LOCUS       NM_022628               5820 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NPHS1 adhesion molecule, nephrin (Nphs1), mRNA.
ACCESSION   NM_022628
VERSION     NM_022628.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5820)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5820)
  AUTHORS   Yang,H., Xie,T., Li,D., Du,X., Wang,T., Li,C., Song,X., Xu,L.,
            Yi,F., Liang,X., Gao,L., Yang,X. and Ma,C.
  TITLE     Tim-3 aggravates podocyte injury in diabetic nephropathy by
            promoting macrophage activation via the NF-kappaB/TNF-alpha pathway
  JOURNAL   Mol Metab 23, 24-36 (2019)
   PUBMED   30862474
REFERENCE   3  (bases 1 to 5820)
  AUTHORS   Schulz,A., Muller,N.V., van de Lest,N.A., Eisenreich,A.,
            Schmidbauer,M., Barysenka,A., Purfurst,B., Sporbert,A.,
            Lorenzen,T., Meyer,A.M., Herlan,L., Witten,A., Ruhle,F., Zhou,W.,
            de Heer,E., Scharpfenecker,M., Panakova,D., Stoll,M. and Kreutz,R.
  TITLE     Analysis of the genomic architecture of a complex trait locus in
            hypertensive rat models links Tmem63c to kidney damage
  JOURNAL   Elife 8, e42068 (2019)
   PUBMED   30900988
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5820)
  AUTHORS   Endlich,N., Lange,T., Kuhn,J., Klemm,P., Kotb,A.M., Siegerist,F.,
            Kindt,F., Lindenmeyer,M.T., Cohen,C.D., Kuss,A.W., Nath,N.,
            Rettig,R., Lendeckel,U., Zimmermann,U., Amann,K., Stracke,S. and
            Endlich,K.
  TITLE     BDNF: mRNA expression in urine cells of patients with chronic
            kidney disease and its role in kidney function
  JOURNAL   J Cell Mol Med 22 (11), 5265-5277 (2018)
   PUBMED   30133147
REFERENCE   5  (bases 1 to 5820)
  AUTHORS   Rogg,M., Yasuda-Yamahara,M., Abed,A., Dinse,P., Helmstadter,M.,
            Conzelmann,A.C., Frimmel,J., Sellung,D., Biniossek,M.L., Kretz,O.,
            Grahammer,F., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     The WD40-domain containing protein CORO2B is specifically enriched
            in glomerular podocytes and regulates the ventral actin
            cytoskeleton
  JOURNAL   Sci Rep 7 (1), 15910 (2017)
   PUBMED   29162887
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5820)
  AUTHORS   Beltcheva,O., Martin,P., Lenkkeri,U. and Tryggvason,K.
  TITLE     Mutation spectrum in the nephrin gene (NPHS1) in congenital
            nephrotic syndrome
  JOURNAL   Hum Mutat 17 (5), 368-373 (2001)
   PUBMED   11317351
REFERENCE   7  (bases 1 to 5820)
  AUTHORS   Putaala,H., Soininen,R., Kilpelainen,P., Wartiovaara,J. and
            Tryggvason,K.
  TITLE     The murine nephrin gene is specifically expressed in kidney, brain
            and pancreas: inactivation of the gene leads to massive proteinuria
            and neonatal death
  JOURNAL   Hum Mol Genet 10 (1), 1-8 (2001)
   PUBMED   11136707
REFERENCE   8  (bases 1 to 5820)
  AUTHORS   Putaala,H., Sainio,K., Sariola,H. and Tryggvason,K.
  TITLE     Primary structure of mouse and rat nephrin cDNA and structure and
            expression of the mouse gene
  JOURNAL   J Am Soc Nephrol 11 (6), 991-1001 (2000)
   PUBMED   10820162
REFERENCE   9  (bases 1 to 5820)
  AUTHORS   Kawachi,H., Koike,H., Kurihara,H., Yaoita,E., Orikasa,M.,
            Shia,M.A., Sakai,T., Yamamoto,T., Salant,D.J. and Shimizu,F.
  TITLE     Cloning of rat nephrin: expression in developing glomeruli and in
            proteinuric states
  JOURNAL   Kidney Int 57 (5), 1949-1961 (2000)
   PUBMED   10792613
REFERENCE   10 (bases 1 to 5820)
  AUTHORS   Ahola,H., Wang,S.X., Luimula,P., Solin,M.L., Holzman,L.B. and
            Holthofer,H.
  TITLE     Cloning and expression of the rat nephrin homolog
  JOURNAL   Am J Pathol 155 (3), 907-913 (1999)
   PUBMED   10487848
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF161715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF161715.1, AF172255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..5820
                     /gene="Nphs1"
                     /note="NPHS1 adhesion molecule, nephrin"
                     /db_xref="GeneID:64563"
                     /db_xref="RGD:620460"
     exon            1..503
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..4162
                     /gene="Nphs1"
                     /note="renal glomerulus-specific cell adhesion receptor;
                     nephrosis 1 homolog, nephrin; nephrosis 1, congenital,
                     Finnish type (nephrin); NPHS1 nephrin"
                     /codon_start=1
                     /product="nephrin precursor"
                     /protein_id="NP_072150.1"
                     /db_xref="GeneID:64563"
                     /db_xref="RGD:620460"
                     /translation="MGAKRVTVRGARTSPIHRTSSLTPLLLMGMLTSGLAESPVPTSA
                     PQGFWALSENLTAVEGTTVKLWCGVRAPGSVVQWAKDGLLLGPNPKMPGFPRYSLEGD
                     RAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPKVILSILVSPKVLLLTPEAGS
                     TVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARV
                     IPQSSDNGQLLVCEGSNPALDTPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLE
                     LPCTARGGNPPATLQWLKNGKPVSTAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSY
                     NSVSAGTQERSITLQVTFPPSAITILGSVSQSENKNVTLCCLTKSSRPRVLLRWWLGG
                     RQLLPTDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFSDAFSKETFKKSLTLN
                     VKYPAQKLWIEGPPEGQYIRTGTRVRLVCLAIGGNPDPSLIWFKDSRPVSEPRQPQEP
                     RRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSCKAGQLSASTQLVVQFPPTNLTILA
                     NSSALRPGDALNLTCVSISSNPPVNLSWDKEGERLEDVAAKPQSAPFKGSAASRSVFL
                     RVSSRDHGQRVTCRAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVEQGQVLLPV
                     SVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEG
                     TAEALLKLDVHYAPTIRALRDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEEEED
                     LNLDDMEKVSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDQ
                     PTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHRYHQGVVH
                     SSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSISPHSVG
                     LEWKPGFDGGLPQRFQIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTRYRIWLLAS
                     NALGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPTELPPGPPRLPLLPVLFAVGGLLL
                     LSNASCVGGLLWRRRLRRLAEEISEKTEAGSEDRIRNEYEESQWTGDRDTRSSTVSTA
                     EVDPNYYSMRDFSPQLPPTLEEVLYHQGAEGEDMAFPGHLHDEVERAYGPPGAWGPLY
                     DEVRMDPYDLRWPEVQCEDPRGIYDQVAADMDAVEASSLPFELRGHLV"
     exon            504..719
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..842
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..971
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1053
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1157
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1285
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1457
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1615
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1760
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1885
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2072
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2202
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2375
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2516
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2657
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2779
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2951
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3108
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3260
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3372
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3554
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3611
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3731
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3756
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3829
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3923
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4030
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4195
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..5803
                     /gene="Nphs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagtgagc tcaccctggg tccaagaaat gttcccatgc tgtgtctgac gcttttggct
       61 ttctgggttc atggaactgc tggacccagc acagctggtg agctctgagt gcctgtgagt
      121 gggtgagagg gagatagtaa aggataagaa agagaaacgg agagaagata ggcggggatt
      181 tttgagcact tgggattgga actgagagaa agaactgtta gcagggggag aaagactgcg
      241 acagtcacag acaatgagag gagtctagga agatagggag aaagaagaaa aggaaggaag
      301 gagagaggaa ggagagaagg ggagttacaa aaagagatca aaagaaaaga aaaggacaca
      361 gagagaggct cagggaagac ctcaacaatc caagctgcca gtaatgggcg ctaagagagt
      421 cactgtcaga ggtgcccgga caagcccaat acacagaacg tccagtttga ctcccctgct
      481 gctcatggga atgctgacct caggcctggc cgagtcgcca gtccccacct cagcacctca
      541 aggcttctgg gctctgtctg aaaacctgac tgcggtggaa gggacaacag ttaagctatg
      601 gtgcggtgtc agggcccctg gcagtgtggt gcagtgggct aaggatgggc tgcttctggg
      661 tccaaacccg aagatgccag gcttcccgag gtacagcctg gaaggagatc gtgctaaagg
      721 cgagttccac ctgcttattg aagcctgtga cctcagtgat gacgcagagt atgaatgcca
      781 agtcggccgc tcagagttgg gtcccgagct tgtgtctcct aaagtaatcc tctccattct
      841 agtttccccc aaggtgcttc tgttgacccc cgaggcagga agcacagtga cctgggtagc
      901 tgggcaggag tatgtggtca cctgtgtgtc tggagatgca aaaccagcac ctgacatcac
      961 cttcatccag agtggacgaa ctatattgga cgtctcctcc aatgtgaatg agggatcaga
     1021 ggagaaactc tgcatcacag aggccgaagc cagggtgata ccccagagct cggataacgg
     1081 gcagttactg gtctgtgagg gttccaaccc agctttggac actcccataa aggcttcatt
     1141 caccatgaat attctgtttc ccccaggacc tcctgtcatt gattggccag gcctgaatga
     1201 ggggcatgtg agggcagggg agaacctgga gctgccctgc acagccagag gtggcaatcc
     1261 acctgctacc ctgcagtggc tgaagaacgg taaaccagtg tccacagcct ggggcaccga
     1321 gcatgcccag gcagtggccc acagcgtgct ggtgatgact gtacgacctg aagaccatgg
     1381 agctcggctc agctgtcagt cctacaacag cgtgtctgca gggacccagg agagaagcat
     1441 cacactacag gtcacctttc ccccaagcgc cattaccatc ctgggatctg tatcacaatc
     1501 ggagaacaag aacgtgaccc tttgctgcct gaccaagtcc agtcgcccac gggtcctgct
     1561 gcgatggtgg ttgggtggac ggcagctgct gcccacagat gagacagtca tggatggcct
     1621 gcatggtggc cacatctcca tgtccaatct cacattcttg gtgcggagag aagacaatgg
     1681 cctgcccctc acctgtgaag ccttcagtga cgccttcagc aaggagacct tcaagaagtc
     1741 actcaccttg aatgtgaaat accctgccca gaagctgtgg attgaggggc ccccagaggg
     1801 acagtacatc cggactggga ctcgggtgag gctggtatgc ttggccatcg gaggcaaccc
     1861 agacccctcc ctcatctggt ttaaggattc acgtccggtg agcgagcccc ggcagcccca
     1921 ggagccccgg cgtgtgcagc tgggcagtgt ggagaagtcc gggagcactt tctcccgcga
     1981 gctggtgttg atcataggtc cgccggacaa ccgagccaag ttctcctgca aggcgggtca
     2041 gctcagtgcg tctacgcagc tggtggtgca gttcccccca accaacctga ccatcctggc
     2101 caactcgtcc gcgctgcgcc caggcgacgc cttgaacttg acctgcgtca gcatcagcag
     2161 caacccccca gtcaacttgt cttgggacaa ggaaggagag aggctggaag atgtggctgc
     2221 aaaaccccag agtgcaccgt tcaaaggctc cgctgcatcc aggagtgttt ttctcagagt
     2281 gtcatcccga gaccacggtc aacgggtcac ctgccgggcc cacagcgagg cactccgtga
     2341 aaccgtgagc tccttctacc gcttcaatgt gctgtatcct ccagaattcc tgggggagca
     2401 agtccgggca gtgaccgtgg tggagcaggg ccaggtgctg ctgccggtgt cggtgtccgc
     2461 taaccccgcc cccgaggcct tcaactggac cttccgaggc taccgcctca gcccagctgg
     2521 gggtccccgg caccgtatcc tgtctggagg ggctctgcag ctgtggaatg tgacccgagc
     2581 tgacgatggc ttttatcagc tgcactgcca gaactcagag ggcaccgctg aggcgctgtt
     2641 gaagctggac gtgcattatg ctcccaccat ccgtgccctc cgggacccta ctgaggtgaa
     2701 tgttgggggt tctgtggaca tagtctgcac cgttgacgcc aatcccatcc tcccagagat
     2761 gttcagctgg gagagactgg gagaagaaga ggaggatctg aacctggacg acatggagaa
     2821 agtttccaag ggatccacgg ggcgtctgcg gattcgccaa gccaagctat cccaggctgg
     2881 tgcctaccag tgcatcgtgg acaatggggt ggctcctgca gccagaggac tggttcgtct
     2941 tgtcgtccga tttgctcccc aggtggatca gcctactccc ctaacaaaag tggctgccgc
     3001 tggggacagc accagctcag ccacactgca ctgccgtgcc cggggtgtcc ccaacatcga
     3061 cttcacttgg accaaaaacg gggtccctct ggatctccaa gaccccaggt acacagagca
     3121 caggtaccac cagggtgttg tccacagcag cctcttgacc atcgctaatg tgtctgcggc
     3181 ccaggactat gccctcttca aatgcacggc caccaatgcc cttggctctg accacaccaa
     3241 catccagctc gtcagcatca gccgccctga ccctccactg ggactgaagg ttgtcagcat
     3301 aagccctcac tcggtggggc tggagtggaa gcctggcttt gatgggggtc tgcctcagag
     3361 gttccaaatc aggtacgagg ccctcgagac cccaggattc ctccacgtgg atgtcctacc
     3421 tacacaggcc actaccttca cgctgactgg gctgaagcct tctacacgat ataggatctg
     3481 gctgttggcc agcaatgccc tgggggacag tggattgacg gacaagggga tccaggtctc
     3541 cgtcactacc ccaggccccg accaggctcc tgaagacaca gaccaccagc tgcccacaga
     3601 gctgcctcca ggacccccaa ggctgcccct gctgcctgtg ctctttgcag ttggtggtct
     3661 tctgctgctc tccaatgcct cctgtgttgg gggtctcctc tggcggagaa gactgaggcg
     3721 ccttgctgag gagatctcag agaagacaga ggcagggtcg gaggacagga tcaggaatga
     3781 atatgaggag agtcagtgga ctggggaccg ggacacgaga agctccacgg ttagcacagc
     3841 agaagtggac ccaaattact actccatgag ggacttcagc ccccagcttc ccccaacact
     3901 ggaggaggtg ctgtatcacc aaggtgctga aggcgaggac atggccttcc ccggacacct
     3961 gcatgatgaa gtggagagag cctatggccc gcctggggcc tggggacccc tctatgatga
     4021 agtacgaatg gacccctatg accttcgctg gcctgaggtc cagtgtgagg atccgagggg
     4081 aatctacgac caggtggcag cagacatgga tgctgtggaa gctagctctc tgccgtttga
     4141 gctgagggga catctggtgt gagacgcttc acaacacccg tttcctacag ccctggagaa
     4201 gatgtgaggg gatgtgttca agtgacaaga ggactcaggc tgacatctgg gatgaccaag
     4261 actcctttaa ttggaatggg cttctctgaa gagacaaagt catttggaaa cgacatttgg
     4321 acaatggaaa tccactttag ggggtcatta tacttttcag aagtaaaatt tttagatgta
     4381 ggaaagactc attaaaaatc ctgttccaag cctggggatg agcccagtgg gagtcctgcc
     4441 attacacaca cacacacaca cacacacaca cacacacaca cacacacaca cagagctgta
     4501 catgctggcc catcactgtc attccagctc tgcaggaagc tgagagagga gaagcacaag
     4561 aacaaagtca ctgaatattt agaggctgga aagatggctc agaagttgaa gctctaacag
     4621 cagtcactgc tcttgcagag gacccgagtt tggttctcag cacccaaatc aggtaaccga
     4681 caatgacatc tgcatcccca gggaatctga tgcttctttc ttctgatctc catgggcaga
     4741 tgcacttatg tgcacatacc cacacataga aacacacata tacgcacaat taaaaataaa
     4801 ataaatccaa ctgtatggtg acccacacct ttaatcctag cacttgagaa gtagaagcag
     4861 ggggatttct ataagtttga ggcttataac ttagtgagtt ctgagatcca tagtgaaacc
     4921 ctgactcaaa acaaataata atttttaaaa cgtcagaatt aaaaggggcg tggctcagtg
     4981 gtaaagcccc tgtctagaat cccccagtga gggactgggg gcgtggctca gtggtagagc
     5041 ccctgcctag aatcccccaa tgagggattg ggggcgtggc tcagtggtag agcccctgcc
     5101 tagaatcccc cagtgagggg ctgggggcgt ggctcagtgg taaagctctt gcctggcatg
     5161 cacaagaatc tgaattctat ccctagtatc caaaagaaca agacaaaggc tccagtttat
     5221 tttaagatca gttacatctg aaatagttaa tattattaag caaaattata gaccatgtca
     5281 gatcttagct gttttttgtt ttatcttcca cagtttgtga aacatatatg cactgacacg
     5341 caaacaggaa cagattgtag caaagggatg aagttatgag agaatgaaca cttgccattt
     5401 tatttatggg cgtagcttag ggaccatgca ctggtgtata cttagaatta aagggtatgg
     5461 tagctttaat tcattttcaa aattttaaaa aatgcacatt tatagagaca gaaaagggta
     5521 agctcagact caaatgttga cactggatgt ggttagcgca gaatgaaaat taaaattgaa
     5581 gagttgatgt aataataaat gatgacgtca cagaagcaag aacgtgattg gcggctagga
     5641 cttaggggct gtggaattct agatgtcaca ctttggaaaa taatctacat cacacttatt
     5701 tgcgcgtgtg tgcgtgtgtg tgtgtccaca cgcatgtgcg atgtgtgcat gcttatgcgc
     5761 ctgacagtgt acgccacaca aaataaataa aatgtaaaca ttaaaaaaaa aaaaaaaaaa
//
