LOCUS       NM_053750               1020 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus natriuretic peptide C (Nppc), mRNA.
ACCESSION   NM_053750
VERSION     NM_053750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1020)
  AUTHORS   Bachmann,J.C., Kirchhoff,J.E., Napolitano,J.E., Sorota,S.,
            Gordon,W.M., Feric,N., Aschar-Sobbi,R., Lv,J., Cao,Z.,
            Coppieters,K., Borghetti,G. and Nyberg,M.
  TITLE     C-type natriuretic peptide induces inotropic and lusitropic effects
            in human 3D-engineered cardiac tissue: Implications for the
            regulation of cardiac function in humans
  JOURNAL   Exp Physiol 108 (9), 1172-1188 (2023)
   PUBMED   37493451
  REMARK    GeneRIF: C-type natriuretic peptide induces inotropic and
            lusitropic effects in human 3D-engineered cardiac tissue:
            Implications for the regulation of cardiac function in humans.
REFERENCE   2  (bases 1 to 1020)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   3  (bases 1 to 1020)
  AUTHORS   Manfra,O., Calamera,G., Froese,A., Arunthavarajah,D., Surdo,N.C.,
            Meier,S., Melleby,A.O., Aasrum,M., Aronsen,J.M., Nikolaev,V.O.,
            Zaccolo,M., Moltzau,L.R., Levy,F.O. and Andressen,K.W.
  TITLE     CNP regulates cardiac contractility and increases cGMP near both
            SERCA and TnI: difference from BNP visualized by targeted cGMP
            biosensors
  JOURNAL   Cardiovasc Res 118 (6), 1506-1519 (2022)
   PUBMED   33970224
  REMARK    GeneRIF: CNP regulates cardiac contractility and increases cGMP
            near both SERCA and TnI: difference from BNP visualized by targeted
            cGMP biosensors.
REFERENCE   4  (bases 1 to 1020)
  AUTHORS   Chen,W.X., Liu,H.H., Li,R.X., Mammadov,G., Wang,J.J., Liu,F.F.,
            Samadli,S., Wu,Y.F., Zhang,D.D., Luo,H.H. and Hu,P.
  TITLE     C-type natriuretic peptide stimulates osteoblastic proliferation
            and collagen-X expression but suppresses fibroblast growth
            factor-23 expression in vitro
  JOURNAL   Pediatr Rheumatol Online J 18 (1), 46 (2020)
   PUBMED   32517762
  REMARK    GeneRIF: C-type natriuretic peptide stimulates osteoblastic
            proliferation and collagen-X expression but suppresses fibroblast
            growth factor-23 expression in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1020)
  AUTHORS   Hirota,K., Furuya,M., Morozumi,N., Yoshikiyo,K., Yotsumoto,T.,
            Jindo,T., Nakamura,R., Murakami,K., Ueda,Y., Hanada,T., Sade,H.,
            Yoshida,S., Enomoto,K., Kanai,Y., Yamauchi,I., Yamashita,T.,
            Ueda-Sakane,Y., Fujii,T., Yasoda,A. and Inagaki,N.
  TITLE     Exogenous C-type natriuretic peptide restores normal growth and
            prevents early growth plate closure in its deficient rats
  JOURNAL   PLoS One 13 (9), e0204172 (2018)
   PUBMED   30235256
  REMARK    GeneRIF: CNP-KO rats might be a valuable animal model for
            investigating growth plate physiology and the mechanism of growth
            plate closure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1020)
  AUTHORS   Igaki,T., Itoh,H., Suga,S., Hama,N., Ogawa,Y., Komatsu,Y.,
            Mukoyama,M., Sugawara,A., Yoshimasa,T., Tanaka,I. and Nakao,K.
  TITLE     C-type natriuretic peptide in chronic renal failure and its action
            in humans
  JOURNAL   Kidney Int Suppl 55, S144-S147 (1996)
   PUBMED   8743538
REFERENCE   7  (bases 1 to 1020)
  AUTHORS   Hama,N., Itoh,H., Shirakami,G., Suga,S., Komatsu,Y., Yoshimasa,T.,
            Tanaka,I., Mori,K. and Nakao,K.
  TITLE     Detection of C-type natriuretic peptide in human circulation and
            marked increase of plasma CNP level in septic shock patients
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1177-1182 (1994)
   PUBMED   8117275
REFERENCE   8  (bases 1 to 1020)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   9  (bases 1 to 1020)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   10 (bases 1 to 1020)
  AUTHORS   Kojima,M., Minamino,N., Kangawa,K. and Matsuo,H.
  TITLE     Cloning and sequence analysis of a cDNA encoding a precursor for
            rat C-type natriuretic peptide (CNP)
  JOURNAL   FEBS Lett 276 (1-2), 209-213 (1990)
   PUBMED   1702395
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D90219.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1020
                     /gene="Nppc"
                     /note="natriuretic peptide C"
                     /db_xref="GeneID:114593"
                     /db_xref="RGD:620850"
     exon            1..206
                     /gene="Nppc"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..497
                     /gene="Nppc"
                     /note="C-type natriuretic peptide; natriuretic peptide
                     precursor type C; natriuretic peptide precursor C"
                     /codon_start=1
                     /product="C-type natriuretic peptide precursor"
                     /protein_id="NP_446202.1"
                     /db_xref="GeneID:114593"
                     /db_xref="RGD:620850"
                     /translation="MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELAEPQ
                     AAGGNQKKGDKTPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGN
                     KKGLSKGCFGLKLDRIGSMSGLGC"
     exon            207..517
                     /gene="Nppc"
                     /inference="alignment:Splign:2.1.0"
     exon            518..1020
                     /gene="Nppc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcacagca gtaggacccg tgctcgcttg gcaatcctgc tctgcaaccg cttgtcggac
       61 tgctcaccgg ccgtcccggc tgcagactgt ctgcacccct cggtcccatc ggcaccatgc
      121 acctctccca gctgatcgcc tgtgccctgc tgctcgcgct actctcactc cggccctccg
      181 aagccaagcc cgggacacca ccgaaggtcc cgagaacccc gccaggggag gagctggcag
      241 agccccaggc agctggtggc aatcagaaaa agggtgacaa gactccaggc ggcgggggag
      301 ccaatctcaa gggagaccga tcgcgactgc ttcgggacct gcgtgtggac accaagtccc
      361 gggcggcgtg ggctcgcctt ctgcacgagc accccaacgc gcgcaaatac aaaggcggca
      421 acaagaaggg cttgtccaaa ggctgctttg gcctcaagct ggaccggatc ggctccatga
      481 gcggtctggg atgttagtgc agcgacccct ggcggcggat tgggaactgc actgtgcact
      541 gaggtcatcc ttggtcatca gcctccagca tctggaaaca cctccaacgc aatgtggctt
      601 ttacatttct ttttattttt tcctcctggt actggcaata cacaacacca gctgttttat
      661 tattatttgg ggaggggagg ggatgatttt attgtttggg gttttttttt tgaaaatgaa
      721 aaataaaaaa ttatatatta tatatatatt atatacatga gacacacact cccacaccga
      781 cttgatgaca agggacggtt tttaaagtga ctgacaaaac cagctagctg taaaaacatt
      841 gctgtttgta aattcacatc atgcataaat gtatttatgt tgtaaagcta tttatattgt
      901 ttataaagag atatttataa aaattttatt tatgtaacta aatgaaagaa gccaaccatt
      961 gtaatgtttt tgtcctaact agttgaaaaa aaatgttaaa aaaaaaaaag ccattccatg
//
