LOCUS       NM_001113197            3140 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 2, group E, member 1
            (Nr2e1), mRNA.
ACCESSION   NM_001113197 XM_001068861
VERSION     NM_001113197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Kozareva,D.A., Foley,T., Moloney,G.M., Cryan,J.F. and Nolan,Y.M.
  TITLE     TLX knockdown in the dorsal dentate gyrus of juvenile rats
            differentially affects adolescent and adult behaviour
  JOURNAL   Behav Brain Res 360, 36-50 (2019)
   PUBMED   30481511
  REMARK    GeneRIF: The current data highlight the temporal importance and
            function of the nuclear receptor TLX during development.
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   O'Leime,C.S., Kozareva,D.A., Hoban,A.E., Long-Smith,C.M.,
            Cryan,J.F. and Nolan,Y.M.
  TITLE     TLX is an intrinsic regulator of the negative effects of IL-1beta
            on proliferating hippocampal neural progenitor cells
  JOURNAL   FASEB J 32 (2), 613-624 (2018)
   PUBMED   28970252
  REMARK    GeneRIF: IL-1beta activated the NF-kappaB pathway in proliferating
            NPCs and that this activation was responsible for IL-1beta-induced
            changes in TLX expression.
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Green,H.F. and Nolan,Y.M.
  TITLE     Unlocking mechanisms in interleukin-1beta-induced changes in
            hippocampal neurogenesis--a role for GSK-3beta and TLX
  JOURNAL   Transl Psychiatry 2 (11), e194 (2012)
   PUBMED   23168994
  REMARK    GeneRIF: IL-1beta causes a decrease in TLX expression in
            hippocampal neural stem/progenitor cells that can be prevented by
            GSK-3beta inhibition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Wang,T., Ren,X., Xiong,J., Zhang,L., Qu,J. and Xu,W.
  TITLE     Tailless-like (TLX) protein promotes neuronal differentiation of
            dermal multipotent stem cells and benefits spinal cord injury in
            rats
  JOURNAL   Cell Mol Neurobiol 31 (3), 479-487 (2011)
   PUBMED   21258860
  REMARK    GeneRIF: Data show that Tailless-like (TLX) promotes the
            proliferation and neuronal differentiation of dermal multipotent
            stem cells and may serve as a promising therapy for spinal cord
            injury in the clinic.
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Elmi,M., Matsumoto,Y., Zeng,Z.J., Lakshminarasimhan,P., Yang,W.,
            Uemura,A., Nishikawa,S., Moshiri,A., Tajima,N., Agren,H. and
            Funa,K.
  TITLE     TLX activates MASH1 for induction of neuronal lineage commitment of
            adult hippocampal neuroprogenitors
  JOURNAL   Mol Cell Neurosci 45 (2), 121-131 (2010)
   PUBMED   20599619
  REMARK    GeneRIF: these results suggest that TLX not only acts as a
            repressor of cell cycle and glial differentiation but also
            activates neuronal lineage commitment in hippocampus-derived
            progenitors.
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Land,P.W. and Monaghan,A.P.
  TITLE     Expression of the transcription factor, tailless, is required for
            formation of superficial cortical layers
  JOURNAL   Cereb Cortex 13 (9), 921-931 (2003)
   PUBMED   12902391
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Roy,K., Thiels,E. and Monaghan,A.P.
  TITLE     Loss of the tailless gene affects forebrain development and
            emotional behavior
  JOURNAL   Physiol Behav 77 (4-5), 595-600 (2002)
   PUBMED   12527005
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Young,K.A., Berry,M.L., Mahaffey,C.L., Saionz,J.R., Hawes,N.L.,
            Chang,B., Zheng,Q.Y., Smith,R.S., Bronson,R.T., Nelson,R.J. and
            Simpson,E.M.
  TITLE     Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular
            abnormalities are background-dependent
  JOURNAL   Behav Brain Res 132 (2), 145-158 (2002)
   PUBMED   11997145
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Yu,R.T., Chiang,M.Y., Tanabe,T., Kobayashi,M., Yasuda,K.,
            Evans,R.M. and Umesono,K.
  TITLE     The orphan nuclear receptor Tlx regulates Pax2 and is essential for
            vision
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2621-2625 (2000)
   PUBMED   10706625
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Monaghan,A.P., Bock,D., Gass,P., Schwager,A., Wolfer,D.P.,
            Lipp,H.P. and Schutz,G.
  TITLE     Defective limbic system in mice lacking the tailless gene
  JOURNAL   Nature 390 (6659), 515-517 (1997)
   PUBMED   9394001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 22, 2022 this sequence version replaced NM_001113197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.3057944.1, EU316216.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               JAXUCZ010000020.1  47652752-47653464   c
            714-859             JAXUCZ010000020.1  47647996-47648141   c
            860-947             JAXUCZ010000020.1  47644585-47644672   c
            948-1183            JAXUCZ010000020.1  47642971-47643206   c
            1184-1330           JAXUCZ010000020.1  47641582-47641728   c
            1331-1427           JAXUCZ010000020.1  47638425-47638521   c
            1428-1577           JAXUCZ010000020.1  47637887-47638036   c
            1578-1683           JAXUCZ010000020.1  47637541-47637646   c
            1684-3140           JAXUCZ010000020.1  47632347-47633803   c
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..3140
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /note="nuclear receptor subfamily 2, group E, member 1"
                     /db_xref="GeneID:684085"
                     /db_xref="RGD:1595162"
     exon            1..713
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     CDS             689..1846
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group E member 1"
                     /protein_id="NP_001106668.2"
                     /db_xref="GeneID:684085"
                     /db_xref="RGD:1595162"
                     /translation="MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSI
                     RRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQ
                     VALYFRGHKEDNGAAAHFPSAALPAPAFFTAVTQLEPHGLELTAVSATPERQTLVSLA
                     QPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLL
                     EDAWRELFVLGIAQWAIPVDANTLLAVSGMNSDNTDSQKLNKIISEIQALQEVVARFR
                     QLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYP
                     TQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI"
     exon            714..859
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            860..947
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1183
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1330
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1427
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1577
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1683
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..3140
                     /gene="Nr2e1"
                     /gene_synonym="TLX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaagtcac agggtaatga acttcgggga cccttcgccg ctgcgtgcgc ggctgtcccc
       61 ggaaactcgg atctggccac ctctcccctt ggaagatctc ccaaccatct agtttcccgt
      121 ctcggcgcct gggctctgca gcgaggagct tctttgcctc tgagactgcg gctgtgattt
      181 ttgtctttcc acagaagatc agcggtctgc agagagctgc ccactgtgct cgcctgtgtg
      241 gagggagatt ggaaacagcc acaggcatgg ggaaagaggg gaagttcgcc ctctttgctc
      301 cgtaggaaga ccatttccgt gtctccatct ctgtccttca atattcccct agcgctgtcc
      361 tccctcttca gtctgcctgt ccgcctgtcc gtctctccat ctgtttgttc aagaccgtgt
      421 ccacatcgag ccgcgtcccc agcagctgca gttttgctag agccgggaaa gaaacttaag
      481 gatgcttaca tttccactgt ggaacgaatt ctgagcgccc gggagagcag ggcagcgcgc
      541 aaccgatagc cacctgtctg tctcgctcgc ctgggagccc tgcaggctgg agggcggctg
      601 gagagcggcg gcgccgggcg gcgacgtggg cgccgtgggc cgggaatccg gcactgccca
      661 ccaaccgctg cgccccggga ccgccagcat gagcaagccc gccggatcaa caagccgcat
      721 tttagatatc ccttgcaaag tgtgtggtga ccgcagctcc gggaagcact acggcgtcta
      781 cgcttgcgac ggctgctctg gattcttcaa aaggagcatc cgaaggaata ggacctatgt
      841 ctgcaagtct ggaaaccagg gaggatgccc cgtagacaag acacacagaa accagtgcag
      901 ggcgtgtcga ctgaagaagt gtttggaagt caacatgaac aaagacgccg tgcagcacga
      961 gcggggccct cggacgtcca ccatccgcaa acaggtggcc ctctacttcc gtgggcacaa
     1021 ggaagacaac ggggcggctg cgcacttccc ctccgcagcg ctgccagccc ccgctttctt
     1081 cacagcggtc acgcagctgg agccgcacgg tctggagttg accgctgtgt ctgccacccc
     1141 tgaacggcag actctcgtga gcctggctca gcccacgccc aagtatcccc atgaagtgaa
     1201 cgggacccca atgtatctct atgaagtggc caccgagtcc gtgtgcgaat cagcagccag
     1261 acttctcttc atgagcatca agtgggcaaa gagtgtgcca gccttttcca cgttgtcttt
     1321 gcaagatcag ctgatgcttt tggaagacgc gtggagagaa ctgtttgttc taggaatagc
     1381 acaatgggcc attccggttg atgctaacac actactggct gtatctggca tgaatagtga
     1441 taacacagac tcccagaagc tgaacaagat catatctgaa atacaggctt tgcaggaggt
     1501 ggtggctcga ttcagacagc tccgattaga cgccactgaa tttgcctgtc tgaaatgcat
     1561 tgttactttt aaagccgttc ctacccacag tggctctgaa ctgagaagtt tccggaatgc
     1621 tgccgccatt gccgctctcc aagatgaagc ccagctgact ctcaacagct acattcatac
     1681 gagatacccc acccaaccct gccgattcgg gaaactcctg ttgcttttac cagctttacg
     1741 gtcgattagc ccatccacca tagaagaagt gtttttcaaa aaaaccatcg gcaacgtgcc
     1801 gataacgaga ctgctttcag atatgtacaa atccagtgac atctaaggtc tccagcaccc
     1861 actttccaag acggggcagt atcagatgga catctaccgt gcagtatgag cctcaaataa
     1921 cgagactttc tggaaggaga aacctgggag gaagtggcct tcaggaaaaa aaatgtcagt
     1981 ggacacagaa aaataactat gacttgctgc tcccctgaag tgggacagct ggaaagacca
     2041 ggggttacaa cgattactgt ctccatgccc tgggatgggg tgaactgggg tcaccagcac
     2101 aggctgagcc aggcgttctg cctctgacct gggagatccg gctgaatcat tcacagctga
     2161 aagacaagcc gtgctttctt ctcctgtgta gcacataaag tcagtcagtg aacagttcgt
     2221 gtgtgacatc gccatatact gcggccttca gaactcggtt gggttggaac actgacttaa
     2281 aaaaaaaaca atgcttaggt tttaaatcaa aagtattatc aaacgttttt cctcctatca
     2341 taatacttca ttaagtggcc ttcagaacca agcgagtaag cggaccatag cttatgctgt
     2401 gtggtggttt cctttccctc cccctcccct acctcctttc tggttttctt ttcttttttt
     2461 ctttttttct tttcttatac cgtaagccag gcaacctcgt cagaggtact gatggcaaag
     2521 gcatttctca gcaagacttc agggtgaatt agcacagctc tactgaaaga accccggtcc
     2581 gggagaatcc cggtctggga ggatgagtcc aaacagcgaa accaaatgga gtggagccag
     2641 gtgactgggt gaggcggtcg ctgtcccgtc atcaaagtgc tgaagccaaa ggccgtaggg
     2701 tcagcgagtc acgctaggca gtgaacaggg aaggaagcca gaaggaactt caaggagatg
     2761 cgtgctaaac ggattcctga acattccact gctaacagcc tgagactctc agatgccttt
     2821 cagaaaactc tggtttctaa taaagcctca aatgcataca ttaccccccc cccccaatgc
     2881 catcctacac tcttaagctg ctccttgggt atgaatctat acttatggaa acatagaaac
     2941 aatttgaaat agctgctgta ctcttcacgt tttgatttat taggtactag caccgagggg
     3001 ggtgggaatt cagcacttgg atggactagc atagtatgag tcagacttct cttgtacaaa
     3061 tcgaattaac tgatttgtga agttaaaagg ttgtactcat tgtatttaca aagaataaaa
     3121 atatattgaa tttaagtaaa
//
