LOCUS       NM_001191882            4413 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus nephrocystin 3 (Nphp3), mRNA.
ACCESSION   NM_001191882 XM_343461
VERSION     NM_001191882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4413)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   2  (bases 1 to 4413)
  AUTHORS   Yamaguchi,T., Lysecki,C., Reid,A., Nagao,S. and Aukema,H.M.
  TITLE     Renal cyclooxygenase products are higher and lipoxygenase products
            are lower in early disease in the pcy mouse model of adolescent
            nephronophthisis
  JOURNAL   Lipids 49 (1), 39-47 (2014)
   PUBMED   24178445
REFERENCE   3  (bases 1 to 4413)
  AUTHORS   Ghosh,A.K., Hurd,T. and Hildebrandt,F.
  TITLE     3D spheroid defects in NPHP knockdown cells are rescued by the
            somatostatin receptor agonist octreotide
  JOURNAL   Am J Physiol Renal Physiol 303 (8), F1225-F1229 (2012)
   PUBMED   22832925
REFERENCE   4  (bases 1 to 4413)
  AUTHORS   Nakata,K., Shiba,D., Kobayashi,D. and Yokoyama,T.
  TITLE     Targeting of Nphp3 to the primary cilia is controlled by an
            N-terminal myristoylation site and coiled-coil domains
  JOURNAL   Cytoskeleton (Hoboken) 69 (4), 221-234 (2012)
   PUBMED   22328406
REFERENCE   5  (bases 1 to 4413)
  AUTHORS   Wright,K.J., Baye,L.M., Olivier-Mason,A., Mukhopadhyay,S., Sang,L.,
            Kwong,M., Wang,W., Pretorius,P.R., Sheffield,V.C., Sengupta,P.,
            Slusarski,D.C. and Jackson,P.K.
  TITLE     An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the
            primary cilium
  JOURNAL   Genes Dev 25 (22), 2347-2360 (2011)
   PUBMED   22085962
REFERENCE   6  (bases 1 to 4413)
  AUTHORS   Bergmann,C., Fliegauf,M., Bruchle,N.O., Frank,V., Olbrich,H.,
            Kirschner,J., Schermer,B., Schmedding,I., Kispert,A., Kranzlin,B.,
            Nurnberg,G., Becker,C., Grimm,T., Girschick,G., Lynch,S.A.,
            Kelehan,P., Senderek,J., Neuhaus,T.J., Stallmach,T., Zentgraf,H.,
            Nurnberg,P., Gretz,N., Lo,C., Lienkamp,S., Schafer,T., Walz,G.,
            Benzing,T., Zerres,K. and Omran,H.
  TITLE     Loss of nephrocystin-3 function can cause embryonic lethality,
            Meckel-Gruber-like syndrome, situs inversus, and
            renal-hepatic-pancreatic dysplasia
  JOURNAL   Am J Hum Genet 82 (4), 959-970 (2008)
   PUBMED   18371931
REFERENCE   7  (bases 1 to 4413)
  AUTHORS   Hoefele,J., Wolf,M.T., O'Toole,J.F., Otto,E.A., Schultheiss,U.,
            Deschenes,G., Attanasio,M., Utsch,B., Antignac,C. and
            Hildebrandt,F.
  TITLE     Evidence of oligogenic inheritance in nephronophthisis
  JOURNAL   J Am Soc Nephrol 18 (10), 2789-2795 (2007)
   PUBMED   17855640
REFERENCE   8  (bases 1 to 4413)
  AUTHORS   Olbrich,H., Fliegauf,M., Hoefele,J., Kispert,A., Otto,E., Volz,A.,
            Wolf,M.T., Sasmaz,G., Trauer,U., Reinhardt,R., Sudbrak,R.,
            Antignac,C., Gretz,N., Walz,G., Schermer,B., Benzing,T.,
            Hildebrandt,F. and Omran,H.
  TITLE     Mutations in a novel gene, NPHP3, cause adolescent
            nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
  JOURNAL   Nat Genet 34 (4), 455-459 (2003)
   PUBMED   12872122
REFERENCE   9  (bases 1 to 4413)
  AUTHORS   Ebihara,I., Nakamura,T., Takahashi,T., Yamamoto,M., Tomino,Y.,
            Nagao,S., Takahashi,H. and Koide,H.
  TITLE     Altered extracellular matrix component gene expression in murine
            polycystic kidney
  JOURNAL   Ren Physiol Biochem 18 (2), 73-80 (1995)
   PUBMED   7539536
REFERENCE   10 (bases 1 to 4413)
  AUTHORS   Aukema,H.M., Yamaguchi,T., Takahashi,H., Celi,B. and Holub,B.J.
  TITLE     Abnormal lipid and fatty acid compositions of kidneys from mice
            with polycystic kidney disease
  JOURNAL   Lipids 27 (6), 429-435 (1992)
   PUBMED   1385849
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_343461.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.21113.1,
                                           SRR26643297.29673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               JAXUCZ010000008.1  113500708-113501088
            382-507             JAXUCZ010000008.1  113502668-113502793
            508-658             JAXUCZ010000008.1  113503699-113503849
            659-811             JAXUCZ010000008.1  113506826-113506978
            812-945             JAXUCZ010000008.1  113507814-113507947
            946-1106            JAXUCZ010000008.1  113510835-113510995
            1107-1263           JAXUCZ010000008.1  113515755-113515911
            1264-1338           JAXUCZ010000008.1  113516482-113516556
            1339-1512           JAXUCZ010000008.1  113518520-113518693
            1513-1616           JAXUCZ010000008.1  113521241-113521344
            1617-1731           JAXUCZ010000008.1  113521760-113521874
            1732-1875           JAXUCZ010000008.1  113523158-113523301
            1876-1973           JAXUCZ010000008.1  113523920-113524017
            1974-2076           JAXUCZ010000008.1  113524733-113524835
            2077-2159           JAXUCZ010000008.1  113525759-113525841
            2160-2298           JAXUCZ010000008.1  113527567-113527705
            2299-2463           JAXUCZ010000008.1  113529346-113529510
            2464-2558           JAXUCZ010000008.1  113531213-113531307
            2559-2681           JAXUCZ010000008.1  113532440-113532562
            2682-2868           JAXUCZ010000008.1  113533731-113533917
            2869-3110           JAXUCZ010000008.1  113534063-113534304
            3111-3186           JAXUCZ010000008.1  113535630-113535705
            3187-3314           JAXUCZ010000008.1  113536705-113536832
            3315-3555           JAXUCZ010000008.1  113537550-113537790
            3556-3681           JAXUCZ010000008.1  113538811-113538936
            3682-3797           JAXUCZ010000008.1  113539864-113539979
            3798-4413           JAXUCZ010000008.1  113540564-113541179
FEATURES             Location/Qualifiers
     source          1..4413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4413
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /note="nephrocystin 3"
                     /db_xref="GeneID:363126"
                     /db_xref="RGD:1563856"
     CDS             1..3978
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /note="nephronophthisis 3 (adolescent)"
                     /codon_start=1
                     /product="nephrocystin-3"
                     /protein_id="NP_001178811.1"
                     /db_xref="GeneID:363126"
                     /db_xref="RGD:1563856"
                     /translation="MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRSS
                     FRRGAGAGPGSLPRAAGAGGLLGASFKSTGSSVPELEYAAAEFERLKKEYEIFRVSKN
                     QELLSMGRREAKLDTENKRLRAELQVLQKTYQKILREKEGALEAKYQAMERAVTFEHD
                     RDRVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNGADV
                     TAAGTQCEYWASRALGSEHSIDSMIQLQQPFRGPEFAHSSIDVEGPFANINRDDWDAA
                     VAGLLQATPLFSHSLWCHPVRCYLIYSEETQPEMELFLKDHSPKLKRMCETMGYFFHA
                     VYFPIDVENQYLTLRKWEIEKSSLVILFLHSTLPSFLLEDCEEAFLQNPEGKLRLIYH
                     RLEDGKATSDSVQRLLDQVSNLSETTKAKIIEHSGDLSEGVYKIYMGVEKIIKQDILG
                     LENTDVEVKDGGSEDSSPEEDDFGDVLWDVHDEQEQIEAFQRASSSAHELGFEKYYQR
                     LDDLVVAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKHFPNTLILSHFVGRPMSSSSE
                     SSLIIKRLTLKLMQHFWAVSALTLDPAKLLEEFPHWLEKLSARHQGSIIIIIDSIDQV
                     QQVEKHMKWLIDPLPVNVRVIVSVNVETCPTAWRLWPTLHLDPLSPKDAISMITAECH
                     SVDVQLNREQEKMLEQHCRPATTRHALYVTLFSKMLACAGRAGDLAETLHRCLQCQDT
                     MSLYRLVLHHVRESMPSDKEKEWMTQILCLINVSHNGVSESELMELYPEMSWASLTSI
                     VHSLHKMHLLTYSCGLLRFQHLQAWETVRQAYMEDPALVSSYRQKLIDYFTSQLSQDR
                     VTWRSADELPWLFQQQGSKQKLHSCLLNLFVSQNLYKRGHFAELLSYWQFVGKDKSAM
                     ATEYFESLKQYENCEGEENMLCLADLYETLGRFLKDLGLLSQAVVPLQRSLEIRETAL
                     DPDHPRVAQSLHQLAGVYVQWKKFSDAEQLYKQALEISENAYGADHPHAARELEALAT
                     LYHKQNKYEQAERFRKKSVIIRQQATRRKGSLYGFALLRRRALQLEELTLGKDKPENA
                     RTLNELGVLYYLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNERKQY
                     ARAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKTGRVDKAVPLYELAVEIRQK
                     SFGPKHPSVATALVNLAVLHSQMKKHSEALPLYERALKIYEDSLGRMHPRVGETLKNL
                     AVLSYEEGNFEKAAELYKRAMEIKEAETSLLGGKAPSRQSSSGDTLLFKTTHSPNVFL
                     PQGQS"
     exon            1..381
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            382..507
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            508..658
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            659..811
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            812..945
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1106
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1263
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1338
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1512
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1616
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1731
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1875
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1973
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2076
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2159
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2298
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2463
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2558
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2681
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2868
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3110
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3186
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3314
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3555
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3681
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3797
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..4413
                     /gene="Nphp3"
                     /gene_synonym="RGD1563856"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcacag cctcgtcgtt ggtgagcccc gctggtgggg aggtgatcga ggacacgtac
       61 ggggcaggcg gcggcgaggc ctgcgagatc ccggtggaag tgaagcccaa ggctcgcctg
      121 ctgcgtagct cgttccgcag gggcgcggga gccgggcccg ggtcgctgcc tcgggcggcg
      181 ggggccggcg ggctgctggg cgccagcttc aagtccaccg gctcgtctgt gcccgagcta
      241 gagtatgcgg cggccgagtt cgagcggctc aagaaagagt acgagatctt ccgggtcagc
      301 aagaaccagg agttgctgtc catgggtcgc cgagaggcca agctggacac ggagaacaag
      361 cggctgcggg cggagctgca ggtacttcag aaaacttacc agaagatact tcgggaaaaa
      421 gagggtgcat tagaagcaaa ataccaagcc atggagagag cagtcacatt tgaacacgat
      481 agagacaggg ttaaaaggca attcaagatt tttagggaga ccaaagaaaa tgaaattcag
      541 gacttgctga gggccaagcg agagctggag agcaaacttc agaggctgca ggcccagggg
      601 atccaggtgt ttgaccctgg ggagtctgac tccgatgaca acggcgccga tgtcactgct
      661 gccggaaccc aatgtgaata ctgggccagc agagccctgg gcagcgagca ttccatagac
      721 agcatgatcc agcttcagca gcctttcaga ggtcccgagt ttgcccacag ttccatagat
      781 gtggaaggac ccttcgcaaa catcaaccga gatgactggg acgctgctgt ggctggttta
      841 ttacaagcca cccccttgtt ctcacattcc ctgtggtgtc acccagtcag atgttacctc
      901 atctattcag aggaaaccca gcccgaaatg gaacttttcc ttaaggacca ttcacctaaa
      961 cttaaaagaa tgtgcgagac aatgggatac ttcttccatg ctgtttattt tccaatagat
     1021 gttgaaaatc agtaccttac tctaagaaaa tgggagattg agaagagttc tttagttatt
     1081 ttattccttc actcgacatt accaagtttt ttactggaag actgtgaaga agcctttctg
     1141 caaaacccag aaggaaaact acgattaatc taccaccgtt tggaggacgg gaaagccact
     1201 tccgactctg tccagcggtt actggatcag gtttctaacc taagcgagac cactaaagcc
     1261 aagataatcg aacactctgg agatctctca gagggagtgt ataagattta catgggtgtg
     1321 gaaaagatta tcaaacagga catccttggc ctcgagaaca cagacgtgga ggtgaaggat
     1381 gggggcagtg aggattccag tccagaagaa gatgattttg gggatgttct gtgggacgta
     1441 cacgacgagc aagaacagat agaagccttt cagcgggctt ctagctccgc ccacgaactg
     1501 ggatttgaga agtattacca gcgcctggat gatctggtgg tggcgccagc cccgatccca
     1561 ccactcctgg tttctggagg accaggttct ggaaagtccc ttcttttatc aaagtggatt
     1621 cagctgcagc agaagcattt ccctaacact ctgatcctgt ctcattttgt ggggaggcca
     1681 atgtcatcca gctcagagtc ctccttgatt atcaagcgtc tgactctgaa gctgatgcag
     1741 cacttctggg cagtttctgc actgacgctg gatcctgcca agctcctgga ggaatttcca
     1801 cactggctgg agaagctctc cgctcggcat cagggcagca tcatcatcat catcgactcc
     1861 atagaccaag ttcagcaagt ggagaagcac atgaagtggc tgatcgaccc cctgccggtg
     1921 aatgtcagag tcattgtttc cgtgaatgtg gagacctgcc ctaccgcctg gaggttgtgg
     1981 cctactctgc atctcgaccc tttaagcccc aaagacgcca tatctatgat aacggcagaa
     2041 tgccactccg tggacgttca gttgaacaga gaacaggaga agatgctaga acagcactgc
     2101 cgtccagcca cgacccgcca cgccctctac gtcacccttt tcagcaagat gctggcctgt
     2161 gccgggagag cgggtgactt agctgaaacc cttcatcgat gcctgcagtg tcaggataca
     2221 atgtcgctgt acagactcgt tctccaccac gtccgggagt ccatgccaag tgacaaggaa
     2281 aaagaatgga tgacacagat tctctgcctc atcaacgtta gtcacaatgg cgtgagtgag
     2341 tccgagctga tggaactgta tccagagatg tcctgggcct ctttgacctc cattgttcac
     2401 agtttacaca aaatgcacct gctgacctac agctgtggcc tgctcaggtt tcaacatcta
     2461 caggcctggg aaacagtgag gcaggcgtac atggaagacc ccgccctcgt ttcctcttat
     2521 aggcaaaagc tgattgacta ttttacctca cagctcagtc aggacagagt gacctggaga
     2581 agcgcagatg agctcccgtg gctgttccag cagcagggga gcaaacagaa gctgcacagc
     2641 tgcctcctca atctcttcgt gtctcagaac ctctacaaaa gaggacactt cgccgagttg
     2701 ctgagttact ggcagtttgt tggcaaagac aaaagcgcca tggcgaccga gtactttgag
     2761 tcactgaagc agtatgagaa ctgcgagggc gaggagaaca tgctgtgctt agccgacctg
     2821 tacgaaactc tcggccggtt tctcaaggac ctaggacttc tcagccaggc cgtggtgcct
     2881 ttgcagaggt ccctagaaat tcgggagaca gccttagatc ccgatcaccc gagagtagcc
     2941 cagtccctcc accagctggc cggtgtgtac gtgcagtgga agaagttcag cgatgccgag
     3001 cagctgtaca aacaggccct ggagatctca gagaacgcct acggtgcgga ccatccacac
     3061 gctgcccgtg aacttgaggc gcttgcgact ttgtaccaca aacaaaataa gtatgaacaa
     3121 gctgaacgtt ttaggaaaaa gtcggttata atccgtcagc aagcgacgag gcgaaaaggc
     3181 agtctgtacg ggtttgccct actacgcagg cgggctctgc agttggaaga gctcacctta
     3241 ggcaaggaca agcccgagaa tgcccgcacc ctcaacgaac tgggtgtcct ctactacctt
     3301 caaaacaatc ttgagacagc agagcagttt ctgaagcgct ccctggaaat gagggagcgg
     3361 gtcctgggac cagatcatcc agactgcgcg cagtccctga ataacctggc cgcgctgtgc
     3421 aatgaaagga agcagtacgc tagagcagag gagctgtatg agcgagccct ggacatccgg
     3481 aggcgagcgc tggctcctga ccacccttcc ctggcctaca cagtgaagca ccttgcaatc
     3541 ttgtataaga aaacgggaag agttgacaaa gctgtacctc tgtatgaatt ggctgttgaa
     3601 attcggcaga aatcctttgg cccaaagcac cccagtgtag ccactgcctt ggtaaacttg
     3661 gcagtccttc atagccaaat gaaaaagcac agcgaagccc tgccgctcta tgaaagagcc
     3721 ttaaagattt acgaagatag cttgggacgg atgcatccta gagttggaga aacattaaaa
     3781 aacttagctg tgctcagcta tgaagaaggg aattttgaaa aggctgctga actgtacaaa
     3841 agggcgatgg aaattaaaga agcagagaca tcacttttgg gtggaaaagc tccttcaagg
     3901 cagtcatcaa gtggagacac gcttctcttt aaaacaactc attctcctaa cgttttcctt
     3961 ccccaaggac aaagctaact gtcaattctt tgcaagaata cttccggctc aaacaactaa
     4021 acatctggaa cactctaact caaaacttaa tgtttttata gaaaaatcat ttttgcaaca
     4081 tcagcagtgt tgtttaactg gcgtttgtat gatgtattga attgttgtgc caagtgtaaa
     4141 ttgattaaag aacctggttc ctatgggatg agatccagga tgaagacatc agcattcagt
     4201 ggcatgagga gtggcttggt ctctgaaaca agagctggca ggatcccatg gtttaagaat
     4261 tccacggttc ttttcctccc tcaagagcct tagttagccc tgttgtttat tgtctgttcc
     4321 tagcagggct ctgagccagc tctctacctc aaagaacttt caagggctac atgtgagggt
     4381 cagaggtcag ccttggatat cattcctcag gtg
//
