     2641 ccatgcatga ggtggttgag aatctcctta cctactgctt ccagacattt ttggataaga
     2701 ccatgagtat tgaattccca gagatgttag ctgaaatcat cactaatcag ataccaaaat
     2761 attcaaatgg aaatatcaaa aagcttctgt ttcatcaaaa atgactgcct tactaagaaa
     2821 ggttgcctta aagaaagttg aatttatagc ttttactgta caaacttatc aatttgtctt
     2881 gtagatgttt tgttgttctt tttgtttctg tcttgttttg ttttaaacac gcactacatg
     2941 tggtttatag agggccaaga cttggcgaca gaagcagttg agtcaacact ctgaagtgat
     3001 agcacagcag acagtgaagt gtattggttg gtgtatcaca gaaactaaca gttacgtgga
     3061 ggcatggcca ctgtcagaga gggaccgcac ctaaaccacc agtgcccaaa gtccatgtga
     3121 tcaactttct gctcagactt tcagttggct gggtaaaact ttctagactt tctgttggtg
     3181 tatttttccc atgtatagtt aggatagcat tttgatttat gcatggaaac ctgaaaaaag
     3241 tttacaagtg tatatcagaa aagggaagtt gtgcctttta tagctattac tgtctggttt
     3301 taacaatttc ctttatattc agtgaactat gcttgctcgt ttctcttcaa taatttttgt
     3361 attccagtta ttgtacagct gtttaagatg ggcagctgct tcacagcttt cctagacgct
     3421 aacattaatt tccgtgtgaa aatgggtcgg tgcttctacc ctgatggcac cagctatcag
     3481 aagaccacag aaattgactc agatctccag tattcttgtt aaaaagctct tactctgtat
     3541 atatctgctt ccatggagaa ttacataggc tgtgcagatt aaccgtccta actggtgtag
     3601 agcacctagt ccagtgacct tctgggtaaa ccgtggatga tggttacaga agactggtgg
     3661 gaaaacagta actaccaaaa ggcccctttc cacctaatgc accatctctt caatggggag
     3721 atagcaacca agtttgtaaa tcagctcttt caggaccttc tggagtggtt tgcataacat
     3781 tttaaaatgt attattccag atagccagct ctgataaagc cgagagattg tttaatcaga
     3841 ccaagtaact tctctcatta aactttaccc ccaactaaat cgctaataca gcaagaatgg
     3901 ctagacaccc attttcacat ctcacccgca ccgattggtc tagctctcct ggtggtccag
     3961 gagaatcagc tactgatttt tgttacttag aactgaatgt caggcatccg tgtttgtcca
     4021 actacacatc cctacatgtg ccatagaatt taacacaagt cctgtgaact tcttcacact
     4081 gagaattatc attttaaaca aaacagaagc tgtagtagcc ctttctgtgt gcaccttacc
     4141 aactttctgt gactcaaagc ttaacacact tactaagcca caagaaatct gatttctact
     4201 taaggtggcc aaattatttg tgtaatagaa aaactgaaaa tctaatatta aaaatatgaa
     4261 acttctaata tatttttata tttagttata gtttcagata tatatcatat tggtattcac
     4321 tgatcttggg aagggaaggg ctactgcagc tttacatgca atttattaac tgactgtaaa
     4381 atagctgtat agtgtaaaat aagaatgact tttagcgaga ttgctttatc atgacatgtt
     4441 atatattttt cgtaggggtc aaagaaatgt tgatggatat gatagcctat atgatttata
     4501 gtgtgtaaaa gcatccaaac aggcctcagc gctcttggaa attaaaacac ctttgttcta
     4561 agctagggaa gggagctgga gactggccct gtgtgcactg gaggttctga ggcttggacc
     4621 caagagacca caggggatct aattccccac ctcccattct aaccatcctc atccacccat
     4681 gaccctgtca gtgcaggttt ggttattaaa tcccccgttg cactaacata aacaggacag
     4741 aagggtggcg ctcacgtcgt tctaggcgcc gtcagtagca gggttatttt cccatgcagc
     4801 ctccccacag gttagcagag ggaggctttg gaagtttggc gatggcgtgc atagaggcac
     4861 cagcaacatg taaacctaaa gagcccatag gaagccagga atacactaat cctccccacc
     4921 cttcaacagt ccatttccaa gtaagatgag gacatgctta tgttttcttt gaatgctttt
     4981 tgaatgttgt tattttcagt attttgcaga aattatttaa taaaaaagta taatcatttg
     5041 ctttttgaat tctctctaaa agggattgtt cagtttgtaa tggtttaaat tggtctcaaa
     5101 gtactttaag ataattgtaa cccagctgga tgtgaaattt atggtgccta agaaatacca
     5161 cttgaatatt atcaatgaca gtgttaagtt ttaaaatgag cttctcaaaa atagattatt
     5221 gtacatttat ggaatgttat atggttaaac ccaaaaaagc acatcacaca taaatctgct
     5281 ttcagtccca accagcttgg ctttcaaaaa tagagctcca aaaacgaaaa aggagaagaa
     5341 aaagatatat atgcgttgtt attaacagaa ggcaacagac attcataaaa ctactaccgg
     5401 aagctttcct tgaagcgtat aaagagccat gctcctttag tatgtgggga agaagagagc
     5461 tgtcatagtt ttgagtacag tgagaagatg cggtactgtc tccgtgtgtg gcttcatacc
     5521 gttcctaact atttaggttt ataataactt cagtgagact tggtgacatg cctgtatgac
     5581 tcatgaccga tcttgaaaga tatctttaat tactggtagg acaaaaaggg acactctggt
     5641 tattttaggc cttggcttgg gatactgtat atgcagaaga aaggagacag gaaacttggg
     5701 gaagggaagg gaacctagga agcactgcct tctgtaagga aagacacacc aataagtgag
     5761 actaccccaa agggacaagg ccacacagtg tggggtctaa ggatgagtca gggtgagctc
     5821 tggtgggcat ggagaagcca gcaactccag tgctacagag cagggcaggg cagggatggg
     5881 acaagatggg acgaggattc ccgctggatc ccagtcccag tagtttgctc cctcttattt
     5941 accatgaggc agtatgacca tgggatgaac catggtagta ttgatctgtc agcactcaag
     6001 gatcatggta gccttcagga gcttgagatt ccggttggtc accccaacgg taagctggag
     6061 ttgaatgtgt ttcttatgtg cctggtttca gtgttagaag gtgaaacaga gtgtacagaa
     6121 gacactgcaa accgcttcag atggaagtct tctcattccc agactatttt cagtcagcct
     6181 gctctatcag gactggtgac caggtcgtca ggacagggtc ggcttctgtc tagaatatgc
     6241 ctgaaaggat tttattttct gataaatggc tgtatgaaaa taccctcctc aataacctgc
     6301 ttaactacat agagatttca gtgtgtcaat attctatttt gtatattaaa caaaggctat
     6361 ataatgggga caaatctata ttatactgtg tatggcatta ttaagaagct ttttcattat
     6421 tttttatcac agtaattttt aaatgtgtaa aaaattaaaa accagtgact cctgtttaaa
     6481 aataaaagtt gtagtttttt attcatgctg aataacctgt agtttaaaaa tctgtctttc
     6541 tacctacaca gtgaaatgtc agactgtaaa attttgtgtg gaaatgttta acttttattt
     6601 ttcatttaaa tttgctgttc tggtattacc aaaccacaca tttgtactga attggcagta
     6661 aatgttagtc agccatttac agcaatgcca aatatggata aacatcataa taaaaatatc
     6721 tgctttttca tca
//
