LOCUS       NM_153626               2460 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus neuronal PAS domain protein 4 (Npas4), mRNA.
ACCESSION   NM_153626
VERSION     NM_153626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Louis Sam Titus,A.S.C., Sharma,D., Kim,M.S. and D'Mello,S.R.
  TITLE     The Bdnf and Npas4 genes are targets of HDAC3-mediated
            transcriptional repression
  JOURNAL   BMC Neurosci 20 (1), 65 (2019)
   PUBMED   31883511
  REMARK    GeneRIF: In healthy cerebellar granule neurons HDAC3 associates
            weakly with the Npas4 promoter, however, this association is
            robustly increased in neurons primed to die. Study found that HDAC3
            also associates differentially with the Bdnfr gene promoter, with
            higher association in dying neurons. Overexpression of HDAC3 leads
            to a suppression of Npas4 and Bdnf expression in cortical neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Wu,H., Huang,Y., Tian,X., Zhang,Z., Zhang,Y., Mao,Y., Wang,C.,
            Yang,S., Liu,Y., Zhang,W. and Ma,Z.
  TITLE     Preoperative anxiety-induced glucocorticoid signaling reduces
            GABAergic markers in spinal cord and promotes postoperative
            hyperalgesia by affecting neuronal PAS domain protein 4
  JOURNAL   Mol Pain 15, 1744806919850383 (2019)
   PUBMED   31041873
  REMARK    GeneRIF: preoperative anxiety led to GABAergic system impairment in
            spinal cord and thus caused hyperalgesia due to
            glucocorticoid-induced downregulation of neuronal PAS domain
            protein 4.
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Greb-Markiewicz,B., Zarebski,M. and Ozyhar,A.
  TITLE     Multiple sequences orchestrate subcellular trafficking of neuronal
            PAS domain-containing protein 4 (NPAS4)
  JOURNAL   J Biol Chem 293 (29), 11255-11270 (2018)
   PUBMED   29899116
  REMARK    GeneRIF: The presence of multiple localization signals and the
            differentiated localization of NPAS4 suggest a precise,
            multifactor-dependent regulation of NPAS4 trafficking, potentially
            crucial for its ability to act as a cellular stress sensor and
            transcription factor.
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Drouet,J.B., Peinnequin,A., Faure,P., Denis,J., Fidier,N.,
            Maury,R., Buguet,A., Cespuglio,R. and Canini,F.
  TITLE     Stress-induced hippocampus Npas4 mRNA expression relates to
            specific psychophysiological patterns of stress response
  JOURNAL   Brain Res 1679, 75-83 (2018)
   PUBMED   29196218
  REMARK    GeneRIF: The main discovery of this study is that the spontaneously
            expressed hippocampus Npas4 mRNA level under stressful conditions
            is associated with differences in hippocampus activation and
            behavior
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Taniguchi,M., Carreira,M.B., Cooper,Y.A., Bobadilla,A.C.,
            Heinsbroek,J.A., Koike,N., Larson,E.B., Balmuth,E.A., Hughes,B.W.,
            Penrod,R.D., Kumar,J., Smith,L.N., Guzman,D., Takahashi,J.S.,
            Kim,T.K., Kalivas,P.W., Self,D.W., Lin,Y. and Cowan,C.W.
  TITLE     HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens
            to Regulate Cocaine-Conditioned Behaviors
  JOURNAL   Neuron 96 (1), 130-144 (2017)
   PUBMED   28957664
  REMARK    GeneRIF: nuclear histone deacetylase 5 (HDAC5) in the nucleus
            accumbens (NAc) reduced cocaine reward-context associations and
            relapse-like behaviors in a cocaine self-administration model. We
            also discovered that HDAC5 associates with an activity-sensitive
            enhancer of the Npas4 gene and negatively regulates NPAS4
            expression.
REFERENCE   6  (bases 1 to 2460)
  AUTHORS   Ooe,N., Kobayashi,K., Motonaga,K., Saito,K. and Kaneko,H.
  TITLE     Dynamic regulation of bHLH-PAS-type transcription factor NXF gene
            expression and neurotrophin dependent induction of the
            transcriptional control activity
  JOURNAL   Biochem Biophys Res Commun 378 (4), 761-765 (2009)
   PUBMED   19083991
  REMARK    GeneRIF: NXF, is a new member genes under the control of
            neurotrophin BDNF.
REFERENCE   7  (bases 1 to 2460)
  AUTHORS   Ooe,N., Motonaga,K., Kobayashi,K., Saito,K. and Kaneko,H.
  TITLE     Functional characterization of basic helix-loop-helix-PAS type
            transcription factor NXF in vivo: putative involvement in an 'on
            demand' neuroprotection system
  JOURNAL   J Biol Chem 284 (2), 1057-1063 (2009)
   PUBMED   19001414
  REMARK    GeneRIF: NXF gene could be induced in response to several
            neurodegenerative stimuli/excitations for the cell protection, and
            thus provide an 'on demand' cell-protection system in nervous
            tissue
REFERENCE   8  (bases 1 to 2460)
  AUTHORS   Lin,Y., Bloodgood,B.L., Hauser,J.L., Lapan,A.D., Koon,A.C.,
            Kim,T.K., Hu,L.S., Malik,A.N. and Greenberg,M.E.
  TITLE     Activity-dependent regulation of inhibitory synapse development by
            Npas4
  JOURNAL   Nature 455 (7217), 1198-1204 (2008)
   PUBMED   18815592
REFERENCE   9  (bases 1 to 2460)
  AUTHORS   Moser,M., Knoth,R., Bode,C. and Patterson,C.
  TITLE     LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in
            limbic tissues and transactivates the CNS midline enhancer element
  JOURNAL   Brain Res Mol Brain Res 128 (2), 141-149 (2004)
   PUBMED   15363889
REFERENCE   10 (bases 1 to 2460)
  AUTHORS   Ooe,N., Saito,K., Mikami,N., Nakatuka,I. and Kaneko,H.
  TITLE     Identification of a novel basic helix-loop-helix-PAS factor, NXF,
            reveals a Sim2 competitive, positive regulatory role in
            dendritic-cytoskeleton modulator drebrin gene expression
  JOURNAL   Mol Cell Biol 24 (2), 608-616 (2004)
   PUBMED   14701734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB050103.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132288 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2460
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /note="neuronal PAS domain protein 4"
                     /db_xref="GeneID:266734"
                     /db_xref="RGD:628866"
     exon            1..209
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2443
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /note="bHLH-PAS type transcription factor NXF; neuronal
                     PAS4; HLH-PAS transcription factor NXF"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 4"
                     /protein_id="NP_705890.1"
                     /db_xref="GeneID:266734"
                     /db_xref="RGD:628866"
                     /translation="MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMS
                     LACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVS
                     EHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQ
                     SAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAM
                     FQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASSQHYRLLAENG
                     DIQAEMVVRLQAKHGGWTWIYCMLYSDGPEGPITANNYPISDTEAWSLRQQLNSENTQ
                     AAYVLGTPAVLPSFSENVFSQEHCSNPLFTPALGTPRSASFPRAPELGVISTSEELAQ
                     PSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPP
                     PSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEEQLTPCTSTF
                     PDQLLPSTATFPEPLGSPTHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEG
                     CSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHY
                     TEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVL
                     SLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTL
                     SPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGG
                     EPTF"
     exon            210..361
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            465..738
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            739..848
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            849..984
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2414
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2460
                     /gene="Npas4"
                     /gene_synonym="Nxf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagccgga gctggagctc cacggccggc agtcatgtac cgatccacca agggcgcctc
       61 caaggcgcgc cgcgaccaga tcaacgccga gattcggaac ctcaaggaac tgctgccgtt
      121 ggctgaagcg gacaaggtcc ggctgtccta cctgcacatc atgagtcttg cctgcatcta
      181 cactcgcaag ggtgtcttct ttgctggagg cactcctttg gctggcccca cggggcttct
      241 ctctgctcaa gagcttgaag acatagtggc agcactacct ggatttctac ttgtgttcac
      301 agctgagggg aagttgctat acctgtcgga gagtgtgagc gagcatctgg gccattctat
      361 ggtggatctg gttgcccagg gtgacagtat ttacgacatc attgaccctg ctgaccatct
      421 cactgtgcgc cagcagctca ccatgccctc tgctctggat gctgatcgcc ttttccgttg
      481 tcgatttaac acatccaagt ccctccggcg ccagagtgca ggcaacaaac tggtgcttat
      541 tcgaggtcga ttccatgctc acccacctgg ggcctactgg gcaggaaacc ccgtgttcac
      601 agctttctgt gccccactgg agccaagacc ccgtcccggc cctggccctg gccctggccc
      661 tggtcctgcc tctctcttcc tggccatgtt ccagagccgg catgctaagg acctagccct
      721 actggacatt tctgaaagtg tcctaatcta cctgggcttt gagcgcagcg aactgctctg
      781 taaatcatgg tatggactgc tacaccccga ggacctggcc cacgcttctt ctcaacacta
      841 ccgcctgttg gctgaaaatg gagatattca ggctgaaatg gtggtgagac ttcaagccaa
      901 gcatggaggc tggacatgga tttactgcat gctatactcg gatggtccag aaggccctat
      961 tactgccaat aactacccta tcagtgacac ggaagcctgg agtcttcgcc agcagctaaa
     1021 ctctgaaaac acccaggcag cctatgtcct aggaacccca gctgtgctac cctcattctc
     1081 tgagaatgtc ttctcccagg agcactgctc taatccactc tttacaccag ccctggggac
     1141 tcctagaagt gccagcttcc ccagggcccc tgaactaggt gtgatctcaa catcagaaga
     1201 gcttgcccaa ccctccaaag aactggactt cagttacctg ccattccctg caaggcctga
     1261 gccttccctc caagcagact tgagcaagga tttggtgtgt actccacctt acacacccca
     1321 ccagccagga ggctgcgcct tcctcttcag cctccatgaa cccttccaga ctcacttgcc
     1381 ccctccatcc agctctctcc aagaacagct gacgccaagc acggtgactt tctctgaaca
     1441 gttgacacca agcagtgcaa ccttcccaga tccactaacc agttcactac aaggacagtt
     1501 gactgaaagc tcagccagaa gctttgaaga acaattgact ccgtgcacct ctaccttccc
     1561 tgaccagctg cttcccagca ctgccacgtt cccagaacct ctgggtagcc ccacccatga
     1621 gcagctgact cctcccagca cagcattcca agcacatctg aacagtccta gccaaacctt
     1681 cccagagcaa ctgagcccta atcctaccaa gacttacttc gcccaggagg gatgcagttt
     1741 tctctatgag aagttgcccc caagtcctag cagccctggt aatggggact gtacactctt
     1801 ggccctagct caactccggg gtcccctctc tgtggacgtc cccctggtgc ctgaaggcct
     1861 gctcacacct gaggcctctc cagtcaagca aagtttcttc cactatacag agaaagagca
     1921 gaatgagata gatcgtctca tccagcagat cagccagttg gctcagggca tggacaggcc
     1981 cttctcagct gaggctggca ctggggggct ggagccactt ggagggctgg agcccctgaa
     2041 ccccaacctg tccctgtcag gggctggacc ccctgtgctt agcctggatc ttaaaccctg
     2101 gaaatgccag gagctggact tcttggttga ccctgataat ttattcctgg aagagacgcc
     2161 agtggaagac atcttcatgg atctttctac tccagacccc aatggggaat ggggttcagg
     2221 ggatcctgag gcagaggtcc caggagggac cctgtcacct tgcaacaacc tgtccccaga
     2281 agatcacagc ttcctggagg acttggccac ctatgaaacc gcctttgaga caggtgtctc
     2341 aacattcccc tatgaagggt ttgctgatga gttgcatcaa ctccagagcc aagttcaaga
     2401 cagcttccat gaagatggaa gtggagggga accaacgttt tgaataagtc tgtgacttaa
//
