LOCUS       NM_031627               1631 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group H, member 3
            (Nr1h3), mRNA.
ACCESSION   NM_031627
VERSION     NM_031627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Yu,X., Ding,X., Feng,H., Bi,Y., Li,Y., Shan,J. and Bian,H.
  TITLE     Excessive exogenous cholesterol activating intestinal
            LXRalpha-ABCA1/G5/G8 signaling pathway can not reverse
            atherosclerosis in ApoE-/- mice
  JOURNAL   Lipids Health Dis 22 (1), 51 (2023)
   PUBMED   37061692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Ali,U., Wabitsch,M., Tews,D. and Colitti,M.
  TITLE     Effects of allicin on human Simpson-Golabi-Behmel syndrome cells in
            mediating browning phenotype
  JOURNAL   Front Endocrinol (Lausanne) 14, 1141303 (2023)
   PUBMED   36936145
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Huang,Q., Su,J., Xu,J., Yu,H., Jin,X., Wang,Y., Yan,M., Yu,J.,
            Chen,S., Wang,Y. and Lv,G.
  TITLE     Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower
            saponins in rats with metabolic hypertension by inhibiting the
            activation of the renin-angiotensin-aldosterone system through
            complement 3
  JOURNAL   BMC Complement Med Ther 23 (1), 13 (2023)
   PUBMED   36653797
  REMARK    Erratum:[BMC Complement Med Ther. 2023 Mar 8;23(1):76. doi:
            10.1186/s12906-023-03893-1.. PMID: 36890530]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Harchegani,A.B., Rostami,S., Mohsenifar,Z., Dafchahi,A.B.,
            Moghadam,F.M., Jaafarzadeh,M., Saraabestan,S.S. and Ranji,N.
  TITLE     Anti-apoptotic properties of N-Acetyl cysteine and its effects on
            of Liver X receptor and Sirtuin 1 expression in the liver of rats
            exposed to Lead
  JOURNAL   J Trace Elem Med Biol 74, 127070 (2022)
   PUBMED   36155419
  REMARK    GeneRIF: Anti-apoptotic properties of N-Acetyl cysteine and its
            effects on of Liver X receptor and Sirtuin 1 expression in the
            liver of rats exposed to Lead.
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Grbic,E., Gorkic,N., Pleskovic,A., Ljuca,F., Gasparini,M., Mrda,B.,
            Cilensek,I., Fras,Z. and Petrovic,D.
  TITLE     Association between the rs2279238 of the Liver X receptor alpha
            gene polymorphism and advanced carotid atherosclerosis in the
            Slovenian cohort
  JOURNAL   Gene 840, 146764 (2022)
   PUBMED   35907563
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Whitney,K.D., Watson,M.A., Goodwin,B., Galardi,C.M., Maglich,J.M.,
            Wilson,J.G., Willson,T.M., Collins,J.L. and Kliewer,S.A.
  TITLE     Liver X receptor (LXR) regulation of the LXRalpha gene in human
            macrophages
  JOURNAL   J Biol Chem 276 (47), 43509-43515 (2001)
   PUBMED   11546778
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Chiang,J.Y., Kimmel,R. and Stroup,D.
  TITLE     Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1)
            transcription by the liver orphan receptor (LXRalpha)
  JOURNAL   Gene 262 (1-2), 257-265 (2001)
   PUBMED   11179691
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Repa,J.J., Liang,G., Ou,J., Bashmakov,Y., Lobaccaro,J.M.,
            Shimomura,I., Shan,B., Brown,M.S., Goldstein,J.L. and
            Mangelsdorf,D.J.
  TITLE     Regulation of mouse sterol regulatory element-binding protein-1c
            gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
  JOURNAL   Genes Dev 14 (22), 2819-2830 (2000)
   PUBMED   11090130
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Lehmann,J.M., Kliewer,S.A., Moore,L.B., Smith-Oliver,T.A.,
            Oliver,B.B., Su,J.L., Sundseth,S.S., Winegar,D.A., Blanchard,D.E.,
            Spencer,T.A. and Willson,T.M.
  TITLE     Activation of the nuclear receptor LXR by oxysterols defines a new
            hormone response pathway
  JOURNAL   J Biol Chem 272 (6), 3137-3140 (1997)
   PUBMED   9013544
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Apfel,R., Benbrook,D., Lernhardt,E., Ortiz,M.A., Salbert,G. and
            Pfahl,M.
  TITLE     A novel orphan receptor specific for a subset of thyroid
            hormone-responsive elements and its interaction with the
            retinoid/thyroid hormone receptor subfamily
  JOURNAL   Mol Cell Biol 14 (10), 7025-7035 (1994)
   PUBMED   7935418
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088750.1.
            
            On Apr 14, 2007 this sequence version replaced NM_031627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088750.1, U11685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1631              BC088750.1         1-1631
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1631
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /note="nuclear receptor subfamily 1, group H, member 3"
                     /db_xref="GeneID:58852"
                     /db_xref="RGD:61909"
     exon            1..60
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1355
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /EC_number="3.4.13.9"
                     /note="RLD-1; liver X receptor alpha; nuclear orphan
                     receptor LXR-alpha"
                     /codon_start=1
                     /product="oxysterols receptor LXR-alpha"
                     /protein_id="NP_113815.2"
                     /db_xref="GeneID:58852"
                     /db_xref="RGD:61909"
                     /translation="MSLWLEAAVPDVSPDSATELWKTEPQDAGDQGGNTCILREEARM
                     PQSTGGALRIGLESSEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDK
                     ASGFHYNVLSCEGCKGFFRRSVIKGARYICHSGGHCPMDTYMRRKCQECRLRKCRQAG
                     MREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAA
                     QQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGF
                     LQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFI
                     NPIFEFSRSMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS
                     INHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE"
     exon            61..243
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            244..510
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            511..719
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            720..899
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            900..999
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1113
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1208
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1597
                     /gene="Nr1h3"
                     /gene_synonym="LXRalpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggctcca ggaagagatg tccttgtggc tggaggccgc agtgcctgat gtttctcctg
       61 actctgcaac ggagttgtgg aagacagaac ctcaagatgc aggagaccag ggaggcaaca
      121 cttgcatcct tagggaggaa gccaggatgc cccaatcaac tgggggtgct ttaaggatag
      181 ggttggagtc atccgagcct acagccctgc tccccagggc agagaccctc ccagagccta
      241 cagaacttcg tccacagaag cggaaaaagg ggccagcccc caaaatgctg gggaacgagc
      301 tatgcagtgt atgtggggac aaggcctctg gcttccatta caatgtgctg agctgcgagg
      361 gctgcaaggg attcttccgc cgcagtgtca tcaagggagc acgctacatt tgccatagcg
      421 gtggccactg ccccatggac acctacatgc ggcggaaatg ccaggagtgt cgccttcgca
      481 aatgccgcca ggcaggcatg agggaggagt gtgtcttatc agaagaacag atccgcttga
      541 agaaactgaa gcgtcaagaa gaggagcagg ctcaagccac atcggtgtcc ccaagggttt
      601 cctcaccgcc ccaggtcctg ccacagctca gcccagaaca actgggcatg attgagaagt
      661 tggtggctgc ccagcaacag tgtaacaggc gctccttctc tgaccgactt cgagtcacgc
      721 cttggcccat tgcacccgac cctcagagcc gggaagcccg ccaacagcgc tttgcccact
      781 ttactgagct ggccatcgtg tccgtgcagg agattgttga ctttgccaaa cagctccctg
      841 gcttcctaca gctgagcagg gaggaccaga tcgccttgct gaagacctct gcgatcgagg
      901 tgatgcttct ggagacatcg cggaggtaca accctgggag tgagagcatc accttcctca
      961 aggatttcag ttacaaccgg gaagactttg ccaaagcagg gctgcaggtg gagttcatta
     1021 accccatctt tgagttctcc agatccatga atgaactgca actcaatgat gctgaatttg
     1081 ctctgctcat agccatcagc atcttctctg cagaccggcc caacgtgcag gaccagctcc
     1141 aagtagagag actgcaacac acatatgtgg aggccctgca tgcctatgtc tccatcaacc
     1201 acccccacga ccgactgatg ttcccacgga tgctaatgaa gctggtgagc ctccggactt
     1261 tgagcagcgt ccattcagag caagtgtttg cacttcgcct gcaggacaaa aaacttcccc
     1321 ctctgctctc cgagatctgg gatgtccacg aatgactgtt tctccgtgtc ctctgtgttg
     1381 gccacgcagc tgaagcttac tgactgcttc ctagaggtgg agcagactga ggagggcaaa
     1441 cattcctggg cgctgggtga aagagaccct tgcatggcac taaagagagt caaagggttg
     1501 ggtgttttgt ggctgctggg cagttgggga cctactaacg ttgtatgcca tctgaaggcc
     1561 ttgttgaccc aaccaaataa actagccagg agagccaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa a
//
