LOCUS       NM_030841               4870 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuronal pentraxin receptor (Nptxr), mRNA.
ACCESSION   NM_030841
VERSION     NM_030841.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4870)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
REFERENCE   2  (bases 1 to 4870)
  AUTHORS   Bilousova,T., Taylor,K., Emirzian,A., Gylys,R., Frautschy,S.A.,
            Cole,G.M. and Teng,E.
  TITLE     Parallel age-associated changes in brain and plasma neuronal
            pentraxin receptor levels in a transgenic APP/PS1 rat model of
            Alzheimer's disease
  JOURNAL   Neurobiol Dis 74, 32-40 (2015)
   PUBMED   25449907
  REMARK    GeneRIF: Results indicate that cerebral accumulation of NPR and
            Abeta occurs with similar temporal and regional patterns in the
            APP/PS1 model, and suggest that a 26 kDa plasma NPR fragment may
            represent a peripheral biomarker of this process
REFERENCE   3  (bases 1 to 4870)
  AUTHORS   Anantharam,V., Lehrmann,E., Kanthasamy,A., Yang,Y., Banerjee,P.,
            Becker,K.G., Freed,W.J. and Kanthasamy,A.G.
  TITLE     Microarray analysis of oxidative stress regulated genes in
            mesencephalic dopaminergic neuronal cells: relevance to oxidative
            damage in Parkinson's disease
  JOURNAL   Neurochem Int 50 (6), 834-847 (2007)
   PUBMED   17397968
REFERENCE   4  (bases 1 to 4870)
  AUTHORS   Andersson,K.B., Florholmen,G., Winer,L.H., Tonnessen,T. and
            Christensen,G.
  TITLE     Regulation of neuronal type genes in congestive heart failure rats
  JOURNAL   Acta Physiol (Oxf) 186 (1), 17-27 (2006)
   PUBMED   16497176
REFERENCE   5  (bases 1 to 4870)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     A novel substrate of receptor tyrosine phosphatase PTPRO is
            required for nerve growth factor-induced process outgrowth
  JOURNAL   J Neurosci 25 (4), 880-888 (2005)
   PUBMED   15673668
REFERENCE   6  (bases 1 to 4870)
  AUTHORS   Kim,Y.D., Sohn,N.W., Kang,C. and Soh,Y.
  TITLE     DNA array reveals altered gene expression in response to focal
            cerebral ischemia
  JOURNAL   Brain Res Bull 58 (5), 491-498 (2002)
   PUBMED   12242102
REFERENCE   7  (bases 1 to 4870)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   8  (bases 1 to 4870)
  AUTHORS   Dodds,D.C., Omeis,I.A., Cushman,S.J., Helms,J.A. and Perin,M.S.
  TITLE     Neuronal pentraxin receptor, a novel putative integral membrane
            pentraxin that interacts with neuronal pentraxin 1 and 2 and
            taipoxin-associated calcium-binding protein 49
  JOURNAL   J Biol Chem 272 (34), 21488-21494 (1997)
   PUBMED   9261167
  REMARK    GeneRIF: non-AUG translation initiation site. Comparison of rat
            determined N-terminal amino acid sequence with cDNA sequence
            indicates that a CUG codon is used as an initiator codon and codes
            for a methionine. The CTG is present in cDNAs of mouse, rat, and
            human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000007.1 and
            BG380575.1.
            
            On Nov 20, 2007 this sequence version replaced NM_030841.2.
            
            Summary: The protein encoded by this gene is an integral membrane
            protein, and functions as a neuronal receptor. It is thought to
            mediate neuronal uptake of the snake venom toxin, taipoxin, and its
            transport into the synapses. Studies in rat indicate that
            translation of this mRNA initiates at a non-AUG (CUG) codon. This
            site is also conserved in human and mouse. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript and
            the encoded protein are supported by transcript alignment and
            orthologous mouse data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.40939.1,
                                           SRR21887623.650003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 9261167
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               JAXUCZ010000007.1  113234400-113235122 c
            724-946             JAXUCZ010000007.1  113224971-113225193 c
            947-1194            JAXUCZ010000007.1  113223361-113223608 c
            1195-1374           JAXUCZ010000007.1  113221001-113221180 c
            1375-4583           JAXUCZ010000007.1  113217318-113220526 c
            4584-4870           BG380575.1         1-287               c
FEATURES             Location/Qualifiers
     source          1..4870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4870
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /note="neuronal pentraxin receptor"
                     /db_xref="GeneID:81005"
                     /db_xref="RGD:628898"
     exon            1..723
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1599
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="neuronal pentraxin receptor precursor"
                     /protein_id="NP_110468.2"
                     /db_xref="GeneID:81005"
                     /db_xref="RGD:628898"
                     /translation="MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGTDNAS
                     AASAAGAPGPQRSLSALQGAGGSAGPSVLPGEPAASVFPPPPGPLLSRFLCTPLAAAC
                     PSGAEQGDAAGERAELLLLQSTAEQLRQTALQQEARIRADRDTIRELTGKLGRCESGL
                     PRGLQDAGPRRDTMADGAWDSPALLVELENAVRALRDRIERIEQELPARGNLSSSAPA
                     PAVPTALHSKMDELEGQLLAKVLALEKERAALSHGSHQQRQEVEKELDALQGRVAELE
                     HGSSAYSPPDAFKVSIPIRNNYMYARVRKAVPELYAFTACMWLRSRSGGSGQGTPFSY
                     SVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICIAWTTRDGLWSAYQD
                     GELRGSGDNLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPA
                     QVLGIANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA"
     exon            724..946
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1194
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1374
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..4855
                     /gene="Nptxr"
                     /gene_synonym="Npr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctccgg ctcctgctcc ggctccggta ccggctcttg ctctcccggg ccctgcgccc
       61 cgaccccgcc gccgcgcctg ccgggggcct cgagcgcccc ctcctcgcct cacgctgaag
      121 ttcctggccg tgctgctggc cgcgggcatg ctggcgttcc tcggtgccgt catctgcatc
      181 atcgccagcg tgcccctggc ggccagcccc gcgcgcgcgc tgcccggcgg caccgacaac
      241 gcctcggccg cctcggccgc cggtgccccg ggtccgcagc gcagcctgag cgccctgcag
      301 ggcgcaggcg gctcggccgg gccctcggtg ttgcccgggg agccggcggc cagcgtcttc
      361 ccgccgccgc ccgggccgct gctcagtcgc ttcctctgca caccgctggc cgccgcttgc
      421 ccgtcggggg ctgagcaggg ggacgcggct ggcgagcgcg cggagctgtt gctgctgcag
      481 agcaccgcgg agcagctgcg ccagacggcg ctgcagcagg aggcgcgcat ccgcgccgac
      541 cgggacacca ttcgcgagct caccggcaag ctgggccgct gcgagagcgg cctgccgcgc
      601 ggcctccagg acgccgggcc ccgccgcgac actatggccg acggcgcctg ggactcaccc
      661 gcgctgctcg tggagctgga gaacgcggtg cgcgcgctgc gagaccgcat cgagcgcatc
      721 gagcaggagc tcccagcccg tgggaacctc tcctcctccg cgccagcccc tgctgtgccc
      781 accgccctgc attccaagat ggacgagcta gaaggccagc tgctggccaa ggtgctggca
      841 ctggagaagg aacgtgctgc cctcagtcat ggcagccacc agcaacgaca ggaagtggag
      901 aaggagctgg atgccctgca gggtcgcgtg gctgagctgg agcacgggtc ctcggcctac
      961 agtcccccag atgccttcaa ggtcagcatc cccatccgca acaactacat gtatgcccgt
     1021 gtgcgcaagg cagtgccaga actctacgcc ttcactgcct gcatgtggct gcgctccagg
     1081 tcgggtggct ctggccaggg cacccccttc tcctactcgg tgcccgggca ggccaatgag
     1141 atcgtgttgc tggaggccgg ccttgagcca atggaactgc tgatcaacga taaggtggcc
     1201 cagctgcctc tgagcctgaa agacagcaac tggcaccata tctgcatcgc ctggactaca
     1261 agggatgggc tgtggtctgc ataccaggac ggagaactgc ggggttctgg tgacaacctg
     1321 gcagcctggc accccatcaa accacatggc atccttatcc tgggccaaga acaggatacc
     1381 ttgggaggcc gatttgatgc cacgcaggcc ttcgtcggtg acattgcaca gttcaacctg
     1441 tgggaccacg ctctgacacc tgcccaggtg ctgggcattg ccaactgcac cgggccactc
     1501 atggggaatg tcctcccctg ggaagacaag ctggtagagg cctttggagg tgcgaagaag
     1561 gccgcctttg atgtgtgcaa gggaagggct aaggcatgag gggccacctc attcagggcc
     1621 cctcccttgc ctgtcagttt ggggacttag aaggggcact tccctcctca gcctgtccac
     1681 atgctggcct tccctcctac cccacccctg gccatacctc ccacttctcc tcacggcccc
     1741 ccacttccca gaatgccctg ccctggatgg atgtcccctc agccacctgg ataggggcta
     1801 gtatctcaca ccaattggtc caatgtaggg gttgaggcag tcctgcctcc tggcaacata
     1861 ttggcttggt ctctcccctc tcatacactg tcccgctgat cacataggat ctcactaatt
     1921 ccaaggacat cccctgaggg atcgtgggta gaagtggcct ttgaccctca catcccttgt
     1981 gcttcaggcc tacatcaggc tgtagaaagg atgccagaga tgtatgagac cagatgctct
     2041 tcctctgtct taatcagttg cccacagggg ctgcagggtc atctcgccaa ctgcccctgc
     2101 ctcctcctcc ctcctctcac agtttctctg tgtgttgtgg tttgaatgtt ggttggatgt
     2161 cagttcaagc cccacctcag ctcccttccc agcccctacc ctaacagcta gggaccaaga
     2221 ccccggaggc caaagggctg taatcaaccc ctgtacccac tggtaacttt gcccacagca
     2281 tggttgtcca tcccctccat gcctgacaca ggacctgctg ggtcactcta gcctatcctg
     2341 agagcatcca aaacagaagc acactatgac tgaggagaca cttccctggc agagcccagt
     2401 tgcttagcca ccatatcatc tctttctgcg tggccttggg aaggatggag gatgctggga
     2461 cggagaatag agcactgagt gagagagaga accacttggt tcctatgact tgctgtgtgg
     2521 ctttcggtaa aaacctaccc tctctgggcc tcactttctc ctagttccta ccaactttcc
     2581 taagagcaca gaagattgtt agagcagaga gaggccatcc attgtaagct cttgctggta
     2641 gaagatggga aagagcagag agagcgcaat taacttgacc aggatcaaaa agcacaacat
     2701 ggcaggcctt cggcctctga gtccctccaa agtgctcctc cctgtgaatc acactgcctg
     2761 tccttgaggg cctttgagcc cagctcaaac ctgtgcaggg aggcacttga gaggacacat
     2821 gcttttcaac agggcaccag aatctcttta agggacaacc caacacattg acagcctcag
     2881 gaggtgaggg aaagagccca gacaggcagc ggaggatgca gggccctgtt ggtcctctcc
     2941 caagtatagg agcagtagca ggtcagctga acagtgggta ctggtgcctc tgccccccac
     3001 ccctgacaca cttttgtcct tctctgtgct ctccatggcc actcggcccg agacatgacg
     3061 ctggagaggc tgccgcccat gcctgggaat cgtgtcaaag acttgcctct ggcctgtaga
     3121 tctgtgtttc cattttgaga gcaactacag ggctcggcac ctccatcccc atccctcgga
     3181 ggtagctgca gaggcttcac ccagacctgc tgagatcccg gttgcccagt aacaaccaat
     3241 gacatcagcc ccagtcttgg gtcaagtgtc tgtcggtgag gacaccgctt gttgctgagt
     3301 gacagctgga ttcagaactt agacctgggg gactctgagc ctcaccgggc tcttgctatt
     3361 gttctagaag aggcctttgc tatttattga tttagaggag gccttgggaa gacagagtct
     3421 taggaaggat gcagcagaaa ctgcctcgtc atttgagccc accagacaca ccatctctgt
     3481 ccttcctgct ttgtctcagt ggtgatgaga aaggacacct cagtcacatt cccatgccag
     3541 gtcatcctgg ttaaacttcc acctccccac ccccaccccc acccaggagg aaaaaaatgg
     3601 agacacggac tcatggctat gggtatggat gactggggaa ggggcggcct ctctatttcc
     3661 aaagtcccca cctgctgtca cctactgtgc tatggatttt gcctgagcac gtggagtgcc
     3721 actcagtctt ctgccgctcc tgagcacatc caacaagaca agccctgagc tgcccctggg
     3781 tctgacgaag atagaactag gccggctaga tagtcttaga cactgaaccc gcagagtgct
     3841 gtatccgcac catctgcgtt acctcacagc acagttacaa gacaagactg ttcttagccc
     3901 tgtgatgcag aagaatgaga ctcggggagg taaagtaact tgcctggtgt cagttggcca
     3961 gctggggaca gcacgatttc catttggagg cagattacat gcctaaagga cggagtcatc
     4021 tccttcagag ttcagaagga gcagaggtgg ggtgtggggc tcgaggctgg ggaaggggtc
     4081 tctcatctat gcccagcctc agcctcaggc tgagctgcag tcttcagggc aagagaggag
     4141 tatctccaga gtgaactcgg aaaggcaggg tgaaagtgat tcttcctcag cccctgttct
     4201 gggcaaggcc taggtcaggt tctctaagct gttttctgcc agattcccca cctgtgaggc
     4261 atggagtggc ctctcccatg tcccaaggga ttatcttaac agttacacat gaccggggac
     4321 cacagactaa ggtgtgagga tctgggaggt ggggttgggg gttggcaact caaccatcgg
     4381 cttgtagatg aggaagctga ggcctagctt ggcactcccc tgactgtcct cttctccagg
     4441 acccagaggc cactccccta cccccagact gggttttacc tactagtccc agcacctttg
     4501 acgtgagaaa actggagaag ggtctcctcc cagataaggg gctagtgtcc tcctcgcccc
     4561 caactccagc tgcctgccac cccagatccc acctcccacc caccctgttc cctgcccctg
     4621 ctgggggaag aacaggttcc ttcacaggct gagcagccag cagcgagtat ggttggacac
     4681 cgagatgagt accctccacc gcccccttcc ccacttcgct ctactttgta tataagtgac
     4741 atgagatgct ctgtgtgtgt gagcgcgtga gtgacctgtg ccatggcttt tgttaccatt
     4801 tcttgttttt tgtaaatttg aacgttcaaa ataaacatgt ggtttactcg gagaaaaaaa
     4861 aaaaaaaaaa
//
