LOCUS       NM_012614                567 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuropeptide Y (Npy), mRNA.
ACCESSION   NM_012614
VERSION     NM_012614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Urata,Y., Salehi,R., Wyse,B.A., Jahangiri,S., Librach,C.L.,
            Tzeng,C.R., Osuga,Y. and Tsang,B.
  TITLE     Neuropeptide Y directly reduced apoptosis of granulosa cells, and
            the expression of NPY and its receptors in PCOS subjects
  JOURNAL   J Ovarian Res 16 (1), 182 (2023)
   PUBMED   37653540
  REMARK    GeneRIF: Neuropeptide Y directly reduced apoptosis of granulosa
            cells, and the expression of NPY and its receptors in PCOS
            subjects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Brancato,A., Castelli,V., Cannizzaro,C. and Tringali,G.
  TITLE     Adolescent binge-like alcohol exposure dysregulates NPY and CGRP in
            rats: Behavioural and immunochemical evidence
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 123, 110699 (2023)
   PUBMED   36565980
  REMARK    GeneRIF: Adolescent binge-like alcohol exposure dysregulates NPY
            and CGRP in rats: Behavioural and immunochemical evidence.
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Yan,W., Liu,W., Wu,J., Wu,L., Xuan,S., Wang,W. and Shang,A.
  TITLE     Neuropeptide Y in the amygdala contributes to neuropathic pain-like
            behaviors in rats via the neuropeptide Y receptor type
            2/mitogen-activated protein kinase axis
  JOURNAL   Bioengineered 13 (4), 8101-8114 (2022)
   PUBMED   35313782
  REMARK    GeneRIF: Neuropeptide Y in the amygdala contributes to neuropathic
            pain-like behaviors in rats via the neuropeptide Y receptor type
            2/mitogen-activated protein kinase axis.
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Carboni,L., El Khoury,A., Beiderbeck,D.I., Neumann,I.D. and
            Mathe,A.A.
  TITLE     Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A
            in brain regions of HAB rats correlate with anxiety-like behaviours
  JOURNAL   Eur Neuropsychopharmacol 57, 1-14 (2022)
   PUBMED   35008014
  REMARK    GeneRIF: Neuropeptide Y, calcitonin gene-related peptide, and
            neurokinin A in brain regions of HAB rats correlate with
            anxiety-like behaviours.
REFERENCE   5  (bases 1 to 567)
  AUTHORS   Stiernborg,M., Efstathopoulos,P., Lennartsson,A., Lavebratt,C. and
            Mathe,A.A.
  TITLE     Sirtuins and neuropeptide y downregulation in Flinders Sensitive
            Line rat model of depression
  JOURNAL   Acta Neuropsychiatr 34 (2), 86-92 (2022)
   PUBMED   34666848
  REMARK    GeneRIF: Sirtuins and neuropeptide y downregulation in Flinders
            Sensitive Line rat model of depression.
REFERENCE   6  (bases 1 to 567)
  AUTHORS   Melas,P.A., Mannervik,M., Mathe,A.A. and Lavebratt,C.
  TITLE     Neuropeptide Y: identification of a novel rat mRNA splice-variant
            that is downregulated in the hippocampus and the prefrontal cortex
            of a depression-like model
  JOURNAL   Peptides 35 (1), 49-55 (2012)
   PUBMED   22406386
  REMARK    GeneRIF: Identification of a novel rat neuropeptide Y mRNA
            splice-variant that is downregulated in the hippocampus and the
            prefrontal cortex of a depression-like model.
REFERENCE   7  (bases 1 to 567)
  AUTHORS   Beal,M.F., Ferrante,R.J., Swartz,K.J. and Kowall,N.W.
  TITLE     Chronic quinolinic acid lesions in rats closely resemble
            Huntington's disease
  JOURNAL   J Neurosci 11 (6), 1649-1659 (1991)
   PUBMED   1710657
REFERENCE   8  (bases 1 to 567)
  AUTHORS   Higuchi,H., Yang,H.Y. and Sabol,S.L.
  TITLE     Rat neuropeptide Y precursor gene expression. mRNA structure,
            tissue distribution, and regulation by glucocorticoids, cyclic AMP,
            and phorbol ester
  JOURNAL   J Biol Chem 263 (13), 6288-6295 (1988)
   PUBMED   2834371
REFERENCE   9  (bases 1 to 567)
  AUTHORS   Beal,M.F., Clevens,R.A. and Mazurek,M.F.
  TITLE     Somatostatin and neuropeptide Y immunoreactivity in Parkinson's
            disease dementia with Alzheimer's changes
  JOURNAL   Synapse 2 (4), 463-467 (1988)
   PUBMED   2903567
REFERENCE   10 (bases 1 to 567)
  AUTHORS   Larhammar,D., Ericsson,A. and Persson,H.
  TITLE     Structure and expression of the rat neuropeptide Y gene
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 2068-2072 (1987)
   PUBMED   3031663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000004.1 and M20373.1.
            
            On Jul 17, 2012 this sequence version replaced NM_012614.1.
            
            Summary: This gene encodes a neuropeptide that is widely expressed
            in the central nervous system and influences many physiological
            processes, including cortical excitability, stress response, food
            intake, circadian rhythms, and cardiovascular function. Studies in
            the rat model of depression (Flinders Sensitive Line) show that
            this gene is downregulated in the hippocampus and the prefrontal
            cortex compared to the control ((Flinders Resistant Line).
            Alternatively spliced transcript variants of this gene have been
            described, but the function of all the variants is not known.
            [provided by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR471341.1, CK844585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000004.1  80212111-80212155
            46-556              M20373.1           1-511
            557-567             JAXUCZ010000004.1  80219300-80219310
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..567
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /note="neuropeptide Y"
                     /db_xref="GeneID:24604"
                     /db_xref="RGD:3197"
     exon            1..96
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..390
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /note="pro-neuropeptide Y; pro-neuropeptide Y-like"
                     /codon_start=1
                     /product="pro-neuropeptide Y preproprotein"
                     /protein_id="NP_036746.1"
                     /db_xref="GeneID:24604"
                     /db_xref="RGD:3197"
                     /translation="MMLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAE
                     DMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENAPRTRLEDPSMW"
     exon            97..284
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /inference="alignment:Splign:2.1.0"
     exon            285..365
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /inference="alignment:Splign:2.1.0"
     exon            366..567
                     /gene="Npy"
                     /gene_synonym="NPY02; RATNPY; RATNPY02"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccgctct acgcatccca ccggtggagc tcattcctcg cagaggcgcc cagagcagag
       61 cacccgctgc gcagagacca cagcccgccc gccatgatgc taggtaacaa acgaatgggg
      121 ctgtgtggac tgaccctcgc tctatccctg ctcgtgtgtt tgggcattct ggctgagggg
      181 tacccctcca agccggacaa tccgggcgag gacgcgccag cagaggacat ggccagatac
      241 tactccgctc tgcgacacta catcaatctc atcaccagac agagatatgg caagagatcc
      301 agccctgaga cactgatttc agatctctta atgagagaaa gcacagaaaa tgcccccaga
      361 acaaggcttg aagacccttc catgtggtga tgggaaatga aacttgctct cctgactttt
      421 cctagtttcc ccccacatct catctcatcc tgtgaaacca gtctgcctgt cccaccaatg
      481 catgccacca ccaggctgga ttccgaccca tttcccttgt tgtcgttgta tatatgtgtg
      541 tttaaataaa gtatcatgca ttcaaaa
//
