LOCUS       NM_001413347            2390 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuroplastin (Nptn), transcript variant 1, mRNA.
ACCESSION   NM_001413347 XM_006243172
VERSION     NM_001413347.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2390)
  AUTHORS   Korthals,M., Langnaese,K., Smalla,K.H., Kahne,T.,
            Herrera-Molina,R., Handschuh,J., Lehmann,A.C., Mamula,D.,
            Naumann,M., Seidenbecher,C., Zuschratter,W., Tedford,K.,
            Gundelfinger,E.D., Montag,D., Fischer,K.D. and Thomas,U.
  TITLE     A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls
            T cell activation
  JOURNAL   Sci Rep 7 (1), 8358 (2017)
   PUBMED   28827723
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2390)
  AUTHORS   Herrera-Molina,R., Sarto-Jackson,I., Montenegro-Venegas,C.,
            Heine,M., Smalla,K.H., Seidenbecher,C.I., Beesley,P.W.,
            Gundelfinger,E.D. and Montag,D.
  TITLE     Structure of excitatory synapses and GABAA receptor localization at
            inhibitory synapses are regulated by neuroplastin-65
  JOURNAL   J Biol Chem 289 (13), 8973-8988 (2014)
   PUBMED   24554721
REFERENCE   3  (bases 1 to 2390)
  AUTHORS   Wilson,M.C., Kraus,M., Marzban,H., Sarna,J.R., Wang,Y., Hawkes,R.,
            Halestrap,A.P. and Beesley,P.W.
  TITLE     The neuroplastin adhesion molecules are accessory proteins that
            chaperone the monocarboxylate transporter MCT2 to the neuronal cell
            surface
  JOURNAL   PLoS One 8 (11), e78654 (2013)
   PUBMED   24260123
  REMARK    GeneRIF: neuroplastins act as key ancillary proteins for MCT2 cell
            surface localisation and activity in some neuronal populations,
            thus playing an important role in facilitating the uptake of
            lactate for use as a respiratory fuel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2390)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   5  (bases 1 to 2390)
  AUTHORS   Sarto-Jackson,I., Milenkovic,I., Smalla,K.H., Gundelfinger,E.D.,
            Kaehne,T., Herrera-Molina,R., Thomas,S., Kiebler,M.A. and
            Sieghart,W.
  TITLE     The cell adhesion molecule neuroplastin-65 is a novel interaction
            partner of gamma-aminobutyric acid type A receptors
  JOURNAL   J Biol Chem 287 (17), 14201-14214 (2012)
   PUBMED   22389504
  REMARK    GeneRIF: neuroplastin-65 can co-localize with a subset of GABA(A)
            receptor subtypes and might contribute to anchoring and/or
            confining GABA(A) receptors to particular synaptic or
            extra-synaptic sites, thus affecting receptor mobility and synaptic
            strength
REFERENCE   6  (bases 1 to 2390)
  AUTHORS   Kreutz,M.R., Langnaese,K., Dieterich,D.C., Seidenbecher,C.I.,
            Zuschratter,W., Beesley,P.W. and Gundelfinger,E.D.
  TITLE     Distribution of transcript and protein isoforms of the synaptic
            glycoprotein neuroplastin in rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 42 (8), 1907-1914 (2001)
   PUBMED   11431460
REFERENCE   7  (bases 1 to 2390)
  AUTHORS   Smalla,K.H., Matthies,H., Langnase,K., Shabir,S., Bockers,T.M.,
            Wyneken,U., Staak,S., Krug,M., Beesley,P.W. and Gundelfinger,E.D.
  TITLE     The synaptic glycoprotein neuroplastin is involved in long-term
            potentiation at hippocampal CA1 synapses
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4327-4332 (2000)
   PUBMED   10759566
REFERENCE   8  (bases 1 to 2390)
  AUTHORS   Langnaese,K., Beesley,P.W. and Gundelfinger,E.D.
  TITLE     Synaptic membrane glycoproteins gp65 and gp55 are new members of
            the immunoglobulin superfamily
  JOURNAL   J Biol Chem 272 (2), 821-827 (1997)
   PUBMED   8995369
REFERENCE   9  (bases 1 to 2390)
  AUTHORS   Willmott,T., Skitsa,I., Hill,I., Mummery,R. and Beesley,P.W.
  TITLE     Molecular characterisation and structural relationship of the
            synapse-enriched glycoproteins gp65 and gp55
  JOURNAL   J Neurochem 58 (6), 2037-2043 (1992)
   PUBMED   1573391
REFERENCE   10 (bases 1 to 2390)
  AUTHORS   Hill,I.E., Selkirk,C.P., Hawkes,R.B. and Beesley,P.W.
  TITLE     Characterization of novel glycoprotein components of synaptic
            membranes and postsynaptic densities, gp65 and gp55, with a
            monoclonal antibody
  JOURNAL   Brain Res 461 (1), 27-43 (1988)
   PUBMED   3224275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 31, 2022 this sequence version replaced XM_006243172.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.834287.1,
                                           SRR26360190.1270737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000008.1  67892710-67892968
            260-607             JAXUCZ010000008.1  67928049-67928396
            608-776             JAXUCZ010000008.1  67933077-67933245
            777-871             JAXUCZ010000008.1  67937375-67937469
            872-1005            JAXUCZ010000008.1  67946776-67946909
            1006-1279           JAXUCZ010000008.1  67949938-67950211
            1280-1301           JAXUCZ010000008.1  67956865-67956886
            1302-1376           JAXUCZ010000008.1  67957622-67957696
            1377-2390           JAXUCZ010000008.1  67958218-67959231
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2390
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /note="neuroplastin"
                     /db_xref="GeneID:56064"
                     /db_xref="RGD:620296"
     exon            1..259
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1362
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gp55/65; glycoprotein 55/65; stromal
                     cell-derived receptor 1; stromal cell derived factor
                     receptor 1; glycoprotein 65"
                     /codon_start=1
                     /product="neuroplastin isoform 1 precursor"
                     /protein_id="NP_001400276.1"
                     /db_xref="GeneID:56064"
                     /db_xref="RGD:620296"
                     /translation="MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLT
                     GDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLR
                     ITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRD
                     SLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCV
                     YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENG
                     VFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRS
                     HLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLR
                     QRNTN"
     exon            260..607
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..776
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..871
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1005
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1279
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1301
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1376
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2390
                     /gene="Nptn"
                     /gene_synonym="Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcttgga cgctgcggcg gtaggaggag gacggggaag gacggagctc ggccgctgct
       61 gcctccctcg ttcactccct cgcgctctcg cccgccccct ccctccctcc cctcccttcc
      121 ccggccccgg ccccggccca ttcgctgctc gctctccggc tagggaggat gtcgggctcg
      181 tcgctccccg gcgccctggc cctctcgctc ttgctggtct ctggctcgct cctcccaggg
      241 ccaggcgctg ctcagaacgc tgggtttgtc aagtcgccca tgtcagaaac taagctcaca
      301 ggggacgcct ttgagctgta ctgtgatgtg gtcgggagtc ccacgccaga gatccagtgg
      361 tggtacgcag aagtcaaccg ggcagagtct ttcagacagc tgtgggacgg tgctcggaag
      421 cgccgtgtca ccgtaaacac cgcctacggg tcaaacggcg tgagtgtgct gagaataacc
      481 cggctcacct tggaggactc tgggacttac gagtgcaggg caagcaacga ccccaaacgg
      541 aatgacttga ggcaaaaccc ttccataaca tggattcgag cccaggccac cataagcgtc
      601 cttcagaaac caagaattgt caccagcgaa gaggtcatta ttcgagacag cctccttcct
      661 gtcaccctgc agtgtaacct cacttccagc tctcacaccc ttatgtacag ctactggaca
      721 aagaatgggg tagaactcac tgccacccgt aagaatgcca gcaacatgga atacaggatc
      781 aataagccaa gagctgagga ttcaggcgaa taccactgtg tatatcattt tgtcagcgct
      841 cctaaagcaa atgccaccat tgaagtgaaa gctgctcctg acatcactgg ccataaacgc
      901 agtgaaaaca aaaatgaagg gcaggatgct atgatgtatt gcaagtctgt tggctacccc
      961 cacccggaat ggatgtggcg caagaaggag aatggtgtgt ttgaggagat ttccaatagc
     1021 tctggtcgct tcttcatcat caacaaggag aattacactg aattgaatat tgtgaatctc
     1081 caaatcacag aagatcctgg agagtatgaa tgtaatgcca ccaactccat tggctctgcc
     1141 tccgtttcca cagtcctcag ggtacggagc caccttgccc cactttggcc tttcttggga
     1201 attctggctg aaatcatcat ccttgtggtg atcattgttg tgtatgagaa gaggaagagg
     1261 ccagatgagg ttcctgatga tgatgaacca gccgggccaa tgaaaaccaa ctctaccaac
     1321 aatcacaaag ataaaaactt gcgccagaga aacacaaatt aagtactgct tttaatctct
     1381 ttaggttcct gaaaaatgat ggcaacatga cctgctaagt tttctgcttg gacctctttg
     1441 gtctctccct ttcaagtgag caacaccaca atgaccgtct aaagcatgcc ttatttagcc
     1501 tctcctataa gggtgaccta gccaggtaca ttttaaacaa tgcttcagtg tagaaggtgt
     1561 aaactatttt gggcttgatg tgctgtgaat gttgctttcc ctccctttgt taaaatattt
     1621 aaatagaagc gaaaggtcct ttgaggatca gatcatgcat gcgccatttt ttacttatac
     1681 agctgttaaa ttggcaaagc tctaaatgca ctgctgccat ctagtgatca ttttgtaaag
     1741 tacagcaaaa cctacagata tatacagtat ataaatatat atatatttat atttttgggg
     1801 gtgggagaaa tccaaaataa agtcaaagct tgtttcattt ttaagctgct gatactcatt
     1861 ccttattatt tgttgtcaga tgaggaagct gcagttctgg tacaaaaaga tgagagtata
     1921 aacttaagtc tgtcattcta agggcttact taccctataa ctttaagaac ctggaacagt
     1981 ccactgaacg gctagaatga attgcagtat atatgtatga ttgcttttta agtgactatt
     2041 tttccttttg tcaaatcatg taaattctga aatcttttgc actgatgtgt cgaaccttat
     2101 tcttgtatat tcaatcaagg caacttttat aatttcccat ttgttttcaa tgaccctgaa
     2161 atgttaatag catggtgata ttctatgcaa ctctagttat accttttggt ttgacactgt
     2221 attttcacat tgatttcatg actgatgata gattttataa cctgactggg ttctcatgcg
     2281 gtactaactg tagatgcatg tacttgtgtt ctgtgtaatt attgaagtgc aatggtgtac
     2341 aaaaaaagtg aattcacctg tttttaacaa taaaacattg ataaaaggtg
//
