LOCUS       NM_023980               1665 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuropeptide FF receptor 2 (Npffr2), transcript
            variant 1, mRNA.
ACCESSION   NM_023980
VERSION     NM_023980.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Lin,Y.T., Yu,Y.L., Hong,W.C., Yeh,T.S., Chen,T.C. and Chen,J.C.
  TITLE     NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in
            Rodents
  JOURNAL   Int J Mol Sci 18 (8), 1810 (2017)
   PUBMED   28825666
  REMARK    GeneRIF: we demonstrate, for the first time, that NPFFR2 positively
            modulates the HPA axis via hypothalamic corticotropin-releasing
            factor (CRF). Our finding that NPFFR2 regulates stress-dependent
            neural pathways advances our understanding of neuroendocrine
            regulation and opens new avenues for probing the functions of NPFF.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Gouarderes,C., Puget,A. and Zajac,J.M.
  TITLE     Detailed distribution of neuropeptide FF receptors (NPFF1 and
            NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset
            monkey brains: a comparative autoradiographic study
  JOURNAL   Synapse 51 (4), 249-269 (2004)
   PUBMED   14696013
  REMARK    GeneRIF: The distribution pattern of NPFF2 receptors in the
            diencephalon and the superficial layers of the spinal cord is
            consistent with a hypothesized potential role for NPFF in the
            modulation of sensory input and opioid analgesia.
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Gouarderes,C., Quelven,I., Mollereau,C., Mazarguil,H., Rice,S.Q.
            and Zajac,J.M.
  TITLE     Quantitative autoradiographic distribution of NPFF1 neuropeptide FF
            receptor in the rat brain and comparison with NPFF2 receptor by
            using [125I]YVP and [(125I]EYF as selective radioligands
  JOURNAL   Neuroscience 115 (2), 349-361 (2002)
   PUBMED   12421602
  REMARK    GeneRIF: In contrast to the rat spinal cord where the NPFF(1)
            system is absent, there is no strict separation between NPFF(1) and
            NPFF(2) system at the supraspinal level.
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Bonini,J.A., Jones,K.A., Adham,N., Forray,C., Artymyshyn,R.,
            Durkin,M.M., Smith,K.E., Tamm,J.A., Boteju,L.W., Lakhlani,P.P.,
            Raddatz,R., Yao,W.J., Ogozalek,K.L., Boyle,N., Kouranova,E.V.,
            Quan,Y., Vaysse,P.J., Wetzel,J.M., Branchek,T.A., Gerald,C. and
            Borowsky,B.
  TITLE     Identification and characterization of two G protein-coupled
            receptors for neuropeptide FF
  JOURNAL   J Biol Chem 275 (50), 39324-39331 (2000)
   PUBMED   11024015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NM_023980.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF268900.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA5760389,
                                    SAMN14984033 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000014.1  18841940-18842186   c
            248-582             JAXUCZ010000014.1  18805706-18806040   c
            583-682             JAXUCZ010000014.1  18802396-18802495   c
            683-1665            JAXUCZ010000014.1  18797234-18798216   c
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1665
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /note="neuropeptide FF receptor 2"
                     /db_xref="GeneID:78964"
                     /db_xref="RGD:620168"
     exon            1..247
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            248..582
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1508
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /note="G-protein coupled receptor 74; neuropeptide
                     G-protein coupled receptor"
                     /codon_start=1
                     /product="neuropeptide FF receptor 2"
                     /protein_id="NP_076470.1"
                     /db_xref="GeneID:78964"
                     /db_xref="RGD:620168"
                     /translation="MGKRWDSNSSGSWDHIWSGNDTQHPWYSDINITYMNYYLHQPHV
                     TAVFISSYFLIFFLCMVGNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPIT
                     LLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTA
                     FVMIVIIWGLAITIMTPSAIMLHVQEEKYYRVRLSSHNKTSTVYWCREDWPNQEMRRI
                     YTTVLFATIYLAPLSLIVIMYARIGASLFKTSAHSTGKQRLEQWHVSKKKQKVIKMLL
                     TVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVYPFAHWLAFCNSSVNPIIYGF
                     FNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVHEPASQNPSGENLGC
                     RKSADNPTQESLMEETGEATNSTET"
     exon            583..682
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1665
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; Npff2; Npgpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagctgct ctgtgactaa ccagcagctg gcccccttgc gatcctgaga gtgaagcccg
       61 ggagcaagag cggaggagag tgcagagccg ccgcgccagc ctcgctgcca ggggagatgg
      121 ctagccagtc tcacctaggt cacctggtag agcagaggtg ccggtgaccc agacagaacc
      181 agttgctcag gctccgctcg gctcctgttt tcaacactac tgggactctg cccttcctca
      241 ggagcgggtc caccatgggc aagagatggg actcaaactc ttcaggaagc tgggatcaca
      301 tctggagtgg caatgacaca cagcatcctt ggtattcaga tatcaacatc acatacatga
      361 actactatct ccaccagccc cacgtgacag ctgtcttcat tagctcctac ttcctgatct
      421 tcttcctgtg catggtggga aacactgtcg tttgctttgt tgtaataagg aataggtaca
      481 tgcacacggt cactaatttc ttcatcttca acctcgcaat aagtgactta ctggttggaa
      541 tattctgcat gcctatcaca ttgctggaca acatcatagc aggatggccg tttggaagca
      601 gcatgtgcaa gatcagcggg ctggtgcaag ggatatcggt tgccgcttct gtcttcacct
      661 tggttgccat agccgtggac agattccggt gtgtggtcta cccctttaag cccaagctca
      721 ctgtcaagac agcctttgtc atgatcgtga tcatctgggg cctggccatc accattatga
      781 ccccatctgc aatcatgtta catgtacagg aagaaaaata ctaccgtgtg aggctcagct
      841 cccacaataa aaccagcaca gtctactggt gtcgggagga ttggccaaac caggaaatga
      901 ggaggatcta caccaccgtg ctctttgcca ctatctacct ggctccactc tccctcattg
      961 ttatcatgta tgcaaggatt ggggcttccc tcttcaagac ctcagcacac agcacaggta
     1021 agcagcgcct ggagcagtgg catgtatcca agaagaaaca gaaggtcatc aagatgctgc
     1081 tgactgtggc cctccttttc atcctttcct ggcttcccct gtggactctg atgatgctct
     1141 cagactatgc tgacctgtca cctaacaaac tacgtgtcat caatatttat gtctaccctt
     1201 ttgcccactg gctcgccttc tgcaatagca gtgtcaaccc catcatttat ggtttcttta
     1261 atgaaaattt tcgcagtggt ttccaagatg ctttccagtt ctgccaaaag aaagtcaaac
     1321 cccaggaagc ctatggccta agagctaaac gcaacctgga cataaacaca tctggcctgt
     1381 tggtccatga acctgcatct caaaacccaa gtggggaaaa cttgggatgt agaaaaagtg
     1441 cagacaatcc cacacaggaa tccttgatgg aggaaacggg agaagctacc aacagtactg
     1501 agacttagaa agatagtatg ctatccaatg ttatatagca tacgagtgtg aatgtgtctt
     1561 taaatatggt ggcttgtcgt ggctttccat ttctcatatt ctgatgaaaa catttactga
     1621 aggccctctt tgtcaaaaat aaaagtatga aagtggtctt tctaa
//
