LOCUS       NP_620813                390 aa            linear   ROD 05-MAY-2025
DEFINITION  nuclear receptor subfamily 2 group F member 6 [Rattus norvegicus].
ACCESSION   NP_620813 XP_001068710
VERSION     NP_620813.2
DBSOURCE    REFSEQ: accession NM_139113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 390)
  AUTHORS   Warnecke,M., Oster,H., Revelli,J.P., Alvarez-Bolado,G. and
            Eichele,G.
  TITLE     Abnormal development of the locus coeruleus in
            Ear2(Nr2f6)-deficient mice impairs the functionality of the
            forebrain clock and affects nociception
  JOURNAL   Genes Dev 19 (5), 614-625 (2005)
   PUBMED   15741322
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Raccurt,M., Smallwood,S., Mertani,H.C., Devost,D., Abbaci,K.,
            Boutin,J.M. and Morel,G.
  TITLE     Cloning, expression and regulation of chicken ovalbumin upstream
            promoter transcription factors (COUP-TFII and EAR-2) in the rat
            anterior pituitary gland
  JOURNAL   Neuroendocrinology 82 (5-6), 233-244 (2005)
   PUBMED   16721029
  REMARK    GeneRIF: Cloning of rat pituitary COUP-TFII and EAR-2 genes,
            demonstrated that they are specifically expressed in lactotropes,
            and strongly suggested that they may play a role in modulating
            prolactin (PRL) gene expression during pregnancy.
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Liu,X., Huang,X. and Sigmund,C.D.
  TITLE     Identification of a nuclear orphan receptor (Ear2) as a negative
            regulator of renin gene transcription
  JOURNAL   Circ Res 92 (9), 1033-1040 (2003)
   PUBMED   12690040
REFERENCE   5  (residues 1 to 390)
  AUTHORS   Zhang,Y. and Dufau,M.L.
  TITLE     Nuclear orphan receptors regulate transcription of the gene for the
            human luteinizing hormone receptor
  JOURNAL   J Biol Chem 275 (4), 2763-2770 (2000)
   PUBMED   10644740
REFERENCE   6  (residues 1 to 390)
  AUTHORS   Chu,K. and Zingg,H.H.
  TITLE     The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers
            of the human oxytocin gene promoter
  JOURNAL   J Mol Endocrinol 19 (2), 163-172 (1997)
   PUBMED   9343308
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NP_620813.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF003926.1, SRR26643298.70826.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     Protein         1..390
                     /product="nuclear receptor subfamily 2 group F member 6"
                     /note="COUPg; V-erbA-related protein EAR-2; orphan nuclear
                     receptor EAR-2; V-erbA-related protein 2; ovalbumin
                     upstream promoter gamma nuclear receptor rCOUPg"
                     /calculated_mol_wt=41719
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O09017.1)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P43136; propagated from
                     UniProtKB/Swiss-Prot (O09017.1)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10588; propagated from
                     UniProtKB/Swiss-Prot (O09017.1)"
     Region          57..129
                     /region_name="NR_DBD_COUP_TF"
                     /note="DNA-binding domain of chicken ovalbumin upstream
                     promoter transcription factors (COUP-TFs) is composed of
                     two C4-type zinc fingers; cd06958"
                     /db_xref="CDD:143516"
     Site            order(57,60,74,77,93,99,109,112)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143516"
     Site            order(66..69,75..76,78,80,83,86,94,106..107,110,113,124)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143516"
     Region          157..387
                     /region_name="NR_LBD_COUP-TF"
                     /note="Ligand binding domain of chicken ovalbumin upstream
                     promoter transcription factors, a member of the nuclear
                     receptor family; cd06948"
                     /db_xref="CDD:132746"
     Site            order(188..189,193,227,231,234,248,269)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:132746"
     Site            order(198,201,205,210,215..216,218..219,222..223)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132746"
     Region          314..390
                     /region_name="Important for dimerization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O09017.1)"
     CDS             1..390
                     /gene="Nr2f6"
                     /coded_by="NM_139113.2:213..1385"
                     /db_xref="GeneID:245980"
                     /db_xref="RGD:621685"
ORIGIN      
        1 mamvtggwgg pggdtngvdk aggsyprate ddsasppgat sdaepgdeer pglqvdcvvc
       61 gdkssgkhyg vftcegcksf fkrsirrnls ytcrsnrdcq idqhhrnqcq ycrlkkcfrv
      121 gmrkeavqrg riphalpgpa acsppgaagv epfagppvse liaqllraep ypaagrfggg
      181 gavlgidnvc elaarllfst vewarhapff pelpaadqva llrlswself vlnaaqaalp
      241 lhtapllaaa glhaapmaae ravafmdqvr afqeqvdklg rlqvdaaeyg clkaialftp
      301 dacglsdpah veslqekaqv alteyvraqy psqpqrfgrl llrlpalrav paslisqlff
      361 mrlvgktpie tlirdmllsg stfnwpygsg
//
