LOCUS       NM_057133               1111 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 0, group B, member 2
            (Nr0b2), mRNA.
ACCESSION   NM_057133
VERSION     NM_057133.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Zhang,T., Yu,F., Guo,L., Chen,M., Yuan,X. and Wu,B.
  TITLE     Small Heterodimer Partner Regulates Circadian Cytochromes p450 and
            Drug-Induced Hepatotoxicity
  JOURNAL   Theranostics 8 (19), 5246-5258 (2018)
   PUBMED   30555544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Marczak,M.M. and Yan,B.
  TITLE     Circadian rhythmicity: A functional connection between
            differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer
            partner (SHP)
  JOURNAL   Arch Biochem Biophys 631, 11-18 (2017)
   PUBMED   28797635
REFERENCE   3  (bases 1 to 1111)
  AUTHORS   Xu,W., Lu,C., Yao,L., Zhang,F., Shao,J. and Zheng,S.
  TITLE     Dihydroartemisinin protects against alcoholic liver injury through
            alleviating hepatocyte steatosis in a farnesoid X
            receptor-dependent manner
  JOURNAL   Toxicol Appl Pharmacol 315, 23-34 (2017)
   PUBMED   27939985
REFERENCE   4  (bases 1 to 1111)
  AUTHORS   Eggink,H.M., Oosterman,J.E., de Goede,P., de Vries,E.M., Foppen,E.,
            Koehorst,M., Groen,A.K., Boelen,A., Romijn,J.A., la Fleur,S.E.,
            Soeters,M.R. and Kalsbeek,A.
  TITLE     Complex interaction between circadian rhythm and diet on bile acid
            homeostasis in male rats
  JOURNAL   Chronobiol Int 34 (10), 1339-1353 (2017)
   PUBMED   29028359
  REMARK    GeneRIF: It has been demonstrated that hepatic gene expression of
            Shp is directed by daily rhythm in food intake but not day/night
            rhythm.
REFERENCE   5  (bases 1 to 1111)
  AUTHORS   Lee,J.H., Kim,H., Park,S.J., Woo,J.H., Joe,E.H. and Jou,I.
  TITLE     Small heterodimer partner SHP mediates liver X receptor
            (LXR)-dependent suppression of inflammatory signaling by promoting
            LXR SUMOylation specifically in astrocytes
  JOURNAL   Sci Signal 9 (439), ra78 (2016)
   PUBMED   27485016
  REMARK    GeneRIF: SHP promoted SUMO1 attachment to LXRbeta by stabilizing
            the E3 SUMO ligase PIAS1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1111)
  AUTHORS   Kim,J.Y., Chu,K., Kim,H.J., Seong,H.A., Park,K.C., Sanyal,S.,
            Takeda,J., Ha,H., Shong,M., Tsai,M.J. and Choi,H.S.
  TITLE     Orphan nuclear receptor small heterodimer partner, a novel
            corepressor for a basic helix-loop-helix transcription factor
            BETA2/neuroD
  JOURNAL   Mol Endocrinol 18 (4), 776-790 (2004)
   PUBMED   14752053
REFERENCE   7  (bases 1 to 1111)
  AUTHORS   Lai,K., Harnish,D.C. and Evans,M.J.
  TITLE     Estrogen receptor alpha regulates expression of the orphan receptor
            small heterodimer partner
  JOURNAL   J Biol Chem 278 (38), 36418-36429 (2003)
   PUBMED   12842887
  REMARK    GeneRIF: orphan receptor small heterodimer partner expression is
            regulated by estrogen receptor alpha
REFERENCE   8  (bases 1 to 1111)
  AUTHORS   Nishigori,H., Tomura,H., Tonooka,N., Kanamori,M., Yamada,S.,
            Sho,K., Inoue,I., Kikuchi,N., Onigata,K., Kojima,I., Kohama,T.,
            Yamagata,K., Yang,Q., Matsuzawa,Y., Miki,T., Seino,S., Kim,M.Y.,
            Choi,H.S., Lee,Y.K., Moore,D.D. and Takeda,J.
  TITLE     Mutations in the small heterodimer partner gene are associated with
            mild obesity in Japanese subjects
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 575-580 (2001)
   PUBMED   11136233
REFERENCE   9  (bases 1 to 1111)
  AUTHORS   Johansson,L., Bavner,A., Thomsen,J.S., Farnegardh,M.,
            Gustafsson,J.A. and Treuter,E.
  TITLE     The orphan nuclear receptor SHP utilizes conserved LXXLL-related
            motifs for interactions with ligand-activated estrogen receptors
  JOURNAL   Mol Cell Biol 20 (4), 1124-1133 (2000)
   PUBMED   10648597
REFERENCE   10 (bases 1 to 1111)
  AUTHORS   Masuda,N., Yasumo,H., Tamura,T., Hashiguchi,N., Furusawa,T.,
            Tsukamoto,T., Sadano,H. and Osumi,T.
  TITLE     An orphan nuclear receptor lacking a zinc-finger DNA-binding
            domain: interaction with several nuclear receptors
  JOURNAL   Biochim Biophys Acta 1350 (1), 27-32 (1997)
   PUBMED   9003453
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D86580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86580.1, CO565826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/Jcl"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1111
                     /gene="Nr0b2"
                     /gene_synonym="Shp"
                     /note="nuclear receptor subfamily 0, group B, member 2"
                     /db_xref="GeneID:117274"
                     /db_xref="RGD:621032"
     exon            1..575
                     /gene="Nr0b2"
                     /gene_synonym="Shp"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..817
                     /gene="Nr0b2"
                     /gene_synonym="Shp"
                     /note="orphan nuclear receptor SHP; small heterodimer
                     partner homologue"
                     /codon_start=1
                     /product="nuclear receptor subfamily 0 group B member 2"
                     /protein_id="NP_476474.1"
                     /db_xref="GeneID:117274"
                     /db_xref="RGD:621032"
                     /translation="MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLC
                     QQHRPVRLCAPHRTCREALDVLGKTVAFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLG
                     LAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPDPPQPSLAAVQWLQHCLESFW
                     SLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWYPASQGRLA
                     RILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR"
     exon            576..1111
                     /gene="Nr0b2"
                     /gene_synonym="Shp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagga agaaacagga acaagacaca gaccatgagc tccagccaat caggggtctg
       61 cccatgccag ggctctgcaa gccaccccac cattctctac acacttctaa gccccggtcc
      121 caggaccagg cccatggcac ccgcatctcg cagccactgc ctgtgccagc aacaccggcc
      181 tgtgcgcctg tgtgctccac accgcacctg cagggaggcc ttggatgtcc taggcaagac
      241 tgtagccttc ctcaggaacc tgccgtcctt ctgcctcctg ccccatgagg atcagcgacg
      301 gctgctagag ggctgctggg gccctctctt cctgcttggg ttggcccagg atactgtgac
      361 ctttgaggtg gccgaggctc cggtccccag catacttaaa aagatcttgc tagaggaacc
      421 caacagtggt gcccagggtg cccagccacc agacccacca caaccctcac tggctgccgt
      481 gcagtggctg cagcactgcc tggagtcttt ctggagcctt gagctgggtc ccaaggagta
      541 cgcatacctg aaaggcacta tcctcttcaa cccagatgtg ccaggcctcc atgcctcctg
      601 ccacattgca cacctgcaac aggaggctca ctgggcattg tgtgaagtcc tggagccctg
      661 gtacccagct agccaaggcc gcctggcccg aatcctcctc atggcttcca ccctcaagaa
      721 catctcctgt acccttctgg tagatctctt cttccgccct gtcatcggag atgttgacat
      781 cactgaactg cttgaagaca tgcttttgtt gaggtgacct gtagaatggg gtccggtgcc
      841 tccaaagggg agcctgaaag gccgcactca gctcccctgg agcagccctc gtctcagccc
      901 cacccccagc ttggatttcc tcggtttgca tacagtgttt gactaactgt ccagcaggcc
      961 cttgatggct cccaaaacct ccaggccaat atgccttccc ttacctgggt agggatggga
     1021 gcatgaggct gtgcttcagg gcagaattcc tccagacttt atatagaact aagttaagtt
     1081 attggttttt gtaataaaag gtgtgaactg c
//
