LOCUS       NM_139113               1752 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 2, group F, member 6
            (Nr2f6), mRNA.
ACCESSION   NM_139113 XM_001068710
VERSION     NM_139113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Warnecke,M., Oster,H., Revelli,J.P., Alvarez-Bolado,G. and
            Eichele,G.
  TITLE     Abnormal development of the locus coeruleus in
            Ear2(Nr2f6)-deficient mice impairs the functionality of the
            forebrain clock and affects nociception
  JOURNAL   Genes Dev 19 (5), 614-625 (2005)
   PUBMED   15741322
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Raccurt,M., Smallwood,S., Mertani,H.C., Devost,D., Abbaci,K.,
            Boutin,J.M. and Morel,G.
  TITLE     Cloning, expression and regulation of chicken ovalbumin upstream
            promoter transcription factors (COUP-TFII and EAR-2) in the rat
            anterior pituitary gland
  JOURNAL   Neuroendocrinology 82 (5-6), 233-244 (2005)
   PUBMED   16721029
  REMARK    GeneRIF: Cloning of rat pituitary COUP-TFII and EAR-2 genes,
            demonstrated that they are specifically expressed in lactotropes,
            and strongly suggested that they may play a role in modulating
            prolactin (PRL) gene expression during pregnancy.
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Liu,X., Huang,X. and Sigmund,C.D.
  TITLE     Identification of a nuclear orphan receptor (Ear2) as a negative
            regulator of renin gene transcription
  JOURNAL   Circ Res 92 (9), 1033-1040 (2003)
   PUBMED   12690040
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Zhang,Y. and Dufau,M.L.
  TITLE     Nuclear orphan receptors regulate transcription of the gene for the
            human luteinizing hormone receptor
  JOURNAL   J Biol Chem 275 (4), 2763-2770 (2000)
   PUBMED   10644740
REFERENCE   6  (bases 1 to 1752)
  AUTHORS   Chu,K. and Zingg,H.H.
  TITLE     The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers
            of the human oxytocin gene promoter
  JOURNAL   J Mol Endocrinol 19 (2), 163-172 (1997)
   PUBMED   9343308
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139113.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF003926.1, SRR26643298.70826.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               JAXUCZ010000016.1  18086957-18087449   c
            494-588             JAXUCZ010000016.1  18084365-18084459   c
            589-1113            JAXUCZ010000016.1  18081729-18082253   c
            1114-1752           JAXUCZ010000016.1  18080003-18080641   c
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1752
                     /gene="Nr2f6"
                     /note="nuclear receptor subfamily 2, group F, member 6"
                     /db_xref="GeneID:245980"
                     /db_xref="RGD:621685"
     exon            1..493
                     /gene="Nr2f6"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1385
                     /gene="Nr2f6"
                     /note="COUPg; V-erbA-related protein EAR-2; orphan nuclear
                     receptor EAR-2; V-erbA-related protein 2; ovalbumin
                     upstream promoter gamma nuclear receptor rCOUPg"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group F member 6"
                     /protein_id="NP_620813.2"
                     /db_xref="GeneID:245980"
                     /db_xref="RGD:621685"
                     /translation="MAMVTGGWGGPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAE
                     PGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQID
                     QHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPGPAACSPPGAAGVEPFAGPPVSE
                     LIAQLLRAEPYPAAGRFGGGGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQ
                     VALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQV
                     DKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQP
                     QRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSG"
     exon            494..588
                     /gene="Nr2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1113
                     /gene="Nr2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1752
                     /gene="Nr2f6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggcctgg aaccggcccg accagttcct gcctggcgcg cggaccggcc gcaggaagtt
       61 gccgcaaaac tttttttggg ggggtgcgac cggagccccc gagcgcgcgg gctgcatgcg
      121 cccgggatag ccgggttccc ctcgggtcgc caggcgtgcc cagaggggac ggactcgtcc
      181 cggggcgccc cggccccgct gtccccgggg ctatggccat ggtgaccggt ggctggggcg
      241 gccccggagg cgacacgaac ggcgtggaca aggcaggtgg gagctaccca cgcgcgaccg
      301 aggacgactc ggcctcgcct cccggggcga ctagcgacgc ggagccgggt gacgaggagc
      361 gtccggggct gcaggtggac tgcgtggtgt gcggggacaa gtccagcggc aagcactacg
      421 gcgtgttcac ctgcgagggc tgcaagagtt tcttcaagcg cagcatccgc cgcaatctca
      481 gctacacctg ccggtccaac cgtgactgtc agattgatca gcatcaccgg aaccagtgtc
      541 agtactgtcg cctcaagaag tgcttccggg tgggcatgcg caaggaggcg gtgcagcgcg
      601 gccgcatccc gcacgctctc ccgggtcccg cggcctgcag ccctccgggc gcggcgggag
      661 tcgagccgtt cgcggggccg ccggtgtccg agctgatcgc gcagctgctg cgcgctgagc
      721 cctaccccgc ggctgggcgc tttggtggcg gcggcgccgt gctgggcatc gacaacgtgt
      781 gcgagctggc ggcgcgccta ctgttcagca cggtcgagtg ggcccgccac gcgcccttct
      841 tcccggagct gccggccgcc gaccaggtgg cgctgctgcg gctcagctgg agcgagctgt
      901 tcgtgctgaa cgcggcgcag gcggcgctac cgctgcacac ggcaccgctg ctggctgccg
      961 cggggctgca cgccgcgccc atggctgcgg agcgcgcggt ggccttcatg gaccaggtgc
     1021 gtgccttcca ggagcaggtg gacaagctgg gccgcctgca ggtggatgct gccgagtacg
     1081 gctgcctcaa ggccatcgcg ctcttcacgc ctgatgcctg tggcctttct gacccagccc
     1141 atgttgagag cctgcaggag aaggcacagg tggccctcac cgagtatgtc cgtgcccagt
     1201 acccatcaca gccccagcgc tttggacgcc tgctgctgcg gctgccggcc ctgcgtgctg
     1261 tgcctgcatc cctcatctcc cagcttttct tcatgcgcct ggtgggcaag acacccatcg
     1321 agacgctcat ccgggacatg cttctgtcag ggagcacctt taactggccc tatggctcgg
     1381 gctagtgatg gtcctttcca ggacacatgg aagctggggc cttgtaggga ccatggggac
     1441 cagggcccca gcttctcttc tgagactgac ttcttttttt aaagactgtg aaatgtttgg
     1501 tttggtttgt tttttaaata atcatgaaac caaaaagatt cggatctccc aggctccagc
     1561 tttgtcctgg cagcccttcg gcagggtggg gctgagggtc tggagccagc atgctagtgc
     1621 ctctggtcct gggtatctgg aagggccact gcagctgggc aggggtgcta tgggccagga
     1681 gggtcccctg gacacatggc ccatggaggg aaccatgaaa tcatggccaa caataaagat
     1741 attcccatcc tt
//
