LOCUS       NM_001002025            4484 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus NPC1 like intracellular cholesterol transporter 1
            (Npc1l1), mRNA.
ACCESSION   NM_001002025
VERSION     NM_001002025.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4484)
  AUTHORS   Kawase,A., Araki,Y., Ueda,Y., Nakazaki,S. and Iwaki,M.
  TITLE     Impact of a high-cholesterol diet on expression levels of
            Niemann-Pick C1-like 1 and intestinal transporters in rats and mice
  JOURNAL   Eur J Drug Metab Pharmacokinet 41 (4), 457-463 (2016)
   PUBMED   25716431
  REMARK    GeneRIF: Decreased mRNA levels of HNF4alpha and SREBP2 in mice
            could be involved in the reduction in NPC1L1 expression.
REFERENCE   2  (bases 1 to 4484)
  AUTHORS   Takada,T., Yamanashi,Y., Konishi,K., Yamamoto,T., Toyoda,Y.,
            Masuo,Y., Yamamoto,H. and Suzuki,H.
  TITLE     NPC1L1 is a key regulator of intestinal vitamin K absorption and a
            modulator of warfarin therapy
  JOURNAL   Sci Transl Med 7 (275), 275ra23 (2015)
   PUBMED   25696002
  REMARK    GeneRIF: demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein,
            a cholesterol transporter, plays a central role in intestinal VK
            uptake and modulates the anticoagulant effect of warfarin. In
REFERENCE   3  (bases 1 to 4484)
  AUTHORS   Cote,I., Ngo Sock,E.T., Levy,E. and Lavoie,J.M.
  TITLE     An atherogenic diet decreases liver FXR gene expression and causes
            severe hepatic steatosis and hepatic cholesterol accumulation:
            effect of endurance training
  JOURNAL   Eur J Nutr 52 (5), 1523-1532 (2013)
   PUBMED   23117815
REFERENCE   4  (bases 1 to 4484)
  AUTHORS   Xie,C., Li,N., Chen,Z.J., Li,B.L. and Song,B.L.
  TITLE     The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1
            (NPC1L1) and controls its movement from endocytic recycling
            compartment to plasma membrane in a cholesterol-dependent manner
  JOURNAL   J Biol Chem 286 (41), 35933-35942 (2011)
   PUBMED   21844200
  REMARK    GeneRIF: Cdc42 controls the cholesterol-regulated transport and
            localization of NPC1L1, and plays a role in cholesterol absorption.
REFERENCE   5  (bases 1 to 4484)
  AUTHORS   Zhu,Y. and Zhou,J.
  TITLE     Increased NPC1L1 and serum cholesterol in a chronic rejection rat
  JOURNAL   Clin Invest Med 34 (3), E172-E178 (2011)
   PUBMED   21631994
  REMARK    GeneRIF: The increased expression of NPC1L1 might contribute to
            hypercholesterolemia, which may be involved in the pathogenesis of
            transplant arteriosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4484)
  AUTHORS   Garcia-Calvo,M., Lisnock,J., Bull,H.G., Hawes,B.E., Burnett,D.A.,
            Braun,M.P., Crona,J.H., Davis,H.R. Jr., Dean,D.C., Detmers,P.A.,
            Graziano,M.P., Hughes,M., Macintyre,D.E., Ogawa,A., O'neill,K.A.,
            Iyer,S.P., Shevell,D.E., Smith,M.M., Tang,Y.S., Makarewicz,A.M.,
            Ujjainwalla,F., Altmann,S.W., Chapman,K.T. and Thornberry,N.A.
  TITLE     The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
  JOURNAL   Proc Natl Acad Sci U S A 102 (23), 8132-8137 (2005)
   PUBMED   15928087
REFERENCE   7  (bases 1 to 4484)
  AUTHORS   Iyer,S.P., Yao,X., Crona,J.H., Hoos,L.M., Tetzloff,G., Davis,H.R.
            Jr., Graziano,M.P. and Altmann,S.W.
  TITLE     Characterization of the putative native and recombinant rat sterol
            transporter Niemann-Pick C1 Like 1 (NPC1L1) protein
  JOURNAL   Biochim Biophys Acta 1722 (3), 282-292 (2005)
   PUBMED   15777641
  REMARK    GeneRIF: NPC1L1 exists as a predominantly cell surface membrane
            expressed protein, consistent with its proposed role as the
            putative intestinal sterol transporter
REFERENCE   8  (bases 1 to 4484)
  AUTHORS   Davies,J.P., Scott,C., Oishi,K., Liapis,A. and Ioannou,Y.A.
  TITLE     Inactivation of NPC1L1 causes multiple lipid transport defects and
            protects against diet-induced hypercholesterolemia
  JOURNAL   J Biol Chem 280 (13), 12710-12720 (2005)
   PUBMED   15671032
REFERENCE   9  (bases 1 to 4484)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   10 (bases 1 to 4484)
  AUTHORS   Altmann,S.W., Davis,H.R. Jr., Zhu,L.J., Yao,X., Hoos,L.M.,
            Tetzloff,G., Iyer,S.P., Maguire,M., Golovko,A., Zeng,M., Wang,L.,
            Murgolo,N. and Graziano,M.P.
  TITLE     Niemann-Pick C1 Like 1 protein is critical for intestinal
            cholesterol absorption
  JOURNAL   Science 303 (5661), 1201-1204 (2004)
   PUBMED   14976318
  REMARK    GeneRIF: NPC1L1 protein plays a critical role in the absorption of
            intestinal cholesterol. NPC1L1 expression is enriched in the small
            intestine and is in the brush border membrane of enterocytes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY437867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY437867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132305,
                                           SAMD00155304 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4484
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /note="NPC1 like intracellular cholesterol transporter 1"
                     /db_xref="GeneID:432367"
                     /db_xref="RGD:1303135"
     CDS             1..3996
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /note="Niemann-Pick C1-like protein 1; Niemann-Pick
                     disease, type C1-like 1; NPC1 (Niemann-Pick disease, type
                     C1, gene)-like 1; NPC1-like 1; solute carrier family 66
                     member 2"
                     /codon_start=1
                     /product="NPC1-like intracellular cholesterol transporter
                     1 precursor"
                     /protein_id="NP_001002025.1"
                     /db_xref="GeneID:432367"
                     /db_xref="RGD:1303135"
                     /translation="MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPEL
                     SGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESS
                     MSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFY
                     QRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDI
                     TFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSF
                     YMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPH
                     TILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARK
                     EKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQER
                     LRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQT
                     LNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGYQGTDYSE
                     AEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDE
                     INRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLA
                     AMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTL
                     GSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLD
                     SKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTL
                     FGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEA
                     GMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYI
                     RGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGL
                     AAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTD
                     PNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSI
                     IMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKD
                     ATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVV
                     LSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAA
                     RSSLPKSDQKF"
     exon            1..51
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..1580
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1681
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1854
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1983
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2166
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2281
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2409
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2547
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2637
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2828
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2956
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3083
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3139
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3290
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3522
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3636
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3799
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..4469
                     /gene="Npc1l1"
                     /gene_synonym="SLC66A2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagctg cctggctggg atggctgctc tgggccctgc tcctgagcgc ggcccagggt
       61 gagctataca cacccaaaca cgaagctggg gtctgcacct tttacgaaga gtgcgggaaa
      121 aacccagagc tctctggagg cctcacgtca ctatccaatg tatcctgcct gtctaacacc
      181 ccggcccgcc acgtcacggg tgaacacctg gctcttctcc agcgcatctg tccccgcctg
      241 tacaacggcc ccaataccac ttttgcctgt tgctctacca agcagctgct gtccttagaa
      301 agcagcatgt ccatcaccaa ggcccttctc acgcgctgcc cggcctgctc tgacaatttt
      361 gtgagcttac actgccacaa cacttgcagc cctgaccaga gcctcttcat caacgtcacc
      421 cgggtggttg agcggggcgc tggagagcct cctgccgtgg tggcctatga ggccttttat
      481 cagcgcagct ttgctgagaa ggcctatgag tcctgcagcc aggtgcgcat ccctgcggcc
      541 gcttccttgg ccgtgggcag catgtgtgga gtgtatggct ccgccctctg caatgctcag
      601 cgctggctca acttccaagg agacacaggg aatggcctgg ctccgctgga tatcaccttc
      661 cacctcttgg agcctggcca ggccctaccg gatgggatcc agccactgaa tgggaagatc
      721 gcaccctgca acgagtctca gggtgatgac tcagcagtct gctcctgcca ggactgtgcg
      781 gcgtcctgcc ctgtcatccc tccgcccgag gccttgcgcc cttccttcta catgggtcgc
      841 atgccaggct ggctggccct catcatcatc ttcactgctg tctttgtgtt gctctctgca
      901 gtccttgtgc gtctccgagt ggtttccaac aggaacaaga acaaggcaga aggcccccag
      961 gaagccccca aactccctca taagcacaaa ctctcacccc ataccatcct gggccggttc
     1021 ttccagaact ggggcacaag ggtggcctcg tggccactca ccgtcttagc actgtccttc
     1081 atcgttgtga tagccttagc agcaggcctg acctttattg aactcaccac agaccctgtg
     1141 gaactgtggt cggcccccaa gagccaggcc cggaaagaga agtctttcca tgatgagcat
     1201 ttcggcccct tctttcgaac caaccagatt ttcgtgacag ctcggaacag gtccagctac
     1261 aagtacgact ccctactgct agggtccaag aacttcagtg ggatcctgtc cctggacttc
     1321 ctgctggagc tgctggagct tcaggagagg cttcgacacc tgcaagtgtg gtcccctgag
     1381 gcagagcgca acatctccct ccaggacatc tgctatgccc ccctcaaccc atataacacc
     1441 agcctctccg actgctgtgt caacagcctc cttcagtact tccagaacaa ccgcaccctc
     1501 ctgatgctca cggccaacca gactctgaat ggccagacct ccctggtgga ctggaaggac
     1561 catttcctct actgtgcaaa tgcccctctc acgttcaaag atggcacgtc tctggccctg
     1621 agctgcatgg ctgactacgg ggctcctgtc ttccccttcc ttgctgttgg gggataccaa
     1681 ggcacggact attccgaggc agaagcgctg atcataacct tctctctcaa taactacccc
     1741 gctgatgatc cccgcatggc ccaggccaag ctctgggagg aggctttctt gaaggaaatg
     1801 gaatccttcc agaggaacac aagtgacaag ttccaggttg cgttctcagc tgagcgctct
     1861 ctggaggatg agatcaaccg caccaccatc caggacctgc ctgtctttgc cgtcagctac
     1921 attatcgtct tcctgtacat ctccctggcc ctgggcagct actccagatg cagccgagta
     1981 gcggtggagt ccaaggctac tctgggccta ggtggggtga ttgttgtgct gggagcagtt
     2041 ctggctgcca tgggcttcta ctcctacctg ggtgtcccct cttctctggt tatcatccaa
     2101 gtggtacctt tcctggtgct agctgtggga gctgacaaca tcttcatctt tgttcttgag
     2161 taccagaggc tacctaggat gcctggggaa cagcgagagg ctcacattgg ccgcaccctg
     2221 ggcagtgtgg cccccagcat gctgctgtgc agcctctctg aggccatctg cttctttcta
     2281 ggggccctga cccccatgcc agctgtgagg accttcgcct tgacctctgg cttagcaatt
     2341 atcctcgact tcctgctcca gatgactgcc tttgtggccc tgctctccct ggatagcaag
     2401 aggcaggagg cctctcgccc ggatgtctta tgctgctttt caacccggaa gctgccccca
     2461 cctaaagaaa aagaaggcct cttactccgc ttcttccgca agatatacgc tcctttcctg
     2521 ctgcacagat tcatccgccc tgttgtgatg ctgctgtttc tgaccctgtt tggagcaaat
     2581 ctctacttaa tgtgcaacat caacgtgggg ctagaccagg agctggctct gcccaaggac
     2641 tcgtacttga tagactactt cctctttctg aaccgatacc ttgaagtggg gcctccagtg
     2701 tactttgtca ccacctcggg cttcaacttc tccagcgagg caggcatgaa cgccacttgc
     2761 tctagcgcag gctgtaagag cttctcccta acccagaaaa tccagtatgc cagtgaattc
     2821 cctgaccagt cttacgtggc tattgctgca tcctcctggg tagatgactt catcgactgg
     2881 ctgaccccgt cctcctcctg ctgtcgcctt tatatacgtg gcccccataa ggatgagttc
     2941 tgtccctcaa cggatacttc cttcaactgc ttaaaaaact gcatgaaccg cactctgggt
     3001 cctgtgaggc ccacagcgga acagtttcat aagtacctgc cctggttcct gaatgatccg
     3061 cccaatatca gatgtcccaa agggggtcta gcagcgtata gaacgtctgt gaatttgagc
     3121 tcagatggcc aggttatagc ctcccagttc atggcctacc acaagccctt aaggaactca
     3181 caggacttca cagaagctct ccgggcgtcc cggttgctag cagccaacat cacagctgac
     3241 ctacggaagg tgcctgggac agatccaaac tttgaggtct tcccttacac gatctccaac
     3301 gtgttctacc agcaatacct gacggtcctt cctgagggaa tcttcaccct tgctctttgc
     3361 tttgtgccca cctttgttgt ctgctacctc ctactgggcc tggacatgtg ctcagggatc
     3421 ctcaacctac tctccatcat tatgattctc gtggacacca ttggcctcat ggctgtgtgg
     3481 ggtatcagct ataatgcggt atccctcatc aaccttgtca cggcagtggg catgtctgtg
     3541 gagtttgtgt cccacatcac tcggtccttt gctgtaagca ccaagcctac ccggctggag
     3601 agggctaaag atgctactgt cttcatgggc agtgcggtgt ttgctggagt ggccatgacc
     3661 aacttcccag gcatcctcat cttgggcttt gcccaagccc agcttattca gatcttcttc
     3721 ttccgcctca accttctgat caccttgctg ggtctgctgc atggcctggt cttcctgccg
     3781 gttgtcctca gctatctggg accagatgtt aaccaagctc tggtacagga ggagaaacta
     3841 gccagcgagg cagcagtggc cccagagcct tcttgcccac agtacccctc ccctgctgat
     3901 gcggatgcca atgttaacta cggctttgcc ccagaacttg cccacggagc taatgctgct
     3961 agaagctctt tgcccaaaag tgaccaaaag ttctaatgga gtaggagctt gtccatgctt
     4021 cttgctgatg agggatcatg aaggtcttcc ctctggttgt cctcaaggcc tggggggagg
     4081 ttgtttcaga gaaaaatggc tggcattcct gccacgaggc aaccggcagc attggcactg
     4141 acctccttgc tctcataggt ccctaaggcc ttggtcagat tacctcctcc atggagagac
     4201 tatcttaagt atcttaagta tcgtatggga tgcatcgcct gtcaattaaa aaggctatgg
     4261 cctatggctc aggcagggcc atccggaaga agagaggatt ctgggataaa gccaggtggg
     4321 agattcgcct ggggaaaatg tgacaatggt tcctgagcat gggcaatcag ccatgtggca
     4381 gaatgtaaat taatataaat gggttgtctt aagttatgat tctagctggg gaggagccta
     4441 gctgtgtagc caagatattt gtaaatataa aaaaaaaaaa aaaa
//
