LOCUS       NM_001108147            6138 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear protein, co-activator of histone
            transcription (Npat), mRNA.
ACCESSION   NM_001108147 XM_001072137 XM_236292
VERSION     NM_001108147.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6138)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6138)
  AUTHORS   Mitra,P., Ghule,P.N., van der Deen,M., Medina,R., Xie,R.L.,
            Holmes,W.F., Ye,X., Nakayama,K.I., Harper,J.W., Stein,J.L.,
            Stein,G.S. and van Wijnen,A.J.
  TITLE     CDK inhibitors selectively diminish cell cycle controlled
            activation of the histone H4 gene promoter by p220NPAT and HiNF-P
  JOURNAL   J Cell Physiol 219 (2), 438-448 (2009)
   PUBMED   19170105
REFERENCE   3  (bases 1 to 6138)
  AUTHORS   Medina,R., Buck,T., Zaidi,S.K., Miele-Chamberland,A., Lian,J.B.,
            Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     The histone gene cell cycle regulator HiNF-P is a unique zinc
            finger transcription factor with a novel conserved auxiliary
            DNA-binding motif
  JOURNAL   Biochemistry 47 (44), 11415-11423 (2008)
   PUBMED   18850719
REFERENCE   4  (bases 1 to 6138)
  AUTHORS   Medina,R., van der Deen,M., Miele-Chamberland,A., Xie,R.L., van
            Wijnen,A.J., Stein,J.L. and Stein,G.S.
  TITLE     The HiNF-P/p220NPAT cell cycle signaling pathway controls
            nonhistone target genes
  JOURNAL   Cancer Res 67 (21), 10334-10342 (2007)
   PUBMED   17974976
REFERENCE   5  (bases 1 to 6138)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   6  (bases 1 to 6138)
  AUTHORS   Mitra,P., Xie,R., Harper,J.W., Stein,J.L., Stein,G.S. and van
            Wijnen,A.J.
  TITLE     HiNF-P is a bifunctional regulator of cell cycle controlled histone
            H4 gene transcription
  JOURNAL   J Cell Biochem 101 (1), 181-191 (2007)
   PUBMED   17163457
REFERENCE   7  (bases 1 to 6138)
  AUTHORS   Gangwani,L.
  TITLE     Deficiency of the zinc finger protein ZPR1 causes defects in
            transcription and cell cycle progression
  JOURNAL   J Biol Chem 281 (52), 40330-40340 (2006)
   PUBMED   17068332
REFERENCE   8  (bases 1 to 6138)
  AUTHORS   Miele,A., Braastad,C.D., Holmes,W.F., Mitra,P., Medina,R., Xie,R.,
            Zaidi,S.K., Ye,X., Wei,Y., Harper,J.W., van Wijnen,A.J., Stein,J.L.
            and Stein,G.S.
  TITLE     HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone
            H4 gene regulation at the G1/S phase cell cycle transition
  JOURNAL   Mol Cell Biol 25 (14), 6140-6153 (2005)
   PUBMED   15988025
REFERENCE   9  (bases 1 to 6138)
  AUTHORS   Mitra,P., Xie,R.L., Medina,R., Hovhannisyan,H., Zaidi,S.K., Wei,Y.,
            Harper,J.W., Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     Identification of HiNF-P, a key activator of cell cycle-controlled
            histone H4 genes at the onset of S phase
  JOURNAL   Mol Cell Biol 23 (22), 8110-8123 (2003)
   PUBMED   14585971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001108147.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236292.4, XM_001072137.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132268 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..6138
                     /gene="Npat"
                     /note="nuclear protein, co-activator of histone
                     transcription"
                     /db_xref="GeneID:315666"
                     /db_xref="RGD:1311947"
     exon            1..257
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..4468
                     /gene="Npat"
                     /note="nuclear protein in the AT region; nuclear protein,
                     ataxia-telangiectasia locus"
                     /codon_start=1
                     /product="protein NPAT"
                     /protein_id="NP_001101617.1"
                     /db_xref="GeneID:315666"
                     /db_xref="RGD:1311947"
                     /translation="MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDE
                     GFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMQSS
                     PGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLAATQTIKP
                     TGQISTPVRSNIVVVNHSQTQNTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQ
                     KKSLPSSGAHSSRNLQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDS
                     NIAQVPKQTESSLTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFD
                     YGKTKNNKNISQSVSSQSVETNPNIVIPEETNLTIKSSFETEESDGQSGQPPFCTSYQ
                     NEDVVLNDLKSGNNHDVLPQESQGNFSQISANIQKTAVPAEQKCALDITFESVSNLSD
                     FNQRGSATECDEHCSELYTSQMPTDAGAAVGEESSLSPDSLNQSQYQPDQPRVPVTSF
                     VSLGGETNDKNLILSGKNSQLLSQSTPLTGKPSKSQFCENSNNIIKVKTNSHASESPD
                     SSDTHSSKDETNSKSPVAAQTQPDCQDNSPLQSRTSPVIIEGLGVNVTEKIEISIEET
                     SPSDKQLPNDSASVDLNPMGSESEPLQSENTQEPPSVKDGDTIFLSLSGHNGCEEVAL
                     VPGEGNPVKNNHSLSSESGGSVGVSAETQNTDGKASDPAEVDASSIVSLKIIISDDPF
                     VSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEVGDSGS
                     MEQNLLVLKPEEPTVNSTQNEDGIAFSANVAPCVPKDGGFIQLMPATSTAFGNSSNIL
                     IATCMTDPTALGPTVSQSNVVVLPGSSAPLTAQPPPQQLQTPPKSNSAFAVSQAVSPN
                     FSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIT
                     QFPIPQKSQKAQGLRNKPITGKQVNNLTSLSSLSEACHTQRTEASDKNTATELGKKME
                     DTTIPLSAERVAPPSRPFESHRRVLCFDSTVSSVANTQGPLYKVTSQNKEKKETSFPR
                     LDSPILSSTLKSPTNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVSPIETT
                     LESFHKATANKENELCSDGERPKNPDTSKLPGGQQNGSLKNEKAMASLQELTRKQATP
                     SNNKNATTVSGTVKDQKQEQSKPAGSLTGLETLQDVPLHNPANRTADSDLPGPRTTGA
                     GAGEKHKEEPTDSMKAPASRRCGEEGSVPRAMIPAVTADLPACSPASETGSENSVSMA
                     AHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSSKNLA
                     NSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE"
     exon            258..376
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            377..437
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            438..510
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            511..551
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            552..776
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            777..864
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            865..949
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1041
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1129
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1226
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1355
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..2972
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3088
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3197
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3258
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..4390
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..6138
                     /gene="Npat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacgacga ttccaaggat tacggaggcg ggtttcattt cggcgccttt ctgtctcccg
       61 cggaagcgat tggttggagt ggcacgaaag aggcgggaca aattgccgcg ggttcagcac
      121 cgccagtgga accgggagat gcggcggcgc cgggactgtc gccgtgtttg ctctgagttg
      181 agtctcgtcc cttcaggcgg ctccctgtgc agctcggatc atgctgttac cctcggatgt
      241 agccaggctg gtattgggtt acttacaaca agaaaacctc acatctactt gccagacttt
      301 tattttggaa agttcaaatt taaaagaata tgcagaacac tgtactgatg aaggttttat
      361 tccagcctgc ttactgtcct tatttggaaa aaacttgaca acaattttaa atgagtatgt
      421 agctatgaaa gcaaaagaaa catcaaatga tgtcccaaca ataatgtcat ctctgtggaa
      481 gaagctggac cacacgctct ctcagatcag gagcatgcag agttctccag ggtttgctgc
      541 ccatcagaga gctcgaacaa gaaatggaat tgcagaaatc aagcggcagc gatggctggc
      601 atctcaagca gctcccgtta gctcagagtt gctggtttta ccttacgctt caggacagtt
      661 caccacttct cctttggcag ccacacaaac tatcaaacca actggacaga tttcaactcc
      721 agtgaggtca aatattgtgg tggtcaacca ttcacagaca caaaatactg taactaatac
      781 agctggagaa tctttgaata tcattcctgg tcctcaggaa aggaaaactc aaaccagttt
      841 aatgtctcct ggtagacgta aaagtgaatc acaaaagaag agtctcccgt catctggagc
      901 acattcatca aggaatcttc aggatccaaa tgcatttgca gtagaaaaac aaatggtcat
      961 tgaaaatgca agagagaaaa tattaagcaa caaatctctt caagaaaaac tagcagaaaa
     1021 cataaataag tttttgacta gtgatagtaa tattgctcaa gtacctaaac agacagaaag
     1081 cagcctgaca gagccagaaa cgtcaattga tgaactccta ggacttccga gtgaaatcca
     1141 catgtctgaa gaagcaatac aagatatact ggagcagaca gaatcagacc cagcctttca
     1201 ggcactcttt gatctatttg actatggtaa aacaaagaac aataaaaaca tatcacaaag
     1261 tgtctctagt caatcagtgg agactaatcc taatatagtc atacctgaag aaactaatct
     1321 aacaattaaa agttcttttg aaacagaaga atcagatggg caatctggtc agcctccatt
     1381 ttgtacatcc tatcaaaacg aagatgtagt gttaaatgat ctgaagagtg gcaacaacca
     1441 tgacgttctt ccacaggagt cccagggaaa cttctcccaa ataagcgcta acattcaaaa
     1501 aacagctgta cctgctgaac agaagtgtgc ccttgacatt acctttgagt ctgtgtctaa
     1561 cttaagtgat tttaaccaaa gaggaagcgc tactgaatgt gatgaacatt gttctgagtt
     1621 atacaccagt cagatgccca ctgacgctgg agcggctgtg ggtgaagaga gttctctgtc
     1681 tccagattca ctgaaccagt ctcagtatca gcctgatcag ccccgcgtgc cagtcacttc
     1741 atttgtatct cttggtggtg agaccaatga caaaaactta attctctcgg ggaaaaattc
     1801 ccagcttttg tcccaaagta ctccactaac tggaaagcca tctaaaagtc aattttgtga
     1861 aaattctaat aatataataa aagtaaaaac taattctcat gcttctgagt caccagattc
     1921 tagtgacact cacagcagta aagatgaaac taacagtaaa tcaccagttg ctgcccagac
     1981 acaaccagat tgccaagata attctccact gcaaagcaga acatctcctg tgattattga
     2041 aggtttaggt gtaaatgtga ctgaaaaaat agaaattagt attgaagaaa catccccttc
     2101 agataaacag ctacctaatg attcagcttc tgttgactta aatcctatgg gaagcgagtc
     2161 agagccactt cagtctgaga acactcaaga gcctccttct gtgaaagatg gagatactat
     2221 ttttctctct ttgagtggac ataacggctg tgaagaagtt gcactggttc ctggagaagg
     2281 taatcctgta aaaaataatc attcactttc ttcagaatct ggtggttcgg tgggagtctc
     2341 tgctgagacc caaaatactg atggcaaagc tagcgaccca gcagaggtag atgcgtcaag
     2401 cattgtctct ctcaaaatca tcattagtga tgacccattt gtttcctcag atgcagagct
     2461 taacagtgct gtgtctagta tcagtggaga aaacttacca acgataattc tgtcttctaa
     2521 atctcctgcc aaaaatgcag aattcgttac atgcctatct tcagaagaaa ctgcaagtgc
     2581 tgttgtatct gttgaagtag gtgattctgg ctccatggag cagaaccttt tagtgctcaa
     2641 acctgaggaa cccacggtaa acagcactca gaatgaagat ggcattgctt tttcagccaa
     2701 tgttgcacca tgtgttccta aggacggagg attcatacaa ttgatgcctg ctacaagcac
     2761 ggcgtttggc aattcaagta acattctgat agctacctgt atgactgacc caacagcctt
     2821 gggaccaact gtcagtcagt ctaatgtagt agtgttgccc gggagttctg cacctttgac
     2881 tgcacagcct cctccacagc agttacagac gccacctaag tctaacagtg catttgctgt
     2941 cagccaagcc gtgtcaccaa acttttcaca aggatctgcc atcataattg cttctccagt
     3001 acagcctgtt cttcaaggaa tggtggggat gatacctgtg tctgtagttg gacagaatgg
     3061 aaatacattc tccactcctc ctcagcaggt ccttcatatg cctttagcag cacctgtttg
     3121 taatagaagt atcactcaat tccccattcc tcaaaaatcc cagaaggctc agggactcag
     3181 aaacaagcct attacaggaa aacaggtaaa taatttgaca agcttgtcca gtctttcaga
     3241 agcatgtcat acacaaagaa ctgaagcttc tgataagaat acagccactg aacttgggaa
     3301 aaaaatggaa gacactacaa ttcccctatc agcagagagg gtagctcctc ccagcaggcc
     3361 atttgaaagt cataggcggg tgctttgttt tgatagtact gtttcttctg ttgcaaatac
     3421 acaggggcca ctatataaag tgacctccca aaacaaagaa aagaaggaaa catcttttcc
     3481 tcgccttgac tcacccattc tgtcctctac cttaaaatca cctactaata atgccatcaa
     3541 gagagagagg gaaaaaactg tgcccaagat tttatctaaa tcagaaactg cctccagtcg
     3601 acacaccact gtgaaagaag tccagtctga aaagaaagtt tcccccatag aaacgaccct
     3661 tgaatctttc cataaagcaa cagcaaacaa ggagaatgaa ctgtgcagtg atggggaaag
     3721 gccgaagaat ccagacacct caaaactgcc tggcgggcag cagaatggga gcttgaagaa
     3781 tgaaaaagcc atggcctcac tgcaggaatt gaccagaaaa caagccacac cctcaaacaa
     3841 taaaaatgcc actactgtaa gtgggactgt gaaggatcaa aaacaagagc agagtaaacc
     3901 tgccggctcg ttaactgggc tagaaactct gcaggatgtt ccactacaca acccagcaaa
     3961 taggactgct gatagtgact tgccgggacc ccggacgact ggcgcaggag caggagaaaa
     4021 gcataaagaa gagcctactg acagtatgaa ggcccctgct agtagacgct gtggtgagga
     4081 aggcagcgtg cccagagcaa tgatcccagc tgtcactgct gacttgcctg cctgcagccc
     4141 agccagtgaa acgggcagcg aaaacagcgt gagcatggct gcccacacgc tcatgattct
     4201 ctctagagca gcaattgcta ggactacagc aactcctcta aaagataaca cgcagcaatt
     4261 tagaacatct tcaaggagca ctacgaagaa acgaaaaatt gaggaattag atgagtgtga
     4321 gaggaactcc cgcacttcta gtaaaaatct tgcaaattca tcagtaccaa tgaaaaagaa
     4381 gaaaatcaag aaaaagaagc tacctagttc atttccagca ggaatggatg tggacaagtt
     4441 cttgctatca ctgcattatg atgagtgaag gacaccctga catagagacc agtagctatt
     4501 taaaactagt gtccttcaga ctgcgcgtag gaaatgggat agagacagac tgcaaacatg
     4561 acctgcactt tgactgtact gaggtttcac tttatatcta agtcatgctg tttctgaagc
     4621 agcttcctag tttgtaaata gactttcatg gaatatttgt attttagaca aaaagaacat
     4681 acgcagaaat gtaagtaaac cctgtctgca aaactgtata gctgtgacac tgtatattgt
     4741 acatgtgtac attgtgtaaa atagagctta aatcaaccta acgttcccac actgtcttga
     4801 ttgacttcct gtgatgcccg aggcttattc ttctggagta gtttctcatc tcctttggag
     4861 gaagatgatg attattctta taaattacct tcagccaata ctagataagc cactaagtaa
     4921 aaaataataa tgatgaccac ctcaactggt tagtaaaata tctaatcaga aaacaacagt
     4981 ttgatgattt ccccctagag tcaatatttt atcaccctaa ataaatttca gtaaaatcta
     5041 tatttctgaa gttttatact ttattctgat catctatcct ctttgtttta aagagatttt
     5101 tataaaccat ttattaagtg ttctgatatt tcacttacaa ctttttgaaa ttttttacag
     5161 aacattaagt ggttagacta ttgagccata aaaatttgag ttgtgtagta gtcgagattt
     5221 cttgattata tgtaaacttt ccctaagcac tgggaataca aagaattgca ctaattcata
     5281 gacttttcat atactagtga ccaatgcaca ttaatttaaa tcttgtatgt aaaagcttat
     5341 atggaggatt gtcttctggt gtcttcgaaa gtcatgtcca tcttaagatg taaaaatgaa
     5401 aatcatagtt atattgtaat ttagtttacc ctcaaatggg atatgtaaat aactgtgttt
     5461 atacataacc tatagaacct cgcgttcttt aaagtgttat aaataattac tctcaaaagg
     5521 tccttagggg agtgagaggt gccttctctg ttagactgac tcataaacaa cagtcaagtt
     5581 gaaaagctgg cttaaacttt aaaggaatga cagaaattat cattaatact tgaccgattg
     5641 tgcctagata ttgaagtgtt ttcttaagtt cttactgctt aaatatcagt atattaaggt
     5701 ttttttctac gggtgtatat tttattaaaa agtcactttc ttcaaccatt ttttgtactg
     5761 ggcctttaag aaataaatcc atccaactgt aacaacaaaa aacgtcttca atatataaat
     5821 tatgtctttt tacttgctag attttactgt acagatttat attttgagaa attttatatg
     5881 actatgatat atacctaagg gactaagcat acagctaatg tttatataac tcagcttggg
     5941 tctatcctac ggttaggttt gaataaatat attttcatta actttaccag tttggattta
     6001 tattgacagt cctatttaga aacttttgat taaatttatt tgtagcttag ttaattctct
     6061 gtgtttttca ggaattcatg aactcccatc tgtgtgatgc ataatgagaa tcatatataa
     6121 attaactcat gctatttt
//
