LOCUS       NM_021745               2070 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group H, member 4
            (Nr1h4), mRNA.
ACCESSION   NM_021745
VERSION     NM_021745.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Li,J.P., Ye,B.L., Li,Q., Zhang,L.L., Zhuang,L. and Yuan,Y.W.
  TITLE     FXR contributes to obstructive jaundice-induced vascular
            hyporeactivity in mesenteric arteries by reconstituting BKCa
            channels
  JOURNAL   Clin Res Hepatol Gastroenterol 48 (8), 102448 (2024)
   PUBMED   39159828
  REMARK    GeneRIF: FXR contributes to obstructive jaundice-induced vascular
            hyporeactivity in mesenteric arteries by reconstituting BKCa
            channels.
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Srimai,N., Tonum,K. and Soodvilai,S.
  TITLE     Activation of farnesoid X receptor retards expansion of renal
            collecting duct cell-derived cysts via inhibition of CFTR-mediated
            Cl- secretion
  JOURNAL   Am J Physiol Renal Physiol 326 (4), F600-F610 (2024)
   PUBMED   38299213
  REMARK    GeneRIF: Activation of farnesoid X receptor retards expansion of
            renal collecting duct cell-derived cysts via inhibition of
            CFTR-mediated Cl[-] secretion.
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Kong,X., Feng,L., Yan,D., Li,B., Yang,Y. and Ma,X.
  TITLE     FXR-mediated epigenetic regulation of GLP-1R expression contributes
            to enhanced incretin effect in diabetes after RYGB
  JOURNAL   J Cell Mol Med 28 (6), e16339 (2024)
   PUBMED   33611845
  REMARK    GeneRIF: FXR-mediated epigenetic regulation of GLP-1R expression
            contributes to enhanced incretin effect in diabetes after RYGB.
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Yan,D., Lv,M., Kong,X., Feng,L., Ying,Y., Liu,W., Wang,X. and Ma,X.
  TITLE     FXR controls insulin content by regulating Foxa2-mediated insulin
            transcription
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119655 (2024)
   PUBMED   38135007
  REMARK    GeneRIF: FXR controls insulin content by regulating Foxa2-mediated
            insulin transcription.
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Sun,D.Q., Yuan,F., Fu,M.Z., Zhong,M.Y., Zhang,S.L., Lu,Y.,
            Targher,G., Byrne,C.D., Zheng,M.H. and Yuan,W.J.
  TITLE     Farnesoid X receptor activation protects against renal fibrosis via
            modulation of beta-catenin signaling
  JOURNAL   Mol Metab 79, 101841 (2024)
   PUBMED   38036169
  REMARK    GeneRIF: Farnesoid X receptor activation protects against renal
            fibrosis via modulation of beta-catenin signaling.
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Saliola,M., Lorenzet,R., Ferro,D., Basili,S., Caroselli,C.,
            Santo,A.D., Sallese,M. and Violi,F.
  TITLE     Enhanced expression of monocyte tissue factor in patients with
            liver cirrhosis
  JOURNAL   Gut 43 (3), 428-432 (1998)
   PUBMED   9863491
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Violi,F., Ferro,D., Basili,S., Saliola,M., Quintarelli,C.,
            Alessandri,C. and Cordova,C.
  TITLE     Association between low-grade disseminated intravascular
            coagulation and endotoxemia in patients with liver cirrhosis
  JOURNAL   Gastroenterology 109 (2), 531-539 (1995)
   PUBMED   7615203
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Forman,B.M., Goode,E., Chen,J., Oro,A.E., Bradley,D.J.,
            Perlmann,T., Noonan,D.J., Burka,L.T., McMorris,T., Lamph,W.W.,
            Evans,R.M. and Weinberger,C.
  TITLE     Identification of a nuclear receptor that is activated by farnesol
            metabolites
  JOURNAL   Cell 81 (5), 687-693 (1995)
   PUBMED   7774010
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Yamagata,H., Nakanishi,T., Furukawa,M., Okuda,H. and Obata,H.
  TITLE     Levels of vitamin K, immunoreactive prothrombin, des-gamma-carboxy
            prothrombin and gamma-glutamyl carboxylase activity in
            hepatocellular carcinoma tissue
  JOURNAL   J Gastroenterol Hepatol 10 (1), 8-13 (1995)
   PUBMED   7620113
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U18374.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2070
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /note="nuclear receptor subfamily 1, group H, member 4"
                     /db_xref="GeneID:60351"
                     /db_xref="RGD:628831"
     exon            1..103
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            104..238
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1581
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /note="farnesol receptor HRR-1; RXR-interacting protein
                     14; farnesoid X-activated receptor; retinoid X
                     receptor-interacting protein 14"
                     /codon_start=1
                     /product="bile acid receptor"
                     /protein_id="NP_068513.1"
                     /db_xref="GeneID:60351"
                     /db_xref="RGD:628831"
                     /translation="MNLIGPSHLQATDEFALSENLFGVLTEHAAGPLGQNLDLESYSP
                     YNNVQFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGLYELRRMPTESVYQGETEVSEM
                     PVTKKPRMAASSAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKC
                     KNGGNCVMDMYMRRKCQDCRLRKCREMGMLAECLLTEIQCKSKRLRKNVKQHADQTVN
                     EDSEGRDLRQVTSTTKLCREKTELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFS
                     AEENFLILTEMATSHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFN
                     KKLPAGHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDR
                     QYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRTFNHHHAEMLMS
                     WRVNDHKFTPLLCEIWDVQ"
     exon            239..607
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            608..748
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            749..882
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            883..981
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1081
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1228
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1342
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2069
                     /gene="Nr1h4"
                     /gene_synonym="Fxr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagttctg agcgtctaca gcgaaagtgc tgggctttgg aaaggagacc tgggctccga
       61 atcctctcag ggccttggac gtctctgacc caaaacaatc caaggttctt atttgaagac
      121 caccatccca gaagcacatt ctcgagttga aaagttggag tggtgttcga aatgaatctg
      181 attgggccct cccatttaca agccacggac gagtttgctc tttctgaaaa cttatttgga
      241 gtgctaacag agcacgcggc aggtcctctg gggcagaatc tggacttgga atcgtactcc
      301 ccatacaaca atgtgcagtt tcctcaagtt cagccacaga tctcctcctc gtcctattat
      361 tccaacctgg gtttctaccc gcaacaaccg gaagactggt actctcctgg actctatgaa
      421 ctcaggcgaa tgcccactga gagtgtgtac cagggagaga ctgaggtatc cgagatgcct
      481 gtgacaaaga agccgcgaat ggccgcctca tcggcgggaa gaataaaagg ggatgagctg
      541 tgtgtggtct gcggagacag ggcctctggg taccattaca acgcgctcac ctgcgagggc
      601 tgcaaaggtt tcttccgaag aagcatcacc aaaaacgccg tgtacaagtg taagaacggg
      661 ggcaactgcg tgatggatat gtacatgcgt cggaagtgcc aggattgccg gctaaggaag
      721 tgcagagaga tgggaatgtt ggctgaatgt ttgttaactg aaattcagtg taaatctaaa
      781 cggctaagga aaaatgtgaa gcagcatgcg gatcagacag tgaatgagga cagcgaaggg
      841 cgtgacttgc ggcaagtgac ctccacgacc aagctatgca gggagaaaac tgaactcact
      901 gtagaccagc agaccctcct ggattatatt atggactcat acagcaaaca gagaatgcca
      961 caggagatca caaataaaat cttaaaagaa gaatttagtg cagaagaaaa ttttctcata
     1021 ttaacagaaa tggctaccag tcacgtacag attctcgtag aattcacaaa aagacttcca
     1081 gggtttcaga cactggacca cgaagaccag attgctttgc tcaaagggtc cgcagtcgag
     1141 gccatgttcc ttcgttcagc ggagattttc aataagaaac ttcctgccgg acacgcagac
     1201 ctgttggaag aaagaattcg aaagagcggc atctccgatg agtacataac cccgatgttt
     1261 agtttctata aaagtgtcgg ggagctgaaa atgacccagg aagagtacgc tctgctcaca
     1321 gcaattgtca tcctctctcc agacagacaa tacataaagg atagagaggc agtggagaag
     1381 cttcaggagc ctctgctcga tgtcctacaa aaactctgca agatctacca gcccgagaac
     1441 cctcagcatt tcgcctgcct cctgggtcgc ctgacagaac tccggacatt caaccatcac
     1501 cacgctgaga tgctgatgtc ttggagggtg aatgaccaca agttcacccc gctcctctgt
     1561 gagatctggg atgtgcagtg aaggacacgg ggagaggcta gctccttgtc ctcctcagag
     1621 cagcaacctg gtattggact tcccttcttt tcatttgtac caggtctcac tcaagaatct
     1681 caatgaatat ttatgtggca attatacaat tcccacaact gtaaatacag gctccataga
     1741 attgcttccc ctacactgta ttttacaagg cttcgggaaa ccccactgac acgccctttt
     1801 tgcctcatta aatcaattgt tacttcaatt ttgtcaactg agctagggac cgcctcgttt
     1861 tatcctccat gcggcaacat tatatatata tatattttat caaatagctg ttttctcttc
     1921 cttttttttt tttttttttt tcggagctgg ggactgaacc cagggccttg cgcttgctag
     1981 gcaagcgctc taccactgag ctaaatcccc aacccctatt aaatagctgt tttcaactga
     2041 gacaataaac tgaacgtaat gccaagagaa
//
