LOCUS       NM_001113422            2611 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 1, group D, member 1
            (Nr1d1), transcript variant 1, mRNA.
ACCESSION   NM_001113422
VERSION     NM_001113422.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Song,W., Ye,L., Tang,Q., Lu,X., Huang,X., Xie,M., Yu,S., Yuan,Z.
            and Chen,L.
  TITLE     Rev-erbalpha attenuates refractory periapical periodontitis via M1
            polarization: An in vitro and in vivo study
  JOURNAL   Int Endod J 57 (4), 451-463 (2024)
   PUBMED   38279698
  REMARK    GeneRIF: Rev-erbalpha attenuates refractory periapical
            periodontitis via M1 polarization: An in vitro and in vivo study.
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Yakmaz,F., Bozkurt,A.S. and Gorucu Yilmaz,S.
  TITLE     PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1,
            and Rev-erbalpha gene regulation, behavioral analysis, and
            antioxidant capacity of Gum Arabic
  JOURNAL   Mol Biol Rep 51 (1), 279 (2024)
   PUBMED   38324049
  REMARK    GeneRIF: PTZ-kindled rat model; evaluation of seizure, hippocampal
            EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and
            antioxidant capacity of Gum Arabic.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Noh,S.G., Jung,H.J., Kim,S., Arulkumar,R., Kim,D.H., Park,D. and
            Chung,H.Y.
  TITLE     Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different
            Manners during Liver Aging
  JOURNAL   Int J Mol Sci 23 (17), 10032 (2022)
   PUBMED   36077427
  REMARK    GeneRIF: Regulation of Circadian Genes Nr1d1 and Nr1d2 in
            Sex-Different Manners during Liver Aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Borba,T.K.F., Toscano,A.E., Costa de Santana,B.J.R., Silva,S.C.A.,
            Lagranha,C.J., Guzman Quevedo,O. and Manhaes-de-Castro,R.
  TITLE     Central administration of REV-ERBalpha agonist promotes opposite
            responses on energy balance in fasted and fed states
  JOURNAL   J Neuroendocrinol 32 (2), e12833 (2020)
   PUBMED   31957097
  REMARK    GeneRIF: Central administration of REV-ERBalpha agonist promotes
            opposite responses on energy balance in fasted and fed states.
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Griffin,P., Dimitry,J.M., Sheehan,P.W., Lananna,B.V., Guo,C.,
            Robinette,M.L., Hayes,M.E., Cedeno,M.R., Nadarajah,C.J.,
            Ezerskiy,L.A., Colonna,M., Zhang,J., Bauer,A.Q., Burris,T.P. and
            Musiek,E.S.
  TITLE     Circadian clock protein Rev-erbalpha regulates neuroinflammation
  JOURNAL   Proc Natl Acad Sci U S A 116 (11), 5102-5107 (2019)
   PUBMED   30792350
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Forman,B.M., Chen,J., Blumberg,B., Kliewer,S.A., Henshaw,R.,
            Ong,E.S. and Evans,R.M.
  TITLE     Cross-talk among ROR alpha 1 and the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Mol Endocrinol 8 (9), 1253-1261 (1994)
   PUBMED   7838158
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Spanjaard,R.A., Nguyen,V.P. and Chin,W.W.
  TITLE     Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone
            receptor, binds to specific thyroid hormone response elements
  JOURNAL   Mol Endocrinol 8 (3), 286-295 (1994)
   PUBMED   8015547
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Harding,H.P. and Lazar,M.A.
  TITLE     The orphan receptor Rev-ErbA alpha activates transcription via a
            novel response element
  JOURNAL   Mol Cell Biol 13 (5), 3113-3121 (1993)
   PUBMED   8474464
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Jannini,E.A., Mitsuhashi,T. and Nikodem,V.M.
  TITLE     Developmental expression of mRNAs from a rat C-erbA genomic locus
  JOURNAL   Biochem Biophys Res Commun 184 (2), 739-745 (1992)
   PUBMED   1315530
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Lazar,M.A., Hodin,R.A., Darling,D.S. and Chin,W.W.
  TITLE     A novel member of the thyroid/steroid hormone receptor family is
            encoded by the opposite strand of the rat c-erbA alpha
            transcriptional unit
  JOURNAL   Mol Cell Biol 9 (3), 1128-1136 (1989)
   PUBMED   2542765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 7, 2020 this sequence version replaced NM_001113422.1.
            
            Summary: This gene encodes a transcription factor that is a member
            of the nuclear receptor subfamily 1. The encoded protein is a
            ligand-sensitive transcription factor that negatively regulates the
            expression of core clock proteins. In particular this protein
            represses the circadian clock transcription factor aryl hydrocarbon
            receptor nuclear translocator-like protein 1 (Arntl). This protein
            may also be involved in regulating genes that function in
            metabolic, inflammatory and cardiovascular processes. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062047.1, SRR26643296.28507.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               JAXUCZ010000010.1  84231299-84231812   c
            515-853             JAXUCZ010000010.1  84228374-84228712   c
            854-942             JAXUCZ010000010.1  84228020-84228108   c
            943-1087            JAXUCZ010000010.1  84227782-84227926   c
            1088-1731           JAXUCZ010000010.1  84226857-84227500   c
            1732-1917           JAXUCZ010000010.1  84226376-84226561   c
            1918-2128           JAXUCZ010000010.1  84225702-84225912   c
            2129-2611           JAXUCZ010000010.1  84224599-84225081   c
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2611
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /note="nuclear receptor subfamily 1, group D, member 1"
                     /db_xref="GeneID:252917"
                     /db_xref="RGD:628827"
     exon            1..514
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2328
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rev-erb alpha; rev-erbA-alpha; V-erbA-related protein
                     EAR-1; V-erbA-related protein 1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 1
                     isoform 1"
                     /protein_id="NP_001106893.2"
                     /db_xref="GeneID:252917"
                     /db_xref="RGD:628827"
                     /translation="MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDSSNGSFQSL
                     TQGCPTYFPPSPTGSLTQDPARSFGTVPPSLSDDSSPSSASSSSSSSSSFYNGSPPGS
                     LQVAMEDSSRVSPSKGTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSI
                     QQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLA
                     EMQNAMNLANNQLSSLCPLETSPAPHPTSGSVGPSPPPAPAPTPLVGFSQFPQQLTPP
                     RSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPPATTPQCWESQ
                     GCPSTPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQPNSNGHRLCPTH
                     VYSAPEGKAPANGLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREV
                     VEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQEL
                     GAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETL
                     LRALRALVLKNRPSETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ"
     exon            515..853
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            854..942
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1087
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1731
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1917
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2128
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2611
                     /gene="Nr1d1"
                     /gene_synonym="REV-ERBAALPHA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatattact gctgaggaaa cgtagcaggg cacacgtctc tctttgcgtc tgggtgcttc
       61 atttctccat cacctactta cttcctggtt gcagcttctc tccctttggg acttttgcac
      121 ccggagctcc agattcacta ccctgcttcg ctgcggagcc ttcaggagtg gcatccggtg
      181 cactgcagag acccgactct ccttgctacc ttatagccag aactgctgca ggctgattct
      241 tcacacacac tctatctgct cttcccatgc aaatcagatc tcggttgcct cagcatccta
      301 cccttctgga gggctgcagt atagccaccc caagacctta ctgctcggtg cctagaatcc
      361 tgattgtgaa ctgcgggctt cactcgtctc tctcagccat tgcccacggg gcgagagagg
      421 gcaccacaac ctccactttg tgtcaaggtc cagtttgaat gaccgctttc agctggtgaa
      481 gacatgacga ccctagactc caacaacaac acaggtggtg ttatcaccta cattggctcc
      541 agcggatcct cccccagccg gaccagccca gagtccctct atagtgacag ctccaatggc
      601 agcttccagt ccctgactca aggttgtccc acatacttcc caccatcacc tactggctcc
      661 ctcacccagg accctgcccg ctcatttggc actgtgccac ccagcctcag tgatgatagc
      721 tccccttctt ctgcttcatc atcatcatca tcttcctcct ccttctataa tgggagcccc
      781 cccggaagtc tacaagtggc catggaagac agcagccgag tgtcccccag caagggcacc
      841 agcaacatta ccaagcttaa cggcatggtg ctactgtgta aagtgtgtgg ggacgtggcc
      901 tcaggcttcc actatggcgt gcatgcctgc gagggctgca agggcttttt ccgccggagc
      961 atccagcaga acatccagta caagcggtgt ttgaaaaacg agaactgctc cattgtccgt
     1021 atcaatcgca accgctgcca gcagtgtcgc ttcaagaagt gtctctccgt tggcatgtct
     1081 agagacgctg tgcgttttgg acgtatcccc aagagagaga agcaacgaat gcttgctgag
     1141 atgcagaacg ccatgaactt ggccaacaac caactgagca gcctgtgccc tctagagacc
     1201 tcacctgccc cgcaccccac ctcaggctcc gtgggcccct caccacctcc tgcaccagcc
     1261 ccgacacctt tggtgggctt ctctcagttc ccacaacagc tgacaccacc cagatccccg
     1321 agtcctgagc ccaccgtgga ggatgtgata tcccaggtgg ccagggccca tcgagaaatc
     1381 ttcacctatg cccatgacaa attaggcacc tcacctggca acttcaatgc caatcatgca
     1441 tcaggtagcc ctccggctac cactccacag tgctgggaga gtcagggatg cccgtctacc
     1501 cccaacgaca acaacctttt ggcggctcag cgtcataatg aagcactgaa tggtctacgc
     1561 cagggcccct cctcctaccc tcctacctgg ccttctggcc ctgcccacca cagctgccac
     1621 cagcctaaca gcaatgggca tcgcctgtgc cccacccacg tatactcggc cccagaaggc
     1681 aaggcacctg ccaacggtct acggcaaggc aacaccaaga atgttctgct ggcatgtccc
     1741 atgaacatgt atccccatgg acgtagtggc cggactgtgc aggagatctg ggaagacttc
     1801 tctatgagct tcacacccgc tgtgcgggag gtggtagaat ttgccaaaca catccccggc
     1861 ttccgtgacc tttctcagca cgaccaggtg accctgctta aggctggcac ctttgaggtg
     1921 ctgatggtgc gctttgcgtc attgttcaac gtgaaggacc agacagtcat gttcctgagc
     1981 cgcacaacct acagcctgca ggagctcggt gccatgggca tgggtgacct gctcaatgcc
     2041 atgtttgact tcagcgagaa gctcaactct ctggcgctta ctgaggagga gctgggcctt
     2101 ttcacggcag tggtacttgt ctctgcagac cgctcgggaa tggagaattc cgcttcggtg
     2161 gagcagctcc aggagacgct gctgcgggct cttcgggctc tggtgctgaa gaaccggccc
     2221 tcggagactt cccgcttcac caaactgctg ctcaagctgc cggacctgcg gaccctgaac
     2281 aacatgcatt ccgagaagct gctgtccttc cgggtggacg cccagtgacc cgcccggccg
     2341 gccttctgcc gctgccccct tgtacagaat cgaactctgc acttctctct cctttacgag
     2401 acgaaaagga aaagcaaacc agaatcttat ttatattgtt ataaaatatt ccaagatgag
     2461 cctctggccc cctgagcctt cttgtaaata actcttcccc cccaccccca tgctcccttc
     2521 ctcccgtatt taaaccactc ttgctctccc accctcctct ggcccctcga tttgttctgt
     2581 tcctgtctca aatccaatag ttcacagctg a
//
