LOCUS       NM_022941               1610 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group I, member 3
            (Nr1i3), transcript variant 1, mRNA.
ACCESSION   NM_022941
VERSION     NM_022941.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Yamada,T., Cohen,S.M. and Lake,B.G.
  TITLE     Critical evaluation of the human relevance of the mode of action
            for rodent liver tumor formation by activators of the constitutive
            androstane receptor (CAR)
  JOURNAL   Crit Rev Toxicol 51 (5), 373-394 (2021)
   PUBMED   34264181
  REMARK    GeneRIF: Critical evaluation of the human relevance of the mode of
            action for rodent liver tumor formation by activators of the
            constitutive androstane receptor (CAR).
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Gabbia,D., Pozza,A.D., Albertoni,L., Lazzari,R., Zigiotto,G.,
            Carrara,M., Baldo,V., Baldovin,T., Floreani,A. and Martin,S.
  TITLE     Pregnane X receptor and constitutive androstane receptor modulate
            differently CYP3A-mediated metabolism in early- and late-stage
            cholestasis
  JOURNAL   World J Gastroenterol 23 (42), 7519-7530 (2017)
   PUBMED   29204052
  REMARK    GeneRIF: nuclear expression virtually disappeared in the late stage
            of cholestatic injury, after an initial increase
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Forbes,K.P., Kouranova,E., Tinker,D., Janowski,K., Cortner,D.,
            McCoy,A. and Cui,X.
  TITLE     Creation and Preliminary Characterization of Pregnane X Receptor
            and Constitutive Androstane Receptor Knockout Rats
  JOURNAL   Drug Metab Dispos 45 (10), 1068-1076 (2017)
   PUBMED   28716828
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Fujino,C., Tamura,Y., Tange,S., Nakajima,H., Sanoh,S., Watanabe,Y.,
            Uramaru,N., Kojima,H., Yoshinari,K., Ohta,S. and Kitamura,S.
  TITLE     Metabolism of methiocarb and carbaryl by rat and human livers and
            plasma, and effect on their PXR, CAR and PPARalpha activities
  JOURNAL   J Toxicol Sci 41 (5), 677-691 (2016)
   PUBMED   27665777
  REMARK    GeneRIF: Metabolism of methiocarb and carbaryl does not alter CAR
            activity.
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Shao,Y.Y., Huang,J., Ma,Y.R., Han,M., Ma,K., Qin,H.Y., Rao,Z. and
            Wu,X.A.
  TITLE     Serum serotonin reduced the expression of hepatic transporter Mrp2
            and P-gp via regulating nuclear receptor CAR in PI-IBS rats
  JOURNAL   Can J Physiol Pharmacol 93 (8), 633-639 (2015)
   PUBMED   26053941
  REMARK    GeneRIF: Serum 5-HT regulates the expression of Mrp2 and P-gp, and
            the underlying mechanism may be related to the altered expression
            of the nuclear receptor constitutive androstane receptor.
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Numazawa,S., Shindo,S., Maruyama,K., Chibana,F., Kawahara,Y.,
            Ashino,T., Tanaka,S. and Yoshida,T.
  TITLE     Impaired nuclear translocation of CAR in hepatic preneoplastic
            lesions: association with an attenuated CYP2B induction by
            phenobarbital
  JOURNAL   FEBS Lett 579 (17), 3560-3564 (2005)
   PUBMED   15953603
  REMARK    GeneRIF: CAR expressed in the hepatic preneoplastic lesions of rats
            is resistant to nuclear translocation and transactivation of the
            phenobarbital(PB) responsive enhancer module upon PB treatment.
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Yoshinari,K., Kobayashi,K., Moore,R., Kawamoto,T. and Negishi,M.
  TITLE     Identification of the nuclear receptor CAR:HSP90 complex in mouse
            liver and recruitment of protein phosphatase 2A in response to
            phenobarbital
  JOURNAL   FEBS Lett 548 (1-3), 17-20 (2003)
   PUBMED   12885400
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Gonzalez,M.M. and Carlberg,C.
  TITLE     Cross-repression, a functional consequence of the physical
            interaction of non-liganded nuclear receptors and POU domain
            transcription factors
  JOURNAL   J Biol Chem 277 (21), 18501-18509 (2002)
   PUBMED   11891224
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Yoshinari,K., Sueyoshi,T., Moore,R. and Negishi,M.
  TITLE     Nuclear receptor CAR as a regulatory factor for the sexually
            dimorphic induction of CYB2B1 gene by phenobarbital in rat livers
  JOURNAL   Mol Pharmacol 59 (2), 278-284 (2001)
   PUBMED   11160864
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Xie,W., Barwick,J.L., Simon,C.M., Pierce,A.M., Safe,S.,
            Blumberg,B., Guzelian,P.S. and Evans,R.M.
  TITLE     Reciprocal activation of xenobiotic response genes by nuclear
            receptors SXR/PXR and CAR
  JOURNAL   Genes Dev 14 (23), 3014-3023 (2000)
   PUBMED   11114890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089763.1 and JAXUCZ010000013.1.
            
            On Aug 3, 2012 this sequence version replaced NM_022941.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB104736.1, SRR26643286.37120.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-873               BC089763.1         1-873
            874-876             JAXUCZ010000013.1  86168676-86168678
            877-1096            BC089763.1         874-1093
            1097-1610           BC089763.1         1112-1625
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1610
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /note="nuclear receptor subfamily 1, group I, member 3"
                     /db_xref="GeneID:65035"
                     /db_xref="RGD:621400"
     exon            1..143
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            144..286
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1226
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     constitutive androstane receptor; strain Fischer nuclear
                     receptor (CAR); nuclear receptor constitutive active
                     receptor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 3
                     isoform 1"
                     /protein_id="NP_075230.1"
                     /db_xref="GeneID:65035"
                     /db_xref="RGD:621400"
                     /translation="MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGF
                     FRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRA
                     RQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQP
                     LAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNT
                     TFCLQTQNFFCGPLCYKMEDAVHVGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMA
                     LFSPDRPGVTQREEIDQLQEEVALILNNHIMEQQSRLQSRFLYAKLMGLLAELRSINS
                     AYSYEIHRIQGLSAMMPLLGEICS"
     exon            287..417
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            418..587
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            588..727
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            728..873
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            874..990
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1096
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1510
                     /gene="Nr1i3"
                     /gene_synonym="CAR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcactga ggaccacaat ccctaattcc tgtcagttgt tcctgagttc acaaggaaag
       61 cagggttatc aaggaggctt ggggagagac atcctaccca agattttgtg acctgcatgt
      121 ggcacgctgc ctaagagaaa caggagacca tgacagctac tctaacacta gagaccatga
      181 ccagtgaaga agagtatggg ccaaggaact gtgtggtgtg tggagaccga gccacgggct
      241 atcatttcca tgccctgact tgtgagggct gcaaaggctt tttcagacga acagtcagca
      301 agaccattgg tcccatctgt ccgtttgctg ggaggtgtga ggtcagcaag gcccagagac
      361 gccattgtcc agcctgcagg ttgcagaagt gtctaaatgt tggcatgagg aaagacatga
      421 tactgtcagc agaagccctg gcactgcgga gagccagaca ggcacggcgg cgggcacaga
      481 aagcatcttt gcaactgagt cagcagcaga aagagctcat ccagaccctc ctgggcgccc
      541 acactcgtca tgtgggcccc atgtttgacc agtttgtgca gttcaggcct ccggcctacc
      601 tgttcagcca tcaccggcct ttccagcccc tggcccccgt gttgcctctg ctcacacact
      661 ttgcagatat caatactttc atggtgcagc agattatcaa gttcaccaag gatctgcccc
      721 ttttccgttc cctgaccatg gaggaccaga tctcccttct caagggagcg gctgtggaaa
      781 tcttgcatat ctcactcaac actacgttct gccttcaaac acagaatttc ttctgcgggc
      841 ccctttgcta caagatggaa gatgcggtcc atgtagggtt ccagtacgag tttttggagt
      901 tgatcatcca cttccacaaa accctgaaaa gattgcagct ccaggagccc gagtatgcgc
      961 tcatggctgc catggctctc ttctctcctg acaggcctgg ggttacccaa agagaagaga
     1021 ttgatcagct gcaggaagag gtcgcgctga tcctcaacaa ccacattatg gagcaacagt
     1081 caagactcca aagtcggttt ctgtatgcaa agctgatggg cctgctagct gagcttcgga
     1141 gtataaacag cgcatactca tatgaaatcc atcgcatcca gggactgtct gctatgatgc
     1201 cgctgcttgg ggagatttgc agctgaggcc caggcttgga tccttcccca gacctcttgg
     1261 gatgcattgg attggaaagg gtaaagtgct ggtacccgaa atgggaacca gaagaaagga
     1321 gctccgttat ggcaaagaaa cactgaacag taactgtctc ttcgtgcggt catcagtggg
     1381 gcagggagtg ggtaggggac agagagaagg gagttgggtg gccatagggc caaagttgtt
     1441 ctctggaaac acagagggtg ggaaagacag gagcctccgg gccaggaggt gaataaagtt
     1501 ccctctggga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
