LOCUS       NM_052980               2360 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group I, member 2
            (Nr1i2), mRNA.
ACCESSION   NM_052980
VERSION     NM_052980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Gogulamudi,V.R., Arita,D.Y., Bourgeois,C.R.T., Jorgensen,J., He,J.,
            Wimley,W.C., Satou,R., Gonzalez,A.A. and Prieto,M.C.
  TITLE     High glucose induces trafficking of prorenin receptor and
            stimulates profibrotic factors in the collecting duct
  JOURNAL   Sci Rep 11 (1), 13815 (2021)
   PUBMED   34226610
  REMARK    GeneRIF: High glucose induces trafficking of prorenin receptor and
            stimulates profibrotic factors in the collecting duct.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Cui,W., Shen,X., Agbas,E., Tompkins,B., Cameron-Carter,H. and
            Staudinger,J.L.
  TITLE     Phosphorylation Modulates the Coregulatory Protein Exchange of the
            Nuclear Receptor Pregnane X Receptor
  JOURNAL   J Pharmacol Exp Ther 373 (3), 370-380 (2020)
   PUBMED   32205367
  REMARK    GeneRIF: Phosphorylation Modulates the Coregulatory Protein
            Exchange of the Nuclear Receptor Pregnane X Receptor.
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Yuan,X., Xiang,D., Min,Q., Ding,Y., Zhao,A. and Wang,R.
  TITLE     [Effects of acute hypoxia on expression of pregnane X receptor in
            liver tissues of rats exposed to high altitude]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 48 (6), 603-608 (2019)
   PUBMED   31955533
  REMARK    GeneRIF: Acute hypoxia at high altitude can affect the expression
            of nuclear receptor PXR in rat liver
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Zhang,J., Zhao,Z., Bai,H., Wang,M., Jiao,L., Peng,W., Wu,T.,
            Liu,T., Chen,H., Song,X., Wu,L., Hu,X., Wu,Q., Zhou,J., Song,J.,
            Lyv,M. and Ying,B.
  TITLE     Genetic polymorphisms in PXR and NF-kappaB1 influence
            susceptibility to anti-tuberculosis drug-induced liver injury
  JOURNAL   PLoS One 14 (9), e0222033 (2019)
   PUBMED   31490979
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Zhang,M., Zhang,Z., Xie,X., Yao,Q., Liu,J., Lai,B., Xiao,L. and
            Wang,N.
  TITLE     Xenobiotic pregnane X receptor promotes neointimal formation in
            balloon-injured rat carotid arteries
  JOURNAL   J Cell Physiol 234 (4), 4342-4351 (2019)
   PUBMED   30132884
  REMARK    GeneRIF: PXR significantly increased neointimal formation in
            balloon-injured rat carotid arteries. PXR increased smooth muscle
            cell proliferation and migration via the induction of
            phosphorylation of ERK1/2 and p38 MAPK.
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Watkins,R.E., Maglich,J.M., Moore,L.B., Wisely,G.B., Noble,S.M.,
            Davis-Searles,P.R., Lambert,M.H., Kliewer,S.A. and Redinbo,M.R.
  TITLE     2.1 A crystal structure of human PXR in complex with the St. John's
            wort compound hyperforin
  JOURNAL   Biochemistry 42 (6), 1430-1438 (2003)
   PUBMED   12578355
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Gonzalez,M.M. and Carlberg,C.
  TITLE     Cross-repression, a functional consequence of the physical
            interaction of non-liganded nuclear receptors and POU domain
            transcription factors
  JOURNAL   J Biol Chem 277 (21), 18501-18509 (2002)
   PUBMED   11891224
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Xie,W., Barwick,J.L., Simon,C.M., Pierce,A.M., Safe,S.,
            Blumberg,B., Guzelian,P.S. and Evans,R.M.
  TITLE     Reciprocal activation of xenobiotic response genes by nuclear
            receptors SXR/PXR and CAR
  JOURNAL   Genes Dev 14 (23), 3014-3023 (2000)
   PUBMED   11114890
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Zhang,H., LeCulyse,E., Liu,L., Hu,M., Matoney,L., Zhu,W. and Yan,B.
  TITLE     Rat pregnane X receptor: molecular cloning, tissue distribution,
            and xenobiotic regulation
  JOURNAL   Arch Biochem Biophys 368 (1), 14-22 (1999)
   PUBMED   10415106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO575646.1, AF151377.1 and BC091138.1.
            
            On Jun 1, 2007 this sequence version replaced NM_052980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CO575646.1         1-36
            37-1305             AF151377.1         10-1278
            1306-2360           BC091138.1         1400-2454
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2360
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /note="nuclear receptor subfamily 1, group I, member 2"
                     /db_xref="GeneID:84385"
                     /db_xref="RGD:69057"
     exon            1..216
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            217..432
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1540
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /note="orphan nuclear receptor PXR; nuclear receptor
                     subfamily 1, group 1, member 2; pregnane X receptor
                     (nuclear receptor sub family 1, group I, member 2)"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 2"
                     /protein_id="NP_443212.1"
                     /db_xref="GeneID:84385"
                     /db_xref="RGD:69057"
                     /translation="MRPEERWNHVGLVQREEADSVLEEPINVDEEDGGLQICRVCGDK
                     ANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLES
                     GMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFD
                     TTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGS
                     IWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGA
                     TFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLRE
                     EEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMA
                     VLTELRSINAQQTQQLLRIQDTHPFATPLMQELFSSTDG"
     exon            433..566
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            567..754
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1029
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1172
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1289
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1395
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2336
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
     polyA_site      1764
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
     polyA_site      2336
                     /gene="Nr1i2"
                     /gene_synonym="PXR"
ORIGIN      
        1 agaggtagag actgctcatt tgtctagcag gacatcggcc tctccctggg agcctgacct
       61 cggcccatac gaaacaccaa agacttaagc tgagacttct gtatgcaacc aggaggctgc
      121 agcaggggtg ctgagctctg ggcagaaaca tcatccctca cccttcaaag tggaccccaa
      181 gggagaaatc caacaaaagc agtggccacc taacagtcca ggacacacag atgtaaacct
      241 ggagatgaga cctgaggaga ggtggaacca tgttggcctt gtacaacgtg aagaagcaga
      301 ttctgtcttg gaagagccta tcaacgtaga tgaggaagat ggaggtcttc aaatctgccg
      361 tgtatgtggg gacaaggcca atggctatca cttcaatgtc atgacctgtg aaggatgtaa
      421 gggatttttc agaagggcca tgaaacgcaa tgtccggctg aggtgcccct tccgcaaggg
      481 gacctgcgag atcacccgga agacccgacg gcagtgccag gcctgccgtt tgcgcaagtg
      541 cctggagagt ggcatgaaga aagagatgat catgtctgat gccgctgtgg aacagaggcg
      601 ggccttgatc aagaggaaga agagggaaaa gattgaggct ccaccgcctg gagggcaggg
      661 gctgacagaa gaacagcagg cgctgatcca ggagctgatg gacgctcaga tgcaaacctt
      721 tgacacaact ttctcccact tcaaggattt ccggctacct gcggtgtttc acagtgactg
      781 cgagcttccg gaggttctgc aggcctcact gttggaagac cctgccacat ggagtcaaat
      841 catgaaagac agtgttccaa tgaagatctc tgtgcagctg cgcggagaag acggcagcat
      901 ctggaactac caacctccct ccaagagcga cgggaaagag atcatccccc tcctgccgca
      961 cctggccgat gtgtcaacct acatgttcaa gggcgtcatc aacttcgcca aagtcatatc
     1021 ccacttcagg gagctgccta tcgaggacca gatctccctg ctgaaggggg ccactttcga
     1081 gatgtgcatc ctgaggttca acacgatgtt cgacacggaa acaggaacct gggagtgcgg
     1141 tcggctggct tactgcttcg aagaccctaa tggcggcttc cagaagctcc tgctggaccc
     1201 gttgatgaaa ttccactgca tgctgaagaa gctacagctg cgtgaggagg agtacgtgct
     1261 gatgcaggcc atctccctct tctccccaga tcgccctggc gtggtacaac gcagcgtggt
     1321 agaccagctg caggagcgat ttgccctcac cctgaaggcc tacatcgagt gtagtcggcc
     1381 ctatcctgca cacaggttcc tgttcctgaa gatcatggct gtcctcaccg agctgcgcag
     1441 tatcaatgcc cagcagaccc agcagctact gcgcatccag gacacgcacc cctttgccac
     1501 acctctcatg caggagttat tcagcagcac ggacggctga gtggctgccc ctgagtggag
     1561 atctcacgga gcagccagac ccagatgttc tgaattgcca cttctagggc tatcagatgg
     1621 acacactgat aacaaacaat gcctctgtct gcagctggct agcatttctc aggaaaagga
     1681 cacaggagct cagcctgtgg aacgtgctgg cctagaaatt agaccatctc tgtggttggg
     1741 aataaacctt caaatcctgc taaattctca ggtgttaggt gagaaaggaa ggatcaggtc
     1801 aaaccaggta acaatggaca cccatgcacc acacattccc agccccaagc ttcttctcaa
     1861 gctgctcgcg tgttccagac ttgagctggt cttatgacaa gtgtcactgc tgaatgccag
     1921 cagcttgtca tgaccttgtt ctggacattt cagtcaagtt cctgcgcctg gccaaacaca
     1981 ttgttaatca ctaaccatgt gatcagctgt ggggggcggg gttccagtac agacccagat
     2041 gcagatcccc acctcagaag acaaagctga aatgtttgct aatagcttat aaaaccttct
     2101 taaataactc gtgtggagct aaagagcatg tggcacacag cccaggaact ttgtgtaggg
     2161 tctggggttc tgtgcgtcac tggaagccaa ggaaaggttc ccaaatgcca agtgtggagg
     2221 aagggggggg aactatggct gtggggacag gtctgcaccc ccatctgacc agggtctggt
     2281 ttgctcccag ggctgtgact tatgacaaag taatagacaa taaatgtata atggcaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa
//
