LOCUS       NM_017000               1480 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus NAD(P)H quinone dehydrogenase 1 (Nqo1), mRNA.
ACCESSION   NM_017000
VERSION     NM_017000.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Liu,Y., Guan,H., Feng,M., Du,C., Zhang,Q., Shou,Y., Qi,G., Yu,D.
            and Jin,Y.
  TITLE     MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced
            hepatotoxicity by directly targeting the key bioactivating enzyme
            NQO1
  JOURNAL   Ecotoxicol Environ Saf 261, 115103 (2023)
   PUBMED   37285672
  REMARK    GeneRIF: MiR-766-3p and miR-671-5p attenuate aristolochic
            acid-induced hepatotoxicity by directly targeting the key
            bioactivating enzyme NQO1.
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Du,Y., Liu,G., Chen,D., Yang,J., Wang,J., Sun,Y., Zhang,Q. and
            Liu,Y.
  TITLE     NQO1 regulates expression and alternative splicing of apoptotic
            genes associated with Alzheimer's disease in PC12 cells
  JOURNAL   Brain Behav 13 (5), e2917 (2023)
   PUBMED   37002649
  REMARK    GeneRIF: NQO1 regulates expression and alternative splicing of
            apoptotic genes associated with Alzheimer's disease in PC12 cells.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Pacheco-Garcia,J.L., Loginov,D., Rizzuti,B., Vankova,P.,
            Neira,J.L., Kavan,D., Mesa-Torres,N., Guzzi,R., Man,P. and Pey,A.L.
  TITLE     A single evolutionarily divergent mutation determines the different
            FAD-binding affinities of human and rat NQO1 due to site-specific
            phosphorylation
  JOURNAL   FEBS Lett 596 (1), 29-41 (2022)
   PUBMED   34817874
  REMARK    GeneRIF: A single evolutionarily divergent mutation determines the
            different FAD-binding affinities of human and rat NQO1 due to
            site-specific phosphorylation.
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Dong,H., Hao,L., Zhang,W., Zhong,W., Guo,W., Yue,R., Sun,X. and
            Zhou,Z.
  TITLE     Activation of AhR-NQO1 Signaling Pathway Protects Against
            Alcohol-Induced Liver Injury by Improving Redox Balance
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (3), 793-811 (2021)
   PUBMED   34082111
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Jiang,Z., Bian,M., Wu,J., Li,D., Ding,L. and Zeng,Q.
  TITLE     Oltipraz Prevents High Glucose-Induced Oxidative Stress and
            Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway
  JOURNAL   Biomed Res Int 2020, 5939815 (2020)
   PUBMED   32685505
  REMARK    GeneRIF: Oltipraz Prevents High Glucose-Induced Oxidative Stress
            and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling
            Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Ma,Q., Wang,R., Yang,C.S. and Lu,A.Y.
  TITLE     Expression of mammalian DT-diaphorase in Escherichia coli:
            purification and characterization of the expressed protein
  JOURNAL   Arch Biochem Biophys 283 (2), 311-317 (1990)
   PUBMED   1703398
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Forrest,G.L., Qian,J., Ma,J.X., Kaplan,W.D., Akman,S., Doroshow,J.
            and Chen,S.A.
  TITLE     Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and
            site-directed mutagenesis
  JOURNAL   Biochem Biophys Res Commun 169 (3), 1087-1093 (1990)
   PUBMED   2141979
REFERENCE   9  (bases 1 to 1480)
  AUTHORS   Bayney,R.M., Morton,M.R., Favreau,L.V. and Pickett,C.B.
  TITLE     Rat liver NAD(P)H: Quinone reductase. Regulation of quinone
            reductase gene expression by planar aromatic compounds and
            determination of the exon structure of the quinone reductase
            structural gene
  JOURNAL   J Biol Chem 264 (36), 21793-21797 (1989)
   PUBMED   2480957
REFERENCE   10 (bases 1 to 1480)
  AUTHORS   Tanaka,S., Tamura,K. and Mizuno,Y.
  TITLE     [Clinical consideration with special reference to autopsy cases of
            malignant tumor in the oral cavity, treated with Bleomycin
            (author's transl)]
  JOURNAL   Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975)
   PUBMED   69641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083542.1.
            
            On Jan 24, 2008 this sequence version replaced NM_017000.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083542.1, J02608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093045, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1480
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /note="NAD(P)H quinone dehydrogenase 1"
                     /db_xref="GeneID:24314"
                     /db_xref="RGD:2503"
     exon            1..96
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..914
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /EC_number="1.6.5.2"
                     /note="DTD; QR1; azoreductase; DT-diaphorase; menadione
                     reductase; quinone reductase 1; phylloquinone reductase;
                     NAD(P)H:quinone oxidoreductase 1; NAD(P)H:menadione
                     oxidoreductase; Diaphorase (NADH/NADPH); NAD(P)H
                     dehydrogenase, quinone 1"
                     /codon_start=1
                     /product="NAD(P)H dehydrogenase [quinone] 1"
                     /protein_id="NP_058696.2"
                     /db_xref="GeneID:24314"
                     /db_xref="RGD:2503"
                     /translation="MAVRRALIVLAHAERTSFNYAMKEAAVEALKKKGWEVVESDLYA
                     MNFNPLISRNDITGEPKDSENFQYPVESSLAYKEGRLSPDIVAEQKKLEAADLVIFQF
                     PLYWFGVPAILKGWFERVLVAGFAYTYATMYDKGPFQNKKTLLSITTGGSGSMYSLQG
                     VHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARVQVLEGWKKRLETVWEE
                     SPLYFAPSSLFDLNFQAGFLLKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK"
     exon            97..261
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
     exon            262..392
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
     exon            393..506
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..608
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1456
                     /gene="Nqo1"
                     /gene_synonym="Dia4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttccgaag catttcaggg tcgtcctggc aaccagctgc tcagccaatc agcgcttgac
       61 actacgatcc gcccccaact tctggagcca tggcggtgag aagagccctg attgtattgg
      121 cccacgcaga gaggacatca ttcaactatg ccatgaagga ggctgctgtg gaggctctga
      181 agaagaaagg atgggaggtg gtcgaatctg acctctatgc tatgaacttt aaccccctca
      241 tttccagaaa cgacatcaca ggggagccga aggactcgga gaactttcag taccctgttg
      301 agtcatctct ggcgtataag gaaggccgcc tgagcccgga tattgtagct gaacagaaaa
      361 agctggaagc tgcagacctg gtgatatttc agttcccatt gtattggttt ggggtgcccg
      421 ccattctgaa aggctggttt gagagagtgc ttgtagcagg attcgcctac acgtatgcca
      481 ccatgtatga caagggtcct ttccagaata agaagacctt gctttccatc accaccgggg
      541 gcagcggctc catgtactct ctgcagggtg tccacgggga catgaacgtc attctctggc
      601 caattcagag tggcattctg cgcttctgtg gcttccaggt cttagaacct caactggtgt
      661 acagcattgg ccacacccca cccgatgccc gcgtgcaggt cctggaaggg tggaagaagc
      721 gtctggagac tgtctgggag gagtcaccac tctactttgc tccaagcagc ttgtttgacc
      781 taaacttcca ggcaggattc ttactgaaaa aagaggttca agaggagcag aaaaagaaca
      841 agtttggcct ttctgtgggc catcatttgg gcaagtccat tccagccgac aaccagatca
      901 aagctagaaa ataaggtttt ccataccatg tagttagacc caggtttctt tttccccagt
      961 ttgcctggct tgctttcagt tttcgccttt gttccacaag gataggaaaa ggaggaggct
     1021 cgcctcatgc gtttttggat agttctgcca cggctgtgac agcaaaatga acgaggtcag
     1081 attaggggcc tcaggtggcc tgggatatga atcagggaga ggtgtagccg cgagcgggga
     1141 aaatactctt ctaggtcttt tgtacactat aagctttttt cttcgggcta gccctggcta
     1201 aatggcatcc aatcctccac ccacttgttg ctattagtta cctctctgtg gtttagggca
     1261 ggagggaatt gctcaaacaa tggctgaggg actaacttgt ttagcagtta gctaaagcct
     1321 gtttatgatc catcctggtt tcaattactg tgcagtgact gacaagcctc gggggattgc
     1381 tctccagctc ttctctgcct tgtacatagc acacccaggt cctgggaaat gaatacaaaa
     1441 acaggtctcc gcctcaaaaa aaaaaaaaaa aaaaaaaaaa
//
