LOCUS       NM_012612                831 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus natriuretic peptide A (Nppa), mRNA.
ACCESSION   NM_012612
VERSION     NM_012612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Huang,Y., Wang,L.L., Liu,Z.B., Chen,C., Ren,X., Luo,A.T., Ma,J.H.,
            Antzelevitch,C., Barajas-Martinez,H. and Hu,D.
  TITLE     Underlying mechanism of atrial fibrillation-associated Nppa-I137T
            mutation and cardiac effect of potential drug therapy
  JOURNAL   Heart Rhythm 21 (2), 184-196 (2024)
   PUBMED   37924963
  REMARK    GeneRIF: Underlying mechanism of atrial fibrillation-associated
            Nppa-I137T mutation and cardiac effect of potential drug therapy.
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Dogra,A., Kour,D., Gour,A., Bhardwaj,M., Bag,S., Dhiman,S.K.,
            Kumar,A., Singh,G. and Nandi,U.
  TITLE     Ameliorating effect of rutin against diclofenac-induced cardiac
            injury in rats with underlying function of FABP3, MYL3, and ANP
  JOURNAL   Drug Chem Toxicol 46 (3), 597-608 (2023)
   PUBMED   35509154
  REMARK    GeneRIF: Ameliorating effect of rutin against diclofenac-induced
            cardiac injury in rats with underlying function of FABP3, MYL3, and
            ANP.
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Zhang,Y., Wang,S., Huang,Y., Yang,K., Liu,Y., Bi,X., Liu,C.,
            Xiong,J., Zhang,B., Zhao,J. and Nie,L.
  TITLE     Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by
            uremic toxin
  JOURNAL   Mol Med Rep 21 (1), 393-404 (2020)
   PUBMED   31746392
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Li,X., Han,Z.N., Liu,Y., Hong,L., Cui,B.R. and Cui,X.
  TITLE     Endogenous ET-1 promotes ANP secretion through activation of
            COX2-L-PGDS-PPARgamma signaling in hypoxic beating rat atria
  JOURNAL   Peptides 122, 170150 (2019)
   PUBMED   31541683
  REMARK    GeneRIF: These results indicate that endogenous ET-1 induced by
            hypoxia promotes hypoxia-induced ANP secretion by activation of
            COX2-L-PGDS-PPARgamma signaling in beating rat atria
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Yu,L., Li,W., Park,B.M., Lee,G.J. and Kim,S.H.
  TITLE     Hypoxia augments NaHS-induced ANP secretion via KATP channel,
            HIF-1alpha and PPAR-gamma pathway
  JOURNAL   Peptides 121, 170123 (2019)
   PUBMED   31386893
  REMARK    GeneRIF: Hypoxia augments NaHS-induced ANP secretion via KATP
            channel, HIF-1A and PPAR-gamma pathway.
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Ramirez,G., Saba,S.R., Dietz,J.R. and Vesely,D.L.
  TITLE     Immunocytochemical localization of proANF 1-30, proANF 31-67 and
            atrial natriuretic factor in the kidney
  JOURNAL   Kidney Int 41 (2), 334-341 (1992)
   PUBMED   1372667
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Levin,E.R. and Frank,H.J.
  TITLE     Natriuretic peptides inhibit rat astroglial proliferation:
            mediation by C receptor
  JOURNAL   Am J Physiol 261 (2 Pt 2), R453-R457 (1991)
   PUBMED   1652217
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   10 (bases 1 to 831)
  AUTHORS   Jin,H., Yang,R.H., Chen,Y.F., Jackson,R.M. and Oparil,S.
  TITLE     Atrial natriuretic peptide attenuates the development of pulmonary
            hypertension in rats adapted to chronic hypoxia
  JOURNAL   J Clin Invest 85 (1), 115-120 (1990)
   PUBMED   2136863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB724799.1, X00665.1 and AI602287.1.
            
            On Oct 17, 2007 this sequence version replaced NM_012612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV765126.1, BC158590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CB724799.1         128-135
            9-576               X00665.1           1-568
            577-831             AI602287.1         1-255               c
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..831
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="natriuretic peptide A"
                     /db_xref="GeneID:24602"
                     /db_xref="RGD:3193"
     exon            1..196
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..535
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Natriuretic peptide precursor A (pronatriodilatin,
                     also Anf, Pnd); natriuretic peptides A;
                     prepronatriodilatin; natriuretic peptide precursor type A;
                     proANF; proANP; preproANF; preproANP; atriopeptigen;
                     cardiodilatin; preproCDD-ANF; atrial natriuretic factor
                     prohormone; atrial natriuretic peptide prohormone"
                     /codon_start=1
                     /product="natriuretic peptides A precursor"
                     /protein_id="NP_036744.1"
                     /db_xref="GeneID:24602"
                     /db_xref="RGD:3193"
                     /translation="MGSFSITKGFFLFLAFWLPGHIGANPVYSAVSNTDLMDFKNLLD
                     HLEEKMPVEDEVMPPQALSEQTDEAGAALSSLSEVPPWTGEVNPSQRDGGALGRGPWD
                     PSDRSALLKSKLRALLAGPRSLRRSSCFGGRIDRIGAQSGLGCNSFRYRR"
     exon            197..523
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
     exon            524..814
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggacaaagg ctgagagaga aaccagagag tgagccgaga cagcaaacat cagatcgtgc
       61 cccgacccac gccagcatgg gctccttctc catcaccaag ggcttcttcc tcttcctggc
      121 cttttggctc ccaggccata ttggagcaaa tcccgtatac agtgcggtgt ccaacacaga
      181 tctgatggat ttcaagaacc tgctagacca cctggaggag aagatgccgg tagaagatga
      241 ggtcatgcct ccgcaggccc tgagcgagca gaccgatgaa gcgggggcgg cacttagctc
      301 cctctctgag gtgcctccct ggactgggga agtcaacccg tctcagagag atggaggtgc
      361 tctcgggcgc ggcccctggg acccctccga tagatctgcc ctcttgaaaa gcaaactgag
      421 ggctctgctc gctggccctc ggagcctgcg aaggtcaagc tgcttcgggg gtaggattga
      481 caggattgga gcccagagcg gactaggctg caacagcttc cggtaccgaa gataacagcc
      541 aaatctgctc gagcagatcg caaaagatcc caagcccttg cggtgtgtca cacagcttgg
      601 tcgcattgcc actgagaggt ggtgaatacc ctcctggagc tgcagcttcc tgtcttcatc
      661 tatcacgatc gatgttaagt gtagatgagt ggtttagtga ggccttacct ctcccactct
      721 gcatattaag gtagatcctc acccctttca gaaagcagtt ggaaaaaaat aaatccgaat
      781 aaacttcagc accacggaca gacgctgagg cctgaaaaaa aaaaaaaaaa a
//
