LOCUS       NM_080395               4126 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus aminopeptidase puromycin sensitive (Npepps),
            mRNA.
ACCESSION   NM_080395 XM_001074182 XM_001074205 XM_001081366 XM_340889
VERSION     NM_080395.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4126)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 4126)
  AUTHORS   Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y and Inui H.
  TITLE     Hypoxia enhances transcriptional activity of androgen receptor
            through hypoxia-inducible factor-1alpha in a low androgen
            environment
  JOURNAL   J Steroid Biochem Mol Biol 123 (1-2), 58-64 (2011)
   PUBMED   21056661
REFERENCE   3  (bases 1 to 4126)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 4126)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4126)
  AUTHORS   Ahmed F, Torrado M, Zinovieva RD, Senatorov VV, Wistow G and
            Tomarev SI.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   6  (bases 1 to 4126)
  AUTHORS   Hui M and Hui KS.
  TITLE     Neuron-specific aminopeptidase and puromycin-sensitive
            aminopeptidase in rat brain development
  JOURNAL   Neurochem Res 28 (6), 855-860 (2003)
   PUBMED   12718438
  REMARK    GeneRIF: a study of the levels in rat cerebellar development
REFERENCE   7  (bases 1 to 4126)
  AUTHORS   Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB,
            Kalbacher H, Stevanovic S, Rammensee HG and Schild H.
  TITLE     Two new proteases in the MHC class I processing pathway
  JOURNAL   Nat Immunol 1 (5), 413-418 (2000)
   PUBMED   11062501
REFERENCE   8  (bases 1 to 4126)
  AUTHORS   Beninga J, Rock KL and Goldberg AL.
  TITLE     Interferon-gamma can stimulate post-proteasomal trimming of the N
            terminus of an antigenic peptide by inducing leucine aminopeptidase
  JOURNAL   J Biol Chem 273 (30), 18734-18742 (1998)
   PUBMED   9668046
REFERENCE   9  (bases 1 to 4126)
  AUTHORS   Lee NH, Weinstock KG, Kirkness EF, Earle-Hughes JA, Fuldner RA,
            Marmaros S, Glodek A, Gocayne JD, Adams MD, Kerlavage AR et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV216619.1, AB062596.1, CA512355.1, CA510536.1, H32677.1,
            DY316730.1, CA503636.1 and BC105844.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_001081366.1, XM_340889.3, XM_001074205.1, XM_001074182.1.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data from multiple strains because no single transcript
            from the same strain was available for the full length of the gene.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               DV216619.1         1-282
            283-791             AB062596.1         7-515
            792-1441            CA512355.1         33-682
            1442-1600           CA510536.1         454-612
            1601-1900           H32677.1           35-334
            1901-2522           DY316730.1         40-661
            2523-3060           CA503636.1         11-548              c
            3061-3454           BC105844.1         404-797
            3455-4126           BC105844.1         799-1470
FEATURES             Location/Qualifiers
     source          1..4126
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4126
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /note="aminopeptidase puromycin sensitive"
                     /db_xref="GeneID:50558"
                     /db_xref="RGD:619962"
     exon            1..360
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2865
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /EC_number="3.4.11.14"
                     /codon_start=1
                     /product="puromycin-sensitive aminopeptidase"
                     /protein_id="NP_536320.1"
                     /db_xref="GeneID:50558"
                     /db_xref="RGD:619962"
                     /translation="MWLAAAVPSLARRLLLLGSPPPPLLLLLSRSSSRRRRLHSLGLA
                     AMPEKRPFERLPTEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADID
                     IITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGF
                     YRSRYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMN
                     VIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKA
                     EQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLI
                     DPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFP
                     EYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLH
                     DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESASGKPIAAVMNTWTKQMGFPLIY
                     VEAEQVEDDRVLKLSQKKFCASGPYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPE
                     MSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLF
                     SLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKD
                     VFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEHVEGKQIL
                     SADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKVLT
                     FALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLS
                     VEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYLLQRK
                     ASPPSV"
     exon            361..445
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            446..523
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            524..645
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            646..753
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            754..954
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1051
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1085
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1200
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1365
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1470
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1531
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1641
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1705
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1845
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1980
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2200
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2343
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2400
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2508
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2664
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2712
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..4104
                     /gene="Npepps"
                     /gene_synonym="Psa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcccgca ccgccgcccg cccggcccag gcgcccgctg ggtctgtccc ccgccccagc
       61 ctccccggtg gctctcggca ggcggtcgcc cgcgcccggt gaatgtggct ggcagccgcc
      121 gtcccctccc tcgctcgccg cctgctcctc ctcggctctc cgcctcctcc cctccttctc
      181 ctcctcagcc gctcctctag ccgccgccgc cgcctccaca gcctgggcct cgccgcgatg
      241 ccggagaagc ggcccttcga gcggctgccc accgaggtgt cgcccatcaa ctacagcctc
      301 tgcctcaagc ccgatttgct ggacttcacc ttcgagggca agctggaggc cgccgcccag
      361 gtaaggcagg caaccaatca gattgtgatg aattgtgctg atattgacat tattacagct
      421 tcatatgcgc cagaaggaga tgaagaaatc catgcgacag gatttaacta tcagaatgaa
      481 gatgagaaag tcaccttgtc ttttcctagt actctccaaa caggtacagg aaccttaaag
      541 atagattttg ttggagaact gaacgacaaa atgaaaggtt tctacagaag tagatatacc
      601 acccccgccg gcgaggtgcg ctatgctgct gtaacacagt ttgaggctac tgatgcccga
      661 agggcttttc cttgctggga tgagcctgct atcaaagcaa cttttgatat ctcgttggtt
      721 gtgcctaaag atagagtggc tttatcaaat atgaatgtca ttgacaggaa accataccct
      781 gatgatgaaa acttagtgga agtgaagttt gctcgcacac ctgttatgtc tacatatctg
      841 gtggcatttg ttgtgggtga atatgacttt gtagaaacaa ggtcaaaaga tggtgtgtgt
      901 gtccgtgttt acacccctgt tggcaaagca gagcaaggaa aatttgcact agaggttgct
      961 gctaaaacct tgccttttta taaagactac ttcaatgttc cttatcctct acctaaaatt
     1021 gatctcattg ctattgctga ctttgcagct ggtgccatgg agaactgggg ccttgttact
     1081 tatagggaga cggcattgct tattgatcca aaaaactcgt gttcttcatc acgccagtgg
     1141 gttgctctgg ttgtgggaca tgaactcgcc catcaatggt ttggaaatct tgttactatg
     1201 gaatggtgga ctcatctctg gttgaacgaa ggctttgcat cctggattga gtacctttgt
     1261 gtagaccact gcttcccaga gtatgatatc tggactcagt ttgtttctgc agattatacc
     1321 cgtgcccagg aactcgatgc cttagataac agccatccta ttgaagtcag tgtgggccat
     1381 ccatctgagg ttgatgagat atttgatgct atatcataca gcaaaggtgc atctgtaatc
     1441 cgaatgctac atgactacat tggcgataag gactttaaga aaggaatgaa tatgtattta
     1501 accaagttcc aacaaaagaa tgctgccaca gaggatcttt gggaaagttt ggaaagtgcc
     1561 agtggcaaac ccatagccgc tgtgatgaac acctggacca aacaaatggg gttccctctc
     1621 atttatgtgg aagctgaaca ggtagaagat gacagagtgc tgaagctgtc tcaaaagaag
     1681 ttctgtgcca gcggacctta tgtcggtgaa gactgtcctc agtggatggt tcctatcacg
     1741 atttcaacta gtgaagatcc caaccaggct aaactgaaaa tactaatgga taagccagag
     1801 atgagtgtgg ttttgaaaaa tgtcaaacca gaccaatggg taaagctaaa cctgggaaca
     1861 gttgggtttt atcgaaccca atacagctct gctatgctgg aaagtttatt accaggcatt
     1921 cgtgaccttt ctctgccccc agtggatcgg cttggattac agaatgacct cttttctctg
     1981 gctcgagctg gaatcattag cactgtagag gttctaaaag tcatggaggc ttttgtgaat
     2041 gagcccaatt atactgtgtg gagcgacctg agctgtaacc tggggattct ttcaactctc
     2101 ttgtcccaca cagacttcta tgaggaaatc caggagtttg tcaaagatgt cttctcacct
     2161 ataggagaga gactgggctg ggaccccaaa cctggagaag gtcatctaga cgcactcctg
     2221 aggggcttgg tgctgggcaa actgggaaaa gcagggcata aggcaacttt ggaagaagcc
     2281 cgccgtcggt ttaaggagca cgtggaaggg aagcagattc tttctgctga cctaaggagt
     2341 cctgtttatc ttactgtttt aaagcatggt gatggcacta ccttagacat tatgctaaag
     2401 cttcacaaac aagctgatat gcaagaagag aaaaacagaa tcgaaagagt tcttggggct
     2461 actctttctc ctgaactgat tcaaaaagtc ctcacttttg cactttcaga agaggtacgt
     2521 ccacaggaca ctgtgtcagt aattggtgga gtggctggag gcagcaagca tgggaggaaa
     2581 gctgcttgga aattcataaa ggacaactgg gaagagcttt ataatcgata ccagggaggg
     2641 tttttaatat ccagactcat aaagctgtca gttgaggggt ttgcagttga taaaatggct
     2701 ggagaagtta aggctttctt cgagagtcac ccagctcctt cagccgaacg taccatccag
     2761 cagtgttgtg agaatatcct gctgaacgct gcttggctaa agcgggatgc tgacagcatt
     2821 caccaatacc tcctgcagcg gaaagcctcc cctccctcgg tgtgaagcct ctgcaccacg
     2881 gtcggtctta ccgcctcgca gggatgaggc ggagctaccc aacagctgat tcacatgcca
     2941 agaatttgga gtcttagacc agtgggggtt ggacaatgaa tgtagttaac tggttcctgc
     3001 tcacactcca gaattaaatt ctattgaaaa aaaggaaaat cagcaattca gcaaaaaaaa
     3061 taaaataaaa taaaaatgta aatatgatag taataaacta gagcataacg aaactgtgaa
     3121 acttcctcaa gcctgccatg gtcaaagtgt tagtgacgga cattgttctg tagcctacca
     3181 gaaggaagag gctttggggc aaagggttct tgtgaagtgg gttctacatg atgcagcctg
     3241 acaagccggg catgtccgtc actggggatg ctgaccagaa ggctggccgc tgactcacat
     3301 aatggagtct gtgcataatt gcaagtgggt tttcttttcc tttttggcat gggaaccgac
     3361 caggaaggta tcttttcctg tataactcaa tctgaaccaa ggattgttgt tccctccttg
     3421 cctcccttct gtgtgatccc caccccccaa aaaagtatga aaagctttaa aaaacaaaac
     3481 aaaaccaccc tccctccctt cccaggttct tctcccttta gctctgccca gccctgacct
     3541 gtccttggat aacagaaaca cctttgatgg ccacgttaaa taagaggagc tgatatgctt
     3601 ttattttcta agataacttt aaaggaaccc tagaatgcat aagaggtgaa agagtagaaa
     3661 taaagatcat cagctcggcc tttctgctca aaactgtccc cgttccctga caggccaaat
     3721 gctgcccctc ttccgaacag tatcggcgag ctctggctca ccacttgtgc atgtgagggg
     3781 ccagtgggga ctgctgtggg gcccagatgt ctgctgcacc gctgtgtggc cagtgcgccc
     3841 actaacgagc ctcgccacct aacccagtgt gtttttacta agtctcagcc cctccttccc
     3901 acctcctttt tcttctcttc cttttccttt tattttttcg gaatcctttt attttgtgtt
     3961 aacagaaatt catatttggt gtggcttaat gtattttgga aggtcatcag attgtgagac
     4021 tgcttccttg aaacattttt gtgctattgt tttaaaaaat aataattaaa aaacagttgg
     4081 cgttaataaa aatgtcaatg tgaaaaaaaa aaaaaaaaaa aaaaaa
//
