LOCUS       NM_001271113             270 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus neuropeptide S (Nps), mRNA.
ACCESSION   NM_001271113 XM_002725724 XM_002728814
VERSION     NM_001271113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 270)
  AUTHORS   Akcali,I., Akkan,S.S. and Bulbul,M.
  TITLE     The regulatory role of central neuropeptide-S in locomotion
  JOURNAL   Peptides 170, 171110 (2023)
   PUBMED   37832875
  REMARK    GeneRIF: The regulatory role of central neuropeptide-S in
            locomotion.
REFERENCE   2  (bases 1 to 270)
  AUTHORS   Kawade,H.M., Awathale,S.N., Subhedar,N.K. and Kokare,D.M.
  TITLE     Neuropeptide S facilitates extinction of fear via modulation of
            mesolimbic dopaminergic circuitry
  JOURNAL   Neuropharmacology 221, 109274 (2022)
   PUBMED   36195130
  REMARK    GeneRIF: Neuropeptide S facilitates extinction of fear via
            modulation of mesolimbic dopaminergic circuitry.
REFERENCE   3  (bases 1 to 270)
  AUTHORS   Sinen,O., Bulbul,M., Derin,N., Ozkan,A., Akcay,G., Aslan,M.A. and
            Agar,A.
  TITLE     The effect of chronic neuropeptide-S treatment on non-motor
            parameters in experimental model of Parkinson's disease
  JOURNAL   Int J Neurosci 131 (8), 765-774 (2021)
   PUBMED   32441169
  REMARK    GeneRIF: The effect of chronic neuropeptide-S treatment on
            non-motor parameters in experimental model of Parkinson's disease.
REFERENCE   4  (bases 1 to 270)
  AUTHORS   Du,J., Fang,J., Xu,Z., Xiang,X., Wang,S., Sun,H., Shao,X.,
            Jiang,Y., Liu,B. and Fang,J.
  TITLE     Electroacupuncture suppresses the pain and pain-related anxiety of
            chronic inflammation in rats by increasing the expression of the
            NPS/NPSR system in the ACC
  JOURNAL   Brain Res 1733, 146719 (2020)
   PUBMED   32044336
  REMARK    GeneRIF: Electroacupuncture suppresses the pain and pain-related
            anxiety of chronic inflammation in rats by increasing the
            expression of the NPS/NPSR system in the ACC.
REFERENCE   5  (bases 1 to 270)
  AUTHORS   Cohen,H., Vainer,E., Zeev,K., Zohar,J. and Mathe,A.A.
  TITLE     Neuropeptide S in the basolateral amygdala mediates an adaptive
            behavioral stress response in a rat model of posttraumatic stress
            disorder by increasing the expression of BDNF and the neuropeptide
            YY1 receptor
  JOURNAL   Eur Neuropsychopharmacol 28 (1), 159-170 (2018)
   PUBMED   29157796
  REMARK    GeneRIF: (1) NPS efficiently prevents development of and reverses
            the posttraumatic stress symptomatology caused by exposure to
            stress; (2) the mechanisms of action involve both the NPS receptor
            and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a
            possible cross talk between the NPYergic system and NPS. Treatment
            with NPS may be a novel approach for the treatment of the
            deleterious consequences of stress exposure.
REFERENCE   6  (bases 1 to 270)
  AUTHORS   Han,R.W., Yin,X.Q., Chang,M., Peng,Y.L., Li,W. and Wang,R.
  TITLE     Neuropeptide S facilitates spatial memory and mitigates spatial
            memory impairment induced by N-methyl-D-aspartate receptor
            antagonist in mice
  JOURNAL   Neurosci Lett 455 (1), 74-77 (2009)
   PUBMED   19429110
REFERENCE   7  (bases 1 to 270)
  AUTHORS   Badia-Elder,N.E., Henderson,A.N., Bertholomey,M.L., Dodge,N.C. and
            Stewart,R.B.
  TITLE     The effects of neuropeptide S on ethanol drinking and other related
            behaviors in alcohol-preferring and -nonpreferring rats
  JOURNAL   Alcohol Clin Exp Res 32 (8), 1380-1387 (2008)
   PUBMED   18564106
  REMARK    GeneRIF: data suggest a role for neuropeptide S in the modulation
            of ethanol drinking and possibly anxiety-like behavior in rats
            selectively bred for high alcohol drinking.
REFERENCE   8  (bases 1 to 270)
  AUTHORS   Lage,R., Gonzalez,C.R., Dieguez,C. and Lopez,M.
  TITLE     Nicotine treatment regulates neuropeptide S system expression in
            the rat brain
  JOURNAL   Neurotoxicology 28 (6), 1129-1135 (2007)
   PUBMED   17645946
  REMARK    GeneRIF: Nicotine treatment up-regulated neuropeptide s (NPS) and
            its receptor (NPS-R) in hypothalamus and brainstem.
REFERENCE   9  (bases 1 to 270)
  AUTHORS   Beck,B., Fernette,B. and Stricker-Krongrad,A.
  TITLE     Peptide S is a novel potent inhibitor of voluntary and fast-induced
            food intake in rats
  JOURNAL   Biochem Biophys Res Commun 332 (3), 859-865 (2005)
   PUBMED   15919054
REFERENCE   10 (bases 1 to 270)
  AUTHORS   Xu,Y.L., Reinscheid,R.K., Huitron-Resendiz,S., Clark,S.D., Wang,Z.,
            Lin,S.H., Brucher,F.A., Zeng,J., Ly,N.K., Henriksen,S.J., de
            Lecea,L. and Civelli,O.
  TITLE     Neuropeptide S: a neuropeptide promoting arousal and
            anxiolytic-like effects
  JOURNAL   Neuron 43 (4), 487-497 (2004)
   PUBMED   15312648
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 2, 2012 this sequence version replaced
            XM_002725724.1, XM_002728814.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000001.1  199506899-199506906
            9-90                JAXUCZ010000001.1  199507021-199507102
            91-270              JAXUCZ010000001.1  199510501-199510680
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..270
                     /gene="Nps"
                     /note="neuropeptide S"
                     /db_xref="GeneID:100360071"
                     /db_xref="RGD:2324597"
     CDS             1..270
                     /gene="Nps"
                     /codon_start=1
                     /product="neuropeptide S precursor"
                     /protein_id="NP_001258042.1"
                     /db_xref="GeneID:100360071"
                     /db_xref="RGD:2324597"
                     /translation="MIGSLKLNLILALSLSVVHVIWSYPVLSSKVPGKPDYFLILLST
                     CPARLEGSDGLAFLKPILEKTSMKRSFRNGVGSGVKKTSFRRAKQ"
     exon            1..8
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
     exon            9..90
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
     exon            91..270
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgattggct cattaaaact caacctcatc ttagctctgt cgctgtccgt ggtacacgtg
       61 atttggagtt atccggtcct ctcttccaag gtgcctggga agcctgatta ctttctcatt
      121 ttgctgagta cctgcccagc caggctggag gggagcgacg ggctagcttt tctaaagcca
      181 attttggaga agacgtcgat gaaaaggtcc tttcgcaacg gagtcggctc aggggtgaaa
      241 aaaacttcat ttcgaagagc aaagcaatga
//
