LOCUS       NM_001398609            2001 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group H, member 2
            (Nr1h2), transcript variant 1, mRNA.
ACCESSION   NM_001398609 XM_039088759
VERSION     NM_001398609.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2001)
  AUTHORS   Zhang,Y., Gu,Y., Chen,Y., Huang,Z., Li,M., Jiang,W., Chen,J.,
            Rao,W., Luo,S., Chen,Y., Chen,J., Li,L., Jia,Y., Liu,M. and Zhou,F.
  TITLE     Dingxin Recipe IV attenuates atherosclerosis by regulating lipid
            metabolism through LXR-alpha/SREBP1 pathway and modulating the gut
            microbiota in ApoE-/- mice fed with HFD
  JOURNAL   J Ethnopharmacol 266, 113436 (2021)
   PUBMED   33011372
REFERENCE   2  (bases 1 to 2001)
  AUTHORS   Rey,M., Kruse,M.S., Magrini-Huaman,R.N. and Coirini,H.
  TITLE     High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus
  JOURNAL   Cell Mol Neurobiol 39 (7), 963-974 (2019)
   PUBMED   31161476
  REMARK    GeneRIF: The present work's main objective was to study the effect
            of different high fat diets on LXRs expression (in hypothalamus and
            liver), and lipid profile.
REFERENCE   3  (bases 1 to 2001)
  AUTHORS   Yonezawa,S., Abe,M., Kawasaki,Y., Natori,Y. and Sugiyama,A.
  TITLE     Each liver X receptor (LXR) type has a different purpose in
            different situations
  JOURNAL   Biochem Biophys Res Commun 508 (1), 92-96 (2019)
   PUBMED   30471864
  REMARK    GeneRIF: We observed increased expression of LXRalpha from an early
            stage of nephrosis. To explore the role of increased LXRalpha in
            diseased kidney in vitro, NRK52E, normal kidney tubular epithelial
            cells, were forced to overexpress LXRalpha. These cells showed
            significantly lower lipid accumulation than mock cells did. In
            contrast, LXRbeta knockdown led to increased lipid accumulation in
            mock cells, and constancy in overexpre...
REFERENCE   4  (bases 1 to 2001)
  AUTHORS   Peng,Z., Deng,B., Jia,J., Hou,W., Hu,S., Deng,J., Lin,W., Hou,L.
            and Sang,H.
  TITLE     Liver X receptor beta in the hippocampus: A potential novel target
            for the treatment of major depressive disorder?
  JOURNAL   Neuropharmacology 135, 514-528 (2018)
   PUBMED   29654801
  REMARK    GeneRIF: Results show that hippocampal LXRbeta levels were
            negatively correlated with the severity of the depressive-like
            behaviors. LXRbeta knockdown in hippocampus produced
            depression-like behaviors and impaired hippocampal neurogenesis,
            and conversely, the LXRbeta activation improved the depression-like
            behaviors and reversed the impaired hippocampal neurogenesis in
            rats.
REFERENCE   5  (bases 1 to 2001)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2001)
  AUTHORS   Wiebel,F.F. and Gustafsson,J.A.
  TITLE     Heterodimeric interaction between retinoid X receptor alpha and
            orphan nuclear receptor OR1 reveals dimerization-induced activation
            as a novel mechanism of nuclear receptor activation
  JOURNAL   Mol Cell Biol 17 (7), 3977-3986 (1997)
   PUBMED   9199332
REFERENCE   7  (bases 1 to 2001)
  AUTHORS   Lehmann,J.M., Kliewer,S.A., Moore,L.B., Smith-Oliver,T.A.,
            Oliver,B.B., Su,J.L., Sundseth,S.S., Winegar,D.A., Blanchard,D.E.,
            Spencer,T.A. and Willson,T.M.
  TITLE     Activation of the nuclear receptor LXR by oxysterols defines a new
            hormone response pathway
  JOURNAL   J Biol Chem 272 (6), 3137-3140 (1997)
   PUBMED   9013544
REFERENCE   8  (bases 1 to 2001)
  AUTHORS   Teboul,M., Enmark,E., Li,Q., Wikstrom,A.C., Pelto-Huikko,M. and
            Gustafsson,J.A.
  TITLE     OR-1, a member of the nuclear receptor superfamily that interacts
            with the 9-cis-retinoic acid receptor
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2096-2100 (1995)
   PUBMED   7892230
REFERENCE   9  (bases 1 to 2001)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
REFERENCE   10 (bases 1 to 2001)
  AUTHORS   Song,C., Kokontis,J.M., Hiipakka,R.A. and Liao,S.
  TITLE     Ubiquitous receptor: a receptor that modulates gene activation by
            retinoic acid and thyroid hormone receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 10809-10813 (1994)
   PUBMED   7971966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 20, 2021 this sequence version replaced XM_039088759.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1828627.1,
                                           SRR26360190.3233365.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000001.1  104183724-104183863 c
            141-272             JAXUCZ010000001.1  104183493-104183624 c
            273-333             JAXUCZ010000001.1  104182583-104182643 c
            334-447             JAXUCZ010000001.1  104182393-104182506 c
            448-738             JAXUCZ010000001.1  104181841-104182131 c
            739-998             JAXUCZ010000001.1  104181485-104181744 c
            999-1178            JAXUCZ010000001.1  104181205-104181384 c
            1179-1278           JAXUCZ010000001.1  104180661-104180760 c
            1279-1487           JAXUCZ010000001.1  104179227-104179435 c
            1488-2001           JAXUCZ010000001.1  104178483-104178996 c
FEATURES             Location/Qualifiers
     source          1..2001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2001
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /note="nuclear receptor subfamily 1, group H, member 2"
                     /db_xref="GeneID:58851"
                     /db_xref="RGD:61906"
     exon            1..140
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..272
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..333
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1634
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /note="isoform a is encoded by transcript variant 1;
                     oxysterols receptor LXR-beta; UR; liver X receptor beta;
                     orphan nuclear receptor OR-1; nuclear orphan receptor
                     LXR-beta; ubiquitously-expressed nuclear receptor;
                     ubiquitous receptor"
                     /codon_start=1
                     /product="oxysterols receptor LXR-beta isoform a"
                     /protein_id="NP_001385538.1"
                     /db_xref="GeneID:58851"
                     /db_xref="RGD:61906"
                     /translation="MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEGQETDPPPGSEG
                     SSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFF
                     RRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKK
                     IQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVA
                     AQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPG
                     FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEF
                     INPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYT
                     RIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE"
     exon            334..447
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..738
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..998
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1178
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1278
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1487
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..2001
                     /gene="Nr1h2"
                     /gene_synonym="LXR beta; LXRB; LXRbeta; OR-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagcggg gttgccggaa gaagtggcga agttactttt gcttttcgct cagcaagcgc
       61 tgttgctccg agctactccc aggcttctga agttacttct gaagtgctgt ggaggagcaa
      121 tcaccggtgc ggacacagag ctcccgcctc ccacagccat ttccagggta acgaagtagg
      181 agaccccctc ctgcgacccc ctcacgatcg ccggtgcagt catgagcccc gcctccccct
      241 ggtgcacgga gaggggcggg gcctggaacg agcaggctgc ttcgtgaccc actatgtctt
      301 cccccacaag ttctctggac actcccttgc ctgggaatgg ttctccccag cccagtacct
      361 cctccacttc acccactatt aaggaggagg gacaggagac tgatccacct ccaggctctg
      421 aagggtccag ctctgcctac atcgtggtca tcttagagcc agaggatgaa cctgagcgca
      481 agcggaagaa gggtccggcc ccgaagatgc tgggccatga gctgtgccgc gtgtgcgggg
      541 acaaggcctc gggcttccac tacaatgtgc tcagttgtga aggctgcaaa ggcttcttcc
      601 ggcgtagcgt ggtccatggt ggggccgggc gctatgcctg tcggggcagc ggaacctgcc
      661 agatggatgc cttcatgcgg cgcaagtgcc agctctgcag actgcgcaag tgcaaggagg
      721 ctggcatgcg ggagcagtgc gtgctttctg aggagcagat tcggaagaaa aagattcaga
      781 agcagcaaca gcagcagcca ccgcccccga ctgagccagc atccggtagc tcagcccggc
      841 ctgcagcctc ccctggcact tcggaagcaa gtagccaggg ctccggggaa ggagagggca
      901 tccagctgac agcggctcag gagctgatga tccaacagtt agttgccgcg cagctgcagt
      961 gcaacaagcg atctttctcc gaccagccta aagtcacgcc ctggcccttg ggtgcagacc
     1021 ctcagtcccg agacgctcgt cagcaacgct ttgcccactt cactgagcta gccatcatct
     1081 cagtccagga gatcgtggac ttcgccaagc aggtgccagg gttcctgcag ctgggccggg
     1141 aggaccagat cgccctcctg aaggcatcca ccatcgagat catgttgcta gagacagcca
     1201 gacgctacaa ccacgagaca gagtgcatca cgttcctgaa ggacttcacc tacagcaagg
     1261 acgacttcca ccgtgcaggc ttgcaggtgg agttcatcaa tcccatcttt gagttctctc
     1321 gggctatgcg tcggctgggc ctagacgatg cagagtatgc cttgctcatt gccatcaaca
     1381 tcttctcagc ggaccggcct aatgtgcagg agcccagccg tgtggaggct ctgcagcagc
     1441 cctatgtgga ggccctcctc tcctacacga ggatcaagcg gccgcaggac cagctgcgct
     1501 tcccacgaat gctcatgaag ctggtgagcc tgcgcaccct cagctccgtg cactcggagc
     1561 aggttttcgc attgcgtctc caggacaaga agctgccgcc tttgctgtcc gagatctggg
     1621 atgtgcatga gtaggggccg ccacaagtgc cccagccttg gtggtgtcta cttgcagatg
     1681 gacgcttcct ttgcctttcc tggggtggga ggacactgtc acagcccagt cccctgggct
     1741 cgggctgagc gagtggcagt tggcactaga aggtcccacc ccacccgctg agtcttccag
     1801 gagtggtgag ggtcacaggc cctagcctct gatctttacc agctgccctt cctcccgagc
     1861 ttacacctca gcctaccaca ccatgcacct tgagtggaga gaggttaggg caggtggctc
     1921 cccacagttg ggagaccaca ggccccctct tctgcccctt ttatttaata aaaaaataaa
     1981 ataaagttcg agtacaagcc a
//
