LOCUS       NM_001402176            4578 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nephronectin (Npnt), mRNA.
ACCESSION   NM_001402176 XM_039103853
VERSION     NM_001402176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4578)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 4578)
  AUTHORS   Tsukasaki,M., Yamada,A., Suzuki,D., Aizawa,R., Miyazono,A.,
            Miyamoto,Y., Suzawa,T., Takami,M., Yoshimura,K., Morimura,N.,
            Yamamoto,M. and Kamijo,R.
  TITLE     Expression of POEM, a positive regulator of osteoblast
            differentiation, is suppressed by TNF-alpha
  JOURNAL   Biochem Biophys Res Commun 410 (4), 766-770 (2011)
   PUBMED   21689636
REFERENCE   3  (bases 1 to 4578)
  AUTHORS   Fujiwara,H., Ferreira,M., Donati,G., Marciano,D.K., Linton,J.M.,
            Sato,Y., Hartner,A., Sekiguchi,K., Reichardt,L.F. and Watt,F.M.
  TITLE     The basement membrane of hair follicle stem cells is a muscle cell
            niche
  JOURNAL   Cell 144 (4), 577-589 (2011)
   PUBMED   21335239
REFERENCE   4  (bases 1 to 4578)
  AUTHORS   Kahai,S., Lee,S.C., Seth,A. and Yang,B.B.
  TITLE     Nephronectin promotes osteoblast differentiation via the epidermal
            growth factor-like repeats
  JOURNAL   FEBS Lett 584 (1), 233-238 (2010)
   PUBMED   19944102
REFERENCE   5  (bases 1 to 4578)
  AUTHORS   Sato,Y., Uemura,T., Morimitsu,K., Sato-Nishiuchi,R., Manabe,R.,
            Takagi,J., Yamada,M. and Sekiguchi,K.
  TITLE     Molecular basis of the recognition of nephronectin by integrin
            alpha8beta1
  JOURNAL   J Biol Chem 284 (21), 14524-14536 (2009)
   PUBMED   19342381
REFERENCE   6  (bases 1 to 4578)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 4578)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (bases 1 to 4578)
  AUTHORS   Linton,J.M., Martin,G.R. and Reichardt,L.F.
  TITLE     The ECM protein nephronectin promotes kidney development via
            integrin alpha8beta1-mediated stimulation of Gdnf expression
  JOURNAL   Development 134 (13), 2501-2509 (2007)
   PUBMED   17537792
REFERENCE   9  (bases 1 to 4578)
  AUTHORS   Morimura,N., Tezuka,Y., Watanabe,N., Yasuda,M., Miyatani,S.,
            Hozumi,N. and Tezuka Ki,K.
  TITLE     Molecular cloning of POEM: a novel adhesion molecule that interacts
            with alpha8beta1 integrin
  JOURNAL   J Biol Chem 276 (45), 42172-42181 (2001)
   PUBMED   11546798
REFERENCE   10 (bases 1 to 4578)
  AUTHORS   Brandenberger,R., Schmidt,A., Linton,J., Wang,D., Backus,C.,
            Denda,S., Muller,U. and Reichardt,L.F.
  TITLE     Identification and characterization of a novel extracellular matrix
            protein nephronectin that is associated with integrin alpha8beta1
            in the embryonic kidney
  JOURNAL   J Cell Biol 154 (2), 447-458 (2001)
   PUBMED   11470831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 8, 2022 this sequence version replaced XM_039103853.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.10072.1,
                                           SRR26643297.9569.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000002.1  224133231-224133435 c
            206-306             JAXUCZ010000002.1  224131336-224131436 c
            307-399             JAXUCZ010000002.1  224102678-224102770 c
            400-492             JAXUCZ010000002.1  224099370-224099462 c
            493-612             JAXUCZ010000002.1  224094924-224095043 c
            613-732             JAXUCZ010000002.1  224093109-224093228 c
            733-867             JAXUCZ010000002.1  224091740-224091874 c
            868-990             JAXUCZ010000002.1  224091363-224091485 c
            991-1377            JAXUCZ010000002.1  224088710-224089096 c
            1378-1464           JAXUCZ010000002.1  224075146-224075232 c
            1465-1563           JAXUCZ010000002.1  224074519-224074617 c
            1564-1820           JAXUCZ010000002.1  224069280-224069536 c
            1821-4578           JAXUCZ010000002.1  224065191-224067948 c
FEATURES             Location/Qualifiers
     source          1..4578
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..4578
                     /gene="Npnt"
                     /note="nephronectin"
                     /db_xref="GeneID:686753"
                     /db_xref="RGD:1593709"
     exon            1..205
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1904
                     /gene="Npnt"
                     /codon_start=1
                     /product="nephronectin precursor"
                     /protein_id="NP_001389105.1"
                     /db_xref="GeneID:686753"
                     /db_xref="RGD:1593709"
                     /translation="MAVLLVAVLASSLYLQVAADFDGRWPRQIVSSIGLCRYGGRIDC
                     CWGWARQSWGQCQPVCQPQCKHGECVGPNKCKCHPGFAGKTCNQDEPFHPTPLDQGSE
                     QPLFQPPDHQATSVPSRDLNECGLKPRPCKHRCMNTFGSYKCYCLNGYMLMPDGSCSS
                     ALSCSMANCQYGCDVIKGQIRCQCPSPGLQLAPDGRTCVDIDECATGRVSCPRFRQCV
                     NTFGSYICKCHTGFDLMYIGGKYQCHDIDECSLGQHQCSSYARCYNIHGSYKCQCKDG
                     YEGDGLNCVYIPKVMIEPSGPIHMPERNGTILKGDGGYANRIPDAGSTRWPLKTPYIP
                     PPVITNRPTSKPTARPTPNPTPQPTPPPPPPLPTELRTTPLPPTPERPATSPTTVAPA
                     TQVVTVDNRIQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADEEAKDDPGILIHSC
                     NFDHGLCGWIREKDSDLHWEPTRDPAGGQYLTVSAAKAPGGKAARLVLPLGHLMHSGD
                     LCLSFRHKVTGLHSGALQVFVRKHGTHGSALWGRNGGHGWRQTQITLRGADVKSVIFK
                     GEKRRGHTGEIGLDDVSLKRGRC"
     exon            206..306
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            307..399
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            400..492
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            493..612
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            613..732
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            733..867
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            868..990
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1377
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1464
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1563
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1820
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..4578
                     /gene="Npnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacttgccc ggctgcgcgc cgcgcccagt gcgtcccagc agccgcgggt gccgcgccga
       61 aggcggccga gagatcccgg gacgcgcagc ttcccgcaac cccccccagc gccctggcgt
      121 cctggtcggc cggcatggct gtgctcctag tggcggtgct agcgtcctcg ctctacctgc
      181 aggtggctgc cgacttcgac gggaggtggc ccaggcaaat agtatcttcc attggcctat
      241 gtcgctatgg tggcaggatt gactgctgct ggggctgggc tcgccagtcc tggggacagt
      301 gtcaacctgt gtgccaacca cagtgcaaac acggagagtg cgtcgggcca aacaagtgca
      361 aatgtcaccc tggatttgct gggaaaacct gcaaccaaga cgagcccttc cacccaactc
      421 ctcttgacca aggcagtgaa cagcctcttt tccaaccccc ggatcatcaa gccacaagtg
      481 taccttcaag ggatttaaac gagtgtggcc tgaagcctcg gccctgcaag cacaggtgca
      541 tgaacacctt cggcagctac aagtgctact gtctcaacgg atacatgctg atgccggacg
      601 ggtcctgctc aagtgctctc tcgtgttcca tggcaaactg tcagtatggc tgtgatgtga
      661 tcaaaggcca aatccgatgc caatgtcctt cccctggcct gcagctagct cctgatggga
      721 ggacctgtgt ggatatcgac gagtgtgcga ctggaagagt ctcctgcccc cggtttaggc
      781 agtgcgtcaa cacgtttggg agctacatct gcaagtgtca cactggtttc gacctcatgt
      841 acattggagg caaatatcaa tgtcacgaca ttgacgagtg ctcccttgga caacaccagt
      901 gcagcagcta tgctcgatgc tacaacatac atggctccta caagtgccaa tgtaaagatg
      961 gatatgaggg ggacggactg aactgtgtgt atatcccgaa agtcatgatt gaaccttcag
     1021 gtccaattca tatgccagag agaaatggta caatcttaaa gggtgatgga ggatacgcta
     1081 ataggattcc tgatgctgga agtactaggt ggcccctgaa gacaccatat attcctcctc
     1141 ctgtcattac caacaggccc acctccaagc caacagcaag acctacacca aacccaacac
     1201 cacagcctac tccaccaccc ccgccacccc tcccaacaga gctcagaaca accccactac
     1261 caccaacccc agaaaggcca gccaccagcc ccaccactgt ggcacctgct acacaagtag
     1321 tcaccgtcga caacaggata cagacggatc cccagaaacc cagaggagat gtgttcattc
     1381 cgaggcagcc ttcgaatgac ctgtttgaaa tatttgaaat cgaaagagga gtcagcgctg
     1441 atgaggaagc gaaggacgac ccaggcattc tcatacacag ctgtaatttt gaccatggac
     1501 tttgtggatg gatcagagaa aaggatagcg acttgcactg ggagccaacc agggacccag
     1561 caggtggaca gtatctcaca gtgtctgcag ccaaagcccc ggggggaaag gctgcccgct
     1621 tggtgttacc tctcggccac ctcatgcatt caggggacct gtgcctgtcc tttaggcaca
     1681 aggtgactgg gctgcactcg ggcgccctgc aggtgtttgt gagaaaacat ggtacccacg
     1741 gatcagccct gtggggaaga aatggtggcc atggctggag gcaaacccag atcaccttgc
     1801 gaggggctga cgtcaaaagc gtcatcttca aaggtgaaaa aaggcgtggt cacacggggg
     1861 agattggatt ggatgatgtg agcttgaaaa gaggtcgctg ctgagaagac cattggcagc
     1921 gccccagctc gcagtgaatt tgtcgctttc ccttgtttcc caatgcttgc cttctcatct
     1981 ccctctgatc aggcccaggg caggagtgga tcaggaggaa ggctgcttgg tgactcaggt
     2041 cttggtggcc tgtttttgtg caatcccagt gaccggtgac actctcgaag ttcaggagca
     2101 tctggagaca cctccaggcc cctctggggt ggtaccttct acctgtgtct tctttaggaa
     2161 ggactttggt gtgtgtgacc cgtgccatcc ttcatcggga ttacagagtg ggcctgctag
     2221 ccaattacgg gagacgtttc attcagtgca aatgctattc tgcgatctgt ccagtgttgt
     2281 accatgagta gtattgactt ggcttacagt acgatgtgca gcgtgcttgt gaaattagtg
     2341 tacccttttc acttaagtta cttctggcct gacctcaact ctgactttta ctgccataca
     2401 ctttttaacg gaaggtgcac aacatattaa gatacattta ttcttgtaaa ctgtgtcttt
     2461 ctattaaaga cagttatata gggtggtcat ggaatttctg attagtagta ctgtgtttgt
     2521 gtaaatgtgc tattaatata agtatttacg tgttcctaaa tattcacaga ctctagttgc
     2581 aaggtcaaag gcagcttatg atcccctgag ttaaaaaata aatggtgacc tgtcatctat
     2641 gaccttaaac tggcagcaag aaaactagca gaggtgtgca actgtctggt agtggagtaa
     2701 tggctttctt tctatgtcct tgagcttgat ctatgcagaa gagagtagac cattaaggga
     2761 agagaggacc tgcagttaat atataaaacc cctataaacc aacagctttt accattgtta
     2821 ctcacctcca ttggtaagaa gctttgtaaa gatactgtgt ggggggagtg gacgactagg
     2881 ggaaggtcca tgagacagga gtttctaatg agctttaaat tggcaaggtt tccacgagtg
     2941 tagctcacga tgttacctga ggctgggatg ggaagccggt ctgtgcactg aggcgatgca
     3001 cgcaatgctg gaaggacact cacgcactaa agaacaagat tggaatttta atatccacag
     3061 agctccaact gcgtctcctc cctgtcagac ctctctgtat taaaaacgca taactttaac
     3121 gagtcaactt tctccttaca gctctctcat ttctgattaa gtaatcgaaa tatttttctg
     3181 ctgtctttgc caggagacat acagatgatt aaagggttgg aaaaaaagat ctatggtgaa
     3241 aagctaaagg aactgggaat gttccgcctg gagaagagaa gactgagggg cagaccatgg
     3301 gtgctcttcc aggctgcgaa cggttggcac cgagagcttg gagagcagcc gttctccatg
     3361 tgtactgaga ataggaccag aggaaacagg gttagggtag agtgtgaggg ggcatttcct
     3421 ggcagggaca gttgctgagc ccaatccttt acaaaaaaca agtgtgagtc atatttgttc
     3481 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tccctgtctc
     3541 tccctcagtc tctccgtctc tctctcttcc ttccctttac ttatatctcc atctctctcc
     3601 ccccctcact gttttcttct tttcctctcc atcttctctc tcccttccct ccattgaaac
     3661 aaaactacat aaaattttat gtatttaagg tgcacttatt tcaaggtaaa ttaccgaatt
     3721 gtgggatcta gaagacgctt tggtcctcac agttgtccat aacaagggca atcttcagaa
     3781 cgaaactaag tggtctgggc tgagctctaa gttaggcttt tggctcttga cctcctgctg
     3841 ggaagggttc aaaaggtcga gctcactaaa atgctcttca ctcaacagcc aacctagcag
     3901 tattaaaaga acaaatcccc aaattattta ctcctggaga ggttgtgtca cacaggtgct
     3961 gtcctctctc actgatgtcc taatatggcg gtgctagtgt tttattccag ggtaaggtgc
     4021 aaccccccat ggtttgttga gtaggtgctt agacttgttc ttcagagatc ccaagaaaca
     4081 tgactgagag attttgtctg gtgcattgcc tctggtttgc attgacaagt taacatggct
     4141 actgaggtcg tgtcaaccac agcaccgtta gccctccccg tcacctcttc ccgtggctca
     4201 ctttctcact gggagccttc caagttccac aagccggtaa tgctttctga acaggtccaa
     4261 gggacttggc cgtttagctc aatagaggca gggttggagt ttctgatgta gaagaacacc
     4321 taaaatgctc ttaggtccat tttttcatga tccatttcct gtttggtcat gtaactgcac
     4381 agcagaagaa gaaaggggaa agtaattgag aagttcacac ttaggtgcca ataagacatt
     4441 gcactggtgg aagaagttat ccaaagtact gtagaacatc ttgtttatta tttaatgttt
     4501 tctaaagtga aaaatgtttg tggttttcaa aatggacgaa caaaagcaat ctttgtaaat
     4561 aaaacactgt taatagtg
//
