LOCUS       NM_031545                628 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus natriuretic peptide B (Nppb), mRNA.
ACCESSION   NM_031545
VERSION     NM_031545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 628)
  AUTHORS   Takizawa,C., Minematsu,T., Nakagami,G., Kitamura,A., Koudounas,S.,
            Kunimitsu,M. and Sanada,H.
  TITLE     Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh
            exudates swabbed from critically colonised and infected
            full-thickness wounds in rats
  JOURNAL   Int Wound J 20 (4), 1088-1097 (2023)
   PUBMED   36307995
  REMARK    GeneRIF: Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1
            in fresh exudates swabbed from critically colonised and infected
            full-thickness wounds in rats.
REFERENCE   2  (bases 1 to 628)
  AUTHORS   Lin,Y.M., Situmorang,J.H., Guan,J.Z., Hsieh,D.J., Yang,J.J.,
            Chen,M.Y., Loh,C.H., Kuo,C.H., Lu,S.Y., Liou,Y.M. and Huang,C.Y.
  TITLE     ZAKbeta Alleviates Oxidized Low-density Lipoprotein
            (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP)
            Upregulation in Cardiomyoblast
  JOURNAL   Cell Biochem Biophys 80 (3), 547-554 (2022)
   PUBMED   35776316
  REMARK    GeneRIF: ZAKbeta Alleviates Oxidized Low-density Lipoprotein
            (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP)
            Upregulation in Cardiomyoblast.
REFERENCE   3  (bases 1 to 628)
  AUTHORS   Manfra,O., Calamera,G., Froese,A., Arunthavarajah,D., Surdo,N.C.,
            Meier,S., Melleby,A.O., Aasrum,M., Aronsen,J.M., Nikolaev,V.O.,
            Zaccolo,M., Moltzau,L.R., Levy,F.O. and Andressen,K.W.
  TITLE     CNP regulates cardiac contractility and increases cGMP near both
            SERCA and TnI: difference from BNP visualized by targeted cGMP
            biosensors
  JOURNAL   Cardiovasc Res 118 (6), 1506-1519 (2022)
   PUBMED   33970224
  REMARK    GeneRIF: CNP regulates cardiac contractility and increases cGMP
            near both SERCA and TnI: difference from BNP visualized by targeted
            cGMP biosensors.
REFERENCE   4  (bases 1 to 628)
  AUTHORS   Ploeg,M.C., Munts,C., Prinzen,F.W., Turner,N.A., van Bilsen,M. and
            van Nieuwenhoven,F.A.
  TITLE     Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb
            Expression in Adult Rat Cardiac Fibroblasts
  JOURNAL   Cells 10 (7), 1745 (2021)
   PUBMED   34359915
  REMARK    GeneRIF: Piezo1 Mechanosensitive Ion Channel Mediates
            Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 628)
  AUTHORS   Yan,J., Song,K., Bai,Z. and Ge,R.L.
  TITLE     WY14643 improves left ventricular myocardial mitochondrial and
            systolic functions in obese rats under chronic persistent hypoxia
            via the PPARalpha pathway
  JOURNAL   Life Sci 266, 118888 (2021)
   PUBMED   33310031
REFERENCE   6  (bases 1 to 628)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   7  (bases 1 to 628)
  AUTHORS   Dagnino,L., Drouin,J. and Nemer,M.
  TITLE     Differential expression of natriuretic peptide genes in cardiac and
            extracardiac tissues
  JOURNAL   Mol Endocrinol 5 (9), 1292-1300 (1991)
   PUBMED   1837590
REFERENCE   8  (bases 1 to 628)
  AUTHORS   Levin,E.R. and Frank,H.J.
  TITLE     Natriuretic peptides inhibit rat astroglial proliferation:
            mediation by C receptor
  JOURNAL   Am J Physiol 261 (2 Pt 2), R453-R457 (1991)
   PUBMED   1652217
REFERENCE   9  (bases 1 to 628)
  AUTHORS   Hoffman,A., Grossman,E. and Keiser,H.R.
  TITLE     Increased plasma levels and blunted effects of brain natriuretic
            peptide in rats with congestive heart failure
  JOURNAL   Am J Hypertens 4 (7 Pt 1), 597-601 (1991)
   PUBMED   1831369
REFERENCE   10 (bases 1 to 628)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M25297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M25297.1, FQ228997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..628
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
                     /note="natriuretic peptide B"
                     /db_xref="GeneID:25105"
                     /db_xref="RGD:3194"
     exon            1..183
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..423
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
                     /note="natriuretic peptides B; brain natriuretic peptide;
                     natriuretic peptide precursor B; iso-ANP; gamma-brain
                     natriuretic peptide; Brain natriuretic factor; proBNP;
                     preproBNP; natriuretic peptide precursor type B; brain
                     natriuretic factor prohormone"
                     /codon_start=1
                     /product="natriuretic peptides B precursor"
                     /protein_id="NP_113733.1"
                     /db_xref="GeneID:25105"
                     /db_xref="RGD:3194"
                     /translation="MDLQKVLPQMILLLLFLNLSPLGGHSHPLGSPSQSPEQSTMQKL
                     LELIREKSEEMAQRQLSKDQGPTKELLKRVLRSQDSAFRIQERLRNSKMAHSSSCFGQ
                     KIDRIGAVSRLGCDGLRLF"
     exon            184..406
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
                     /inference="alignment:Splign:2.1.0"
     exon            407..628
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      628
                     /gene="Nppb"
                     /gene_synonym="Bnf; BNP"
ORIGIN      
        1 gcgagacaag agagagcagg acaccatcgc agctgcctgg cccatcactt ctgcagcatg
       61 gatctccaga aggtgctgcc ccagatgatt ctgctcctgc ttttccttaa tctgtcgccg
      121 ctgggaggtc actcccatcc cctgggaagt cctagccagt ctccagaaca atccacgatg
      181 cagaagctgc tggagctgat aagagaaaag tcagaggaaa tggctcagag acagctctca
      241 aaggaccaag gccctacaaa agaacttcta aaaagagtcc ttaggtctca agacagcgcc
      301 ttccggatcc aggagagact tcgaaattcc aagatggcac atagttcaag ctgctttggg
      361 cagaagatag accggatcgg cgcagtcagt cgcttgggct gtgacgggct gaggttgttt
      421 taggaagacc tcctggctgc agactccggc ttctgactct gcctgcggct cttctttccc
      481 cagctctggg accacctctc aagtgatcct gtttatttat ttgtttattt atttattttt
      541 atgttgctga ttttctacaa gactgtttct tatcttccag cacaaacttg ccacagtgta
      601 ataaacatag cctatttctt gcttttgg
//
