LOCUS       NM_001034199            1906 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus neuronal pentraxin 2 (Nptx2), mRNA.
ACCESSION   NM_001034199 XM_221901
VERSION     NM_001034199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Lang,Y., Li,Y., Yu,H., Lin,L., Chen,X., Wang,S. and Zhang,H.
  TITLE     HOTAIR drives autophagy in midbrain dopaminergic neurons in the
            substantia nigra compacta in a mouse model of Parkinson's disease
            by elevating NPTX2 via miR-221-3p binding
  JOURNAL   Aging (Albany NY) 12 (9), 7660-7678 (2020)
   PUBMED   32396526
  REMARK    GeneRIF: HOTAIR drives autophagy in midbrain dopaminergic neurons
            in the substantia nigra compacta in a mouse model of Parkinson's
            disease by elevating NPTX2 via miR-221-3p binding.
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Blouin,A.M., Stern,A.L., Han,S., Theberge,F.R., Wang,C.,
            During,M.J., Baraban,J.M. and Reti,I.M.
  TITLE     Neuronal activity-regulated pentraxin expressed in medial
            prefrontal cortex neurons is not necessary for extinction of heroin
            self-administration
  JOURNAL   Behav Pharmacol 24 (4), 332-336 (2013)
   PUBMED   23751516
  REMARK    GeneRIF: This study suggested that mPFC Narp is necessary for
            extinction of opiate seeking in the Pavlovian-conditioned place
            preference paradigm but not in the operant paradigm of drug
            self-administration.
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Johnson,A.W., Crombag,H.S., Takamiya,K., Baraban,J.M.,
            Holland,P.C., Huganir,R.L. and Reti,I.M.
  TITLE     A selective role for neuronal activity regulated pentraxin in the
            processing of sensory-specific incentive value
  JOURNAL   J Neurosci 27 (49), 13430-13435 (2007)
   PUBMED   18057201
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Li,S.Y., Xu,D.S. and Jia,H.T.
  TITLE     AGS-induced expression of Narp is concomitant with expression of
            AMPA receptor subunits GluR1 and GluR2 in hippocampus but not
            inferior colliculus of P77PMC rats
  JOURNAL   Neurobiol Dis 14 (3), 328-335 (2003)
   PUBMED   14678750
  REMARK    GeneRIF: Downregulation of GluR2 subunit in the inferior colliculus
            may contribute to audiogenic seizure mediated epileptogenesis,
            while upregulation of Narp may also be involved.
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Reti,I.M., Minor,L.B. and Baraban,J.M.
  TITLE     Prominent expression of Narp in central vestibular pathways:
            selective effect of labyrinth ablation
  JOURNAL   Eur J Neurosci 16 (10), 1949-1958 (2002)
   PUBMED   12453059
  REMARK    GeneRIF: Narp expression is stimulated by naturally occurring
            vestibular input. Narp may mediate ongoing adjustments in synaptic
            strength or connectivity in several pathways linked to the
            vestibular system.
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Mi,R., Tang,X., Sutter,R., Xu,D., Worley,P. and O'Brien,R.J.
  TITLE     Differing mechanisms for glutamate receptor aggregation on
            dendritic spines and shafts in cultured hippocampal neurons
  JOURNAL   J Neurosci 22 (17), 7606-7616 (2002)
   PUBMED   12196584
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   O'Brien,R.J., Xu,D., Petralia,R.S., Steward,O., Huganir,R.L. and
            Worley,P.
  TITLE     Synaptic clustering of AMPA receptors by the extracellular
            immediate-early gene product Narp
  JOURNAL   Neuron 23 (2), 309-323 (1999)
   PUBMED   10399937
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Tsui,C.C., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Barnes,C. and
            Worley,P.F.
  TITLE     Narp, a novel member of the pentraxin family, promotes neurite
            outgrowth and is dynamically regulated by neuronal activity
  JOURNAL   J Neurosci 16 (8), 2463-2478 (1996)
   PUBMED   8786423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB578587.1, CO403402.1, CO395871.1 and CO388671.1.
            
            On Oct 17, 2005 this sequence version replaced XM_221901.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840111,
                              SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CB578587.1         6-43
            39-679              CO403402.1         1-641
            680-1317            CO395871.1         8-645
            1318-1906           CO388671.1         66-654
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1906
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /note="neuronal pentraxin 2"
                     /db_xref="GeneID:288475"
                     /db_xref="RGD:1309447"
     exon            1..622
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1492
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /note="neuronal activity-regulated pentraxin; Neuronal
                     activity regulated pentraxin; neuro activity regulated
                     petaxin; neuronal pentraxin II"
                     /codon_start=1
                     /product="neuronal pentraxin-2 precursor"
                     /protein_id="NP_001029371.1"
                     /db_xref="GeneID:288475"
                     /db_xref="RGD:1309447"
                     /translation="MLALLTAGVALAVAAGQAQDNPIPGSRFVCTALPPEAARAGCPL
                     PAMPMQGGALSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTSKLARCEGLAGGK
                     ARGTGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLHTNASNAGLPSDFR
                     EVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTENTLNALLQRVTELERGNS
                     AFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQ
                     ANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLG
                     TGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINI
                     ANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL"
     exon            623..839
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1084
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1264
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1906
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagaaccc cagccagaac gccgcgcaga gtggagagct gtattctgcg acggcaggca
       61 gcgctggtgc tggcgtttcc ctgcttgcac gcggttccct cgagcgccgc gctccgaccg
      121 acgtagccgg ccgcgaaggc gcccagacgg caagccagcg acccatgctg aagtgagcgc
      181 ccaggtcagc gagatgctgg cgctgctgac cgccggcgtg gcgctcgccg tggccgcggg
      241 acaagcccag gataacccga tacctggcag tcgcttcgtg tgcaccgcgc tgccccccga
      301 agcggcgcgc gccggctgcc cgctgcccgc gatgcccatg cagggaggcg cgctgagccc
      361 tgaggaggag ctgcgagccg ctgtgctgca gctgcgcgag accgtcgtgc agcagaagga
      421 gacgctgggc gctcagcgag aagccatccg agaactcacc agcaagctgg cccgctgtga
      481 gggactagcc ggcggtaagg cgcgcggcac gggggccacg ggcaaggaca ccatgggcga
      541 cctgccgcgg gacccgggcc acgtcgtgga gcagcttagc cgctcgctgc agaccctcaa
      601 ggaccgcttg gagagcctcg agctccaact ccacaccaac gcgtctaatg ccgggctgcc
      661 gagcgacttc cgagaggtgc tccagcggag gctgggggag ctggagaggc agttgctacg
      721 caaggtggcc gagctggaag acgagaagtc cctgctccac aatgagacct cggctcaccg
      781 gcagaagaca gagaacacac tgaatgcact gctgcagagg gtgactgagc tggagagagg
      841 caacagtgca ttcaagtcac cagatgcatt caaagtgtcc ctccctctcc gtacaaacta
      901 cctatacggc aagatcaaga agacgttgcc cgagctgtat gccttcacca tctgcctgtg
      961 gctgcggtcc agcgcctcgc caggcatcgg cacgccattc tcctacgctg tgcctgggca
     1021 agccaatgag attgtgctga tagagtgggg taacaatccc atagagctgc ttatcaacga
     1081 caaggtcgca cagctgcccc tgtttgtcag cgatggcaag tggcaccata tctgcatcac
     1141 ctggaccact cgagacggca tgtgggaagc attccaggac ggggagaagc tgggcaccgg
     1201 ggagaacctg gcaccctggc atcccatcaa gccagggggt gtgctcatcc tggggcagga
     1261 gcaggacact gtgggaggca gatttgatgc cacacaggcc ttcgttggag agcttagcca
     1321 gttcaacata tgggaccgtg tcctccgggc acaagagatc atcaacatcg ccaactgctc
     1381 cacgaacatg cctggaaaca tcatcccatg ggtggacaac aatgtcgatg tgtttggagg
     1441 ggcttccaag tggcctgtgg agacgtgcga agagcgtctc ctggacttgt agctaccttc
     1501 tccctgtccc agaggccaag agcgggctgt tctggggagt tcaaggcatc tattcccgag
     1561 ttcaactaaa atctctggcc tgagtaggaa agaaccagag cccctaaggc aggctgtgtg
     1621 gcctcctttg tcttaggctc ctatgttctt actgctttgt tctttggtgg gaagtgaccg
     1681 aagccctggg aagagtcctg agccacttcc tgctggggtt tctagtaaag tctgtgagcc
     1741 tctccacccc tcctgtaaat gctagtgcaa cccagccctg cctgtcattt tggatcctta
     1801 gtgtctcgtg tgtgcttccc gtctgtcccc tttgatggct gtgtggtcat cctaccgggg
     1861 tggcctgggt cccttgtgtg tgtagcacat ccctgctttt gactga
//
