LOCUS       NM_012613               4068 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus natriuretic peptide receptor 1 (Npr1), mRNA.
ACCESSION   NM_012613
VERSION     NM_012613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4068)
  AUTHORS   Nagaraj,G. and Vellaichamy,E.
  TITLE     Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for
            natriuretic peptide receptor-A) transcription in H9c2 cells:
            involvement of beta-AR-ROS signaling
  JOURNAL   Endocrine 85 (3), 1075-1090 (2024)
   PUBMED   38713329
  REMARK    GeneRIF: Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding
            for natriuretic peptide receptor-A) transcription in H9c2 cells:
            involvement of beta-AR-ROS signaling.
REFERENCE   2  (bases 1 to 4068)
  AUTHORS   Tokudome,T., Otani,K., Mao,Y., Jensen,L.J., Arai,Y., Miyazaki,T.,
            Sonobe,T., Pearson,J.T., Osaki,T., Minamino,N., Ishida,J.,
            Fukamizu,A., Kawakami,H., Onozuka,D., Nishimura,K., Miyazato,M. and
            Nishimura,H.
  TITLE     Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for
            Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic
            Peptide
  JOURNAL   Hypertension 79 (7), 1409-1422 (2022)
   PUBMED   35534926
  REMARK    GeneRIF: Endothelial Natriuretic Peptide Receptor 1 Play Crucial
            Role for Acute and Chronic Blood Pressure Regulation by Atrial
            Natriuretic Peptide.
REFERENCE   3  (bases 1 to 4068)
  AUTHORS   Manivasagam,S. and Vellaichamy,E.
  TITLE     Suppression of Npr1, not Npr2 gene function induces hypertrophic
            growth in H9c2 cells in vitro
  JOURNAL   Biochem Biophys Res Commun 491 (2), 250-256 (2017)
   PUBMED   28743500
  REMARK    GeneRIF: Suppression of Npr1, not Npr2 gene function induces
            hypertrophic growth in cardiomyocytes in vitro.
REFERENCE   4  (bases 1 to 4068)
  AUTHORS   Manivasagam,S., Subramanian,V., Tumala,A. and Vellaichamy,E.
  TITLE     Differential expression and regulation of anti-hypertrophic genes
            Npr1 and Npr2 during beta-adrenergic receptor activation-induced
            hypertrophic growth in rats
  JOURNAL   Mol Cell Endocrinol 433, 117-129 (2016)
   PUBMED   27283501
  REMARK    GeneRIF: Atenolol treatment normalized the altered expression of
            Npr1 and Npr2 genes.
REFERENCE   5  (bases 1 to 4068)
  AUTHORS   Sen,A., Kumar,P., Garg,R., Lindsey,S.H., Katakam,P.V.,
            Bloodworth,M. and Pandey,K.N.
  TITLE     Transforming growth factor beta1 antagonizes the transcription,
            expression and vascular signaling of guanylyl cyclase/natriuretic
            peptide receptor A - role of deltaEF1
  JOURNAL   FEBS J 283 (9), 1767-1781 (2016)
   PUBMED   26934489
  REMARK    GeneRIF: The results suggest that an antagonistic cascade exists
            between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression
            and receptor signaling that is relevant to renal and vascular
            remodeling, and may be critical in the regulation of blood pressure
            and cardiovascular homeostasis.
REFERENCE   6  (bases 1 to 4068)
  AUTHORS   Deng,Y. and Rapp,J.P.
  TITLE     Cosegregation of blood pressure with angiotensin converting enzyme
            and atrial natriuretic peptide receptor genes using Dahl
            salt-sensitive rats
  JOURNAL   Nat Genet 1 (4), 267-272 (1992)
   PUBMED   1363813
REFERENCE   7  (bases 1 to 4068)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 4068)
  AUTHORS   Duda,T., Goraczniak,R.M. and Sharma,R.K.
  TITLE     Site-directed mutational analysis of a membrane guanylate cyclase
            cDNA reveals the atrial natriuretic factor signaling site
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7882-7886 (1991)
   PUBMED   1679239
REFERENCE   9  (bases 1 to 4068)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   10 (bases 1 to 4068)
  AUTHORS   Yamaguchi,M., Rutledge,L.J. and Garbers,D.L.
  TITLE     The primary structure of the rat guanylyl cyclase A/atrial
            natriuretic peptide receptor gene
  JOURNAL   J Biol Chem 265 (33), 20414-20420 (1990)
   PUBMED   1978722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05677.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128742.1, X14773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4068
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /note="natriuretic peptide receptor 1"
                     /db_xref="GeneID:24603"
                     /db_xref="RGD:3195"
     exon            1..1079
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..3544
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /EC_number="4.6.1.2"
                     /note="atrial natriuretic peptide receptor A; atrial
                     natriuretic peptide receptor 1; GC-A; ANP-A; atrial
                     natriuretic peptide A-type receptor; ANPR-A; guanylate
                     cyclase A; atrial natriuretic peptide receptor type A;
                     natriuretic peptide receptor A/guanylate cyclase A
                     (atrionatriuretic peptide receptor A)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 1 precursor"
                     /protein_id="NP_036745.1"
                     /db_xref="GeneID:24603"
                     /db_xref="RGD:3195"
                     /translation="MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSY
                     PWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKW
                     EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVK
                     LGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVE
                     GDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSL
                     KSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFN
                     FTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYL
                     KIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPK
                     CGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRW
                     EDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN
                     RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENES
                     ITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD
                     PEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGL
                     DLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALR
                     KFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQ
                     LKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVY
                     KVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIH
                     TGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELEL
                     RGDVEMKGKGKVRTYWLLGERGCSTRG"
     exon            1080..1279
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1393
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1529
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1621
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1757
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1842
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1963
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2038
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2116
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2221
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2293
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2450
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2606
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2775
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2922
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3046
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3115
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3290
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3389
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3481
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..4068
                     /gene="Npr1"
                     /gene_synonym="Anpra; Gca; NPR-A; Npra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctgggg caagcgcgag cgcacactcc cctttccttg ctggcgctcc ctctcccctc
       61 gctctctctc tctagaccgt cctctccttc cctcgctctc caccgactcc cttcgggtgc
      121 tgtgcttgct cccacctgct ctgaagcgct ctccgctctc ggacgctccc aatttagcgc
      181 tcctgctcga cggccgaacc gtcgcagcct ccgcaggcag cgtgccctcg gggttgcggc
      241 ttcaacccac cccagcttcc tccctcgcta cgactcgggc gccctggacg ttcgaccctc
      301 gccgctgagc ccgaggatgg cgagcagacc atggtgacag cgctgcccgg tcgctgcact
      361 cgctgaggcc atgccgggct cccgacgcgt ccgtccgcgc ctaagggcgc tgctgctgct
      421 gccgccgctt ctgctactcc ggggcggcca cgcgagcgac ctgaccgtgg ctgtggtgct
      481 gccgctgacc aacacctcgt acccgtggtc ctgggcgcgt gtagggccgg ccgtggaact
      541 ggctctcgcg cgggtgaagg ctcggccgga cttgctgccg ggttggacgg tccgcatggt
      601 gctgggcagc agtgagaacg cggcgggcgt ctgctcggac accgccgcac cgctggccgc
      661 ggtggacctc aagtgggagc acagccccgc ggtgttcctg ggccccggct gcgtctactc
      721 cgctgccccg gtggggcgct tcaccgcgca ctggcgggtg ccgctgctga ccgccggcgc
      781 cccggctctg ggcatcgggg tcaaggatga gtatgcgcta accacccgca caggacccag
      841 ccatgtcaag ctgggcgatt tcgtgacggc gctgcatcga cggctgggct gggagcacca
      901 ggcgctggtg ctctatgcag atcggctggg cgacgaccgg ccttgcttct tcatagtgga
      961 ggggctgtac atgcgggtgc gtgaacgcct caacatcaca gtgaatcacc aggagttcgt
     1021 cgagggcgac ccggaccact accccaagct actgcgggcc gtgcggcgaa agggcagagt
     1081 tatctacatc tgcagttctc cggatgcctt caggaatctg atgcttctgg ccctgaacgc
     1141 tggcctgact ggggaggact atgttttctt ccacctggat gtgtttgggc aaagccttaa
     1201 gagtgctcag ggccttgttc cccagaaacc ctgggaaaga ggagatgggc aggacaggag
     1261 tgcccgccag gcctttcagg ctgccaaaat tattacttac aaagagcctg ataatcctga
     1321 gtacttggaa ttcctgaagc agctgaaact cttggctgac aagaagttca acttcaccgt
     1381 ggaggatggc ctgaagaata tcatcccagc ctccttccac gacgggctcc tgctctatgt
     1441 ccaggcagtg acagagactc tggcacaggg gggaactgtc acagatggag agaacatcac
     1501 tcagcggatg tggaaccgaa gcttccaagg tgtgacagga tacctgaaaa ttgatagaaa
     1561 cggagatcgg gacaccgatt tctctctctg ggatatggat ccagagacgg gtgccttcag
     1621 ggttgtcctg aactataatg gtacttccca ggagctaatg gctgtgtcag aacacaaatt
     1681 atactggcct ctgggatatc cacctcctga cgtccctaaa tgtggctttg acaatgagga
     1741 cccagcctgc aaccaagacc acttttccac actggaggtt ctggctttgg tgggcagcct
     1801 ctctctgatt agctttctga ttgtgtcttt cttcatatac aggaagatgc agctggaaaa
     1861 ggagctggtc tcagagttgt ggcgggtgcg ctgggaggac ttgcagccca gcagcctgga
     1921 gaggcatctt cggagcgctg gcagccggct gaccctgagt gggcgaggct ccaattatgg
     1981 ctccctgcta accaccgagg gccagttcca agtctttgcc aagacagcat actataaggg
     2041 caaccttgtg gctgtgaaac gtgtgaaccg gaaacgcatt gagttgacac gaaaagtcct
     2101 gtttgaactt aaacatatgc gggatgtgca gaatgagcac ttgacaagat ttgtgggtgc
     2161 ttgtaccgac ccccccaaca tctgtatcct cacagagtac tgtccccgtg gaagcctaca
     2221 ggacattcta gagaatgaga gtatcaccct ggactggatg tttcggtact cgctcaccaa
     2281 tgacattgtc aagggaatgc tctttctaca caatggggcc atttgttccc atgggaacct
     2341 caagtcatcc aactgtgtgg tagacgggcg cttcgtgtta aagatcacag actacggtct
     2401 tgagagcttc agagacccgg agccagagca aggacacacc ctctttgcca aaaaattgtg
     2461 gacggcacct gagctcctgc gaatggcttc gccacctgcc cgtggctccc aagctgggga
     2521 tgtgtacagc tttggtatca tcctgcagga gattgcccta agaagtgggg tcttctatgt
     2581 ggaaggtttg gacctcagcc caaaagagat cattgagcgt gtgactcggg gtgagcagcc
     2641 cccattccga ccctccatgg atctgcagag ccacctggag gaactggggc agctgatgca
     2701 gcggtgctgg gcagaggacc cacaggagcg gccacccttt cagcagattc gcctggcgct
     2761 gcgcaagttc aacaaggaga acagcagcaa catcctggac aacctgctgt cacgcatgga
     2821 gcagtatgct aacaacctgg aggaactggt agaggagaga acacaagctt atctggagga
     2881 gaagcgcaaa gctgaggcct tgctttacca gattctgcct cactccgtgg ctgagcagct
     2941 gaagagaggc gagacagtcc aggctgaggc ctttgatagt gttaccatct acttcagtga
     3001 tattgtgggc tttacagctc tttcagcaga aagcacaccc atgcaggtgg tgactctgct
     3061 caatgatctg tacacctgtt ttgatgctgt catagacaac tttgatgtgt acaaggtgga
     3121 gaccattggt gatgcttaca tggtggtgtc agggctccca gtgcggaatg gacaactcca
     3181 cgcccgagag gtggcccgaa tggcacttgc actactggat gctgtgcgct ccttccgcat
     3241 ccgccatagg ccccaggaac agctgcgctt gcgcattggc atccacacag gtcctgtgtg
     3301 tgctggtgtg gtagggctaa agatgccccg atactgcctc tttggagaca cagtcaacac
     3361 agcttcaaga atggagtcta atggagaagc cctcaagatc cacttgtctt cagagaccaa
     3421 ggctgtgctg gaagagttcg atggtttcga gctggagctc cgaggggatg tggaaatgaa
     3481 gggcaaaggc aaggttcgga cctattggct cctgggggag cggggatgta gcactcgagg
     3541 ctgacctact gccctgctgt tccttgtcac ccctcctccc tgtgccagag gtgacagagg
     3601 tgtccagctt ccacctctcc cacagcagcc cagccactgt ggaaggatta gggacctgac
     3661 cagcacagtc accagatgtg acctctgaga gaggatggag atggtgggga ctgcagggga
     3721 cacctaagtt tgtaggactg actgaaacac acagtccctc ccatggcacc cttgtggcac
     3781 acatgcccag tcccaccctt actctgctgc ctagattggg acagcgattc cttctctgcc
     3841 ctcaacttag ctccactgtg acttataggg agggaattgc cacctgaagg aaacagaaag
     3901 aggttagagt ttgcaggagg cgggcagtcc tgtgtcacaa atactcccct cacttccagc
     3961 ccaccacctg ccccacagac tttggacaca gctcactgag gagaagagaa gctgccggtt
     4021 accttgcttc tcctgtgaac caaaccatta aagtctttat tcctgtga
//
