LOCUS       NM_012869               2414 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus neuropeptide Y receptor Y5 (Npy5r), mRNA.
ACCESSION   NM_012869
VERSION     NM_012869.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Domin,H., Przykaza,L., Jantas,D., Kozniewska,E., Boguszewski,P.M.
            and Smialowska,M.
  TITLE     Neuropeptide Y Y2 and Y5 receptors as promising targets for
            neuroprotection in primary neurons exposed to oxygen-glucose
            deprivation and in transient focal cerebral ischemia in rats
  JOURNAL   Neuroscience 344, 305-325 (2017)
   PUBMED   28057538
  REMARK    GeneRIF: NPY and agonists of Y2R and Y5R may be neuroprotective
            against oxygen-glucose deprivation-induced neuronal cell death in
            primary cortical cell cultures after delayed treatment. A Y2R
            agonist not only diminished transient cerebral ischemia-induced
            neuronal injury, but also improved functional outcome after delayed
            treatment. Y5 and especially Y2 receptors may be promising targets
            for neuroprotection against ischemic damage
REFERENCE   2  (bases 1 to 2414)
  AUTHORS   Long,M., Zhou,J., Li,D., Zheng,L., Xu,Z. and Zhou,S.
  TITLE     Long-Term Over-Expression of Neuropeptide Y in Hypothalamic
            Paraventricular Nucleus Contributes to Adipose Tissue Insulin
            Resistance Partly via the Y5 Receptor
  JOURNAL   PLoS One 10 (5), e0126714 (2015)
   PUBMED   25993471
  REMARK    GeneRIF: long-term over-expression of NPY in paraventricular
            nucleus contributes to the establishment of adipose tissue insulin
            resistance, at least partly via the Y5 receptor
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2414)
  AUTHORS   Li,P., Tiwari,H.K., Lin,W.Y., Allison,D.B., Chung,W.K.,
            Leibel,R.L., Yi,N. and Liu,N.
  TITLE     Genetic association analysis of 30 genes related to obesity in a
            European American population
  JOURNAL   Int J Obes (Lond) 38 (5), 724-729 (2014)
   PUBMED   23900445
REFERENCE   4  (bases 1 to 2414)
  AUTHORS   Xu,X., Guo,F., He,Q., Cai,X., Min,D., Wang,Q., Wang,S., Tian,L.,
            Cai,J. and Zhao,Y.
  TITLE     Altered expression of neuropeptide Y, Y1 and Y2 receptors, but not
            Y5 receptor, within hippocampus and temporal lobe cortex of tremor
            rats
  JOURNAL   Neuropeptides 48 (2), 97-105 (2014)
   PUBMED   24444822
  REMARK    GeneRIF: Our results showed the altered expression of NPY, Y1R and
            Y2R but not Y5R in hippocampus and temporal lobe cortex of tremor
            rat brain.
REFERENCE   5  (bases 1 to 2414)
  AUTHORS   Loktev,A.V. and Jackson,P.K.
  TITLE     Neuropeptide Y family receptors traffic via the Bardet-Biedl
            syndrome pathway to signal in neuronal primary cilia
  JOURNAL   Cell Rep 5 (5), 1316-1329 (2013)
   PUBMED   24316073
REFERENCE   6  (bases 1 to 2414)
  AUTHORS   Tang-Christensen,M., Kristensen,P., Stidsen,C.E., Brand,C.L. and
            Larsen,P.J.
  TITLE     Central administration of Y5 receptor antisense decreases
            spontaneous food intake and attenuates feeding in response to
            exogenous neuropeptide Y
  JOURNAL   J Endocrinol 159 (2), 307-312 (1998)
   PUBMED   9795372
REFERENCE   7  (bases 1 to 2414)
  AUTHORS   Parker,E.M., Babij,C.K., Balasubramaniam,A., Burrier,R.E.,
            Guzzi,M., Hamud,F., Mukhopadhyay,G., Rudinski,M.S., Tao,Z.,
            Tice,M., Xia,L., Mullins,D.E. and Salisbury,B.G.
  TITLE     GR231118 (1229U91) and other analogues of the C-terminus of
            neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists
            and neuropeptide Y Y4 receptor agonists
  JOURNAL   Eur J Pharmacol 349 (1), 97-105 (1998)
   PUBMED   9669502
REFERENCE   8  (bases 1 to 2414)
  AUTHORS   Woldbye,D.P., Larsen,P.J., Mikkelsen,J.D., Klemp,K., Madsen,T.M.
            and Bolwig,T.G.
  TITLE     Powerful inhibition of kainic acid seizures by neuropeptide Y via
            Y5-like receptors
  JOURNAL   Nat Med 3 (7), 761-764 (1997)
   PUBMED   9212103
REFERENCE   9  (bases 1 to 2414)
  AUTHORS   Hu,Y., Bloomquist,B.T., Cornfield,L.J., DeCarr,L.B.,
            Flores-Riveros,J.R., Friedman,L., Jiang,P., Lewis-Higgins,L.,
            Sadlowski,Y., Schaefer,J., Velazquez,N. and McCaleb,M.L.
  TITLE     Identification of a novel hypothalamic neuropeptide Y receptor
            associated with feeding behavior
  JOURNAL   J Biol Chem 271 (42), 26315-26319 (1996)
   PUBMED   8824284
REFERENCE   10 (bases 1 to 2414)
  AUTHORS   Gerald,C., Walker,M.W., Criscione,L., Gustafson,E.L.,
            Batzl-Hartmann,C., Smith,K.E., Vaysse,P., Durkin,M.M., Laz,T.M.,
            Linemeyer,D.L., Schaffhauser,A.O., Whitebread,S., Hofbauer,K.G.,
            Taber,R.I., Branchek,T.A. and Weinshank,R.L.
  TITLE     A receptor subtype involved in neuropeptide-Y-induced food intake
  JOURNAL   Nature 382 (6587), 168-171 (1996)
   PUBMED   8700207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66274.1, SRR26360194.1526001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000016.1  27822055-27822286
            233-2414            JAXUCZ010000016.1  27827831-27830012
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2414
                     /gene="Npy5r"
                     /gene_synonym="NPYR5"
                     /note="neuropeptide Y receptor Y5"
                     /db_xref="GeneID:25340"
                     /db_xref="RGD:3199"
     exon            1..232
                     /gene="Npy5r"
                     /gene_synonym="NPYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            233..2414
                     /gene="Npy5r"
                     /gene_synonym="NPYR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1579
                     /gene="Npy5r"
                     /gene_synonym="NPYR5"
                     /note="NPY5-R; Y5 receptor; NPY-Y5 receptor; NPYY5-R;
                     Neuropeptide Y5 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 5"
                     /protein_id="NP_037001.1"
                     /db_xref="GeneID:25340"
                     /db_xref="RGD:3199"
                     /translation="MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFL
                     IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSV
                     LLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLI
                     ATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLV
                     QYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQK
                     WSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPI
                     CFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDF
                     NDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS"
ORIGIN      
        1 ttggactatg ggggccggga acaggcgatc ttgagccggg tgtccggggt ctcagggact
       61 gtcacgtgtt cccgaggcgc ttctaaaacc ctggcggctc cggagcccct ccttcccacc
      121 accgcctcca ggtcctgctc ctgccgccac cgcttccatc tggagcagaa gcgaccgcgc
      181 tcagccacgt accccggagt ccaggcaccc gcagcggccg gggcatcccg aggattctag
      241 tatggagttt aagcttgagg agcattttaa caagacattt gtcacagaga acaatacagc
      301 tgctgctcgg aatgcagcct tccctgcctg ggaggactac agaggcagcg tagacgattt
      361 acaatacttt ctgattgggc tctatacatt cgtaagtctt cttggcttta tgggcaatct
      421 acttatttta atggctgtta tgaaaaagcg caatcagaag actacagtga actttctcat
      481 aggcaacctg gccttctccg acatcttggt cgtcctgttt tgctcccctt tcaccctgac
      541 ctctgtcttg ttggatcagt ggatgtttgg caaagccatg tgccatatca tgccgttcct
      601 tcaatgtgtg tcagttctgg tttcaactct gattttaata tcaattgcca ttgtcaggta
      661 tcatatgata aagcacccta tttctaacaa tttaacggca aaccatggct acttcctgat
      721 agctactgtc tggacactgg gctttgccat ctgttctccc ctcccagtgt ttcacagtct
      781 tgtggaactt aaggagacct ttggctcagc actgctgagt agcaaatatc tctgtgttga
      841 gtcatggccc tctgattcat acagaattgc tttcacaatc tctttattgc tagtgcagta
      901 tatcctgcct ctagtatgtt taacggtaag tcataccagc gtctgccgaa gcataagctg
      961 tggattgtcc cacaaagaaa acagactcga agaaaatgag atgatcaact taaccctaca
     1021 gccatccaaa aagagcagga accaggcaaa aacccccagc actcaaaagt ggagctactc
     1081 attcatcaga aagcacagaa ggaggtacag caagaagacg gcctgtgtct tacccgcccc
     1141 agcaggacct tcccagggga agcacctagc cgttccagaa aatccagcct ccgtccgtag
     1201 ccagctgtcg ccatccagta aggtcattcc aggggtccca atctgctttg aggtgaaacc
     1261 tgaagaaagc tcagatgctc atgagatgag agtcaagcgt tccatcacta gaataaaaaa
     1321 gagatctcga agtgttttct acagactgac catactgata ctcgtgttcg ccgttagctg
     1381 gatgccactc cacgtcttcc acgtggtgac tgacttcaat gataacttga tttccaatag
     1441 gcatttcaag ctggtatact gcatctgtca cttgttaggc atgatgtcct gttgtctaaa
     1501 tccgatccta tatggtttcc ttaataatgg tatcaaagca gacttgagag cccttatcca
     1561 ctgcctacac atgtcatgat tctctctgtg caccaaagag agaagaaacg tggtaattga
     1621 cacataattt atacagaagt attctggatc tgaatgccag ttcgtaatct acgtaagatc
     1681 atcttcatgt tataatatgg ttaattcaat cagttgtaca gagtcaatgt ccatctaata
     1741 caatttcatg tgttgaagta gtttacatta ttttccattt tatgtcattg gtaataagtt
     1801 gagtgatact ctgtggttta gtgtaaaaga tatagctatc caaattgtta cgttgtacaa
     1861 aaatgtatga agtgacaagt tgtcccaaag agcatttaac tacagattta aggaatttct
     1921 attatctggg tatcttcatt tctatttcac aggcttctta acattttttt tgtaaaagta
     1981 caaaaatatt caaaagtcag aactctatta cagatgtatg cataaaagat gattataatt
     2041 ttgtaggaga aagatctgct cctattagtg aagattggta aaattgtcag tttaacccgg
     2101 ctgtcctact actaatattt aatttttcaa atatgaaaag gtttcagatt ttgtttagat
     2161 ttatatcaca ttaaacactg tcaaataaag gctgttttta tatgcatcgt tgatgttcca
     2221 aaatgtgaag tctaaatggt gtctgtattt ccaattatta aataacttct aagatcattt
     2281 ttaaaagtct gtagatggta tggatagcta gttgtttgtt aatataaagt aaaagtagat
     2341 agctgattta tgttgtacct atgtcgtatg tatattaggt atcgtgttgt ctcactaaag
     2401 tgaaagcaaa cgaa
//
