LOCUS       NM_012868               1720 bp    mRNA    linear   ROD 17-MAR-2024
DEFINITION  Rattus norvegicus natriuretic peptide receptor 3 (Npr3), mRNA.
ACCESSION   NM_012868
VERSION     NM_012868.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Dou,Q., Ba,F., Hu,S., Xu,G.Y., Wei,J. and Jiang,G.Q.
  TITLE     LncRNA NONRATT014888.2 contributes to cancer-induced bone pain
            through downregulation of natriuretic peptide receptor 3 in rats
  JOURNAL   Biochem Biophys Res Commun 683, 149114 (2023)
   PUBMED   37857164
  REMARK    GeneRIF: LncRNA NONRATT014888.2 contributes to cancer-induced bone
            pain through downregulation of natriuretic peptide receptor 3 in
            rats.
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Li,Y. and Anand-Srivastava,M.B.
  TITLE     Downregulation of natriuretic peptide receptor-C in vascular smooth
            muscle cells from spontaneously hypertensive rats contributes to
            vascular remodeling
  JOURNAL   Peptides 158, 170894 (2022)
   PUBMED   36243172
  REMARK    GeneRIF: Downregulation of natriuretic peptide receptor-C in
            vascular smooth muscle cells from spontaneously hypertensive rats
            contributes to vascular remodeling.
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Wang,B., Huang,Q., Li,S., Wu,J., Yuan,X., Sun,H. and Tang,L.
  TITLE     [Changes of guanylate cyclase C in colon tissues of rats with
            intestinal injury associated with severe acute pancreatitis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (3), 376-383 (2021)
   PUBMED   33849828
  REMARK    GeneRIF: [Changes of guanylate cyclase C in colon tissues of rats
            with intestinal injury associated with severe acute pancreatitis].
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Madiraju,P., Hossain,E. and Anand-Srivastava,M.B.
  TITLE     Natriuretic peptide receptor-C activation attenuates angiotensin
            II-induced enhanced oxidative stress and hyperproliferation of
            aortic vascular smooth muscle cells
  JOURNAL   Mol Cell Biochem 448 (1-2), 77-89 (2018)
   PUBMED   29417337
  REMARK    GeneRIF: These results indicate that C-ANP4-23, via the activation
            of NPR-C, attenuates Ang II-induced enhanced nitroxidative stress,
            overexpression of Gialpha proteins, increased activation of the
            p38/JNK/ERK 1,2 signaling pathways.
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Lin,D., Chai,Y., Izadpanah,R., Braun,S.E. and Alt,E.
  TITLE     NPR3 protects cardiomyocytes from apoptosis through inhibition of
            cytosolic BRCA1 and TNF-alpha
  JOURNAL   Cell Cycle 15 (18), 2414-2419 (2016)
   PUBMED   27494651
  REMARK    GeneRIF: NPR3 protects cardiomyocytes from apoptosis through
            inhibition of cytosolic BRCA1 and TNF-alpha, which are regulators
            of apoptosis.
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Oliver,P.M., Fox,J.E., Kim,R., Rockman,H.A., Kim,H.S.,
            Reddick,R.L., Pandey,K.N., Milgram,S.L., Smithies,O. and Maeda,N.
  TITLE     Hypertension, cardiac hypertrophy, and sudden death in mice lacking
            natriuretic peptide receptor A
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14730-14735 (1997)
   PUBMED   9405681
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Anand-Srivastava,M.B., Sehl,P.D. and Lowe,D.G.
  TITLE     Cytoplasmic domain of natriuretic peptide receptor-C inhibits
            adenylyl cyclase. Involvement of a pertussis toxin-sensitive G
            protein
  JOURNAL   J Biol Chem 271 (32), 19324-19329 (1996)
   PUBMED   8702617
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Lin,X., Hanze,J., Heese,F., Sodmann,R. and Lang,R.E.
  TITLE     Gene expression of natriuretic peptide receptors in myocardial
            cells
  JOURNAL   Circ Res 77 (4), 750-758 (1995)
   PUBMED   7554122
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Engel,A.M., Schoenfeld,J.R. and Lowe,D.G.
  TITLE     A single residue determines the distinct pharmacology of rat and
            human natriuretic peptide receptor-C
  JOURNAL   J Biol Chem 269 (25), 17005-17008 (1994)
   PUBMED   7911802
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L27339.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27339.1, X75605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1720
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /note="natriuretic peptide receptor 3"
                     /db_xref="GeneID:25339"
                     /db_xref="RGD:3196"
     exon            1..770
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1624
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /note="atrial natriuretic peptide clearance receptor;
                     atrial natriuretic peptide receptor 3; ANP-C; ANPRC;
                     NPR-C; atrial natriuretic peptide C-type receptor; ANPR-C;
                     atrial natriuretic peptide receptor type C; Atrial
                     natriuretic peptide clearence receptor 3; natriuretic
                     peptide receptor C/guanylate cyclase C (atrionatriuretic
                     peptide receptor C)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 3 precursor"
                     /protein_id="NP_037000.1"
                     /db_xref="GeneID:25339"
                     /db_xref="RGD:3196"
                     /translation="MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALA
                     AQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSD
                     CGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQ
                     HKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEV
                     FQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTS
                     GDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEV
                     KSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTF
                     EGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSL
                     KLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIER
                     RNHQEESNIGKHRELREDSIRSHFSVA"
     exon            771..893
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1060
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1196
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1291
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1427
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1512
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1720
                     /gene="Npr3"
                     /gene_synonym="ANP-CR; NPRC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgctggc aacaggatgc ggtccctgct gctgttcact ttctcggcgt gcgtgctgct
       61 ggcccgggcg ctgctggctg gcggtgcgag tagtggcggt ggggacaccg ggccaggcaa
      121 caggcgccgg gagagagagg cgctggcggc tcaaaagatc gaggtgcttg tgctattgcc
      181 ccgggacgat tcgtacttgt tctcgctggc ccgggtgagg ccggccatcg agtacgcgct
      241 gcgtagcgtg gagggcaatg gcaccggcag gaagctgctg ccgcccggca ctcgcttcca
      301 ggtggcctat gaagactctg actgtggcaa ccgtgcgctc ttcagtttgg tggaccgcgt
      361 ggcggcggcg cgcggcgcca agccggacct catcctgggt ccggtgtgcg agtacgctgc
      421 ggcgccggtg gcccggctgg cgtctcactg ggacctgccg atgctgtccg caggagcgct
      481 ggccgcgggt ttccagcaca aggacacgga gtactcgcac ctcacgcgcg tggcgcctgc
      541 ctacgccaag atgggagaga tgatgctcgc tctgttccgc caccaccact ggagccgcgc
      601 tgccctgctc tacagcgacg acaaactcga gagaaactgc tacttcactc tcgagggggt
      661 ccacgaggtt ttccaggagg agggcttgca cacgtctgcc tacaatttcg acgagaccaa
      721 agacttggac ctggacgaca tagtgcgcta catccagggc agtgagcgag tggtgatcat
      781 gtgtgccagt ggtgacacca ttcggagaat catgttggcg gtgcacagac acggcatgac
      841 cagtggagac tatgctttct tcaacattga actcttcaac agttcttctt acggagatgg
      901 ctcgtggaag agaggggaca aacacgactt tgaagctaag caagcttact catccctcca
      961 aacagtcacc ctgctgagga ccgcgaagcc tgagtttgag aagttttcca tggaggtgaa
     1021 aagttctgtt gagaaacaag ggctcaatga ggaggattac gtgaacatgt tcgttgaagg
     1081 cttccatgat gccatcctcc tctacgttct ggctttgcat gaagtgctca gagctggcta
     1141 cagcaagaag gatgggggga aaatcatcca gcagacttgg aacaggacat ttgaaggtat
     1201 cgccgggcag gtgtccatag atgctaatgg ggatcggtat ggagacttct ctgtggttgc
     1261 catgactgat acagaagcag gtacccagga ggtcattggt gattactttg gaaaagaagg
     1321 ccggttcaaa atgcgatcca atgtcaaata tccttggggc tctttgaaat tgagaataga
     1381 tgaaaccaga attgtggagc acaccaacag ctctccttgc aaatcatgtg gcctagaaga
     1441 atcagcagtg acaggaattg ttgtgggggc cctactaggt gctggtttgc taatggcctt
     1501 ctactttttc aggaagaaat acagaataac cattgagagg cgaaatcacc aagaagaaag
     1561 caacattggg aaacatcgag agctgcggga agattccatc agatcacatt tttcggtggc
     1621 ttaaaagaaa tgcccccctt gctttgtctg cttgagattc cttaaagaga tagttgaagg
     1681 acagacatca atggaacaga aagggtgttc ttggagaatt
//
