LOCUS       NM_145780               2285 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 2, group C, member 1
            (Nr2c1), mRNA.
ACCESSION   NM_145780
VERSION     NM_145780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Gupta,P., Ho,P.C., Huq,M.M., Ha,S.G., Park,S.W., Khan,A.A.,
            Tsai,N.P. and Wei,L.N.
  TITLE     Retinoic acid-stimulated sequential phosphorylation, PML
            recruitment, and SUMOylation of nuclear receptor TR2 to suppress
            Oct4 expression
  JOURNAL   Proc Natl Acad Sci U S A 105 (32), 11424-11429 (2008)
   PUBMED   18682553
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Tanabe,O., Shen,Y., Liu,Q., Campbell,A.D., Kuroha,T., Yamamoto,M.
            and Engel,J.D.
  TITLE     The TR2 and TR4 orphan nuclear receptors repress Gata1
            transcription
  JOURNAL   Genes Dev 21 (21), 2832-2844 (2007)
   PUBMED   17974920
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Khan,S.A., Park,S.W., Huq,M. and Wei,L.N.
  TITLE     Protein kinase C-mediated phosphorylation of orphan nuclear
            receptor TR2: effects on receptor stability and activity
  JOURNAL   Proteomics 5 (15), 3885-3894 (2005)
   PUBMED   16130175
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Franco,P.J., Farooqui,M., Seto,E. and Wei,L.N.
  TITLE     The orphan nuclear receptor TR2 interacts directly with both class
            I and class II histone deacetylases
  JOURNAL   Mol Endocrinol 15 (8), 1318-1328 (2001)
   PUBMED   11463856
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Lee,C.H., Chinpaisal,C. and Wei,L.N.
  TITLE     Cloning and characterization of mouse RIP140, a corepressor for
            nuclear orphan receptor TR2
  JOURNAL   Mol Cell Biol 18 (11), 6745-6755 (1998)
   PUBMED   9774688
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Yu,Z., Lee,C.H., Chinpaisal,C. and Wei,L.N.
  TITLE     A constitutive nuclear localization signal from the second
            zinc-finger of orphan nuclear receptor TR2
  JOURNAL   J Endocrinol 159 (1), 53-60 (1998)
   PUBMED   9795341
REFERENCE   7  (bases 1 to 2285)
  AUTHORS   Chinpaisal,C., Chang,L., Hu,X., Lee,C.H., Wen,W.N. and Wei,L.N.
  TITLE     The orphan nuclear receptor TR2 suppresses a DR4 hormone response
            element of the mouse CRABP-I gene promoter
  JOURNAL   Biochemistry 36 (46), 14088-14095 (1997)
   PUBMED   9369481
REFERENCE   8  (bases 1 to 2285)
  AUTHORS   Lee,C.H., Chang,L. and Wei,L.N.
  TITLE     Distinct expression patterns and biological activities of two
            isoforms of the mouse orphan receptor TR2
  JOURNAL   J Endocrinol 152 (2), 245-255 (1997)
   PUBMED   9071982
REFERENCE   9  (bases 1 to 2285)
  AUTHORS   Lee,C.H., Chang,L. and Wei,L.N.
  TITLE     Molecular cloning and characterization of a mouse nuclear orphan
            receptor expressed in embryos and testes
  JOURNAL   Mol Reprod Dev 44 (3), 305-314 (1996)
   PUBMED   8858600
REFERENCE   10 (bases 1 to 2285)
  AUTHORS   Teglund,S., Zhou,G.Q. and Hammarstrom,S.
  TITLE     Characterization of cDNA encoding novel pregnancy-specific
            glycoprotein variants
  JOURNAL   Biochem Biophys Res Commun 211 (2), 656-664 (1995)
   PUBMED   7794280
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26398.1, SRR21887623.3282682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000007.1  30602607-30602766
            161-233             JAXUCZ010000007.1  30612220-30612292
            234-428             JAXUCZ010000007.1  30617533-30617727
            429-507             JAXUCZ010000007.1  30618998-30619076
            508-687             JAXUCZ010000007.1  30619517-30619696
            688-835             JAXUCZ010000007.1  30623567-30623714
            836-926             JAXUCZ010000007.1  30623804-30623894
            927-1111            JAXUCZ010000007.1  30627400-30627584
            1112-1271           JAXUCZ010000007.1  30628361-30628520
            1272-1393           JAXUCZ010000007.1  30638147-30638268
            1394-1533           JAXUCZ010000007.1  30645655-30645794
            1534-1671           JAXUCZ010000007.1  30648100-30648237
            1672-1777           JAXUCZ010000007.1  30650851-30650956
            1778-2285           JAXUCZ010000007.1  30653641-30654148
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2285
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /note="nuclear receptor subfamily 2, group C, member 1"
                     /db_xref="GeneID:252924"
                     /db_xref="RGD:3200"
     exon            1..160
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            161..233
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1952
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /note="orphan receptor, TR2-11; pregnancy specific
                     beta-1-glycoprotein 4; nuclear receptor subfamily 2, group
                     H, member 1; testicular receptor 2; orphan nuclear
                     receptor TR2"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group C member 1"
                     /protein_id="NP_665723.1"
                     /db_xref="GeneID:252924"
                     /db_xref="RGD:3200"
                     /translation="MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQF
                     ILANHEGSTPGKVFLTTPDAAGVNQLFFASPDLSTPHLQLLTENSPDQGPNKVFDLCV
                     VCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQR
                     CIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETA
                     RSTGLLDSGMFVNIHPSGIKTEPALLMTPDKAESCQGDLGTLASVVTSLANLGKAKDL
                     SHCGGDLPVVQSLRNGDTSFGAFHQDIQTNGDVSRAFDNLAKALTPGENPACQSPGES
                     MEGSTHLIAGEPSCMEREGPLLSDSHVVFRLTMPSPMPEYLNVHYIGESASRLLFLSM
                     HWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQ
                     QDKMSPERRKLLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELI
                     EKFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRI
                     DSVIPHILKMEPADYNSQIIGHSL"
     exon            234..428
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            429..507
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            508..687
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            688..835
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            836..926
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1111
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1271
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1393
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1533
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1671
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1777
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2285
                     /gene="Nr2c1"
                     /gene_synonym="Psg4; Tr2; TR2-11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcgcca agagcaccgc gcaccgccaa gccgagggtg gggtcacgaa ctctgacccc
       61 cacccccaaa tacacaaacc cagaaagctc tcctgtcccc ttggcctcgg gtcccctcgc
      121 ctctgctctc tccagcccag cggccgccac ggcgggaggg atattttgac aattagatca
      181 tggcgaccat agaagaaatt gcacatcaga ttattgacca acagatgggt gagattgtta
      241 cagagcagca gactggacag aaaatccaga tcgtgacagc acttgaccac agcacacagg
      301 gcaagcagtt cattctagca aaccatgagg gatccacccc agggaaagtc ttcctcacga
      361 caccagatgc tgcaggtgtc aaccagttgt tttttgccag tcctgatctg tccacaccac
      421 acctccagct cttaacagaa aattctcctg accagggacc aaataaggtc tttgaccttt
      481 gcgttgtgtg tggagacaaa gcatcaggcc gccattacgg agcaataact tgtgagggct
      541 gcaaagggtt ttttaaaaga agcatccgga agaatctagt gtactcgtgc cgggggtcca
      601 aagactgcat cattaacaag caccaccgga accgctgcca atactgccgg ctgcagcggt
      661 gcatagcctt cgggatgaag caagactccg ttcagtgtga aagaaagccc attgaagtgt
      721 cccgagaaaa gtcttccaac tgtgcagctt ctacagagaa aatctacatc cgcaaagacc
      781 tccgaagccc tctggctgca acgccaacct ttgtaacgga cagcgagact gccaggtcaa
      841 ctggactgtt ggattcgggg atgtttgtga atattcatcc atctggaata aagacagaac
      901 cagctctgct aatgacacca gataaggctg agtcctgtca gggagacttg ggcacattgg
      961 ccagtgtggt cacgtcatta gcgaatctcg gcaaggctaa agacctttct cactgtggtg
     1021 gcgatctgcc tgtggtgcag agcttgcgca atggagatac atcctttggt gcatttcatc
     1081 aggatatcca gaccaatggt gatgtgtcaa gggcatttga caatcttgca aaagcattga
     1141 ctcccggaga aaacccagcc tgccagagcc caggagagag catggaagga agcacacatc
     1201 taatcgctgg agagccaagc tgcatggaga gagaggggcc actgctcagc gattcgcatg
     1261 tcgttttcag gctcaccatg ccttctccta tgcccgagta cctgaatgtg cactacattg
     1321 gggagtcggc ctccagactg ctgttcttat cgatgcactg ggcgctttcc ataccttctt
     1381 tccaggcgct cgggcaagaa aacagcatat cactggtaaa agcctattgg aatgaactct
     1441 ttaccctcgg tctcgcccag tgctggcaag tgatgaacgt cgcaactata ttagcaacgt
     1501 ttgtcaactg tcttcacaat agccttcagc aagataaaat gtccccggag aggaggaagt
     1561 tgttgatgga gcacatcttc aagctgcagg agttctgtaa tagcatggtg aagctctgca
     1621 tagacgggca tgagtacgcc tacctcaagg ccatcgttct cttcagtccc gaccatccag
     1681 gcctggagaa catggagctg attgagaaat ttcaggaaaa ggcttatgtg gaattccaag
     1741 attacatcac caggacatat ccagatgaca cctacaggct gtctagatta cttctcagac
     1801 tgccggcctt gcggctgatg aatgccacca tcactgagga attgttcttc aaaggtctca
     1861 ttggcaacgt acggatcgac agtgtcatcc cacacatttt aaaaatggag cctgcagatt
     1921 acaactctca aataattggt cacagccttt gaaagtggag gtcaccctgc tccaggctaa
     1981 gtttaccgtt ccttctcgga acacatgaaa ccaaatcgaa ctgtttcttc cagggcatct
     2041 gcgaatatta actttaagag taaccaaaat caaaagtatt tttcttttgg attccttaag
     2101 aagaatttaa gtgaccaggc aggggtcagg aattatacta ccctgtctgt cctataggaa
     2161 tgaatcaaca atggtacggg gctgttcttg gggaggatga cacttaagac tctctcctcc
     2221 tgactgtcta cactaagctt tctcattcta ttttataaaa caaataaact agtctttccc
     2281 ccctg
//
