LOCUS       NM_153294                684 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus neuropeptide W (Npw), mRNA.
ACCESSION   NM_153294
VERSION     NM_153294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 684)
  AUTHORS   Pandey,S., Tuma,Z., Peroni,E., Monasson,O., Papini,A.M. and
            Chottova Dvorakova,M.
  TITLE     Identification of NPB, NPW and Their Receptor in the Rat Heart
  JOURNAL   Int J Mol Sci 21 (21), 7827 (2020)
   PUBMED   33105700
  REMARK    GeneRIF: Identification of NPB, NPW and Their Receptor in the Rat
            Heart.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 684)
  AUTHORS   Wang,R., Yan,F., Liao,R., Wan,P., Little,P.J. and Zheng,W.
  TITLE     Role of brain-derived neurotrophic factor and nerve growth factor
            in the regulation of Neuropeptide W in vitro and in vivo
  JOURNAL   Mol Cell Endocrinol 447, 71-78 (2017)
   PUBMED   28249734
  REMARK    GeneRIF: the effect and underlying mechanisms of NGF/BDNF on the
            production of NPW in PC12 cells and hypothalamus, is reported.
REFERENCE   3  (bases 1 to 684)
  AUTHORS   Naso,T., Shousha,S. and El-Kirdasy,A.
  TITLE     Central neuropeptide W has anorexigenic effect in rats
  JOURNAL   J Anim Physiol Anim Nutr (Berl) 98 (2), 228-234 (2014)
   PUBMED   23510017
  REMARK    GeneRIF: These results strongly suggest that neuropeptide W may
            play an important central role in the feeding intake and energy
            balance control in mammals.
REFERENCE   4  (bases 1 to 684)
  AUTHORS   Pate,A.T., Yosten,G.L.C. and Samson,W.K.
  TITLE     Compromise of endogenous neuropeptide W production abrogates the
            dipsogenic and pressor effects of angiotensin II in adult male rats
  JOURNAL   J Neuroendocrinol 25 (12), 1290-1297 (2013)
   PUBMED   24028220
  REMARK    GeneRIF: NPW-producing neurones appear to participate in the
            hypothalamic mechanisms controlling prolactin (but not
            corticosterone) secretion
REFERENCE   5  (bases 1 to 684)
  AUTHORS   Skrzypski,M., Pruszynska-Oszmalek,E., Rucinski,M.,
            Szczepankiewicz,D., Sassek,M., Wojciechowicz,T., Kaczmarek,P.,
            Kolodziejski,P.A., Strowski,M.Z., Malendowicz,L.K. and Nowak,K.W.
  TITLE     Neuropeptide B and W regulate leptin and resistin secretion, and
            stimulate lipolysis in isolated rat adipocytes
  JOURNAL   Regul Pept 176 (1-3), 51-56 (2012)
   PUBMED   22484289
  REMARK    GeneRIF: The Neuropeptide W can affect glucose and lipid
            homeostasis, and food intake in rats.
REFERENCE   6  (bases 1 to 684)
  AUTHORS   Taylor,M.M., Yuill,E.A., Baker,J.R., Ferri,C.C., Ferguson,A.V. and
            Samson,W.K.
  TITLE     Actions of neuropeptide W in paraventricular hypothalamus:
            implications for the control of stress hormone secretion
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 288 (1), R270-R275 (2005)
   PUBMED   15345475
  REMARK    GeneRIF: Neuropeptide W effects on the
            hypothalamic-pituitary-adrenal axis.
REFERENCE   7  (bases 1 to 684)
  AUTHORS   Mondal,M.S., Yamaguchi,H., Date,Y., Shimbara,T., Toshinai,K.,
            Shimomura,Y., Mori,M. and Nakazato,M.
  TITLE     A role for neuropeptide W in the regulation of feeding behavior
  JOURNAL   Endocrinology 144 (11), 4729-4733 (2003)
   PUBMED   12959997
REFERENCE   8  (bases 1 to 684)
  AUTHORS   Baker,J.R., Cardinal,K., Bober,C., Taylor,M.M. and Samson,W.K.
  TITLE     Neuropeptide W acts in brain to control prolactin, corticosterone,
            and growth hormone release
  JOURNAL   Endocrinology 144 (7), 2816-2821 (2003)
   PUBMED   12810535
REFERENCE   9  (bases 1 to 684)
  AUTHORS   Brezillon,S., Lannoy,V., Franssen,J.D., Le Poul,E., Dupriez,V.,
            Lucchetti,J., Detheux,M. and Parmentier,M.
  TITLE     Identification of natural ligands for the orphan G protein-coupled
            receptors GPR7 and GPR8
  JOURNAL   J Biol Chem 278 (2), 776-783 (2003)
   PUBMED   12401809
REFERENCE   10 (bases 1 to 684)
  AUTHORS   Shimomura,Y., Harada,M., Goto,M., Sugo,T., Matsumoto,Y., Abe,M.,
            Watanabe,T., Asami,T., Kitada,C., Mori,M., Onda,H. and Fujino,M.
  TITLE     Identification of neuropeptide W as the endogenous ligand for
            orphan G-protein-coupled receptors GPR7 and GPR8
  JOURNAL   J Biol Chem 277 (39), 35826-35832 (2002)
   PUBMED   12130646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB084278.1.
            
            [WARNING] On Jan 8, 2025 this sequence was replaced by NM_153294.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB084278.1, BQ194351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..684
                     /gene="Npw"
                     /note="neuropeptide W"
                     /db_xref="GeneID:259224"
                     /db_xref="RGD:727858"
     exon            1..542
                     /gene="Npw"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..654
                     /gene="Npw"
                     /note="PPL8; preproprotein L8; prepro-Neuropeptide W
                     polypeptide"
                     /codon_start=1
                     /product="neuropeptide W precursor"
                     /protein_id="NP_695206.1"
                     /db_xref="GeneID:259224"
                     /db_xref="RGD:727858"
                     /translation="MDLSALASSREVRGPGPGAPVNRPLLPLLLLLLLLPLPASAWYK
                     HVASPRYHTVGRASGLLMGLRRSPYLWRRALGGAAGPLVGLPGQMARSALLLPSPGQE
                     LWEVRSRSSPAGLPVHATRSLRDLEGAGQPEQSLSFQSWTSAEPAARAFGETLRAQPW
                     FLQQIIFADPVRLDDRLKNRWRPRA"
     exon            543..684
                     /gene="Npw"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtagtcgca ccaactgact agtctcttcc atcctccgga gctccgacgt tctcggggac
       61 ataaaccctg ttcttgtcct aacccgccaa ggggccatgg acttgagcgc gctggcgtcg
      121 agcagagaag tacggggccc tgggcccggg gctccggtga accggcccct gctaccgcta
      181 ctgctgcttc tgctcttgct acctctgccc gccagcgcct ggtacaagca cgtggcgagc
      241 cctcgctatc acacagtggg tcgtgcctcc gggctgctca tggggctgcg ccgctcgccc
      301 tacctgtggc gccgtgcctt gggtggggcc gctggaccgc tcgtggggct cccgggacag
      361 atggcccgca gcgctctcct gcttccttcc cccgggcagg agctgtggga ggtacgaagc
      421 aggagttcac cggcaggact tcccgtgcat gcaacccgga gtctgcggga cctggaggga
      481 gccggccaac ctgagcagtc gctaagcttt cagtcctgga cttcagcaga gcccgctgct
      541 agagccttcg gtgagacgct tcgtgcccag ccatggttcc tgcagcaaat catctttgcc
      601 gatcctgtca ggctcgacga ccgtctcaag aaccgatggc gcccccgtgc ttgacctaag
      661 caggagcaca gcttgtagct ccag
//
