LOCUS       NP_695205                119 aa            linear   ROD 31-MAR-2024
DEFINITION  neuropeptide B precursor [Rattus norvegicus].
ACCESSION   NP_695205
VERSION     NP_695205.1
DBSOURCE    REFSEQ: accession NM_153293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 119)
  AUTHORS   Pandey,S., Tuma,Z., Peroni,E., Monasson,O., Papini,A.M. and
            Chottova Dvorakova,M.
  TITLE     Identification of NPB, NPW and Their Receptor in the Rat Heart
  JOURNAL   Int J Mol Sci 21 (21), 7827 (2020)
   PUBMED   33105700
  REMARK    GeneRIF: Identification of NPB, NPW and Their Receptor in the Rat
            Heart.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 119)
  AUTHORS   Skrzypski,M., Pruszynska-Oszmalek,E., Rucinski,M.,
            Szczepankiewicz,D., Sassek,M., Wojciechowicz,T., Kaczmarek,P.,
            Kolodziejski,P.A., Strowski,M.Z., Malendowicz,L.K. and Nowak,K.W.
  TITLE     Neuropeptide B and W regulate leptin and resistin secretion, and
            stimulate lipolysis in isolated rat adipocytes
  JOURNAL   Regul Pept 176 (1-3), 51-56 (2012)
   PUBMED   22484289
  REMARK    GeneRIF: The Neuropeptide B can affect glucose and lipid
            homeostasis, and food intake in rats.
REFERENCE   3  (residues 1 to 119)
  AUTHORS   Ziolkowska,A., Rucinski,M., Tyczewska,M. and Malendowicz,L.K.
  TITLE     Neuropeptide B (NPB) and neuropeptide W (NPW) system in cultured
            rat calvarial osteoblast-like (ROB) cells: NPW and NPB inhibit
            proliferative activity of ROB cells
  JOURNAL   Int J Mol Med 24 (6), 781-787 (2009)
   PUBMED   19885618
  REMARK    GeneRIF: RT-PCR technique revealed the presence of NPB mRNA, NPW
            mRNA, and NPBWR1 mRNA, but not similar to NPBWR2 mRNA in ROB cells.
REFERENCE   4  (residues 1 to 119)
  AUTHORS   Schulz,S., Stumm,R. and Hollt,V.
  TITLE     Immunofluorescent identification of neuropeptide B-containing nerve
            fibers and terminals in the rat hypothalamus
  JOURNAL   Neurosci Lett 411 (1), 67-71 (2007)
   PUBMED   17067739
  REMARK    GeneRIF: NPB-immunoreactivity was enriched in many regions within
            the hypothalamus which also contained high levels of GPR7 mRNA.
REFERENCE   5  (residues 1 to 119)
  AUTHORS   Jackson,V.R., Lin,S.H., Wang,Z., Nothacker,H.P. and Civelli,O.
  TITLE     A study of the rat neuropeptide B/neuropeptide W system using in
            situ techniques
  JOURNAL   J Comp Neurol 497 (3), 367-383 (2006)
   PUBMED   16736466
  REMARK    GeneRIF: demonstrates the expression patterns of GPR7, NPB, and NPW
            precursor messenger ribonucleic acid (mRNA) in the rat brain by
            using in situ hybridization and in situ binding experiments
REFERENCE   6  (residues 1 to 119)
  AUTHORS   Fujii,R., Yoshida,H., Fukusumi,S., Habata,Y., Hosoya,M.,
            Kawamata,Y., Yano,T., Hinuma,S., Kitada,C., Asami,T., Mori,M.,
            Fujisawa,Y. and Fujino,M.
  TITLE     Identification of a neuropeptide modified with bromine as an
            endogenous ligand for GPR7
  JOURNAL   J Biol Chem 277 (37), 34010-34016 (2002)
   PUBMED   12118011
  REMARK    GeneRIF: neuropeptide B, a neuropeptide modified with bromine is an
            endogenous ligand for GPR7.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG376816.1, AB085944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..119
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     Protein         1..119
                     /product="neuropeptide B precursor"
                     /note="rPPL7; preproprotein L7; preproneuropeptide B"
                     /calculated_mol_wt=10870
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2168
     Region          22..118
                     /region_name="NPBW"
                     /note="Neuropeptides B and W; pfam15180"
                     /db_xref="CDD:464547"
     CDS             1..119
                     /gene="Npb"
                     /coded_by="NM_153293.2:1..360"
                     /db_xref="GeneID:259222"
                     /db_xref="RGD:708513"
ORIGIN      
        1 mvrcrtlvaa alallltpal awykpaagsh hysvgraagl lssfhrfpst rrsespalrv
       61 gtvplrnlem rpsvrslalc vkdvtpnlqs cqrqlnsrgt fqckadvfls lhkaecqsa
//
