LOCUS       NM_023952                813 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuropeptide VF precursor (Npvf), mRNA.
ACCESSION   NM_023952
VERSION     NM_023952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 813)
  AUTHORS   Voigt,C. and Bennett,N.C.
  TITLE     Gene expression pattern of Kisspeptin and RFamide-related peptide
            (Rfrp) in the male Damaraland mole-rat hypothalamus
  JOURNAL   J Chem Neuroanat 118, 102039 (2021)
   PUBMED   34655735
  REMARK    GeneRIF: Gene expression pattern of Kisspeptin and RFamide-related
            peptide (Rfrp) in the male Damaraland mole-rat hypothalamus.
REFERENCE   2  (bases 1 to 813)
  AUTHORS   Huo,K., Li,X., Hu,W., Song,X., Zhang,D., Zhang,X., Chen,X.,
            Yuan,J., Zuo,J. and Wang,X.
  TITLE     RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator
            Involved in Food Intake and Glucose Homeostasis
  JOURNAL   Front Endocrinol (Lausanne) 11, 194 (2020)
   PUBMED   32328034
  REMARK    GeneRIF: RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel
            Modulator Involved in Food Intake and Glucose Homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 813)
  AUTHORS   Squicciarini,V., Riquelme,R., Wilsterman,K., Bentley,G.E. and
            Lara,H.E.
  TITLE     Role of RFRP-3 in the development of cold stress-induced polycystic
            ovary phenotype in rats
  JOURNAL   J Endocrinol 239 (1), 81-91 (2018)
   PUBMED   30307156
  REMARK    GeneRIF: role in modulating ovarian physiology in response to
            sympathetic stress
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 813)
  AUTHORS   Wang,X., Guo,G., Zhang,X., Li,M., Xiao,K., Hu,C. and Li,X.
  TITLE     Effect of RFRP-3, the mammalian ortholog of GnIH, on the epididymis
            of male rats
  JOURNAL   Theriogenology 118, 196-202 (2018)
   PUBMED   29913425
  REMARK    GeneRIF: study concluded that RFamide-related peptide- (3RFRP-3)
            plays a regulatory role in male rat reproduction
REFERENCE   5  (bases 1 to 813)
  AUTHORS   Geraghty,A.C., Muroy,S.E., Zhao,S., Bentley,G.E., Kriegsfeld,L.J.
            and Kaufer,D.
  TITLE     Knockdown of hypothalamic RFRP3 prevents chronic stress-induced
            infertility and embryo resorption
  JOURNAL   Elife 4, e04316 (2015)
   PUBMED   25581095
  REMARK    GeneRIF: Chronic stress has long-term effects on pregnancy success,
            even post-stressor, that are mediated by RFRP3.[RFRP3]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 813)
  AUTHORS   Johnson,M.A. and Fraley,G.S.
  TITLE     Rat RFRP-3 alters hypothalamic GHRH expression and growth hormone
            secretion but does not affect KiSS-1 gene expression or the onset
            of puberty in male rats
  JOURNAL   Neuroendocrinology 88 (4), 305-315 (2008)
   PUBMED   18628614
  REMARK    GeneRIF: Endogenous rat RFRP-3 does not affect the timing of
            puberty in male rats but may be associated with peripubertal rise
            in growth hormone secretion.
REFERENCE   7  (bases 1 to 813)
  AUTHORS   Johnson,M.A., Tsutsui,K. and Fraley,G.S.
  TITLE     Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH
            secretion, and has variable effects on sex behavior in the adult
            male rat
  JOURNAL   Horm Behav 51 (1), 171-180 (2007)
   PUBMED   17113584
  REMARK    GeneRIF: These results indicate that RFRP-3 has similar effects on
            LH as observed with GnIH in avian species; in the rat RFRP-3 has
            additional roles in regulating feeding and growth.
REFERENCE   8  (bases 1 to 813)
  AUTHORS   Ukena,K., Iwakoshi,E., Minakata,H. and Tsutsui,K.
  TITLE     A novel rat hypothalamic RFamide-related peptide identified by
            immunoaffinity chromatography and mass spectrometry
  JOURNAL   FEBS Lett 512 (1-3), 255-258 (2002)
   PUBMED   11852091
REFERENCE   9  (bases 1 to 813)
  AUTHORS   Liu,Q., Guan,X.M., Martin,W.J., McDonald,T.P., Clements,M.K.,
            Jiang,Q., Zeng,Z., Jacobson,M., Williams,D.L. Jr., Yu,H.,
            Bomford,D., Figueroa,D., Mallee,J., Wang,R., Evans,J., Gould,R. and
            Austin,C.P.
  TITLE     Identification and characterization of novel mammalian neuropeptide
            FF-like peptides that attenuate morphine-induced antinociception
  JOURNAL   J Biol Chem 276 (40), 36961-36969 (2001)
   PUBMED   11481330
REFERENCE   10 (bases 1 to 813)
  AUTHORS   Hinuma,S., Shintani,Y., Fukusumi,S., Iijima,N., Matsumoto,Y.,
            Hosoya,M., Fujii,R., Watanabe,T., Kikuchi,K., Terao,Y., Yano,T.,
            Yamamoto,T., Kawamata,Y., Habata,Y., Asada,M., Kitada,C.,
            Kurokawa,T., Onda,H., Nishimura,O., Tanaka,M., Ibata,Y. and
            Fujino,M.
  TITLE     New neuropeptides containing carboxy-terminal RFamide and their
            receptor in mammals
  JOURNAL   Nat Cell Biol 2 (10), 703-708 (2000)
   PUBMED   11025660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_023952.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB616539.1, AB040288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000004.1  81046869-81047045   c
            178-557             JAXUCZ010000004.1  81044879-81045258   c
            558-813             JAXUCZ010000004.1  81043128-81043383   c
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..813
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /note="neuropeptide VF precursor"
                     /db_xref="GeneID:60570"
                     /db_xref="RGD:61815"
     exon            1..177
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..651
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /note="FMRFamide-related peptides; RFamide-related
                     peptide; pro-FMRFamide-related neuropeptide VF"
                     /codon_start=1
                     /product="pro-FMRFamide-related neuropeptide VF precursor"
                     /protein_id="NP_076442.2"
                     /db_xref="GeneID:60570"
                     /db_xref="RGD:61815"
                     /translation="MEIISSKRFILLTLATSSFLTSNTLCSDELMMPHFHSKEGYGKY
                     YQLRGIPKGVKERSVTFQELKDWGAKKDIKMSPAPANKVPHSAANLPLRFGRNIEDRR
                     SPRARANMEAGTMSHFPSLPQRFGRTTARCITKTLAGLPQKSLHSLASSELLYAMTRQ
                     HQEIQSPGQEQPRKRVFTETDDAERKQEKIGNLQPVLQGAMKL"
     exon            178..557
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            558..813
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggctgaa tgtattaacc taatttacat ttagacaaaa tggaaattat ttcatcaaag
       61 cgattcattt tattgacttt agcaacttca agcttcttaa cttcaaacac cctttgttca
      121 gatgaattaa tgatgcccca ttttcacagc aaagaaggtt atggaaaata ttaccagctg
      181 agaggaatcc caaaaggggt aaaggaaaga agtgtcactt ttcaagaact caaagattgg
      241 ggggcaaaga aagatattaa gatgagtcca gcccctgcca acaaagtgcc ccactcagca
      301 gccaaccttc ccctgaggtt tgggaggaac atagaagaca gaagaagccc cagggcacgg
      361 gccaacatgg aggcagggac catgagccat tttcccagcc tgccccaaag gtttgggaga
      421 acaacagcca gatgcatcac caagacactg gctggtttgc cccagaaatc cctgcactcc
      481 ctggcctcca gtgaattgct ctatgccatg acccgccagc atcaagaaat tcagagtcct
      541 ggtcaagagc aacctaggaa acgggtgttc acggaaacag atgatgcaga aaggaaacaa
      601 gaaaaaatag gaaacctcca gccagtcctt caaggggcta tgaagctgtg acctgcggtc
      661 tgagcagctc tgtggtgttg gcaggaggag catcgaggag agccatcatt cctgtcagta
      721 taggtgatgt tgaaagttgt taaacgggat caaggatgct tgtaacgtaa atgtaaagta
      781 acctttgtca gaataaacag tattgtaaat aaa
//
