LOCUS       NM_053838               3469 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus natriuretic peptide receptor 2 (Npr2), mRNA.
ACCESSION   NM_053838
VERSION     NM_053838.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3469)
  AUTHORS   Egbert,J.R., Silbern,I., Uliasz,T.F., Lowther,K.M., Yee,S.P.,
            Urlaub,H. and Jaffe,L.A.
  TITLE     Phosphatases modified by LH signaling in ovarian follicles: testing
            their role in regulating the NPR2 guanylyl cyclasedagger
  JOURNAL   Biol Reprod 110 (1), 102-115 (2024)
   PUBMED   37774352
  REMARK    GeneRIF: Phosphatases modified by LH signaling in ovarian
            follicles: testing their role in regulating the NPR2 guanylyl
            cyclasedagger.
REFERENCE   2  (bases 1 to 3469)
  AUTHORS   Robinson,J.W., Egbert,J.R., Davydova,J., Schmidt,H., Jaffe,L.A. and
            Potter,L.R.
  TITLE     Dephosphorylation is the mechanism of fibroblast growth factor
            inhibition of guanylyl cyclase-B
  JOURNAL   Cell Signal 40, 222-229 (2017)
   PUBMED   28964968
  REMARK    GeneRIF: We conclude that FGF rapidly inactivates GC-B by a
            reversible dephosphorylation mechanism, which may contribute to the
            signaling network by which activated FGFR3 causes dwarfism.
REFERENCE   3  (bases 1 to 3469)
  AUTHORS   Manivasagam,S. and Vellaichamy,E.
  TITLE     Suppression of Npr1, not Npr2 gene function induces hypertrophic
            growth in H9c2 cells in vitro
  JOURNAL   Biochem Biophys Res Commun 491 (2), 250-256 (2017)
   PUBMED   28743500
  REMARK    GeneRIF: Suppression of Npr1, not Npr2 gene function induces
            hypertrophic growth in cardiomyocytes in vitro.
REFERENCE   4  (bases 1 to 3469)
  AUTHORS   Lu,J. and Pan,S.S.
  TITLE     Elevated C-type natriuretic peptide elicits exercise
            preconditioning-induced cardioprotection against myocardial injury
            probably via the up-regulation of NPR-B
  JOURNAL   J Physiol Sci 67 (4), 475-487 (2017)
   PUBMED   27557795
  REMARK    GeneRIF: Cardiac CNP and NPR-B play an important role in exercise
            preconditioning-mediated cardioprotection against high-intensity
            exercise-induced myocardial injury in rats.
REFERENCE   5  (bases 1 to 3469)
  AUTHORS   Buttgereit,J., Shanks,J., Li,D., Hao,G., Athwal,A.,
            Langenickel,T.H., Wright,H., da Costa Goncalves,A.C., Monti,J.,
            Plehm,R., Popova,E., Qadri,F., Lapidus,I., Ryan,B., Ozcelik,C.,
            Paterson,D.J., Bader,M. and Herring,N.
  TITLE     C-type natriuretic peptide and natriuretic peptide receptor B
            signalling inhibits cardiac sympathetic neurotransmission and
            autonomic function
  JOURNAL   Cardiovasc Res 112 (3), 637-644 (2016)
   PUBMED   27496871
  REMARK    GeneRIF: C-type natriuretic peptide reduces cardiac sympathetic
            neurotransmission via a reduction in neuronal calcium signalling
            and NE release through the NPR-B receptor. Situations impairing
            CNP-NPR-B signalling lead to hypertension, tachycardia, and
            impaired left ventricular systolic function secondary to
            sympatho-excitation.
REFERENCE   6  (bases 1 to 3469)
  AUTHORS   Sorci,G., Spreca,A., Donato,R. and Rambotti,M.G.
  TITLE     Detection of membrane-bound guanylate cyclase activity in rat C6
            glioma cells at different growth states following activation by
            natriuretic peptides
  JOURNAL   Brain Res 683 (1), 51-58 (1995)
   PUBMED   7552344
REFERENCE   7  (bases 1 to 3469)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 3469)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   9  (bases 1 to 3469)
  AUTHORS   Schulz,S., Singh,S., Bellet,R.A., Singh,G., Tubb,D.J., Chin,H. and
            Garbers,D.L.
  TITLE     The primary structure of a plasma membrane guanylate cyclase
            demonstrates diversity within this new receptor family
  JOURNAL   Cell 58 (6), 1155-1162 (1989)
   PUBMED   2570641
REFERENCE   10 (bases 1 to 3469)
  AUTHORS   Johnson,D.R.
  TITLE     The growth of femur and tibia in three genetically distinct
            chondrodystrophic mutants of the house mouse
  JOURNAL   J Anat 125 (Pt 2), 267-275 (1978)
   PUBMED   624676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M26896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3469
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3469
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /note="natriuretic peptide receptor 2"
                     /db_xref="GeneID:116564"
                     /db_xref="RGD:620851"
     exon            1..739
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..3216
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /EC_number="4.6.1.2"
                     /note="natriuretic peptide receptor-B; atrial natriuretic
                     peptide receptor B; atrial natriuretic peptide receptor 2;
                     ANP-B; ANPRB; guanylate cyclase B; atrial natriuretic
                     peptide B-type receptor; ANPR-B; atrial natriuretic
                     peptide receptor type B; natriuretic peptide receptor
                     B/guanylate cyclase B (atrionatriuretic peptide receptor
                     B)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 2 precursor"
                     /protein_id="NP_446290.1"
                     /db_xref="GeneID:116564"
                     /db_xref="RGD:620851"
                     /translation="MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPR
                     VGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCV
                     YPAASVARFASHWHLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHF
                     NWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQATHFIR
                     ANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD
                     NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIA
                     GCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDF
                     VLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDK
                     TPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYH
                     KGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLF
                     ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI
                     NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA
                     KKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKV
                     RNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSIL
                     DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEA
                     FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV
                     VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL
                     KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGK
                     MRTYWLLGERKGPPGLL"
     exon            740..945
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1059
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1195
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1290
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1423
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1508
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1629
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1704
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1782
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1887
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1959
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2119
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2275
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2444
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2591
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2715
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2784
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2959
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3058
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3150
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3469
                     /gene="Npr2"
                     /gene_synonym="GC-B; NPR-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcttgtg cctgcccagt aggccagagc agcccctggt tcgggggacc gtgggtcagc
       61 tgctctatcc ccatggcact gccatccctg ctactggtgg tggcagccct ggcaggtggg
      121 gtgcgtcctc cgggggcacg gaacctgacg ctggcggtgg tgctgccaga acacaacctg
      181 agctatgcct gggcctggcc acgggtgggt cctgctgtgg cactggctgt ggaggcgctg
      241 ggccgggcac tgcccgtgga cctgcggttt gtcagctccg aactagacgg cgcctgctct
      301 gagtacctgg caccactgcg cgctgtggat ctcaagctgt accatgaccc cgaccttctg
      361 ttgggccctg gttgtgtgta ccctgctgcc tctgtggctc gctttgcctc gcactggcac
      421 cttcccctcc tgactgcggg tgcagtggcc tctggctttg cagctaagaa tgagcattat
      481 cgtaccctgg ttcgcactgg cccctctgcg cccaagctgg gtgagttcgt agtgacatta
      541 cacgggcact tcaattggac tgctcgggct gctttgctgt atctggatgc tcgcacagat
      601 gaccggcccc actacttcac catcgagggg gtgtttgagg ccctgcaggg cagcaacctc
      661 agtgtgcaac accaggtgta tacccgagag ccaggtggcc ctgagcaagc cacccacttc
      721 atcagagcca acgggcgcat tgtgtatatc tgcggcccgc tggagatgct tcatgagatc
      781 ctgcttcagg cccagaggga gaacctgacc aatggggact atgtcttctt ttaccttgat
      841 gtctttgggg agagtctacg agcaggcccc acacgtgcga caggccggcc atggcaggac
      901 aatcgaaccc aggaacaagc tcaggccctc agagaggcct ttcagactgt cctggtgatc
      961 acgtaccgag agcccccgaa tcccgagtat caggagttcc agaaccgcct gctgatcaga
     1021 gcccgggaag acttcggcgt ggagctggcc ccatccctga tgaacctcat tgcgggctgc
     1081 ttctatgatg gaatcctgct ctatgcccaa gtcctgaatg agacaataca ggaagggggc
     1141 acccgggaag atggacttcg aattgtggag aagatgcagg gacgaagata ccatggtgta
     1201 actggactgg ttgttatgga caagaacaat gacagagaga ctgatttcgt cctgtgggcc
     1261 atgggagact tggagtctgg cgactttcag cctgcagccc attactcagg agctgagaag
     1321 cagatttggt ggacaggccg gccaattccc tgggtgaagg gggccccacc tttggacaac
     1381 cccccctgtg cctttgactt ggacgaccca tcctgtgata aaactccact ttccactctg
     1441 gcaattgtgg ccctgggcac gggaatcact ttcatcatgt ttggtgtttc cagcttccta
     1501 attttccgaa aactgatgct ggagaaggag ctggctagca tgctgtggcg cattcgctgg
     1561 gaagaactgc agttcggcaa ctcggatcga tatcacaaag gtgcaggcag tcgcctgacg
     1621 ctgtcgctgc ggggatccag ttacggctcg ctcatgacag cccatgggaa ataccagatc
     1681 tttgccaaca ccggtcactt caagggaaat gtcgttgcca tcaaacatgt gaataagaag
     1741 cgcattgagc tgacccggca agttctgttt gaactcaaac acatgagaga tgttcagttc
     1801 aaccatctta ctcgattcat cggagcttgc atagaccctc ccaacatctg catcgtcacc
     1861 gagtattgtc ctcgggggag cttacaagat attctagaaa atgacagcat caatttggac
     1921 tggatgtttc gctactcgct cattaatgac cttgtgaagg gtatggcctt tctccacaac
     1981 agcattattt catctcatgg aagcctcaag tcctctaact gcgtggtgga tagtcgattt
     2041 gtgctcaaaa taacggatta cgggctggct agcttccgat caactgctga accagatgac
     2101 agtcatgccc tctatgccaa gaagctgtgg actgctccag aacttcttag tgggaacccc
     2161 ctgccaacca cgggcatgca gaaggcggat gtctatagct ttgccatcat tctgcaggaa
     2221 atagcgctcc gcagtggtcc tttctacttg gaaggcctgg acctcagtcc caaagagatt
     2281 gtccagaagg tgcgaaatgg tcagaggccg tatttccggc caagcattga ccggacacaa
     2341 ctgaacgaag agttagtttt gctgatggag aggtgctggg cccaggaccc aacagaacgt
     2401 ccagactttg ggcaaatcaa gggcttcatt cgccggttta acaaggaggg tggtaccagc
     2461 atattggaca acctcttgct tcgcatggaa cagtatgcca ataacctgga aaaactggtg
     2521 gaggagcgca cacaggccta cctagaggag aagcgcaagg ctgaggctct gctgtaccaa
     2581 attctacccc actctgtggc agagcagtta aaacggggag agacggttca ggcggaggcc
     2641 tttgacagtg tcactatcta cttcagtgac atcgtgggct tcacagcgct gtcagctgag
     2701 agcaccccca tgcaggtggt gacacttctt aatgaccttt atacctgctt tgatgccata
     2761 atcgacaact ttgatgtcta caaggtggaa accattgggg atgcctacat ggtggtatct
     2821 ggccttccgg gccgaaatgg tcagcgccat gcaccagaaa ttgctcgaat ggctctagca
     2881 ttactagatg cagtttcttc cttccgcatt cgccatcgac cccacgacca gctaaggtta
     2941 cgcataggcg tccatactgg gccagtctgt gctggggttg ttggcctgaa gatgccccgg
     3001 tactgtcttt ttggagacac agtaaacact gcttctcgaa tggagtctaa tggtcaagct
     3061 ctaaagatcc atgtctcctc gaccaccaag gatgccctgg atgagctagg atgcttccag
     3121 ctagaactcc gtggggatgt ggagatgaag ggaaaaggaa aaatgcgaac ttattggctc
     3181 ttaggagagc gaaaaggacc tcctggactc ctgtaaatcc caagcagaca atttcttgct
     3241 gttggtactt ggatgggcaa tggtcactgt gtctccactt gacagaaaca gacgtcatat
     3301 gagatggaaa atatgcatat acacaatccc cctgccttat ctggaagtca tataagccct
     3361 ctgccgctca gccttgtaca tatgcctgcc cctccctatc ttggtcctct tcctgccttc
     3421 tgtaaatacc tgtatctaga ccagaatatt ttgtccaagt ataaaacaa
//
