LOCUS       NM_080778               1571 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 2, group F, member 2
            (Nr2f2), mRNA.
ACCESSION   NM_080778
VERSION     NM_080778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Han,S.H., Kim,Y.H., Park,S.J., Cho,J.G., Shin,Y.K., Hong,Y.B.,
            Yun,J., Han,J.Y., Park,H.T. and Park,J.I.
  TITLE     COUP-TFII plays a role in cAMP-induced Schwann cell differentiation
            and in vitro myelination by up-regulating Krox20
  JOURNAL   J Neurochem 165 (5), 660-681 (2023)
   PUBMED   36648143
  REMARK    GeneRIF: COUP-TFII plays a role in cAMP-induced Schwann cell
            differentiation and in vitro myelination by up-regulating Krox20.
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Kumarasamy,S., Waghulde,H., Gopalakrishnan,K., Mell,B., Morgan,E.
            and Joe,B.
  TITLE     Mutation within the hinge region of the transcription factor Nr2f2
            attenuates salt-sensitive hypertension
  JOURNAL   Nat Commun 6, 6252 (2015)
   PUBMED   25687237
  REMARK    GeneRIF: Nr2f2 mutation in the hinge region attenuates
            salt-sensitive hypertension
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Tornari,C., Towers,E.R., Gale,J.E. and Dawson,S.J.
  TITLE     Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15
            deafness gene Pou4f3
  JOURNAL   PLoS One 9 (11), e112247 (2014)
   PUBMED   25372459
  REMARK    GeneRIF: These data demonstrate that Nr2f2 is a direct target of
            POU4F3 in vitro and that this regulatory relationship may be
            relevant to hair cell development and survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Howell,M., Li,R., Zhang,R., Li,Y., Chen,W. and Chen,G.
  TITLE     The expression of Apoc3 mRNA is regulated by HNF4alpha and
            COUP-TFII, but not acute retinoid treatments, in primary rat
            hepatocytes and hepatoma cells
  JOURNAL   Mol Cell Biochem 387 (1-2), 241-250 (2014)
   PUBMED   24234421
  REMARK    GeneRIF: Apoc3 expression is regulated by HNF4a and COUP-TFII but
            not by retinoic acid in rat hepatocytes.
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Kim,B.J. and Scott,D.A.
  TITLE     Mouse model reveals the role of RERE in cerebellar foliation and
            the migration and maturation of Purkinje cells
  JOURNAL   PLoS One 9 (1), e87518 (2014)
   PUBMED   24466353
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Zhang,Y. and Dufau,M.L.
  TITLE     Repression of the luteinizing hormone receptor gene promoter by
            cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB
  JOURNAL   Mol Cell Biol 23 (19), 6958-6972 (2003)
   PUBMED   12972613
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Kang,S., Spann,N.J., Hui,T.Y. and Davis,R.A.
  TITLE     ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a
            transcriptional repressor of microsomal triglyceride transfer
            protein and an inducer of CYP7A1
  JOURNAL   J Biol Chem 278 (33), 30478-30486 (2003)
   PUBMED   12777384
  REMARK    GeneRIF: ARP-1/COUP-TFII acts as both a transcriptional repressor
            of microsomal triglyceride transfer protein and as a transcription
            activator of CYP7A1.
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Chu,K. and Zingg,H.H.
  TITLE     The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers
            of the human oxytocin gene promoter
  JOURNAL   J Mol Endocrinol 19 (2), 163-172 (1997)
   PUBMED   9343308
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   Marcus,S.L., Winrow,C.J., Capone,J.P. and Rachubinski,R.A.
  TITLE     A p56(lck) ligand serves as a coactivator of an orphan nuclear
            hormone receptor
  JOURNAL   J Biol Chem 271 (44), 27197-27200 (1996)
   PUBMED   8910285
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   Ben-Shushan,E., Sharir,H., Pikarsky,E. and Bergman,Y.
  TITLE     A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and
            retinoic acid receptor:retinoid X receptor heterodimers regulates
            Oct-3/4 expression in embryonal carcinoma cells
  JOURNAL   Mol Cell Biol 15 (2), 1034-1048 (1995)
   PUBMED   7823919
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF003944.1.
            
            On Aug 31, 2012 this sequence version replaced NM_080778.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF003944.1, EV770714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1571              AF003944.1         2-1572
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1571
                     /gene="Nr2f2"
                     /gene_synonym="Tfcoup2"
                     /note="nuclear receptor subfamily 2, group F, member 2"
                     /db_xref="GeneID:113984"
                     /db_xref="RGD:69305"
     exon            1..626
                     /gene="Nr2f2"
                     /gene_synonym="Tfcoup2"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1429
                     /gene="Nr2f2"
                     /gene_synonym="Tfcoup2"
                     /note="ARP-1; COUPb; COUP-TF2; COUP-TF II; apolipoprotein
                     AI regulatory protein 1; ovalbumin upstream promoter beta
                     nuclear receptor; COUP transcription factor II;
                     apolipoprotein A-I regulatory protein 1"
                     /codon_start=1
                     /product="COUP transcription factor 2"
                     /protein_id="NP_542956.1"
                     /db_xref="GeneID:113984"
                     /db_xref="RGD:69305"
                     /translation="MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPG
                     QGGPASTPAQTAAGSQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSF
                     FKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPT
                     HGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAAR
                     MLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLH
                     ASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHV
                     ESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPI
                     ETLIRDMLLSGSSFNWPYMAIQ"
     exon            627..1154
                     /gene="Nr2f2"
                     /gene_synonym="Tfcoup2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1571
                     /gene="Nr2f2"
                     /gene_synonym="Tfcoup2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaaggaaa aactaactaa cctcaatcaa ctagccctga gccacccggg gcgccctccc
       61 gcgccctctc gcaccctcgc acacacaaaa ggcggcgcgc cggagcccga gacccgggag
      121 ccgccgccac cccgccgccg cccgcagcca ggggagcaga agtccggacg cggcccccat
      181 agatatggca atggtagtca gcacgtggcg cgacccccag gacgaggtgc ccggctctca
      241 gggcagccag gcctcgcagg cgccgcccgt gccgggcccg ccgcctggcg ccccgcacac
      301 gccacagacg ccgggccaag ggggcccggc cagcacgccg gcccagacag cggctggcag
      361 ccagggcggc cctggcggcc caggcagcga caaacagcag cagcagcagc acatcgagtg
      421 cgtggtgtgc ggggacaagt cgagcggcaa gcactacggc cagttcacgt gcgagggctg
      481 caagagcttc ttcaagcgca gcgtgcggag gaacctgagc tacacgtgcc gcgccaaccg
      541 gaactgtccc atcgaccagc accaccgcaa ccagtgccag tactgccgcc tcaaaaagtg
      601 cctcaaagtg ggcatgagac gggaagctgt acagaggggc aggatgccgc ccacccagcc
      661 tactcacggg cagtttgcac tgaccaacgg ggaccccctc aactgccact cgtacctgtc
      721 cggatatatt tccctgctgc tgcgcgcgga gccctacccc acgtcgcgct tcggcagtca
      781 gtgcatgcag cctaacaaca tcatgggcat cgagaacatt tgcgaactgg ccgcacggat
      841 gctcttcagc gccgttgagt gggcccggaa catccccttc ttccctgacc tgcagatcac
      901 ggaccaggtg gccctccttc gcctcacctg gagcgagctg ttcgtgttga atgcagcaca
      961 gtgctccatg cccctccatg ttgccccgct ccttgccgct gctggcctgc acgcttcacc
     1021 catgtcagcc gaccgggtgg tcgcctttat ggaccacata cggatcttcc aagagcaagt
     1081 ggagaagctc aaggcactgc acgtcgactc cgccgagtac agctgcctca aggccatagt
     1141 cctgttcacc tcagatgcct gtggtctgtc tgatgtagcc cacgtggaaa gtttgcagga
     1201 aaagtcccag tgtgctttgg aagagtacgt taggagccag taccccaacc agccaacacg
     1261 gttcggaaag cttttgcttc gtctcccttc cctccgcacg gtctcctcct cagtcataga
     1321 gcaattgttt ttcgtccgtt tggtaggtaa aacccccatc gaaaccctca tccgggatat
     1381 gttactgtcc ggcagcagtt ttaactggcc atacatggca attcaataaa taaataaatc
     1441 aaaataaggg ggagtgaaac agagaaagaa aaggcaaaag actggttttt gtttgcttaa
     1501 tttccttctg ttaagaaagg atgttacaag tttgctaaaa gaagagaggg gaagaactta
     1561 atggactttg a
//
