LOCUS       NM_022291               1307 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus neuropeptide FF receptor 1 (Npffr1), mRNA.
ACCESSION   NM_022291
VERSION     NM_022291.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Jorgensen,S.R., Andersen,M.D., Overgaard,A. and Mikkelsen,J.D.
  TITLE     Changes in RFamide-related peptide-1 (RFRP-1)-immunoreactivity
            during postnatal development and the estrous cycle
  JOURNAL   Endocrinology 155 (11), 4402-4410 (2014)
   PUBMED   25144921
  REMARK    GeneRIF: Adult females, as compared with males, have significantly
            more RFRP-1-ir per cell, and these cells are regulated during the
            estrous cycle.
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Gojska,N.M. and Belsham,D.D.
  TITLE     Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and
            Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons
  JOURNAL   Mol Cell Endocrinol 384 (1-2), 23-31 (2014)
   PUBMED   24412804
  REMARK    GeneRIF: Rfrp (GnIH)-expressing neurons serve as potential upstream
            mediators of stress-induced effects through Gpr147
            (GnIH-R)-dependent mechanisms.
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Sukhbaatar,U., Kanasaki,H., Mijiddorj,T., Oride,A. and Miyazaki,K.
  TITLE     Expression of gonadotropin-inhibitory hormone receptors in mouse
            pituitary gonadotroph LbetaT2 cells and hypothalamic
            gonadotropin-releasing hormone-producing GT1-7 cells
  JOURNAL   Endocr J 61 (1), 25-34 (2014)
   PUBMED   24088662
  REMARK    GeneRIF: two central controllers of reproductive function,
            gonadotropin-releasing hormone (GnRH) and kisspeptin, stimulate the
            expression of Gonadotropin-inhibitory hormone (GnIH) receptors in
            pituitary gonadotroph cells and hypothalamic GnRH neurons
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Kovacs,A., Laszlo,K., Galosi,R., Toth,K., Ollmann,T., Peczely,L.
            and Lenard,L.
  TITLE     Microinjection of RFRP-1 in the central nucleus of amygdala
            decreases food intake in the rat
  JOURNAL   Brain Res Bull 88 (6), 589-595 (2012)
   PUBMED   22691952
  REMARK    GeneRIF: RFRP-1 injected into the central nucleus of the rat
            amygdala decreases food intake. This is a NPFF-1 linked effect,
            because it could be prevented by NPFF-receptor antagonist RF9.
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Quennell,J.H., Rizwan,M.Z., Relf,H.L. and Anderson,G.M.
  TITLE     Developmental and steroidogenic effects on the gene expression of
            RFamide related peptides and their receptor in the rat brain and
            pituitary gland
  JOURNAL   J Neuroendocrinol 22 (4), 309-316 (2010)
   PUBMED   20136694
  REMARK    GeneRIF: Developmental and steroidogenic effects on the gene
            expression of RFamide related peptides and their receptor in the
            rat brain and pituitary gland.
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Gouarderes,C., Puget,A. and Zajac,J.M.
  TITLE     Detailed distribution of neuropeptide FF receptors (NPFF1 and
            NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset
            monkey brains: a comparative autoradiographic study
  JOURNAL   Synapse 51 (4), 249-269 (2004)
   PUBMED   14696013
  REMARK    GeneRIF: The constant presence of NPFF1 receptors in the septum,
            the nucleus of the tractus solitarius, and the hypothalamus suggest
            its participation in neuroendocrine functions.
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Bonini,J.A., Jones,K.A., Adham,N., Forray,C., Artymyshyn,R.,
            Durkin,M.M., Smith,K.E., Tamm,J.A., Boteju,L.W., Lakhlani,P.P.,
            Raddatz,R., Yao,W.J., Ogozalek,K.L., Boyle,N., Kouranova,E.V.,
            Quan,Y., Vaysse,P.J., Wetzel,J.M., Branchek,T.A., Gerald,C. and
            Borowsky,B.
  TITLE     Identification and characterization of two G protein-coupled
            receptors for neuropeptide FF
  JOURNAL   J Biol Chem 275 (50), 39324-39331 (2000)
   PUBMED   11024015
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Hinuma,S., Shintani,Y., Fukusumi,S., Iijima,N., Matsumoto,Y.,
            Hosoya,M., Fujii,R., Watanabe,T., Kikuchi,K., Terao,Y., Yano,T.,
            Yamamoto,T., Kawamata,Y., Habata,Y., Asada,M., Kitada,C.,
            Kurokawa,T., Onda,H., Nishimura,O., Tanaka,M., Ibata,Y. and
            Fujino,M.
  TITLE     New neuropeptides containing carboxy-terminal RFamide and their
            receptor in mammals
  JOURNAL   Nat Cell Biol 2 (10), 703-708 (2000)
   PUBMED   11025660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Apr 14, 2010 this sequence version replaced NM_022291.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2273217.1,
                                           SRR26360194.1717379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN14984027
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                JAXUCZ010000020.1  30082604-30082618
            16-330              JAXUCZ010000020.1  30102539-30102853
            331-430             JAXUCZ010000020.1  30110389-30110488
            431-1307            JAXUCZ010000020.1  30113121-30113997
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1307
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /note="neuropeptide FF receptor 1"
                     /db_xref="GeneID:64107"
                     /db_xref="RGD:621570"
     exon            1..15
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1307
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /note="G-protein coupled receptor 147; RFamide-related
                     peptide receptor OT7T022"
                     /codon_start=1
                     /product="neuropeptide FF receptor 1"
                     /protein_id="NP_071627.2"
                     /db_xref="GeneID:64107"
                     /db_xref="RGD:621570"
                     /translation="MEAEPSQPPNGSWPLGQNGSDVETSIATSLTFSSYYQHSSPVAA
                     MFIAAYVLIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLV
                     DNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALF
                     TIAVIWALALLIMCPSAVTLTVTREEHHFMLDARNRSYPLYSCWEAWPEKGMRKVYTA
                     VLFAHIYLVPLALIVVMYVRIARKLCQAPGPARDTEEAVAEGGRTSRRRARVVHMLVM
                     VALFFTLSWLPLWVLLLLIDYGELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYF
                     NENFRRGFQAAFRAQLCWPPWAAHKQAYSERPNRLLRRRVVVDVQPSDSGLPSESGPS
                     SGVPGPGRLPLRNGRVAHQDGPGEGPGCNHMPLTIPAWNI"
     exon            16..330
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     exon            331..430
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     exon            431..1307
                     /gene="Npffr1"
                     /gene_synonym="Gpr147; NPFF1; OT7T022"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacagtat ggaggcggag ccctcccagc ctcccaacgg cagctggccc ctgggtcaga
       61 acgggagtga tgtggagacc agcatagcaa ccagcctcac cttctcctcc tactaccaac
      121 actcctctcc ggtggcagcc atgttcatcg cggcctacgt gctcatcttc ctcctctgca
      181 tggtgggcaa caccctggtc tgcttcattg tgctcaagaa ccggcacatg cgcactgtca
      241 ccaacatgtt tatcctcaac ctggccgtca gcgacctgct ggtgggcatc ttctgcatgc
      301 ccacaaccct tgtggacaac cttatcactg gttggccttt tgacaacgcc acatgcaaga
      361 tgagcggctt ggtgcagggc atgtccgtgt ctgcatcggt tttcacactg gtggccatcg
      421 ctgtggaaag gttccgctgc atcgtgcacc ctttccgcga gaagctgacc cttcggaagg
      481 cgctgttcac catcgcggtg atctgggctc tggcgctgct catcatgtgt ccctcggcgg
      541 tcactctgac agtcacccga gaggagcatc acttcatgct ggatgctcgt aaccgctcct
      601 acccgctcta ctcgtgctgg gaggcctggc ccgagaaggg catgcgcaag gtctacaccg
      661 cggtgctctt cgcgcacatc tacctggtgc cgctggcgct catcgtagtg atgtacgtgc
      721 gcatcgcgcg caagctatgc caggcccccg gtcctgcgcg cgacacggag gaggcggtgg
      781 ccgagggtgg ccgcacttcg cgccgtaggg cccgcgtggt gcacatgctg gtcatggtgg
      841 cgctcttctt cacgttgtcc tggctgccac tctgggtgct gctgctgctc atcgactatg
      901 gggagctgag cgagctgcaa ctgcacctgc tgtcggtcta cgccttcccc ttggcacact
      961 ggctggcctt cttccacagc agcgccaacc ccatcatcta cggctacttc aacgagaact
     1021 tccgccgcgg cttccaggct gccttccgtg cacagctctg ctggcctccc tgggccgccc
     1081 acaagcaagc ctactcggag cggcccaacc gcctcctgcg caggcgggtg gtggtggacg
     1141 tgcaacccag cgactccggc ctgccatcag agtctggccc cagcagcggg gtcccagggc
     1201 ctggccggct gccactgcga aatgggcgtg tggcccatca ggatggcccg ggggaagggc
     1261 caggctgcaa ccacatgccc ctcaccatcc cggcctggaa catttga
//
