LOCUS       NM_001113357            2618 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus neuropeptide Y receptor Y1 (Npy1r), mRNA.
ACCESSION   NM_001113357
VERSION     NM_001113357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Borroto-Escuela,D., Serrano-Castro,P., Sanchez-Perez,J.A.,
            Barbancho-Fernandez,M.A., Fuxe,K. and Narvaez,M.
  TITLE     Enhanced neuronal survival and BDNF elevation via long-term
            co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors
            (NPY1R): potential therapeutic targets for major depressive
            disorder
  JOURNAL   Expert Opin Ther Targets 28 (4), 295-308 (2024)
   PUBMED   38622072
  REMARK    GeneRIF: Enhanced neuronal survival and BDNF elevation via
            long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1
            receptors (NPY1R): potential therapeutic targets for major
            depressive disorder.
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Sanchez-Marin,L., Flores-Lopez,M., Pastor,A., Gavito,A.L.,
            Suarez,J., de la Torre,R., Pavon,F.J., Rodriguez de Fonseca,F. and
            Serrano,A.
  TITLE     Acute stress and alcohol exposure during adolescence result in an
            anxious phenotype in adulthood: Role of altered
            glutamate/endocannabinoid transmission mechanisms
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 113, 110460 (2022)
   PUBMED   34695542
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Peles,E., Levran,O., Randesi,M., Ott,J., Kreek,M.J. and Adelson,M.
  TITLE     Polymorphisms in Stress-Related Genes Are Associated with Reduced
            Cocaine Abuse and Longer Retention in Methadone Maintenance
            Treatment for Opioid Use Disorder
  JOURNAL   Eur Addict Res 27 (3), 198-205 (2021)
   PUBMED   33242852
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Chen,F., Zhou,Y., Yang,K., Shen,M. and Wang,Y.
  TITLE     NPY stimulates cholesterol synthesis acutely by activating the
            SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine
            hepatocytes
  JOURNAL   Life Sci 262, 118478 (2020)
   PUBMED   32976883
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Randesi,M., Levran,O., van den Brink,W., Blanken,P., van Ree,J.M.,
            Ott,J. and Kreek,M.J.
  TITLE     Further evidence for the association of GAL, GALR1 and NPY1R
            variants with opioid dependence
  JOURNAL   Pharmacogenomics 21 (13), 903-917 (2020)
   PUBMED   32757697
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   Pesini,P., Kopp,J., Wong,H., Walsh,J.H., Grant,G. and Hokfelt,T.
  TITLE     An immunohistochemical marker for Wallerian degeneration of fibers
            in the central and peripheral nervous system
  JOURNAL   Brain Res 828 (1-2), 41-59 (1999)
   PUBMED   10320723
REFERENCE   7  (bases 1 to 2618)
  AUTHORS   Kushi,A., Sasai,H., Koizumi,H., Takeda,N., Yokoyama,M. and
            Nakamura,M.
  TITLE     Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1
            receptor-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15659-15664 (1998)
   PUBMED   9861026
REFERENCE   8  (bases 1 to 2618)
  AUTHORS   Prieto,D., Garcia-Sacristan,A. and Simonsen,U.
  TITLE     Characterization of NPY receptors mediating contraction in rat
            intramyocardial coronary arteries
  JOURNAL   Regul Pept 75-76, 155-160 (1998)
   PUBMED   9802404
REFERENCE   9  (bases 1 to 2618)
  AUTHORS   Pedrazzini,T., Seydoux,J., Kunstner,P., Aubert,J.F., Grouzmann,E.,
            Beermann,F. and Brunner,H.R.
  TITLE     Cardiovascular response, feeding behavior and locomotor activity in
            mice lacking the NPY Y1 receptor
  JOURNAL   Nat Med 4 (6), 722-726 (1998)
   PUBMED   9623984
REFERENCE   10 (bases 1 to 2618)
  AUTHORS   Eva,C., Keinanen,K., Monyer,H., Seeburg,P. and Sprengel,R.
  TITLE     Molecular cloning of a novel G protein-coupled receptor that may
            belong to the neuropeptide receptor family
  JOURNAL   FEBS Lett 271 (1-2), 81-84 (1990)
   PUBMED   2172008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50432.1,
                                           SRR26360186.1168127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000016.1  27813363-27813387   c
            26-868              JAXUCZ010000016.1  27806276-27807118   c
            869-2618            JAXUCZ010000016.1  27804416-27806165   c
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2618
                     /gene="Npy1r"
                     /gene_synonym="NPY-1"
                     /note="neuropeptide Y receptor Y1"
                     /db_xref="GeneID:29358"
                     /db_xref="RGD:3198"
     exon            1..25
                     /gene="Npy1r"
                     /gene_synonym="NPY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            26..868
                     /gene="Npy1r"
                     /gene_synonym="NPY-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1321
                     /gene="Npy1r"
                     /gene_synonym="NPY-1"
                     /note="FC5; NPY1-R; Neuropepetide Y1 Receptor;
                     neuropeptide Y1 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 1"
                     /protein_id="NP_001106828.1"
                     /db_xref="GeneID:29358"
                     /db_xref="RGD:3198"
                     /translation="MNSTLFSRVENYSVHYNVSENSPFLAFENDDCHLPLAVIFTLAL
                     AYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLM
                     DHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITV
                     IWVLAVASSLPFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQ
                     YFGPLCFIFICYFKIYVRLKRRNNMMDKIRDSKYRSSETKRINVMLLSIVVAFAVCWL
                     PLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF
                     NFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKI"
     exon            869..2618
                     /gene="Npy1r"
                     /gene_synonym="NPY-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgaacaga cggattcttt aaaagagtat tcagttcaag ggaacgaaga attgagaatt
       61 atttttggtg aatggattca aataaatgga ataagagaca gctgaagatc tgatccattt
      121 cgaagaaccc taacagtcca tttgtctaat ccataacaac aaaacgtaaa aaatgaattc
      181 aactctgttc tccagggttg aaaattactc agttcactat aatgtctcag agaattctcc
      241 atttctggcc tttgagaatg atgactgcca cctgcccttg gctgtgatat tcaccttagc
      301 tcttgcttat ggggctgtga ttattcttgg ggtctctgga aacctggcat tgatcataat
      361 catcctaaaa cagaaagaga tgaggaatgt caccaacatt ctgatcgtga acctctcctt
      421 ctcagacttg ctggtcgcag tcatgtgtct cccgttcacc tttgtgtaca cactgatgga
      481 ccactgggtc ttcggggaga ccatgtgcaa actgaatcct tttgtgcaat gcgtctccat
      541 tacagtatcc attttctctc tggttctcat cgctgtggaa cgtcatcagc taatcatcaa
      601 cccaagaggg tggagaccaa acaatagaca tgcttacata ggcattactg tcatttgggt
      661 actggcggtg gcttcttctc tgcccttcgt gatctatcaa attctgactg atgagccctt
      721 ccaaaatgta tcacttgcgg cgttcaagga caagtatgta tgttttgaca aattcccgtc
      781 agactctcac aggctgtctt acacgactct tcttctggtg ctgcagtatt ttggcccact
      841 ctgtttcata ttcatatgct acttcaagat atacgttcgc ttgaaaagga gaaacaacat
      901 gatggacaaa atcagggaca gtaagtacag gtccagtgag accaaacgaa tcaacgtcat
      961 gctgctctcc atcgtggtcg ccttcgcggt ctgctggctg ccccttacca tcttcaacac
     1021 tgtgttcgac tggaatcacc agatcattgc cacctgcaac cacaatctgc tgttcctgct
     1081 ctgccacctc acggccatga tctccacctg cgtcaacccc atcttttatg gattcctgaa
     1141 caaaaatttc cagagagact tgcagttctt cttcaacttt tgtgacttcc ggtctcgaga
     1201 cgacgactac gagactatag ccatgtctac catgcatacg gacgtgtcca agacttcttt
     1261 gaagcaggca agcccggttg catttaaaaa aatcagtatg aatgacaatg aaaaaatctg
     1321 aagctgctga gaacatacgg tcccaggcta catctgtgga aaaacaagca cagcctgtca
     1381 catgctttca ttacctgtgc tcccagggaa tggattgagg caggtttgga aagtccagga
     1441 catcctgtgt tgggttttac tgcttttgtg atggttgccg tgattacttg gcaatctaga
     1501 ttactttgta atctatctgg caacagtttt gaccagactc tgtgtgtgtg tgtgtgtgtg
     1561 tgtgtgtgtc tgtctgtctg tctgtctgtg ggtatgtgtg tgaaattatc cataacaagg
     1621 agtcttatat cgtatttatt ggagtgaatt tgtctgaagt aatgtcatga gctcacttca
     1681 aaagcagtac ctacctgata ttctcaagat aattagattt tcaagatcag atgagatttc
     1741 caagaccttg gactaccttc attccatgct aggcattatg ttagtctgtt acaagggtga
     1801 cagtatacaa aagtcacctt ttaggatgtg ccggagccaa aagagagtct gaagtcattt
     1861 ggcagtatct tttttctctc tctctttttg agaggtctag atttgttatt cagctacaat
     1921 tgagtcttgc ttaagataaa taagaaggcg gctttcagct gtgtatatat ccgggcgtta
     1981 ggccattcac aagaatgaag tggcaaagca ggtcgctgat ttcaaaattc ctctgacaac
     2041 caaagcatta attagtcatt taatatgtaa actagtcttg ctacagatag ataaattgca
     2101 tccaaaggac ttgatcatca agaggttttt gcatcgctca tcagagcatt cagcaccatc
     2161 aagctttctt gcgcaagcac gtgactctga gagcatttct aactcatact gcatagaaac
     2221 ataagatgcg ttttccatac aacagtgcct gcatagtaac tagtgtttaa ctctcaccat
     2281 ttatccttca tggcagatga cacatggaca atgtttatgt aggtaccctc atcgaactgg
     2341 taactgttcc taaaaatgtc atgtggccag cccatcctaa tttgtataaa ctgtataacg
     2401 tgtggagttt tataatcata tactattata tcatagaata ctgagtagcc ctgtaatatt
     2461 aatatattta ctttcacata tcttgtaatc atgatttaga ctcagaaaag atactttgaa
     2521 gaacaagaga gtttcaatgt attatataaa aatgttgcct gtatgtgatt ttagaagggc
     2581 aaacactttc tgtattaaaa ctgggctttt tcagagga
//
