LOCUS       NM_023968               1147 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus neuropeptide Y receptor Y2 (Npy2r), mRNA.
ACCESSION   NM_023968
VERSION     NM_023968.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Yang,T., Hei,R., Li,X., Ma,T., Shen,Y., Liu,C., He,W., Zhu,L.,
            Gu,Y., Hu,Y., Wei,W. and Shen,Y.
  TITLE     The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands
            for sebum synthesis
  JOURNAL   Cell Mol Biol Lett 28 (1), 60 (2023)
   PUBMED   37501148
  REMARK    GeneRIF: The role of NPY2R/NFATc1/DYRK1A regulatory axis in
            sebaceous glands for sebum synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Yan,W., Liu,W., Wu,J., Wu,L., Xuan,S., Wang,W. and Shang,A.
  TITLE     Neuropeptide Y in the amygdala contributes to neuropathic pain-like
            behaviors in rats via the neuropeptide Y receptor type
            2/mitogen-activated protein kinase axis
  JOURNAL   Bioengineered 13 (4), 8101-8114 (2022)
   PUBMED   35313782
  REMARK    GeneRIF: Neuropeptide Y in the amygdala contributes to neuropathic
            pain-like behaviors in rats via the neuropeptide Y receptor type
            2/mitogen-activated protein kinase axis.
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Schmitz,J., Zakrzewicz,A., Wilker,S., Kuncova,J., Hecker,A.,
            Grau,V., Padberg,W. and Holler,J.P.N.
  TITLE     Non-neuronal neuropeptide Y and its receptors during acute
            rejection of rat pulmonary allografts
  JOURNAL   Transpl Immunol 43-44, 49-53 (2017)
   PUBMED   28438668
  REMARK    GeneRIF: NPY and Y1 were expressed by pulmonary intravascular and
            intraalveolar leukocytes. Y1 was up-regulated by pulmonary
            intravascular and intraalveolar leukocytes during allograft
            rejection while Y2 could not be detected.
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Domin,H., Przykaza,L., Jantas,D., Kozniewska,E., Boguszewski,P.M.
            and Smialowska,M.
  TITLE     Neuropeptide Y Y2 and Y5 receptors as promising targets for
            neuroprotection in primary neurons exposed to oxygen-glucose
            deprivation and in transient focal cerebral ischemia in rats
  JOURNAL   Neuroscience 344, 305-325 (2017)
   PUBMED   28057538
  REMARK    GeneRIF: NPY and agonists of Y2R and Y5R may be neuroprotective
            against oxygen-glucose deprivation-induced neuronal cell death in
            primary cortical cell cultures after delayed treatment. A Y2R
            agonist not only diminished transient cerebral ischemia-induced
            neuronal injury, but also improved functional outcome after delayed
            treatment. Y5 and especially Y2 receptors may be promising targets
            for neuroprotection against ischemic damage
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Knauf,C., Chuoi,M.M., Jirou-Najou,J.L., Mortreux,G.,
            Beauvillain,J.C. and Croix,D.
  TITLE     Involvement of NPY Y2 receptor subtype in the control of the
            spontaneous NO/GnRH release at the rat median eminence
  JOURNAL   Neuroreport 12 (15), 3365-3369 (2001)
   PUBMED   11711887
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Goumain,M., Voisin,T., Lorinet,A.M., Ducroc,R., Tsocas,A., Roze,C.,
            Rouet-Benzineb,P., Herzog,H., Balasubramaniam,A. and Laburthe,M.
  TITLE     The peptide YY-preferring receptor mediating inhibition of small
            intestinal secretion is a peripheral Y(2) receptor: pharmacological
            evidence and molecular cloning
  JOURNAL   Mol Pharmacol 60 (1), 124-134 (2001)
   PUBMED   11408607
REFERENCE   8  (bases 1 to 1147)
  AUTHORS   Kanatani,A., Mashiko,S., Murai,N., Sugimoto,N., Ito,J.,
            Fukuroda,T., Fukami,T., Morin,N., MacNeil,D.J., Van der Ploeg,L.H.,
            Saga,Y., Nishimura,S. and Ihara,M.
  TITLE     Role of the Y1 receptor in the regulation of neuropeptide
            Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient,
            and Y5 receptor-deficient mice
  JOURNAL   Endocrinology 141 (3), 1011-1016 (2000)
   PUBMED   10698177
REFERENCE   9  (bases 1 to 1147)
  AUTHORS   Pheng,L.H., Perron,A., Quirion,R., Cadieux,A., Fauchere,J.L.,
            Dumont,Y. and Regoli,D.
  TITLE     Neuropeptide Y-induced contraction is mediated by neuropeptide Y Y2
            and Y4 receptors in the rat colon
  JOURNAL   Eur J Pharmacol 374 (1), 85-91 (1999)
   PUBMED   10422644
REFERENCE   10 (bases 1 to 1147)
  AUTHORS   Goumain,M., Voisin,T., Lorinet,A.M. and Laburthe,M.
  TITLE     Identification and distribution of mRNA encoding the Y1, Y2, Y4,
            and Y5 receptors for peptides of the PP-fold family in the rat
            intestine and colon
  JOURNAL   Biochem Biophys Res Commun 247 (1), 52-56 (1998)
   PUBMED   9636652
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY004257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY004257.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1147
                     /gene="Npy2r"
                     /note="neuropeptide Y receptor Y2"
                     /db_xref="GeneID:66024"
                     /db_xref="RGD:620475"
     exon            1..1147
                     /gene="Npy2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..1146
                     /gene="Npy2r"
                     /note="neuropeptide Y-Y2 receptor; neuropeptide Y/peptide
                     YY-Y2 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 2"
                     /protein_id="NP_076458.1"
                     /db_xref="GeneID:66024"
                     /db_xref="RGD:620475"
                     /translation="MGPLGAEADENQTVEVKVELYGSGPTTPRGELPPDPEPELIDST
                     KLVEVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTL
                     CLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKI
                     SKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTV
                     YSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVV
                     FAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK
                     AFLSAFRCEQRLDAIHSEVSMTFKAKKNLEVKKNNGLTDSFSEATNV"
ORIGIN      
        1 atgggcccat taggtgcaga ggcagatgag aatcaaactg tagaagtgaa agtggaactc
       61 tatgggtcgg ggcccaccac tcctagaggt gagttgcccc ctgatccaga gccggagctc
      121 atagacagca ccaaactggt tgaggtgcag gtggtcctta tactggccta ttgttccatc
      181 atcttgctgg gcgtagttgg caactctctg gtaatccatg tggtgatcaa attcaagagc
      241 atgcgcacag taaccaactt ttttattgcc aacctggctg tggcggatct tttggtgaac
      301 accctgtgcc tgccattcac tcttacctat accttgatgg gggagtggaa aatgggtcca
      361 gttttgtgcc atttggtgcc ctatgcccag ggtctggcag tacaagtgtc cacaataact
      421 ttgacagtca ttgctttgga ccgacatcgt tgcattgtct accacctgga gagcaagatc
      481 tccaagcaaa tcagcttcct gattattggc ctggcgtggg gtgtcagcgc tctgctggca
      541 agtccccttg ccatcttccg ggagtactca ctgattgaga ttattcctga ctttgagatt
      601 gtagcctgta ctgagaaatg gcccggggag gagaagagtg tgtacggtac agtctacagc
      661 ctttccaccc tgctaatcct ctacgttttg cctctgggca tcatatcttt ctcctacacc
      721 cggatctgga gtaagctaaa gaaccacgtt agtcctggag ctgcaagtga ccattaccat
      781 cagcgaaggc acaaaacgac caaaatgctc gtgtgcgtgg tagtggtgtt tgcagtcagc
      841 tggctgcccc tccatgcctt ccaacttgct gtggacatcg acagccatgt cctggacctg
      901 aaggagtaca aactcatctt caccgtgttc cacattattg cgatgtgctc caccttcgcc
      961 aacccccttc tctatggctg gatgaacagc aactacagaa aagctttcct ctcagccttc
     1021 cgctgtgagc agaggttgga tgccattcac tcggaggtgt ccatgacctt caaggctaaa
     1081 aagaacctgg aagtcaaaaa gaacaatggc ctcactgact ctttttcaga ggccaccaac
     1141 gtgtaag
//
