LOCUS       NP_001029371             432 aa            linear   ROD 30-JUL-2024
DEFINITION  neuronal pentraxin-2 precursor [Rattus norvegicus].
ACCESSION   NP_001029371 XP_221901
VERSION     NP_001029371.1
DBSOURCE    REFSEQ: accession NM_001034199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 432)
  AUTHORS   Lang,Y., Li,Y., Yu,H., Lin,L., Chen,X., Wang,S. and Zhang,H.
  TITLE     HOTAIR drives autophagy in midbrain dopaminergic neurons in the
            substantia nigra compacta in a mouse model of Parkinson's disease
            by elevating NPTX2 via miR-221-3p binding
  JOURNAL   Aging (Albany NY) 12 (9), 7660-7678 (2020)
   PUBMED   32396526
  REMARK    GeneRIF: HOTAIR drives autophagy in midbrain dopaminergic neurons
            in the substantia nigra compacta in a mouse model of Parkinson's
            disease by elevating NPTX2 via miR-221-3p binding.
REFERENCE   2  (residues 1 to 432)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
REFERENCE   3  (residues 1 to 432)
  AUTHORS   Blouin,A.M., Stern,A.L., Han,S., Theberge,F.R., Wang,C.,
            During,M.J., Baraban,J.M. and Reti,I.M.
  TITLE     Neuronal activity-regulated pentraxin expressed in medial
            prefrontal cortex neurons is not necessary for extinction of heroin
            self-administration
  JOURNAL   Behav Pharmacol 24 (4), 332-336 (2013)
   PUBMED   23751516
  REMARK    GeneRIF: This study suggested that mPFC Narp is necessary for
            extinction of opiate seeking in the Pavlovian-conditioned place
            preference paradigm but not in the operant paradigm of drug
            self-administration.
REFERENCE   4  (residues 1 to 432)
  AUTHORS   Johnson,A.W., Crombag,H.S., Takamiya,K., Baraban,J.M.,
            Holland,P.C., Huganir,R.L. and Reti,I.M.
  TITLE     A selective role for neuronal activity regulated pentraxin in the
            processing of sensory-specific incentive value
  JOURNAL   J Neurosci 27 (49), 13430-13435 (2007)
   PUBMED   18057201
REFERENCE   5  (residues 1 to 432)
  AUTHORS   Li,S.Y., Xu,D.S. and Jia,H.T.
  TITLE     AGS-induced expression of Narp is concomitant with expression of
            AMPA receptor subunits GluR1 and GluR2 in hippocampus but not
            inferior colliculus of P77PMC rats
  JOURNAL   Neurobiol Dis 14 (3), 328-335 (2003)
   PUBMED   14678750
  REMARK    GeneRIF: Downregulation of GluR2 subunit in the inferior colliculus
            may contribute to audiogenic seizure mediated epileptogenesis,
            while upregulation of Narp may also be involved.
REFERENCE   6  (residues 1 to 432)
  AUTHORS   Reti,I.M., Minor,L.B. and Baraban,J.M.
  TITLE     Prominent expression of Narp in central vestibular pathways:
            selective effect of labyrinth ablation
  JOURNAL   Eur J Neurosci 16 (10), 1949-1958 (2002)
   PUBMED   12453059
  REMARK    GeneRIF: Narp expression is stimulated by naturally occurring
            vestibular input. Narp may mediate ongoing adjustments in synaptic
            strength or connectivity in several pathways linked to the
            vestibular system.
REFERENCE   7  (residues 1 to 432)
  AUTHORS   Mi,R., Tang,X., Sutter,R., Xu,D., Worley,P. and O'Brien,R.J.
  TITLE     Differing mechanisms for glutamate receptor aggregation on
            dendritic spines and shafts in cultured hippocampal neurons
  JOURNAL   J Neurosci 22 (17), 7606-7616 (2002)
   PUBMED   12196584
REFERENCE   8  (residues 1 to 432)
  AUTHORS   O'Brien,R.J., Xu,D., Petralia,R.S., Steward,O., Huganir,R.L. and
            Worley,P.
  TITLE     Synaptic clustering of AMPA receptors by the extracellular
            immediate-early gene product Narp
  JOURNAL   Neuron 23 (2), 309-323 (1999)
   PUBMED   10399937
REFERENCE   9  (residues 1 to 432)
  AUTHORS   Tsui,C.C., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Barnes,C. and
            Worley,P.F.
  TITLE     Narp, a novel member of the pentraxin family, promotes neurite
            outgrowth and is dynamically regulated by neuronal activity
  JOURNAL   J Neurosci 16 (8), 2463-2478 (1996)
   PUBMED   8786423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB578587.1, CO403402.1, CO395871.1 and CO388671.1.
            
            On Oct 17, 2005 this sequence version replaced XP_221901.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840111,
                              SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     Protein         1..432
                     /product="neuronal pentraxin-2 precursor"
                     /note="neuronal activity-regulated pentraxin; Neuronal
                     activity regulated pentraxin; neuro activity regulated
                     petaxin; neuronal pentraxin II"
                     /calculated_mol_wt=46052
     sig_peptide     1..14
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97738.1)"
                     /calculated_mol_wt=1314
     mat_peptide     15..432
                     /product="Neuronal pentraxin-2. /id=PRO_0000023553"
                     /note="propagated from UniProtKB/Swiss-Prot (P97738.1)"
                     /calculated_mol_wt=46052
     Region          <58..>215
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Site            149
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97738.1)"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97738.1)"
     Region          220..425
                     /region_name="PTX"
                     /note="Pentraxin / C-reactive protein / pentaxin family;
                     smart00159"
                     /db_xref="CDD:128463"
     Site            order(278,356,358,365,368)
                     /site_type="active"
                     /note="calcium mediated ligand binding site [active]"
                     /db_xref="CDD:238086"
     Site            order(318,335,373,420)
                     /site_type="active"
                     /note="intermolecular salt bridges [active]"
                     /db_xref="CDD:238086"
     Site            394
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97738.1)"
     CDS             1..432
                     /gene="Nptx2"
                     /gene_synonym="Narp; NP-II; NP2"
                     /coded_by="NM_001034199.1:194..1492"
                     /db_xref="GeneID:288475"
                     /db_xref="RGD:1309447"
ORIGIN      
        1 mlalltagva lavaagqaqd npipgsrfvc talppeaara gcplpampmq ggalspeeel
       61 raavlqlret vvqqketlga qreairelts klarceglag gkargtgatg kdtmgdlprd
      121 pghvveqlsr slqtlkdrle slelqlhtna snaglpsdfr evlqrrlgel erqllrkvae
      181 ledeksllhn etsahrqkte ntlnallqrv telergnsaf kspdafkvsl plrtnylygk
      241 ikktlpelya fticlwlrss aspgigtpfs yavpgqanei vliewgnnpi ellindkvaq
      301 lplfvsdgkw hhicitwttr dgmweafqdg eklgtgenla pwhpikpggv lilgqeqdtv
      361 ggrfdatqaf vgelsqfniw drvlraqeii niancstnmp gniipwvdnn vdvfggaskw
      421 pvetceerll dl
//
