LOCUS       NM_001106808            3668 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neuropeptide S receptor 1 (Npsr1), mRNA.
ACCESSION   NM_001106808 XM_001053598 XM_235968
VERSION     NM_001106808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3668)
  AUTHORS   Du,J., Fang,J., Xu,Z., Xiang,X., Wang,S., Sun,H., Shao,X.,
            Jiang,Y., Liu,B. and Fang,J.
  TITLE     Electroacupuncture suppresses the pain and pain-related anxiety of
            chronic inflammation in rats by increasing the expression of the
            NPS/NPSR system in the ACC
  JOURNAL   Brain Res 1733, 146719 (2020)
   PUBMED   32044336
  REMARK    GeneRIF: Electroacupuncture suppresses the pain and pain-related
            anxiety of chronic inflammation in rats by increasing the
            expression of the NPS/NPSR system in the ACC.
REFERENCE   2  (bases 1 to 3668)
  AUTHORS   Cohen,H., Vainer,E., Zeev,K., Zohar,J. and Mathe,A.A.
  TITLE     Neuropeptide S in the basolateral amygdala mediates an adaptive
            behavioral stress response in a rat model of posttraumatic stress
            disorder by increasing the expression of BDNF and the neuropeptide
            YY1 receptor
  JOURNAL   Eur Neuropsychopharmacol 28 (1), 159-170 (2018)
   PUBMED   29157796
  REMARK    GeneRIF: (1) NPS efficiently prevents development of and reverses
            the posttraumatic stress symptomatology caused by exposure to
            stress; (2) the mechanisms of action involve both the NPS receptor
            and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a
            possible cross talk between the NPYergic system and NPS. Treatment
            with NPS may be a novel approach for the treatment of the
            deleterious consequences of stress exposure.
REFERENCE   3  (bases 1 to 3668)
  AUTHORS   Palasz,A. and Rojczyk,E.
  TITLE     Neuroleptics Affect Neuropeptide S and NPSR mRNA Levels in the Rat
            Brain
  JOURNAL   J Mol Neurosci 57 (3), 352-357 (2015)
   PUBMED   26227793
  REMARK    GeneRIF: NPSR expression decreased after single-dose and chronic
            chlorpromazine administration in the hypothalamus, as well as after
            chronic olanzapine and chlorpromazine administration in the
            striatum and hippocampus.
REFERENCE   4  (bases 1 to 3668)
  AUTHORS   Parks,G.S., Wang,L., Wang,Z. and Civelli,O.
  TITLE     Identification of neuropeptide receptors expressed by
            melanin-concentrating hormone neurons
  JOURNAL   J Comp Neurol 522 (17), 3817-3833 (2014)
   PUBMED   24978951
  REMARK    GeneRIF: This study demonistrated that neuropeptide S receptor and
            Melanin-concentrating hormone colization in neuron in the lateral
            hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely
            expressed throughout the brain.
REFERENCE   5  (bases 1 to 3668)
  AUTHORS   Medina,G., Ji,G., Gregoire,S. and Neugebauer,V.
  TITLE     Nasal application of neuropeptide S inhibits arthritis pain-related
            behaviors through an action in the amygdala
  JOURNAL   Mol Pain 10, 32 (2014)
   PUBMED   24884567
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3668)
  AUTHORS   Lage,R., Gonzalez,C.R., Dieguez,C. and Lopez,M.
  TITLE     Nicotine treatment regulates neuropeptide S system expression in
            the rat brain
  JOURNAL   Neurotoxicology 28 (6), 1129-1135 (2007)
   PUBMED   17645946
  REMARK    GeneRIF: Nicotine treatment up-regulated neuropeptide s (NPS) and
            its receptor (NPS-R) in hypothalamus and brainstem.
REFERENCE   7  (bases 1 to 3668)
  AUTHORS   Bernier,V., Stocco,R., Bogusky,M.J., Joyce,J.G., Parachoniak,C.,
            Grenier,K., Arget,M., Mathieu,M.C., O'Neill,G.P., Slipetz,D.,
            Crackower,M.A., Tan,C.M. and Therien,A.G.
  TITLE     Structure-function relationships in the neuropeptide S receptor:
            molecular consequences of the asthma-associated mutation N107I
  JOURNAL   J Biol Chem 281 (34), 24704-24712 (2006)
   PUBMED   16790440
REFERENCE   8  (bases 1 to 3668)
  AUTHORS   Pulkkinen,V., Haataja,R., Hannelius,U., Helve,O., Pitkanen,O.M.,
            Karikoski,R., Rehn,M., Marttila,R., Lindgren,C.M., Hastbacka,J.,
            Andersson,S., Kere,J., Hallman,M. and Laitinen,T.
  TITLE     G protein-coupled receptor for asthma susceptibility associates
            with respiratory distress syndrome
  JOURNAL   Ann Med 38 (5), 357-366 (2006)
   PUBMED   16938805
REFERENCE   9  (bases 1 to 3668)
  AUTHORS   Vendelin,J., Pulkkinen,V., Rehn,M., Pirskanen,A.,
            Raisanen-Sokolowski,A., Laitinen,A., Laitinen,L.A., Kere,J. and
            Laitinen,T.
  TITLE     Characterization of GPRA, a novel G protein-coupled receptor
            related to asthma
  JOURNAL   Am J Respir Cell Mol Biol 33 (3), 262-270 (2005)
   PUBMED   15947423
REFERENCE   10 (bases 1 to 3668)
  AUTHORS   Laitinen,T., Polvi,A., Rydman,P., Vendelin,J., Pulkkinen,V.,
            Salmikangas,P., Makela,S., Rehn,M., Pirskanen,A., Rautanen,A.,
            Zucchelli,M., Gullsten,H., Leino,M., Alenius,H., Petays,T.,
            Haahtela,T., Laitinen,A., Laprise,C., Hudson,T.J., Laitinen,L.A.
            and Kere,J.
  TITLE     Characterization of a common susceptibility locus for
            asthma-related traits
  JOURNAL   Science 304 (5668), 300-304 (2004)
   PUBMED   15073379
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474007.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053598.1, XM_235968.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3668
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /note="neuropeptide S receptor 1"
                     /db_xref="GeneID:300458"
                     /db_xref="RGD:1564154"
     exon            1..44
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            45..232
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1201
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /note="G-protein coupled receptor 154"
                     /codon_start=1
                     /product="neuropeptide S receptor"
                     /protein_id="NP_001100278.1"
                     /db_xref="GeneID:300458"
                     /db_xref="RGD:1564154"
                     /translation="MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALEAEEWGSF
                     YSSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINI
                     LTDIIWRFTGDFMAPDLVCRIVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGE
                     KQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLV
                     YFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGELCCSYNRGLISKAKIKAIKYS
                     IVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPLIYCIFS
                     GSLCSPCKVQRSQDSRMTYRERSERHEMQILSKPEFI"
     exon            233..365
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            366..469
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            470..563
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            564..765
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            766..842
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            843..929
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1110
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..3668
                     /gene="Npsr1"
                     /gene_synonym="RGD1564154"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacgtgga tcttccttgt tgtcaggcag aactcttcaa tgaggctgca ggtgcagaga
       61 cataagactt gaccctgcct gagccatgcc ggccaacctc acagagggca gctttcatgc
      121 caaccagact gtgccgatgc tagattcttc ccctgtagct tgcactgaaa ttgtgacttt
      181 cactgaagcg ctggaggctg aggagtgggg ctccttctac tcgtccttta agacagagca
      241 gctgataacc ctgtgggtcc tgtttgtctt cactattgtg ggaaactcgg tcgtgctgtt
      301 ctccacatgg agaagaaaaa gaaagtccag aatgaccttc tttgtgactc aattggccat
      361 cacagactcc ttcacaggcc tgatcaacat cctgacagac attatttggc gattcacggg
      421 agacttcatg gcccctgacc tggtctgcag aatcgtccgc tacttacagg ttgtcctgct
      481 ttatgcctct acctatgtcc tggtgtccct cagcatagac agataccatg ccatcgttta
      541 ccccatgaaa ttccttcaag gagagaagca agccaaagtc ctcatcggaa tagcatggag
      601 cctctccttc ctgttctcca tccccacact gatcatattt gggaaaagga cactttccaa
      661 tggtgaggta cagtgctggg cactgtggcc agacgactcc tactggaccc catatatgac
      721 catcgttgcc tttctggtgt acttcatccc cttgacaatt atcagcgtca tctatggcct
      781 tgtgatccga actatttgga ttaaaagcaa agcccatgag acggtgattt ccaactgctc
      841 agatggagaa ctatgctgca gctacaaccg aggcctcatc tcaaaagcaa aaatcaaggc
      901 catcaagtac agcatcgtca taatccttgc tttcatctgc tgctggagtc catacttcct
      961 ctttgacatg ttagacaact tcaacctcct tccagacacc aaggagcgtt tctatgcctc
     1021 tgtgattatc cagaacctgc ctgccttgaa cagtgccatt aaccccctca tctactgcat
     1081 cttcagcggc tccctctgct ccccctgcaa ggtgcaaaga tcccaggatt ccagaatgac
     1141 gtaccgagag agaagcgaga ggcatgagat gcagattctc tccaagcctg aattcatcta
     1201 aaccccgagg caacagtgct aggctgagct cagtcccctc acccagacct tcaccatcag
     1261 ttagtgcatg aatcctgagc ctgttcctcc tcctgcatca tctaccagat acatgatgca
     1321 aactttctag tgagggcctg caatccatgc actagccaac atggtctcaa cacctctttg
     1381 tgtcagcttg gaaagatact tttctttcta atgtctccca gctctttgtc ccacagctca
     1441 gcatctgccc cagcatctgt gtccttgtgg actgatgaca caggcaagca gaaagatatt
     1501 ggagggctac ccttgagtca tctaattgca cttttgaaag taaataggag gacaacaaag
     1561 gttagacttc tttacaccag gtttatattg gaagtttagt gggtgtagat gagatgtttg
     1621 cccctgaaat gccaagaaag tcacgttcag accctgctac tgtatacatc tccatgtgga
     1681 ggagaagatg ttagcaggaa cgagctccca agcgctgtga tttgtgggaa aggacagtac
     1741 agtctcctgt aaaccaagga cactatgcag gcacattctc acctagcaga aaaatcacac
     1801 caaatagtga tagaccctgg ccataactcc agagagagag agagagagag agagagagag
     1861 agagagagct ggaaccgtga actcacagct ctttcagctg tgtaaaggag cttcccttcc
     1921 ctgtatcaac atttaagcca acctgtgctc attccacatg cctcagggac atttttagtc
     1981 ccactgttag tcccagaatc ctcttccgct ggggactcag cttcctggct tccccaacat
     2041 gatgttcgtg caagctcttt gctgtgtgct gtagcctttg cctacctggc acctctgcaa
     2101 ggaagtgctg gtcttatttt gacaggtctg caattcagta tttataagta taattcaaat
     2161 gaaatatggc taaatgtttt ctagccattt tttttcttca gattttgcca gaagtgaaaa
     2221 tggcatcatt tgactatgtg tacatctcca cccacagccc tatgacgcac gtgaacaccc
     2281 tatttttagc ttctcattca gtctttgaca ttgaaatctc cttggcaaaa tcctcccttc
     2341 cagagttgaa accttttctt gtccttttgg ctgacggctc gttcagtcgt taacatgttc
     2401 agtcaatttt aaaagcaccc cattcctcat tatcttatca gcccaaagac tgcctgctta
     2461 aggtcatggt ggcaattttt ccacaaattt ctttttcaat tccacccgac attagggaaa
     2521 gcatctcttt aggtagaaat taggcactga actaactgtc tctcagttat tattccctat
     2581 gtttgaggag acagaataat ccacctttct gttcacacaa cagttttgaa agccacttcc
     2641 ttctccatcc aatcagctaa acgtgagcaa gcagaagcat ggagtggctg agaaggactt
     2701 ctgaacattt ctctttaaat catggtgtgc cacagaagac tcacaggact ggtgctgaaa
     2761 tcgctgcctg cctaggagcc aattaaccag tagaatctgg cgggtgtcct agctagcaaa
     2821 acagaaggcc aaggcccttg atagatactt tcaatctctg tcaagttcgg gtctgcaaga
     2881 cctgtcacat gccgacacca tccccttatc gattcttaaa gagagagtgc cctgaaggtt
     2941 attttgccat ccacagtctg taaagggagc tgtcaggagc ctgtggctct catcctcata
     3001 ggagccagga gatcagtaag gtaatgggac agactgctgt aggaaggtgc catctatgta
     3061 aaactagctt tacattgaga tggagtctga aatcttcacc agccttgttt tcccaacttc
     3121 ggaaacagtt taagaatggc agtcattagt cctatgatgc tggatgaatc atgctgtgtc
     3181 tctgggcacc actaatctat ctctaacagg gaggcaaaat agcagtgtag cagaggatgt
     3241 tgaagtttag aggctgtaat ggattaaatt agacttacac agagtgctgc ttgaattctc
     3301 ccctttgaag actaacactt cagtgagtca aggttgagtc atgcctcttg gaggtataaa
     3361 ttttctctgt accatatgaa ctcagaaact catgtgcatc ccaaccagga aagagaatga
     3421 tggaaaatta taatgtaaac tacagttgct atttgtagcc cttgatgctt ccatgggacc
     3481 agaaatggca gcaaggtggt gtgtaaaata aaggtgccca ccttccacac caagatgtaa
     3541 aatgtgtgat gttatttcac tgcttcaagg acaggtaaaa gttaggctaa cagggcaaat
     3601 gtgtttaata tattcagtca cactgcagaa aatatctctg ctttattgaa ctaaattcaa
     3661 tgtgaatg
//
