LOCUS       NM_012992               1307 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus nucleophosmin 1 (Npm1), transcript variant 1,
            mRNA.
ACCESSION   NM_012992
VERSION     NM_012992.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Pfister,J.A. and D'Mello,S.R.
  TITLE     Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is
            Dependent on Its Expression Level, Subcellular Localization, and
            Oligomerization Status
  JOURNAL   J Biol Chem 291 (39), 20787-20797 (2016)
   PUBMED   27510036
  REMARK    GeneRIF: study suggests that although neurons need NPM1 for
            survival, an increase in its expression beyond physiological levels
            and its translocation to the cytoplasm leads to death through
            abortive cell cycle induction.
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Kim,J.Y., Cho,Y.E. and Park,J.H.
  TITLE     The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of
            the Oncogenic Nucleophosmin-MYC Axis
  JOURNAL   Am J Pathol 185 (7), 2061-2068 (2015)
   PUBMED   25956029
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Kuzelova,K., Brodska,B., Fuchs,O., Dobrovolna,M., Soukup,P. and
            Cetkovsky,P.
  TITLE     Altered HLA Class I Profile Associated with Type A/D Nucleophosmin
            Mutation Points to Possible Anti-Nucleophosmin Immune Response in
            Acute Myeloid Leukemia
  JOURNAL   PLoS One 10 (5), e0127637 (2015)
   PUBMED   25992555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Milochau,A., Lagree,V., Benassy,M.N., Chaignepain,S., Papin,J.,
            Garcia-Arcos,I., Lajoix,A., Monterrat,C., Coudert,L.,
            Schmitter,J.M., Ochoa,B. and Lang,J.
  TITLE     Synaptotagmin 11 interacts with components of the RNA-induced
            silencing complex RISC in clonal pancreatic beta-cells
  JOURNAL   FEBS Lett 588 (14), 2217-2222 (2014)
   PUBMED   24882364
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Mitrea,D.M., Grace,C.R., Buljan,M., Yun,M.K., Pytel,N.J.,
            Satumba,J., Nourse,A., Park,C.G., Madan Babu,M., White,S.W. and
            Kriwacki,R.W.
  TITLE     Structural polymorphism in the N-terminal oligomerization domain of
            NPM1
  JOURNAL   Proc Natl Acad Sci U S A 111 (12), 4466-4471 (2014)
   PUBMED   24616519
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Takemura,M., Ohta,N., Furuichi,Y., Takahashi,T., Yoshida,S.,
            Olson,M.O. and Umekawa,H.
  TITLE     Stimulation of calf thymus DNA polymerase alpha activity by
            nucleolar protein B23
  JOURNAL   Biochem Biophys Res Commun 199 (1), 46-51 (1994)
   PUBMED   8123045
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Biggiogera,M., Burki,K., Kaufmann,S.H., Shaper,J.H., Gas,N.,
            Amalric,F. and Fakan,S.
  TITLE     Nucleolar distribution of proteins B23 and nucleolin in mouse
            preimplantation embryos as visualized by immunoelectron microscopy
  JOURNAL   Development 110 (4), 1263-1270 (1990)
   PUBMED   2100262
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Chang,J.H. and Olson,M.O.
  TITLE     Structure of the gene for rat nucleolar protein B23
  JOURNAL   J Biol Chem 265 (30), 18227-18233 (1990)
   PUBMED   2211699
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Chang,J.H. and Olson,M.O.
  TITLE     A single gene codes for two forms of rat nucleolar protein B23 mRNA
  JOURNAL   J Biol Chem 264 (20), 11732-11737 (1989)
   PUBMED   2745414
REFERENCE   10 (bases 1 to 1307)
  AUTHORS   Chang,J.H., Dumbar,T.S. and Olson,M.O.
  TITLE     cDNA and deduced primary structure of rat protein B23, a nucleolar
            protein containing highly conserved sequences
  JOURNAL   J Biol Chem 263 (26), 12824-12827 (1988)
   PUBMED   3417636
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060579.1.
            
            On Aug 30, 2012 this sequence version replaced NM_012992.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060579.1, J03969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093048 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              BC060579.1         5-1311
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1307
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /note="nucleophosmin 1"
                     /db_xref="GeneID:25498"
                     /db_xref="RGD:3192"
     exon            1..151
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..972
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar protein B23.1; NPM; numatrin; nucleolar protein
                     NO38; nucleolar phosphoprotein B23; nucleophosmin
                     (nucleolar phosphoprotein B23, numatrin)"
                     /codon_start=1
                     /product="nucleophosmin isoform 1"
                     /protein_id="NP_037124.1"
                     /db_xref="GeneID:25498"
                     /db_xref="RGD:3192"
                     /translation="MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSL
                     RTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRL
                     KCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDE
                     DDDEDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTP
                     RSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRM
                     TDQEAIQDLWQWRKSL"
     exon            152..231
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            232..351
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            352..445
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..552
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            553..614
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            615..672
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            673..756
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            757..858
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            859..933
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1280
                     /gene="Npm1"
                     /gene_synonym="B23NP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgattc cgtcctgcgt gtctgttctg cggaacagta ggcagttgtt ttccgtccgg
       61 cttctctcac actcaagtgc gcgcctccac ctcatggaag actcgatgga catggacatg
      121 agccctctta ggcctcagaa ctaccttttc ggttgtgaac taaaggctga caaagattat
      181 cactttaaag tggataatga tgaaaatgag caccagttat cattaagaac ggtcagttta
      241 ggagcagggg caaaagatga gttgcacatc gtagaggcag aagcaatgaa ctatgaaggc
      301 agcccaatta aagtaacact ggcaactttg aaaatgtctg tacaaccaac agtttccctt
      361 gggggcttcg aaattacacc acctgtggtc ttgaggttga agtgtggttc tgggcctgtg
      421 cacataagtg gacagcacct agtagctgta gaggaagatg cagagtcaga agatgaagat
      481 gaggaagatg taaaactctt aggcatgtct ggaaagagat ctgctcccgg aggtggtaac
      541 aaagtcccac agaaaaaagt aaaacttgat gaagatgatg atgaggatga tgaagatgat
      601 gaggatgatg aagatgatga tgatgatgat tttgatgaag aggaaactga agaaaaggtt
      661 ccagtgaaga aatctgtacg agatacccca gccaaaaatg cacaaaaatc aaaccaaaat
      721 gggaaagatt taaaaccatc aacaccaagg tcaaagggtc aagagtcctt caaaaaacag
      781 gaaaaaactc ccaaaacacc caaaggacct agctctgtag aagacattaa ggcaaaaatg
      841 caagcaagta tagaaaaagg tggttctctt cccaaagtgg aagccaagtt cattaattat
      901 gtgaagaatt gtttccggat gactgaccag gaggctattc aagatctctg gcagtggagg
      961 aagtctcttt aagaaaatgg tttaaacagt ttgaaataat tctgtcttca tttctgtaat
     1021 agttgctatc tggctgtcct ttttataatg caaagtgaga actttcccta ctgtgtttga
     1081 taaatgttgt ccaggttcaa ttgccaagaa tgtgttgtct aaaatgcctg tttagttttc
     1141 aaggatggaa ctccgccctt tacttggttt taagtatgta tggaatgtta tgataggaca
     1201 tagtagtagt ggtggtcaga tgtggaaatg gtagggagac aaatatacat gtgaaataaa
     1261 ctcagtattt taataaagta aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
