LOCUS       NM_147210               4610 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group D, member 2
            (Nr1d2), mRNA.
ACCESSION   NM_147210 XM_006251710
VERSION     NM_147210.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4610)
  AUTHORS   Noh,S.G., Jung,H.J., Kim,S., Arulkumar,R., Kim,D.H., Park,D. and
            Chung,H.Y.
  TITLE     Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different
            Manners during Liver Aging
  JOURNAL   Int J Mol Sci 23 (17), 10032 (2022)
   PUBMED   36077427
  REMARK    GeneRIF: Regulation of Circadian Genes Nr1d1 and Nr1d2 in
            Sex-Different Manners during Liver Aging.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4610)
  AUTHORS   Pariollaud,M., Gibbs,J.E., Hopwood,T.W., Brown,S., Begley,N.,
            Vonslow,R., Poolman,T., Guo,B., Saer,B., Jones,D.H., Tellam,J.P.,
            Bresciani,S., Tomkinson,N.C., Wojno-Picon,J., Cooper,A.W.,
            Daniels,D.A., Trump,R.P., Grant,D., Zuercher,W., Willson,T.M.,
            MacDonald,A.S., Bolognese,B., Podolin,P.L., Sanchez,Y., Loudon,A.S.
            and Ray,D.W.
  TITLE     Circadian clock component REV-ERBalpha controls homeostatic
            regulation of pulmonary inflammation
  JOURNAL   J Clin Invest 128 (6), 2281-2296 (2018)
   PUBMED   29533925
REFERENCE   3  (bases 1 to 4610)
  AUTHORS   Amador,A., Campbell,S., Kazantzis,M., Lan,G., Burris,T.P. and
            Solt,L.A.
  TITLE     Distinct roles for REV-ERBalpha and REV-ERBbeta in oxidative
            capacity and mitochondrial biogenesis in skeletal muscle
  JOURNAL   PLoS One 13 (5), e0196787 (2018)
   PUBMED   29723273
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4610)
  AUTHORS   Ohba,Y. and Tei,H.
  TITLE     Phosphorylation of N-terminal regions of REV-ERBs regulates their
            intracellular localization
  JOURNAL   Genes Cells 23 (4), 285-293 (2018)
   PUBMED   29508494
REFERENCE   5  (bases 1 to 4610)
  AUTHORS   Yang,F., Inoue,I., Kumagai,M., Takahashi,S., Nakajima,Y. and
            Ikeda,M.
  TITLE     Real-time analysis of the circadian oscillation of the Rev-Erb beta
            promoter
  JOURNAL   J Atheroscler Thromb 20 (3), 267-276 (2013)
   PUBMED   23221024
REFERENCE   6  (bases 1 to 4610)
  AUTHORS   Giambiagi,N., Cassia,R., Petropoulos,I., Part,D., Cereghini,S.,
            Zakin,M.M. and Ochoa,A.
  TITLE     Rev-erb beta 2, a novel isoform of the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Biochem Mol Biol Int 37 (6), 1091-1102 (1995)
   PUBMED   8747539
REFERENCE   7  (bases 1 to 4610)
  AUTHORS   Enmark,E., Kainu,T., Pelto-Huikko,M. and Gustafsson,J.A.
  TITLE     Identification of a novel member of the nuclear receptor
            superfamily which is closely related to Rev-ErbA
  JOURNAL   Biochem Biophys Res Commun 204 (1), 49-56 (1994)
   PUBMED   7945391
REFERENCE   8  (bases 1 to 4610)
  AUTHORS   Forman,B.M., Chen,J., Blumberg,B., Kliewer,S.A., Henshaw,R.,
            Ong,E.S. and Evans,R.M.
  TITLE     Cross-talk among ROR alpha 1 and the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Mol Endocrinol 8 (9), 1253-1261 (1994)
   PUBMED   7838158
REFERENCE   9  (bases 1 to 4610)
  AUTHORS   Retnakaran,R., Flock,G. and Giguere,V.
  TITLE     Identification of RVR, a novel orphan nuclear receptor that acts as
            a negative transcriptional regulator
  JOURNAL   Mol Endocrinol 8 (9), 1234-1244 (1994)
   PUBMED   7838156
REFERENCE   10 (bases 1 to 4610)
  AUTHORS   Pena de Ortiz,S., Cannon,M.M. and Jamieson,G.A. Jr.
  TITLE     Expression of nuclear hormone receptors within the rat hippocampus:
            identification of novel orphan receptors
  JOURNAL   Brain Res Mol Brain Res 23 (3), 278-283 (1994)
   PUBMED   7914660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Feb 11, 2014 this sequence version replaced
            XM_006251710.1, NM_147210.1.
            
            Summary: This gene encodes a member of the nuclear hormone receptor
            family, specifically the NR1 subfamily of receptors. The encoded
            protein functions as a transcriptional repressor and may play a
            role in circadian rhythms and carbohydrate and lipid metabolism.
            [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.39821.1, X82777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000015.1  9955034-9955257
            225-491             JAXUCZ010000015.1  9963685-9963951
            492-580             JAXUCZ010000015.1  9965352-9965440
            581-725             JAXUCZ010000015.1  9968624-9968768
            726-1351            JAXUCZ010000015.1  9970129-9970754
            1352-1537           JAXUCZ010000015.1  9973539-9973724
            1538-1748           JAXUCZ010000015.1  9977035-9977245
            1749-4610           JAXUCZ010000015.1  9978468-9981329
FEATURES             Location/Qualifiers
     source          1..4610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..4610
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /note="nuclear receptor subfamily 1, group D, member 2"
                     /db_xref="GeneID:259241"
                     /db_xref="RGD:628828"
     exon            1..224
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1945
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /note="orphan receptor; EAR4; rev-erb-beta; orphan nuclear
                     receptor HZF-2; Rev-ErbA-beta; Rev-erb-Beta2"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 2"
                     /protein_id="NP_671743.2"
                     /db_xref="GeneID:259241"
                     /db_xref="RGD:628828"
                     /translation="MELNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSP
                     NSSNCDANGNPKNTDVSSIDGVLKSDRTDCPVKTGKPGAPGMTKSHSGMTKFSGMVLL
                     CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCR
                     FKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMSTQFGGHLQSDTLAEPHEQ
                     SVPPAQEQLRPKPQLEQENIKSTPPPSDFAKEEVIGMVTRAHKDTFLYNQEHRENSSE
                     SMPPHRGERIPRNVEQYNLNHDHRGGGLHSHFPCSESQQHLSGQYKGRNMMHYPNGHT
                     VCISNGHCVNFSSAYPQRVCDRIPVGGCSQTESRNSYLCSTGGRMHLVCPMSKSPYVD
                     PQKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFA
                     SLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLSSMFEFSEKLNGLQLSDEEMSLFTAV
                     VLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNM
                     HSEELLAFKVHP"
     exon            225..491
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..580
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..725
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1351
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1537
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1748
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..4610
                     /gene="Nr1d2"
                     /gene_synonym="HZF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggtgtgc gcgggtcaca tggttgagga gccctccccg tcagctgccg tgcccgctgc
       61 cgagcactgc cacaggaagc cgctgcgccg cgcttgtgcc gtgcggcccg caggagccgc
      121 ccgcacccgg tgctcatgag gcgggcccgc gagccccacc gcctgcagcc ccgggcggcg
      181 cggtgagggc cgcaccccgc tgagcgccat ggaactgaac gcgggaggtg tgattgccta
      241 catcagttcc tccagctctg cctccagccc tgcctcctgt cacagcgagg gctctgagaa
      301 cagtttccag tcctcgtcct cgtccgttcc gtcttctcca aacagctcca actgtgatgc
      361 caacggcaac cccaagaaca cggatgtctc tagcattgac ggtgttctca agagcgaccg
      421 cacagactgt cctgtgaaaa caggcaaacc tggtgcccct ggcatgacca agagtcacag
      481 cggaatgaca aaatttagtg gcatggttct gctatgtaaa gtctgtgggg atgtggcctc
      541 aggattccac tatggagttc atgcttgtga aggctgtaag ggcttcttca ggaggagcat
      601 tcagcagaac atccagtaca agaagtgcct gaagaacgag aattgctcca tcatgaggat
      661 gaacaggaac cgctgccagc agtgccgctt caagaagtgt ctgtccgtgg gaatgtcgcg
      721 ggacgctgtt cgatttggcc ggattcccaa gcgtgaaaaa cagagaatgc taattgagat
      781 gcaaagtgca atgaagacca tgatgagcac ccagttcggt ggccacctgc agagtgacac
      841 cttagcagag ccgcatgagc agtcagtacc accggctcag gagcagctgc ggcccaagcc
      901 ccagctggag caagaaaaca tcaaaagcac ccctcctcct tctgattttg caaaggagga
      961 agtgattggc atggtgacca gagcccacaa ggataccttt ctgtataatc aggaacatcg
     1021 agaaaactca tctgagagca tgccacccca tagaggagaa cggattccca ggaatgtgga
     1081 gcaatataat ttaaatcatg accatcgtgg cggtgggctt cacagccact tcccctgtag
     1141 tgagagccag cagcatctca gtggacagta caaagggagg aacatgatgc actacccaaa
     1201 cgggcatacc gtttgtattt cgaatggaca ctgtgtgaac ttctccagtg cttaccctca
     1261 aagagtctgt gataggattc cagtaggtgg atgttctcag actgagagca ggaatagcta
     1321 cctgtgcagc actggaggga ggatgcatct ggtttgtcct atgagcaagt ctccatatgt
     1381 ggatcctcag aaatctggac atgaaatctg ggaagaattt tcaatgagtt ttaccccagc
     1441 agtaaaagag gtggtagaat ttgcaaaacg tattcctggc ttccgagatc tgtctcagca
     1501 tgatcaggtc aacctgttaa aagctgggac ttttgaggtt ttaatggtgc gatttgcttc
     1561 gttatttgat gcaaaggagc ggactgtcac cttcctgagt ggtaagaagt acagtgtgga
     1621 tgacctgcac tccatgggag caggcgatct gctcagctct atgtttgagt tcagcgagaa
     1681 gctgaatggc ctccagctca gcgacgagga aatgagcttg ttcacagctg ttgttctggt
     1741 gtctgcagat cgatctggaa ttgaaaatgt caactcagtg gaggctctgc aggaaacact
     1801 catccgtgca ctaaggacct taataatgaa aaaccatcca aatgaggcct ccatttttac
     1861 aaaattactt ctaaagttgc cagatcttcg atctttaaac aacatgcact ctgaggaact
     1921 cttggccttt aaagttcatc cttaaggcct ttgaacatga actgatgcta atgtacattt
     1981 tatgctgaga tgtttattta tatgtgtata ccatattgtg aaaatagaaa aggacttagc
     2041 gccaggtcct ggactgtctg tagtcagtca ccagtagctg ttcagatgag aactcattgt
     2101 cttgttagac attggcccac cctccctgta gaccaaccag ctgtgttgca cttagactgg
     2161 agaagttaca ctgaattata atcacactga atgttagact ttttcatctg ccaaagccaa
     2221 aataccattt gatctccccg tggtataaat ctagcgcaca ttgcagatat aggaggactt
     2281 agacattaac cctttgtgcc aggaattcgg ttgtaccaca agactgaaat gtggtaaagg
     2341 agactgagag ccaagaggtt tgctctgcca ctgtcaaagt acatggtcct ggcagtccct
     2401 gggttgtggg aaatgataat tgatagtgtc cccaatgtcc tgcctcacag agatactgaa
     2461 aaaatgtcca taaagcgtct ttacctcttg ggagataggc actatgtaaa taaggtgaag
     2521 tttttattat aattgctcat aataatattc ttgtcttatt tctaagcatt tctgggaaac
     2581 tttgacagtc cacaccaatt tattcagggt tcctgctcaa gtggggttcc ctactgataa
     2641 acacatattc caggtttatg gacacctcag atagtatgtg tacatagtgt gtatgtgaat
     2701 ataattatat ataaaatctt acttcacaat attttaaact gtgaagaact ttatcataca
     2761 ataaacttaa acaagaggtg tcaaggaccc aaattaggtg cattttacct gttgctgctg
     2821 atgtataacc attgctttat gatgtttaga tggtagaata ctgaagttaa ttctcatatt
     2881 tttgtttaag caacatttaa tgtaaaagtg taatgagcag tcaaatccag gtcagaaaaa
     2941 acatggattt tagaatacat ctttgataca atctgcagtt gaaggtaata gatgtttcag
     3001 tgtttcagat ttctaccttg cgctattaat agaggtggtg ttgctgcttc ttacctgctg
     3061 caggtggatg gcagatttgg attctgtgtg gaggatgttt tgtttgggaa aactttgtga
     3121 cctattggca tgtctgtgcc aagtccactt ttctttcttt ccttaaataa cactacaggg
     3181 attttgtcaa tttagattta atataatttg aaaaaccttt aataagtgac ctacctacag
     3241 gcttagagat cgtggtagga gaggtagcca aagttaaaga ttcgtgaaca acacccctgt
     3301 tcccccctga gctgtaattc attgtatttt gggggcaaaa ttattttctg tgtaatgcta
     3361 gattatgtga aattgtaaag acattaagaa catgctttac tatttaaagc atgcctatta
     3421 cttttatgac atgtaagcag aatgccttat tttgtagttc taacttgttg ctacaggatt
     3481 tgaacttctg tggtacagtt aagagagctt gaaaaagata aacccctgtt gtcgaagaag
     3541 aaagctgatg gtgcgtctgt tatgcagtag ggaccataac tgctgtttac attcagtggg
     3601 tatggctttc gtgggataca cagctagggt ttgtgaattc tttacatgat agcattatca
     3661 ttttatattt ttttcaagga taaaccaatg catagttttc ttctatgggg gatagagagc
     3721 tttgtgaagt aatactgaaa acctcaaagg ttatgttgat tcttcatttt tgcctttttc
     3781 ataagtgtct ttataacatg tatctttaaa gcagtttgcg tctttggaaa tatgtaacca
     3841 gagctgttag tgttgcttgt gatgcttgag ttagggtcag tatatacatg tacacaccta
     3901 gatagaagca tgtagatttg tattttgtct cgtaaaattt tatttcaata aattcttcct
     3961 gaagtaacgg gaaacaaaat ccatagttcc tatgccacct gtagtattcc tgtatttgga
     4021 agtagcccaa ggatgagcat tctgattcta caatgaagcc agcagccgca tacaagcaca
     4081 ttcttgattg agtcatggtc taacaataga tgatcagcca gatagggaac ttctggggca
     4141 ctgtggataa ttaacaatgt actgtatgga ttaagtgacg ctttaactct gactttatgt
     4201 ttcaaggcta aaatatgggc attatctcac cagacttacg ggcattatgt taacaagatg
     4261 aaccattttt tttcctgtgc ttttagtatg tctttacatg atatgagaaa ggattccagc
     4321 ttccagagag agaacactga agaaaaggag agacatcttg ggatgaagta tggtaatggt
     4381 taatcgcaga taaaaatttt tgaagattat ttcagtagat tagtatatag atttcatatc
     4441 tacattgtaa gaaattgcca ttgtgattgg gtcagaattg atacgtgtta tgtgaacatt
     4501 gcaaagcaaa gctgtgagag gagctcaggt agatgtattc ttgtgcagga aagcaaacac
     4561 ctgtctcagt tgttctttat ctttttgcaa tataaagttt gctgaatgta
//
