LOCUS       NM_053317               1780 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor subfamily 0, group B, member 1
            (Nr0b1), mRNA.
ACCESSION   NM_053317
VERSION     NM_053317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1780)
  AUTHORS   Oka,S., Matsukuma,H., Horiguchi,N., Kobayashi,T. and Shiraishi,K.
  TITLE     Heat stress upregulates aromatases expression through nuclear DAX-1
            deficiency in R2C Leydig tumor cells
  JOURNAL   Mol Cell Endocrinol 558, 111766 (2022)
   PUBMED   36075317
  REMARK    GeneRIF: Heat stress upregulates aromatases expression through
            nuclear DAX-1 deficiency in R2C Leydig tumor cells.
REFERENCE   2  (bases 1 to 1780)
  AUTHORS   Suh,Y.J., Yun,H.J., Kim,Y.B., Kang,E.J., Choi,J.H., Choi,Y.K.,
            Lee,I.B., Choi,D.H., Seo,Y.J., Noh,J.R., Lee,J.S., Kim,Y.H. and
            Lee,C.H.
  TITLE     Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from
            Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling
  JOURNAL   Int J Mol Sci 23 (19), 11786 (2022)
   PUBMED   36233086
  REMARK    GeneRIF: Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from
            Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1780)
  AUTHORS   Spade,D.J., Hall,S.J., Wortzel,J.D., Reyes,G. and Boekelheide,K.
  TITLE     All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate
            Toxicity
  JOURNAL   Toxicol Sci 168 (1), 149-159 (2019)
   PUBMED   30476341
REFERENCE   4  (bases 1 to 1780)
  AUTHORS   Spade,D.J., Dere,E., Hall,S.J., Schorl,C., Freiman,R.N. and
            Boekelheide,K.
  TITLE     All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and
            Testicular Cell Fate
  JOURNAL   Toxicol Sci 167 (2), 546-558 (2019)
   PUBMED   30329139
REFERENCE   5  (bases 1 to 1780)
  AUTHORS   Zielinska-Gorska,M., Gorski,K., Biernacka,K., Sawosy,E.,
            Kaminska,T. and Gajewska,A.
  TITLE     Gonadotropin-releasing hormone and kisseptin-10 regulate nuclear
            receptor subfamily 5 group a member 1/catenin beta 1/ nuclear
            receptor subfamily 0 group B member 1 activity in female rat
            anterior pituitary gland
  JOURNAL   J Physiol Pharmacol 69 (3) (2018)
   PUBMED   30342431
  REMARK    GeneRIF: In conclusion, the presented data revealed that the
            pituitary Nr5a1/Ctnnb1/Nr0b1 system is controlled by endogenous
            Gnrh network activity, and hypothalamic-derived regulatory inputs
            can affect the processes responsible for gene transcription,
            translation, and protein intracellular translocation.
REFERENCE   6  (bases 1 to 1780)
  AUTHORS   Zazopoulos,E., Lalli,E., Stocco,D.M. and Sassone-Corsi,P.
  TITLE     DNA binding and transcriptional repression by DAX-1 blocks
            steroidogenesis
  JOURNAL   Nature 390 (6657), 311-315 (1997)
   PUBMED   9384387
REFERENCE   7  (bases 1 to 1780)
  AUTHORS   Tamai,K.T., Monaco,L., Alastalo,T.P., Lalli,E., Parvinen,M. and
            Sassone-Corsi,P.
  TITLE     Hormonal and developmental regulation of DAX-1 expression in
            Sertoli cells
  JOURNAL   Mol Endocrinol 10 (12), 1561-1569 (1996)
   PUBMED   8961266
REFERENCE   8  (bases 1 to 1780)
  AUTHORS   Majdic,G. and Saunders,P.T.
  TITLE     Differential patterns of expression of DAX-1 and steroidogenic
            factor-1 (SF-1) in the fetal rat testis
  JOURNAL   Endocrinology 137 (8), 3586-3589 (1996)
   PUBMED   8754790
REFERENCE   9  (bases 1 to 1780)
  AUTHORS   Muscatelli,F., Strom,T.M., Walker,A.P., Zanaria,E., Recan,D.,
            Meindl,A., Bardoni,B., Guioli,S., Zehetner,G., Rabl,W. et al.
  TITLE     Mutations in the DAX-1 gene give rise to both X-linked adrenal
            hypoplasia congenita and hypogonadotropic hypogonadism
  JOURNAL   Nature 372 (6507), 672-676 (1994)
   PUBMED   7990958
REFERENCE   10 (bases 1 to 1780)
  AUTHORS   Zanaria,E., Muscatelli,F., Bardoni,B., Strom,T.M., Guioli,S.,
            Guo,W., Lalli,E., Moser,C., Walker,A.P., McCabe,E.R. et al.
  TITLE     An unusual member of the nuclear hormone receptor superfamily
            responsible for X-linked adrenal hypoplasia congenita
  JOURNAL   Nature 372 (6507), 635-641 (1994)
   PUBMED   7990953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 3, 2020 this sequence version replaced NM_053317.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99470.1, CN543533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1181              JAXUCZ010000021.1  54707658-54708838
            1182-1780           JAXUCZ010000021.1  54711188-54711786
FEATURES             Location/Qualifiers
     source          1..1780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..1780
                     /gene="Nr0b1"
                     /gene_synonym="Ahch; DAX-1"
                     /note="nuclear receptor subfamily 0, group B, member 1"
                     /db_xref="GeneID:58850"
                     /db_xref="RGD:62028"
     exon            1..1181
                     /gene="Nr0b1"
                     /gene_synonym="Ahch; DAX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1426
                     /gene="Nr0b1"
                     /gene_synonym="Ahch; DAX-1"
                     /note="nuclear receptor DAX-1; adrenal hypoplasia,
                     congenital homolog"
                     /codon_start=1
                     /product="nuclear receptor subfamily 0 group B member 1"
                     /protein_id="NP_445769.2"
                     /db_xref="GeneID:58850"
                     /db_xref="RGD:62028"
                     /translation="MAGEDHPWQGSILYNLLMSAKQKHGSREEREVRLGAQCWGCACG
                     TQPVLGGEGLPGGQALSLLYRCCFCGENHPRQGGILYSMLTNARQPSGATEAPRARFR
                     APCWGCACSSAEPLVGREGLPAGQVPSLLYRCCFCGEEHPRQGSILYSLLTSAQQTHV
                     SREVPEAHRGGEWWQLSYCTQSVGGPEGLQSTQAMAFLYRSYVCGEEQPQQSSVASDT
                     PVRADQTPAAPQEQPRAPWWDASSGVQRPIALKDPQVVCEAASAGLLKTLRFVKYLPC
                     FQILPLDQQLVLVRSCWAPLLMLELAQDHLHFEMMEISEPNLMHEMLTTRRQETEGPE
                     PADPQATEQPQTVSAEAGHVLSVAAVQAIKSFFFKCWSLNIDTKEYAYLKGTVLFNPD
                     LPGLQCVKYIESLQWRTQQILTEHIRLMQREYQIRSAELNSALFLLRFINTDVVTELF
                     FRPIIGAVSMDDMMLEMLCAKL"
     exon            1182..1780
                     /gene="Nr0b1"
                     /gene_synonym="Ahch; DAX-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaggccatg gcgggtgagg accacccgtg gcagggcagc atcctctaca atctgttgat
       61 gagcgcgaag cagaagcacg ggtctaggga agagcgagag gtgcgcttgg gggctcagtg
      121 ctggggttgc gcctgcggta ctcagcccgt cctgggtggg gagggactgc ccggcgggca
      181 agccttgtcc cttctgtacc gctgctgctt ttgtggggag aaccacccgc gccagggtgg
      241 catcctctac tctatgctca ccaacgccag gcagcctagc ggggcgaccg aggcgcccag
      301 ggcgcgattc agagctcctt gctggggctg cgcctgcagc agcgcagagc ccctggtggg
      361 cagagagggg ctgccagctg gccaggtccc ctcgctcctg taccgctgct gcttctgcgg
      421 agaagagcac ccgaggcagg gcagcatctt atacagcttg ctcactagtg cccagcaaac
      481 gcacgtgtct cgggaagtac ccgaggcaca tcgcggaggc gagtggtggc agctgtccta
      541 ctgtacccag agtgtgggtg gcccggaggg gcttcagagc acacaggcca tggcgttcct
      601 gtaccgtagc tatgtgtgcg gtgaagagca gccccagcag agcagcgttg cctccgacac
      661 gcccgtgaga gcagatcaaa caccagcagc tccgcaagag cagccgaggg ccccctggtg
      721 ggacgcctcc tctggtgtgc agcgtccgat tgcactcaag gatccacagg tggtgtgcga
      781 ggcagcgtcg gctggcctat tgaagaccct gcgctttgtc aagtacttgc cttgcttcca
      841 gatcctgccc ttagatcagc agctggtgct ggtgcggagc tgttgggcgc ccctactcat
      901 gcttgagttg gcccaagatc acctgcactt cgagatgatg gagatttccg agcccaacct
      961 gatgcacgaa atgctcacca ccaggcggca ggagaccgaa ggcccagagc ccgcagatcc
     1021 ccaggccaca gagcagccac agacggtgtc tgcggaggct gggcacgtgc tctcagtcgc
     1081 tgcggtccag gccatcaaga gtttcttttt taagtgctgg agtctgaaca ttgacaccaa
     1141 agagtacgcc tatctgaagg ggaccgtgct ttttaaccca gacctgcctg gcctgcagtg
     1201 cgtgaaatac atcgagagtc ttcagtggag aactcagcag atcctcactg agcacatcag
     1261 gctgatgcaa agagagtacc agatcagatc ggctgaactg aatagtgccc ttttcctgct
     1321 gagattcatc aacaccgatg ttgtcactga actctttttc aggcccatca ttggtgccgt
     1381 cagcatggat gatatgatgc tggagatgct ctgtgcaaag ctgtgaaggc atgcagccac
     1441 tcaagtgcat tttactacac atggagaaag ggggggctgt aggcagaaga gtgctcaaat
     1501 ttgtgaaaac aaactttctt gtatttttac atgcatagta tatttgtatc caattgaaga
     1561 aatactttag ttacagacaa tgtaaaaacc cctctgctcc atactggttc cttgtgaaga
     1621 aaagcatttg ttaacaaata attatttcca tagatcttta agagtgttat actatgctaa
     1681 caagctaatt tccacaaaaa taacatctct ttccattaac cctgccaaat aaaatttata
     1741 atattaactt ttaataaaat ttaatgtact aaccattaaa
//
